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Compsns. of thymopentin and interferon

A technology of interferon and composition, which is applied in the field of adjuvant treatment of hepatitis B and tumors, and can solve problems such as shedding of rubber particles, increase of infusion particles, and increased chance of bacterial infection

Active Publication Date: 2006-09-20
SINOPHARM A THINK PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the injection is dispensed, the needle inserted into the bottle stopper may cause the rubber particles to fall off, the infusion particles will increase, and the chance of bacterial infection will increase

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Take an appropriate amount of interferon α-2b, dissolve it in water for injection, measure the content, add water for injection to make a solution of 2 million IU / ml, and take an appropriate amount of thymopentin and dissolve it in water for injection to make a solution of 2 mg / ml. The two are mixed according to the ratio of 1:1, and after adding appropriate auxiliary materials, the volume is constant to make a solution containing 1 million IU of interferon α-2b per milliliter and 1 mg of thymopentin, and divide it into 1 ml per bottle. Freeze drying yields the final product.

Embodiment 2

[0038] Weigh an appropriate amount of interferon α-2b, dissolve it in water for injection, add appropriate excipients, decolorize, filter, measure the content, add water for injection to make a solution of 2 million IU / ml; in addition, take an appropriate amount of thymopentin and dissolve it in water for injection , add appropriate excipients, decolorize, filter, measure the content, add water for injection to make a solution of 2mg / ml, mix the two according to the ratio of 1:1, add water for injection to make a solution containing interferon α per milliliter -2b is a solution of 1 million IU containing 1 mg of thymopentin, divided into 1 ml per bottle, and freeze-dried to obtain the final product.

Embodiment 3

[0040] Weigh an appropriate amount of interferon α-2b, dissolve it in water for injection, add appropriate excipients, decolorize, filter, measure the content, add water for injection to make a solution of 6 million IU / ml; in addition, take an appropriate amount of thymopentin and dissolve it in water for injection , add appropriate excipients, decolorize, filter, measure the content, add water for injection to make a solution of 2mg / ml, mix the two according to the ratio of 1:1, add water for injection to make a solution containing interferon α per milliliter -2b is a solution of 3 million IU containing 1 mg of thymopentin, divided into 1 ml bottles, and freeze-dried to obtain the final product.

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PUM

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Abstract

A composition used to prepare the medicine for treating viral disease, especially the viral hepatitis B, and tumor is prepared from themopeptide-5 (TP-5) and an interferon. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a composition of thymopentin and interferon, which can be used for the treatment of viral diseases, especially for the treatment of viral hepatitis, especially hepatitis B, and can also be used for the adjuvant treatment of tumors . Background technique: [0002] Interferon (IFN) is currently one of the two main drugs for the treatment of hepatitis B (the other is lamivudine), and its curative effect is definite. It mainly improves the immune response of the body through a series of endogenous biological reactions, promotes The body's clearance of exogenous viruses. According to the different producing cells and physiological functions, it is divided into families and subtypes such as IFNα, IFNβ, IFNγ, and IFNω. [0003] Chronic hepatitis B virus (hereinafter referred to as HBV) is divided into three consecutive stages in immunopathology, that is, the immune tolerance period of high replication, the immune clearance period o...

Claims

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Application Information

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IPC IPC(8): A61K38/21A61K38/08A61P35/00A61P31/12
Inventor 王淑娟贾志丹朴志松王振国
Owner SINOPHARM A THINK PHARMA
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