108 results about "D-mannitol" patented technology

A stabilized human monoclonal antibody preparation containing 1 to 20 mg of D-mannitol per 1 mg of a human monoclonal antibody. This preparation is excellent in stability in a solution state, a freeze drying state and a freezing state, particularly stability against aggregation and precipitation of the human monoclonal antibody at the time of redissolution after freeze drying.

According to the present invention, provided are an intraorally rapidly disintegrable tablet which comprises D-mannitol and a disintegrator in addition to fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent; a process for producing an intraorally rapidly disintegrable tablet which comprises mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, and subjecting the material to compression molding; and an intraorally rapidly disintegrable tablet which is prepared by mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, subjecting the material to compression molding.

The invention discloses plukenetia volubilis linneo health-care nougat. The nougat comprises maltose syrup, white granulated sugar, ovalbumin, plukenetia volubilis linneo powder, diglycerol fatty acid ester, D-mannitol, banana resistant starch, trehalose, plukenetia volubilis linneo oil, edible essence, Pu-Er raw tea extract and water. The nougat is prepared by the following steps of: extruding plukenetia volubilis linneo kernels by a cold press to prepare the plukenetia volubilis linneo oil, crushing plukenetia volubilis linneo dregs into the plukenetia volubilis linneo powder by a low-temperature liquid nitrogen crushing technology, preparing the banana resistant starch by a spray drying technology, and mixing and boiling the nutrients including the trehalose, the plukenetia volubilis linneo oil, the plukenetia volubilis linneo powder, the banana resistant starch and the Pu-Er raw tea extract and other accessories. The nougat is stable in preservation, delicate in mouthfeel during eating, moderate in toughness, non-sticky, high in sweetness and low in calorie, has less possibility of softening, has the effects of clearing free radicals in body, improving the immunity of organism, regulating the level of blood sugar and the like, can prevent human osteoporosis and promote proliferation of human bifidobacteria, and is beneficial to gastrointestinal health.

The present invention relates to fast water-dispersible tablets containing domperidone for oral administration. The formulations comprise domperidone or pharmaceutically acceptable salts thereof, about 60-80% of a “auxiliary” granulate (w/w), and about 10-30% of microcrystalline cellulose (w/w), expressed in relation to the total weight of the tablets, a sweetener, a flavouring agent and a lubricant. The “auxiliary” granulate is obtained by wet granulation of D-mannitol and maize starch gum in a high shear granulator, it facilitates the flowability and the compressibility of the mixture and, because of its high solubility in water, contributes to the fast dispersion of the tablet. The formulations have an enhanced structural integrity, for instance having a friability lower than 1.0% and hardness values between 3 and 6 Kp, and are able to disperse in water within 3 minutes, preferably within 2 minutes and most preferably within 1 minute, to provide a dispersion that passes through a 710 μm diameter mesh size sieve and presents a pleasant taste and the absence of perceptible granules in the mouth. This invention also refers to the process for the preparation of said pharmaceutical preparations.

The invention discloses a phase-change microcapsule composition material and a preparation method thereof. The material is a microcapsule of a core-wall structure and consists of a core material (1) and a wall material (2), wherein the core material is one or some of phase-change materials, namely, MgCl2.6H2O and Mg(NO3)2.2H2O and D-mannitol; the wall material is one or some of polystyrene, polymethyl methacrylate, urea resin and polyacrylonitrile or a composition material of the high-molecular polymer above and graphene; the core material (1) is 35 to 85% by mass based on the total mass of the microcapsule composition material, and the wall material (2) is 15 to 65% by mass based on the total mass of the microcapsule composition material; the phase-change point of the prepared phase-change microcapsule composition material is between 100 to 200 DEG C, and the particle size is 3 to 4 microns. The prepared phase-change microcapsule composition material is good in wrapping rate, high in sealing performance, high in phase-change latent heat, small in raw material cost, and simple in preparation process.

The invention concerns improved sugar-free products, their production and use, in particular, coated products, their production and use. The products are characterized by their content in enriched mixtures of 1-O-α-D-glucopyranosyl-D-mannitol (1,1-GPM) and 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS).

The invention discloses a procyanidin capsules and a process for manufacturing the same. The capsules are manufactured by taking procyanidin and astragalus polysaccharide as main materials and caseinphospho peptides or D-mannitol, magnesium stearate and gelatin as auxiliary materials. The capsule has the advantages of being conveniently taken, avoiding absorbing moisture and having functions of immunoregulation, anti-ageing and radiation hardening, protecting cardiovascular health by removing free radicals in vivo, and preventing crosslinking of skin collagens, inhibiting pigmentation, dispelling wrinkles and whitening the skin, keeping skin elasticity and delaying ageing.

The invention concerns improved sugar-free products, their production and use, in particular, coated products, their production and use. The products are characterized by their content in enriched mixtures of 1-O-α-D-glucopyranosyl-D-mannitol (1,1-GPM) and 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS).

