438 results about "Oxytetracycline" patented technology

The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.

The invention discloses an abricycline molecule stamp polymer, which is characterized by the following: mixing mold fermentmycin molecule, functional monomer methacrylic acid, cross linker dimethyl acroleic acid glycol ester and trigger azobisisobutyronitrile with mass ratio at 1-5 : 2-10 : 80 : 0. 1-0. 5; polymerizing at original position; possessing 'memory' function for the spatial structure of the abricycline mold molecule; possessing high selective separating enriched property for abricycline and oxytetracycline in residue analysis sample solution; filling the product into small column of polypropene shell; getting abricycline molecule stamp solid phase extraction column.

The invention discloses a compound long-acting terramycin injection for animals and preparing method, which is characterized by the following: incorporating 50-300g supercidin, 20-60g trimethoprim or di-trimethoprim, 100-700g composite organic dissolvent, 20-100g magnesium chloride or magnesium oxide, 20-160g aminoethyl alcohol, 1g-10g anti-oxidant and surplus as injecting water. This invention possesses the advantages pf good drug effect, long operational time and low cost.

The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. The compounds precipitate in aqueous environments. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a period of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.

The invention relates to a culture method of meat rabbits. The culture method comprises the following steps: (1) making a rabbit hutch: enabling the ground height in the rabbit hutch to be 20-30cm from the ground outside the rabbit hutch, dividing the rabbit hutch into small rooms with the length being 70-80cm and the width being 60-70cm, and arranging feces supporting plates in the small rooms, wherein a door of the rabbit hutch is woody; (2) performing daily management: maintaining the temperature in the rabbit hutch to be 10-30 DEG C; simultaneously, paying attention to ventilation and air change in the hutch so as to reduce the stimulation of ammonia gas generated by feces on the rabbits; feeding each rabbit one piece of oxytetracycline once in every 2-3 months to prevent occurrence of cold and pneumonia, wherein feedstuff comprises concentrated food and forages, the feeding at high-temperature period is avoided, the preferred feeding is twice per day, i.e., in the morning and the evening, drinking water is supplied sufficiently, and a little amount of salt iodine tincture is added into the drinking water. The culture method is simple, the requirement for equipment is low, the illness rate is obviously reduced, the meat quality of the rabbits is good, and the taste is good, so that the culture method is especially suitable for large-scale culture in rural areas, especially the areas with hard conditions.

The present invention relates to a method for determining 10 kinds of antibiotics in a water environment through combination of a sample pre-treatment technology and HPLC-MS, and belongs to the field of detection of safety of trace organic contaminant residue in the water environment. The method is characterized in that a water sample is separated and enriched through combination of solid phase extraction and dispersive liquid-liquid microextraction (SPE-DLLME), and then an ultra-high performance liquid chromatography-mass spectrometry instrument (UPLC-MS / MS) is adopted as a detection tool to directly determine the contents of 10 kinds of common antibiotics in the water environment (drinking water, tap water, river water, sewage treatment plant influent and effluent), wherein the 10 kinds of the common antibiotics respectively are sulfadiazine, sulfamethoxazole, oxytetracycline, tetracycline, doxycycline, ciprofloxacin, levofloxacin, chloramphenicol, cefuroxime axetil and tinidazole. According to the present invention, the water sample pre-treatment method and the instrument detection conditions are investigated and optimized, and the optimal SPE-DLLME-UPLC-MS / MS method is established and is successfully applied for the real sample determination; and compared with the traditional method, the method of the present invention has advantages of high sensitivity, high extraction recovery rate, wide application objects, environmental protection, and the like.

The invention relates to a method for removing oxytetracycline in biological medicine waste residues. The steps of pretreatment, catalytic oxydative degradation, bacterium inactivation, neutralizing treatment and the like are adopted, and an organic matter waste residue product containing no oxytetracycline can be formed after drying and can be used for preparing subsequent soil conditioners and organic and inorganic compound fertilizer. Compared with the prior art, purchase, use and management are easy, and hydrogen peroxide is convenient to use; and the method is used for treating the biological medicine waste residues, the oxytetracycline waste residue cost is low, the treatment process is fast, environment-friendly and small in harm, finally, the biological medicine waste residues are used as raw materials of the organic fertilizer or the soil conditioners, and the utilization value is high.

