12 results about "Biological availability" patented technology

This invention discloses an intelligent intravenous nutrition solution preparation and monitoring system, method, and storage medium, belonging to the field of medical and health technology. The invention includes determining the scope of basic disease data collection, collecting key physiological indicators of the target patient and marking them as raw physiological data to provide core data support for subsequent preparation analysis; combining raw physiological data with historical preparation record data to divide the system into a set of routine preparation areas and a set of error-prone preparation areas, using historical data as a threshold reference to achieve differentiated preparation analysis; this invention solves the problems of indiscriminate control, high misjudgment rate in complex scenarios, and delayed risk response in traditional monitoring, ensuring the chemical stability and biological effectiveness of the nutrient solution, reducing the probability of adverse reactions, achieving precise monitoring and hierarchical risk management of nutrient solution preparation, and significantly reducing the risk of human error in preparation.

The invention provides a biological medicine containing borneol liquid oil for skin diseases and a preparation method, and relates to the technical field of biological medicine manufacturing. The main points of the technical scheme are as follows: the anti-inflammatory and antibacterial borneol skin care lotion comprises the following components in percentage by weight: 5-25% of borneol liquid oil, 2.5-7.5% of an anti-inflammatory and antibacterial double-effect plant extract, 1.5-5.5% of a skin micro-ecological regulation type active substance, 1-3% of a skin barrier repairing and moisturizing type active substance, 0.5-3% of a skin antioxidant protection type active substance, 0.5-2% of a cooling, soothing, anti-inflammatory and analgesic double-effect substance and 60-75% of a special solvent for the fields of medicine and skin care. According to the skin disease biological medicine containing the borneol liquid oil and the preparation method provided by the invention, skin irritation and drug resistance risks are reduced, the bioavailability is improved, and meanwhile, the skin disease biological medicine also has the advantages of promoting skin micro-ecological regulation, resisting inflammation and bacteria synergism and realizing multi-target treatment of complex skin diseases.

The invention discloses a method for tracing organophosphorus pollution of a water body, which comprises the following steps of: investigating and surveying the water body, collecting a sample, analyzing mass spectrum, determining an enzymolysis rate coefficient, constructing an APCS-MLR model, and fundamentally correcting the model by utilizing the enzymolysis rate coefficient. The water body organophosphorus pollution traceability technology changes from molecular abundance analysis to ecological risk quantification, the goodness of fit between a model result and an on-site pollution source investigation result is greatly improved, and the problem of treatment resource mismatching caused by neglect of bio-availability difference in a traditional method is thoroughly solved. According to the method, the enzymolysis rate coefficient alpha is introduced, the ecological risk contribution proportion of organic phosphorus input by different pollution sources is accurately quantified, and the problem of source analysis distortion caused by neglecting of DOP degradation characteristics in a traditional method is solved.

The invention relates to the field of chemical medicines, and in particular relates to a crystal form of wedograssex as well as a preparation method and application of the crystal form. The compound I has a crystal form D, the XRPD pattern of the compound I has characteristic peaks at the following diffraction angles 2 theta: 3.7 + / -0.2 degrees, 7.0 + / -0.2 degrees, 15.2 + / -0.2 degrees, 15.4 + / -0.2 degrees and 23.2 + / -0.2 degrees, and further, the XRPD pattern of the crystal form D is basically shown in figure 1. The crystal form D has the advantages in at least one aspect of solubility, hygroscopicity, purification effect, stability, adhesion, compressibility, fluidity, in-vivo and in-vitro dissolution, bioavailability and the like, particularly, the stability and hygroscopicity weight gain is small, no organic solvent residue exists, the purity is high, the purification effect is good, the crystal morphology is good, and the problems existing in the prior art are solved. The compound I has very important significance on development of medicines containing the compound I.

The invention belongs to the technical field of medical detection, and discloses a method and system for quantifying the relative bioavailability of the internal irradiation dose of a nuclide drug, and the method comprises the steps: dividing the same batch of experimental animals carrying tumors into two groups, and respectively carrying out the internal irradiation of a to-be-detected treatment nuclide drug and the external irradiation of a contrast nuclide drug, radiation damage information and / or radiation response information of the two groups of experimental animals are / is obtained, then the two groups of information are compared, dose pairing is carried out, and finally the relative bioavailability of the internal irradiation dose of the to-be-detected nuclide drug is calculated. The defects that in the prior art, the biological effect of nuclide medicine internal irradiation treatment is greatly different from that of traditional external irradiation radiotherapy, and a means for effectively quantifying the relative bioavailability of the nuclide medicine internal irradiation dose is lacked are overcome. The relative bioavailability of the irradiation dose in the nuclide medicine can be accurately quantified, and a scientific basis is provided for research, development and clinical application of targeted radiopharmaceuticals.

