43 results about "Immune clearance" patented technology

The invention relates to bio-pharmaceutical engineer technology domain. At present, the therapeutic drugs for HBV infection mainly depend on IFN-Alpha and nucleotide analog, which can not kill virus thoroughly with worse remote therapeutic effect. The invention provides a cytotoxic T cell epitope vaccine for hepatitis B, comprising a fused polypeptide formed by connecting 21 CTL epitopes selectedfrom CTL epitopes data of HBV antigen and two universal epitopes of auxiliary T lymphocyte. Saccharomyces Serevisiae is selected to express the fused antigen and mixes with immunologic adjvant. The said vaccine can activate and enhance the cellular immune response of patient with chronic HBV infection. The vaccine can also promote the immune elimination of HBV, and can be used for treatment of chronic hepatitis B.

The invention discloses an antigen peptide combination related to liver cancer driver gene mutation. The liver cancer driver genes are NFE2L2, PREX2 and ZFHX3; the sequences of the antigen peptide combination are as shown in SEQ ID NO.7, SEQ ID NO.14 and SEQ ID NO.15; according to the application of the antigen peptide combination, the antigen peptide combination is used for inducing generation of specific cytotoxic T cell clone; the antigen peptide combination has high affinity with MHC I molecules on DC cells, can effectively stimulate and induce generation of specific cytotoxic T lymphocytes, can be used for immune clearance of tumor cells with driver gene mutation related to liver cancer, and has good treatment potential.

The invention discloses antigen peptides related to lung cancer driver gene mutation. The sequences of the antigen peptides are SEQ ID NO.5, SEQ ID NO.9 and SEQ ID NO.24; according to the application of the antigen peptide, the antigen peptide is used for inducing generation of specific cytotoxic T cell clone; the antigen peptide has high affinity with MHC I molecules on DC cells, can effectively stimulate and induce generation of specific cytotoxic T lymphocytes, can be used for immune clearance of tumor cells with lung cancer related driver gene mutation, and has good treatment potential.

The invention relates to a bionic magnetosome loaded with siRNA and a preparation method of the magnetosome, and belongs to the field of chemistry and biomedicine. According to the bionic magnetosome, water-soluble MNC serves as the kernel and is wrapped by a white cell membrane, and siRNA is loaded between the MNC and the white cell membrane; antibodies or peptides with modifying groups can be coupled outside the white cell membrane of the bionic magnetosome in a covalence mode. By preparing MNC, M and MNC:siRNA and mixing an MNC:siRNA solution, an M solution and a buffer solution, the bionic magnetosome is obtained; the white cell membrane of the bionic magnetosome is modified by the peptides or antibodies through the modifying groups, and the bionic magnetosome coupled with the antibodies or peptides is obtained. The MNC in the bionic magnetosome has positive charges, can adsorb siRNA and is wrapped by M for bionics, a focus is reached efficiently and rapidly, and meanwhile immune elimination of organisms is avoided.

The invention discloses an antigenic peptide related to mutations of esophageal cancer driver genes. The esophageal cancer driver genes are MUC1 and PREX2; the sequences of the antigenic peptide are SEQ ID NO.3 and SEQ ID NO.11; the application of the antigenic peptide is to The antigenic peptide is used to induce the production of specific cytotoxic T cell clones; the antigenic peptide has a high affinity with MHC I molecules on DC cells, and can effectively stimulate and induce the production of specific cytotoxic T lymphocytes, which can be used to fight esophageal cancer The immune clearance of tumor cells with mutations in related driver genes has good therapeutic potential.

The hydrogen peroxide-responsive multifunctional liposome and its preparation method and application of the present invention belong to the technical field of nanomaterials. The hydrogen peroxide-responsive multifunctional liposome is composed of phosphatidylserine and double-block polymerization Polyethylene glycol-polypropylene sulfide is jointly constituted; its preparation method comprises the steps of preparation of PEG-PPS and preparation of hydrogen peroxide-responsive multifunctional liposomes. The bimodal probe FITC-SiO was coated with the described hydrogen peroxide-responsive multifunctional liposome 2 @Fe 3 o 4 It can be applied to in vivo imaging; coating anti-atherosclerotic drugs with hydrogen peroxide-responsive multifunctional liposomes can be used for drug release in vivo. In the present invention, biodegradable polyethylene glycol is conjugated to the outer surface of liposomes to produce stealth carriers to prevent immune clearance; at the same time, traditional polyethylene glycol is specially modified to retain biocompatibility Capable of releasing imaging agents or drugs in response to hydrogen peroxide.