The invention provides a method for removing oxytetracycline from livestock and poultry breeding wastewater by biomass charcoal of straws. The method comprises the following steps of: adding biomass charcoal into aqueous solution containing the oxytetracycline and Cu<2+> according to the solid-liquid ratio (g / mL) of (1:50)-(1:100), adjusting the pH to 3.5-7.5, and stirring for 24-48 hours. According to the method provided by the invention, the agricultural straws are used as a raw material to prepare the biomass charcoal so as to realize reasonable and effective utilization of the agricultural waste, so the method is not only low in cost, but also is environment-friendly. The rate of adsorbing and removing the oxytetracycline from the aqueous solution by the biomass charcoal at 600 DEG C is highest; when the initial concentration is lower than 92mg / L, both the adsorption rate and the removal rate can be above 92%; while with respect to the biomass charcoal at 300 DEG C, the removal rate of the oxytetracycline is relatively low, but under the synergetic promotion of the Cu<2+>, the adsorption removal rate can be increased above 99%, the Cu<2+> can be adsorbed and the Cu<2+> concentration in the treated wastewater can be controlled to be lower than 0.2mg / L at the same time to meet the surface water II grade and the irrigation water quality standard.

The invention belongs to the field of environmental technology and water treatment and specifically relates to a preparation method of a catalyst for photocatalytic degradation of antibiotic, a catalyst prepared by the method and application of the catalyst for photocatalytic degradation of antibiotic. The catalyst is anatase-phase banded-structure nanocrystal titanium dioxide exposing the crystal face {100}, and is synthesized by a homogeneous hydrothermal reaction and a calcination technology. The catalyst shows outstanding photocatalytic degradation performance on the photocatalytic degradation of broad-spectrum antibiotic medicines such as oxytetracycline, tetracycline hydrochloride, amoxicillin, norfloxacin and enrofloxacin. The catalyst has the characteristics of high activity, stable performance, easiness in separation, no toxicity and the like; the synthesis technology is pollution-free; the catalyst has a broad application prospect while the antibiotic medicine pollution is increasingly severe.

The invention discloses an application of a Pd catalyst in a hydrogenation process for producing doxycycline, belonging to the field of pharmaceutical chemistry synthesis. The method is as follows: based on polyvinyl chloride-polyethylene polyamine-loaded palladium complex (pvc-pp-Pd) used as a catalyst, and 11 alpha-chlorine-6-methylene oxytetracycline or 11 alpha-chlorine-6,12-hemiketal oxytetracycline or metacycline or salts thereof used as raw material, introducing hydrogen, stirring and reacting, filtering, adding sulfo-group salicylic acid to filtrate so as to form salt; and cooling, filtering, washing and drying so as to obtain alpha-6-deoxytetracycline sulfo-group salicylic acid salt, wherein the yield is higher than 90%, the content of the corresponding beta-6-deoxytetracycline sulfo-group salicylic acid salt isomer is less than 1%. The method has the advantages of mild reaction conditions, good reaction directionality and less side reactions; a toxic agent is not required inthe hydrogenation process, and pollutant emission is reduced, thereby being beneficial to protecting the environment; and the catalyst can be recycled, and production cost is reduced, thereby extremely being beneficial to industrial production.

The invention discloses a feed special for a low-fat meat duck without antibiotic and fishy smell, which consists of the following components by weight percentage: 10-25 of lactobacillus fermented material and 75-90 of main material, wherein the lactobacillus fermented material consists of the following raw materials: cotton dregs, rapeseed dregs, bran, peanut meal, maize and lactobacillus fermented liquid; and the main material consists of the following raw materials: bean dregs, maize protein powder, orexin and growth promotion agents, de-fishy agents, stone dust, calcium hydrophosphate, trace elements and maize flour. 10-25 percent of the obtained lactobacillus fermented material is taken according to the percentage of the total weight of the feed for bagging, and 75-90 percent of the obtained main material is taken according to the percentage of the total weight of the feed for packing after bagging, thus the feed special for the meat duck is prepared. The duck fed by the feed which is prepared by uniformly mixing the lactobacillus fermented material and the main material has pork type meat quality, abundant muscles, less fat and high protein content, is inspected to have no chloromycetin, terramycin, aureomycin and sulfanilamide medicaments by the national meat product supervision and inspection center and completely reaches a non-antibiotic standard and meets the requirement of food security of the European Union.