This invention relates to the field of crystal chemistry, and more particularly to a crystalline form OA1 of ellastatin oxalate, its preparation method, pharmaceutical composition, and applications. The crystalline form OA1 of ellastatin oxalate, when subjected to Cu-Kα radiation, exhibits an X-ray powder diffraction pattern including two or more 2θ values ​​selected from the group consisting of: 8.9±0.2°, 9.6±0.2°, 12.0±0.2°, 12.7±0.2°, 18.2±0.2°, 19.4±0.2°, and 24.2±0.2°. The crystalline form OA1 of ellastatin oxalate provided by this invention offers advantages in terms of stability, hygroscopicity, melting point, process scale-up feasibility, purification effect, solubility, in vitro and in vivo dissolution, bioavailability, compressibility, flowability, formulation quality, and processing performance, providing a better option for the development of drugs containing ellastatin oxalate.

The present application relates to phosphorus chemical technology field, specifically to a kind of phosphogypsum soil conditioner in calcium, magnesium, sulfur element intelligent analysis and comprehensive evaluation system of detection, including hardware analysis module, data acquisition and processing module and intelligent evaluation core module.Hardware analysis module is used to determine the total amount of element, chemical form and sample physicochemical property;Intelligent evaluation core module is based on pre-training model, according to the form analysis result, the biological availability coefficient of element is calculated, and the comprehensive agronomic effect index and environmental adaptability index are calculated by combining environmental and crop parameters.Finally, the system outputs comprehensive evaluation report covering product performance classification, applicability diagnosis and optimization suggestion.The present application solves the problem that traditional detection method cannot associate element form and agronomic effectiveness, realizes scientific, accurate and comprehensive intelligent evaluation and application guidance of phosphogypsum soil conditioner.

The present application belongs to the technical field of zooplankton culture, and particularly relates to a culture medium for metal chronic toxicity experiment and application thereof. The culture medium provided by the present application does not contain EDTA or other chelating agents, and can also meet the normal reproduction and growth requirements of model organisms, is suitable for long-term culture of model organisms, is conducive to reducing the influence of the components of the culture medium on the bioavailability and toxicity evaluation and determination results of metals, improving the accuracy and reliability of the evaluation results, and thus more accurately determining the chronic toxicity or bioavailability of rare earth elements, and is conducive to accurately exploring the long-term ecological risk of rare earth elements, and provides a new reference approach for metal environmental standard formulation and scientific environmental decision-making.

The invention discloses a pig growth prediction method based on all-organism computing power and biochemical antagonism correction, which comprises the following steps: acquiring pig growth related data and carrying out data preprocessing to obtain a standard data set; according to the standard data set, effective net energy is calculated by adopting a host-microorganism double-track system model; according to the effective net energy, dynamically adjusting the bio-availability of the nutrients through a biochemical antagonism correction mechanism to obtain corrected nutrient data; according to the corrected nutrient data, enforced fat energy distribution logic and multi-factor limitation arbitration are executed, and the final protein deposition amount and fat deposition amount are determined; according to the final protein deposition amount and fat deposition amount, pig growth performance parameters are predicted, and a pig growth prediction result is obtained. According to the method, digital twinborn simulation and high-precision prediction of the growth performance of the pigs in a complex nutrition environment and under an atypical feeding condition are realized.

The present application relates to the chemical medicine technical field, especially to the crystal form of isoquinoline compound and preparation method and application, the present application provides the crystal form B and crystal form F of formula (I) compound, at least one of solubility, melting point, stability, dissolution, hygroscopicity, adhesion, fluidity, biological effectiveness and processing performance, purification effect, preparation, safety and so on in aspect, there is superiority, provides new and better choice for the preparation of drug preparation containing formula (I) compound, has very important significance for drug development.

The invention discloses a preparation method and application of a lignin-carbohydrate complex based gel system. Comprising the following steps: carrying out enzyme modification on a lignin-carbohydrate complex; after enzyme modification is finished, centrifugally collecting precipitate, washing the precipitate, and freeze-drying; dissolving the freeze-dried precipitate in a dichloromethane-ethanol mixed solution, stirring, centrifugally collecting the precipitate, and freeze-drying the precipitate to obtain modified LCC; dispersing the modified LCC in an oil phase; adding water into the oil phase to obtain an LCC emulsion; and adding a gelling agent into the LCC emulsion to obtain the lignin-carbohydrate complex based gel system. The lignin-carbohydrate complex based gel system disclosed by the invention has wide application prospects in the aspects of preparing health foods and medicines for improving the bioavailability of nutrients and realizing targeted release of intestinal tracts, developing healthy grease products, improving the functional activity of bioactive substances and the like.