The invention discloses a method for detecting a trace amount of oxytetracycline by utilizing a CdTe quantum dot fluorescent probe. According to the invention, CdTe quantum dots are taken as the fluorescent probe, and oxytetracycline and CdTe quantum dots are utilized to be combined to form a new composite system through electrostatic interaction to cause the quenching of fluorescent light of CdTe quantum dots, so that a method for detecting the trace amount of oxytetracycline is established. A favorable linear relation is formed by the quenching amount of fluorescent light of CdTe quantum dots and the concentration of gibberellin within the concentration range of 8*10<-9>-2*10<-7> mol / L, and the detection limit of the method is 2.72*10<-10> mol / L. According to the invention, defects of low sensitivity, long reaction time, poor stability and narrow application range during detecting in the prior art are overcome, the sensitivity and selectivity are better improved, and the detection to the low-concentration oxytetracycline is more convenient and faster.

The invention provides an oxytetracycline SERS detection method based on nanomaterial self-assembly. The oxytetracycline SERS detection method is used for detecting content of oxytetracycline (OTC) in aquatic products such as fish meal. According to the OTC SERS detection method, gold nanoparticles (80 nm particle size) are connected with gold nanoparticles (15 nm particle size) through a base sequence containing OTC aptamers, and 4-mercaptobenzoic acid is incubated on the surfaces of the gold nanoparticles, thereby generating Raman signals. When the OTC is in contact with a detection system, the OTC aptamers are in specific binding with the OTC, thus the distance between the 80nm gold nanoparticles and the 15nm gold nanoparticles is reduced, the hotspot is enhanced, and the Raman signals are enhanced, thereby achieving the detection purpose. The detection system can detect the oxytetracycline quantitatively, the linearity range is from 0.046 to 460 fg / mL, and the detection limit is 0.004 fg / mL. The oxytetracycline SERS detection method used for oxytetracycline detection has the advantages of being high in sensitivity and being fast and convenient, can be applied to detection of samples such as fish meal, and is accurate and reliable in result.

The invention relates to a preparation method of a molecularly imprinted polymer which can distinguish terramycin and enrofloxacin base in the biochemistry engineering technology field. The method has the following steps: terramycin, enrofloxacin base, metallic ions, methacrylic acid and ethylene glycol dimethacrylate are mixed according to the mol ratio of 0.2-1: 0.6-1:1:2-10:20, and then dissolved in a porosity-making agent and added with an evocating agent azodiisobutyronitrile; the mixed liquor is placed in an ampere bottle and charged with nitrogen; the mouth of the ampere bottle is sealed under the protection of nitrogen; the water bath heat preservation reaction is carried out; after the synthetic polymer is stirred and scattered, kernels with the grain diameter of 0.1-1.5 Mum are obtained and subtle kernels are removed; the Soxhlet extraction is carried out; and the polymer which is gotten rid of template molecules is dried and stays the night, and the molecularly imprinted polymer is obtained. The polymer prepared by the method can be applied to the detection of residual terramycin and enrofloxacin base in the high water content environment or organism samples, and the enrichment of trace analytes and the removal of the matrix.

The invention relates to a method for preparing a veterinary oxytetracycline-artemisinin injection and clinical application of the veterinary oxytetracycline-artemisinin injection. Raw materials of the injection mainly comprise oxytetracycline, artemisinin, trimethoprim, flunixin meglumine, magnesium oxide or magnesium chloride, an antioxidant, a pH regulator, a compound organic solvent and water. As a veterinary compound preparation, the veterinary oxytetracycline-artemisinin injection is mainly used for treating infectious diseases and secondary infection which are caused by sensitive gram positive bacteria and negative bacteria, eperythrozoon, rickettsia and mycoplasma. The method for preparing the veterinary compound oxytetracycline-artemisinin injection is simple, the production process is mild, the chelating temperature is low, the stability is high, and the injection is convenient to use and is suitable for industrialized production.

A terramycin injection composition has long pharmacodynamic action time, wherein each unit of the terramycin injection composition contains 30% terramycin free alkali, 2%-3% magnesium compound, 30%-50% 2-ketopyrrolidine, 5%-20% propylene glycol, 5%-20% glycerol formal, 1%-5% moderator and the rest is water for injection. The invention prolongs pharmacodynamic action time of terramycin, decreases possibilities of pain, swelling, tissue stimulation and tissue necrosis at the injection sites of animals and improves stability of terramycin at high temperature.

The invention discloses a production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid. The production technology comprises the following steps of: (1) fermenting; (2) acidizing and filtering; (3) decoloring and crystallizing; (4) drying, mixing and packaging to prepare an oxytetracycline dihyclorate product, wherein the step (2) is as follows: acidizing a fermentation liquor, namely adding oxalate to the fermentation liquor prepared in the step (1) to adjust the PH value of the fermentation liquor to 2.10-2.20; and then adding hydrochloric acid to the fermentation liquor, and adjusting the PH value of the fermentation liquor to 1.80-2.0. The production technology has the advantages that adjustment is carried out by an extraction and acidification process; the production cost of a company is greatly reduced by the hydrochloric acid and the oxalate; the purchasing cost of raw materials is reduced; the production cost can be saved by **-** each month; the production cost is reduced; and the market competitiveness of an enterprise is improved.

The invention discloses a method for detecting oxytetracycline (OTC) in food by virtue of a functional magnetic bead separation-enzyme linked aptamer. The method is characterized by comprising the following steps: with a nucleic acid aptamer-magnetic nanoparticle composite probe, binding an OTC aptamer on the surface of a magnetic bead through direct competition between HRP-OTC and OTC in a sample, and detecting the change of a light absorption value through substrate chromogenic assay so as to quantitatively analyze the content of OTC in a sample. Compared with conventional enzyme-linked immuno sorbent assay (ELISA) and enzyme linked aptamer (ELAA), the method disclosed by the invention achieves the full combination of the rapid separation and enrichment effects of magnetic nano material, the high specificity of a nucleic acid aptamer and the high-throughput screening characteristic of an ELISA plate, so as to greatly shorten detection time, improve detection sensitivity and specificity and reduce detection cost.

The invention provides an animal nutrition pelletized feedstuff and preparation method thereof, wherein the feed stuff is prepared from rice straw stem, maize stalk, banana stems, red radish, soya bean waste, pachyrhizus, cassava, sugar-cane, rank grass, beef-wood, oxytetracycline, honeysuckle flower, wild chrysanthemum flower, erythrocin, lycine, banthionine, threonine, yeasts, sea fish meal, and fresh water fish.

The invention discloses a method for preparing an injection-grade oxytetracycline, which mainly comprises the following steps: directly dissolving the active pharmaceutical ingredient oral-grade oxytetracycline, and decolorizing with activated carbon to remove impurities; and converting oxytetracycline salt into oxytetracycline alkali without adding any flocculant, carrying out vacuum drying and the like. The technical process disclosed by the invention is simple and convenient to operate, and achieves the standard for injection-grade oxytetracycline; and the yield is enhanced by more than 5% as compared with the traditional technique.

The invention provides a preparation method of doxycycline hydrochloride. The preparation method provided by the invention comprises the following steps: carrying out hydrogenation reaction on 11a-chloro-6-methenyloxytetracycline p-toluenesulfonate under the conditions of a catalyst and a toxic agent; then reacting with sulfosalicylic acid to obtain alpha-6-deoxytetracycline sulfosalicylate; afterreacting with a hydrogen chloride-ethanol solution, adding and stirring to separate out a crystal, so as to obtain the doxycycline hydrochloride, wherein the toxic agent contains a mixture of an organic matter containing sulfur and an organic matter containing nitrogen. According to the method provided by the invention, the yield and stereoselectivity of the doxycycline hydrochloride can be improved and high-quality crude drugs are obtained.

The invention provides a method for simultaneous determination of multiple nutrient compositions and antibiotic titer changes by using near infrared spectroscopy during a production process of antibiotics from microbial fermentation. The method comprises the following steps: spectrums of antibiotic (including aureomycin, terramycin, neomycin and other fermentation type antibiotics) fermentation liquor in different fermentation periods are acquired by using the near infrared spectroscopy technology; each acquired sample is detected by a chemical method, and physical and chemical data of multiple nutrient composition contents and antibiotic titer changes are obtained; the acquired near infrared spectrums as well as the physical and chemical data are fitted for establishing a model. After verification, the model is suitable for detecting nutrient composition contents and antibiotic titer changes in antibiotic fermentation liquor in different periods. The method is used for rapidly feeding back and understanding fermentation cases, timely carrying out nutrition supplement and process control, and monitoring antibiotic titer changes; the whole detection process is highly efficient and saving without pollution.

The invention discloses a preparation method and application of an antibiotic composite adsorbent, aiming at the problem that a great amount of antibiotics exists in pharmaceutical wastewater. The preparation method of the antibiotic composite adsorbent comprises the following steps: mixing reproducible raw material, namely grapefruit peel and flesh with cheap natural mineral bentonite, and heating intensely in a tubular furnace insulated with air by adopting a high-temperature solid phase method; and then compounding a composite adsorbent by a saline solution impregnating method. Taking example for three most commonly seen antibiotics of oxytetracycline, tetracycline and amoxicillin, the prepared composite adsorbent has excellent adsorption effect. Compared with the prior art, the preparation method and the application have the advantages that the used raw material grapefruit peel and flesh are agricultural reproducible wastes; the raw material bentonite is low in price and is easily available; the preparation technology is simple, and can achieve industrial production so as to achieve the aim of reducing waste by waste.

The invention discloses a preparation method of a filter medium for removing oxytetracycline in drinking water. The preparation method is characterized by comprising the following steps of: (a) mixing raw materials including high molecular weight polyethylene powder, mesoporous molecular sieve powder, activated carbon power and a gas generation agent, wherein the mesoporous molecular sieve powder has specific surface area of 1200m<2> / g, the aperture of 2-20nm and the pore volume of 0.5-1.5cm<3> / g, and the weight ratio of the high molecular weight polyethylene powder to the mesoporous molecular sieve powder to the activated carbon power to the gas generation agent is (100-300):(100-250):(80-110):(50-110); and (b) pressing the obtained mixture in the die, sintering and cooling. In the raw materials, the high molecular weight polyethylene powder not only can be used as a framework of the filter medium, but also has favorable adsorption capability; and the mesoporous molecular sieve powder has larger specific area, aperture and pore volume and favorable adsorption effect for the oxytetracycline in water. By detecting, the removing rate of the filter medium for the oxytetracycline in water reaches over 90 percent.

The invention discloses a preparation method of a fluorescent probe and an oxytetracycline detection method based on the same. The oxytetracycline detection method includes that the fluorescent probe high in water solubility is synthesized by structurally modifying a fluorine-boron fluorescent dye master ring; on the basis that oxytetracycline has good and high-sensitivity fluorescence quenching effect on the probe, a linear formula is built according to changing values of fluorescent strength of the fluorescent probe and concentration of acid oxytetracycline before and after an oxytetracycline standard solution is added; the fluorescent strength of the probe before and after an oxytetracycline sample is added is detected in same conditions, and then content of oxytetracycline in the sample can be calculated according to changing of the fluorescent strength. Related toxic reagents are avoided being used, expensive instruments do not need to be used, detection time is shortened, detection sensitivity and specificity are improved, and the oxytetracycline detection method has good application prospect.

The invention belongs to the technical field of environmental monitoring, and relates to a method for detecting oxytetracycline fluorescence based on surface passivated and DNA covalent coupling modified metal organic skeleton nanosheets. The covalent coupling of the surface of the two-dimensional MOF nanosheets with DNA effectively utilizes the limited adsorption sites on the surface of the MOF nanosheets to enhance the ability of the nanosheets to adsorb DNA molecules and reduce the background fluorescence signal. At the same time, the use of short-chain DNA molecules as signal reporter molecules effectively improves the efficiency of fluorescence recovery, and the addition of surface passivator sodium polystyrene sulfonate in the reaction system further weakens the adsorption capacity of nanosheets to signal reporter molecules, thereby making the MOF nanosheet sensor improve the linear response to low-concentration OTC and enhancing the detection performance of the OTC. The detection method provided by the invention can effectively reduce the fluorescence background value, improve the signal response value induced by the target, and effectively improve the detection performanceof the oxytetracycline on the fluorescence sensing platform constructed based on the physical adsorption principle.

The invention relates to a method for preparing a standard substance for detecting antibiotics in cosmetics. The standard substance is formed by mixing aqueous solution of the antibiotics or solution of propylene glycol and cosmetic cream, wherein the cosmetic cream comprises the following components in percentage by weight: 73 to 78 percent of de-ionized water, 3 to 3.5 percent of propylene glycol and 0.2 to 0.25 percent of carbomer in phase A, 4.5 to 5 percent of stearate, 3 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of 26# white oil in phase B and 1.2 to 1.25 percent of phenoxyethanol and ethylhexylglycerin in phase C; and the concentration of the antibiotics in the standard substance reaches 0.1g / 100mL. The method has the advantages that: the antibiotics and the cosmetic cream are mixed to form the standard substance for detecting the antibiotics such as minocycline hydrochloride, oxytetracycline dehydrate, tetracycline hydrochloride, chlortetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol in the cosmetic; and the standard substance is the same as a sample of the cosmetic containing the antibiotics in the actual use; thus the detection of the antibiotics in the cosmetic conforms to the state of the actual application better and is more accurate.

The invention discloses a preparation and use method of a ratio fluorescent probe for visual distinguishing detection. The preparation method specifically comprises the following steps: step 1, preparation of silicon-based carbon quantum dots; step 2, preparation of the nano mesoporous molecularly imprinted material coated with the silicon-based carbon quantum dots; step 3, performing surface modification on the nano mesoporous molecularly imprinted material; and step 4, preparing the ratio fluorescent probe based on the nano mesoporous molecularly imprinted material. The use method comprises the following steps: (1) diluting tetracycline or oxytetracycline into solutions with different gradient concentrations; (2) dispersing the prepared ratiometric fluorescent probe based on the nano mesoporous molecularly imprinted material in ultrapure water; (3) adding a Tris-HCl buffer solution with the pH value of 8 into a quartz cuvette, uniformly mixing the Tris-HCl buffer solution and the solution, and respectively dropwise adding the tetracycline solution or the oxytetracycline solution in the step (1) for fluorescence determination; the main substrate is the silicon dioxide molecular imprinting layer with the mesoporous structure, the method is reliable, mass production can be carried out, and the probe is widely applied to the society.

The invention provides a specific beriberi medicament, which is mainly prepared from the following raw materials in portion by weight: 3 to 12 portions of calcined alum, 1 to 4 portions of almond, 0.25 to 1 portion of metronidazole tablet, 0.15 to 1 portion of nystatin tablet, 0.15 to 1 portion of furazolidone tablet, 0.25 to 1 portion of oxytetracycline tablet, 0.15 to 1 portion of vitamin B1 tablet, 0.25 to 1 portion of vitamin B2 tablet, and 10 to 30 portions of clotrimazole cream. The medicament takes antibacterial medicaments as main ingredients, and can kill bacteria and fungi which cause the beriberi; the adding of vitamin B complex and vitamin C aims to repair wound surfaces, promote the healing, and ensure that the skin restores to normal more quickly; the calcined alum ensures that medicament application positions keep relatively dry; the almond relieves internal heat; various components supplement each other, can quickly and effectively treat the beriberi, and enables patients to recover; and at the same time, the medicament also has better efficacies in treating sole sweating and foot odor.