The invention provides a pharmaceutical composition for improving sleeping. The pharmaceutical composition contains the following raw material components: nepenthe, inulin, D-mannitol, lotus seeds, roses, spina date seeds, gastrodia elata, American ginseng, lucid ganoderma, stigma croci, gamma-aminobutyric acid, phosphatidylserine, taurine andcalcium glycinate, and the raw materials generate a mutual synergistic effect and a common effect at a specific proportion, so that the sleeping improvement effect is achieved; and ultrafine powder is easily absorbed by a human body, so that the bioavailability is high. Clinical statistical materials show that a pharmaceutical preparation provided by the invention has a remarkable effect on the improvement of sleeping, has no toxic or side effect, andis very high in safety, simple in constitution, relatively low in cost and convenient and fast to use.

The invention discloses the compounding method for hydrochloric acid Gemcitabine. It uses D-mannitol as raw material and takes the processes of hydroxyl protection, oxidation, and addition of reformatsky, hydroxy benzoylation, hydrolysis, hydroxyl sulfonylation, ring closure, carbonyl reduction, hydroxyl sulfonylation, condensation, hydrolysis and crystallization to gain hydrochloric acid Gemcitabine. It has the advantages of high yield, simple operation, and is suitable to industrial producing.

A tablet candy comprising endothelium corneum gigeriae galli, hawthorns and malts and a preparation method of same. The tablet candy is prepared from, by weight, 1-5 parts of an extract of endothelium corneum gigeriae galli, 5-15 parts of an extract of hawthorns, 5-15 parts of an extract of malt, 10-20 parts of an extract of Chinese yam, 2-10 parts of an extract of jujube, 1-5 parts of an extract of pericarpium citri reticulatae, 15-25 parts of maltodextrin, and 40-80 parts of D-mannitol. The tablet candy is prepared from various natural plant extracts, has a refreshing taste, and has the effects of fortifying stomach to promote digestion and treating deficiency of the spleen and stomach and dyspepsia.

An oral disintegrating tablet containing (1) D-mannitol, (2) an active ingredient, (3) one or more disintegrating agents selected from the group consisting of crospovidone and carmellose, and (4) one or more lubricants selected from the group consisting of sodium stearyl fumarate and sucrose esters of fatty acids. The oral disintegrating tablet of the present invention has some excellent properties of (1) allowing easy production in a common facility without necessitating a specialized pharmaceutical technique, (2) having an appropriate strength that does not breakdown in the process of distribution, (3) having a fast disintegrating ability in the oral cavity, and (4) also having excellent ingestion feel such as greatly reduced bitterness or gritty feel; therefore, the tablet can be suitably used as a dosage form that is suitable for aged individuals, children, and seriously ill patients.

The invention discloses a preparation method for 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribono-gamma-lactone. The preparation method comprises the following steps: subjecting a starting raw material D-mannitol to acetone protection and sodium periodate oxidation; then subjecting the treated D-mannitol and a self-made ylide reagent to the Witting reaction; then carrying out selective oxidation by using an aqueous sodium permanganate solution; then successively carrying out sulfonylation, fluorination with potassium fluoride, and ring closing with a concentrated protective group protective group; protecting the hydroxyl group by using benzoyl chloride; and then carrying out purification so as to obtain the final product 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribono-gamma-lactone. The preparation method provided by the invention uses easily available and cheap raw materials, so production cost is greatly reduced; and the operation of the preparation method is coherent and simple, and the quantity of waste gas, waste water and industrial residues is lower than the quantity of waste gas, waste water and industrial residues reported in the prior art.

The invention discloses astaxanthin and hippophae rhamnoides fruit powder tabletting sweets and a preparation method thereof. The tabletting sweets are prepared from the following raw materials and auxiliary materials in parts: 30-50 parts of astaxanthin, 30-250 parts of hippophae rhamnoides fruit powder, 90-250 parts of beta-cyclodextrin, 30-300 parts of D-mannitol, 1-12 parts of citric acid, 1-150 parts of microcrystalline cellulose, 6-12 parts of calcium chloride, and 1-10 parts of magnesium stearate. According to the astaxanthin and hippophae rhamnoides fruit powder tabletting sweets disclosed by the invention, through experiments, a formula proportion of the astaxanthin to the hippophae rhamnoides fruit powder, an embedding proportion of the astaxanthin to an embedding medium, an addition amount of correctant citric acid and the like are preferably selected, and appropriate technological parameters are also preferably selected, so that antioxidative activity in the astaxanthin and the hippophae rhamnoides fruit powder is reserved to the maximum extent, and a strong antioxidative function that the function of the tabletting sweets is better than the function of the astaxanthin and the function of the hippophae rhamnoides fruit powder is generated, and the problem that the mouth feel is poor is solved.

The invention discloses a composition containing lutein and lutein ester, pressed lutein candy, a preparation method and application. The composition comprises lutein, lutein ester, zeaxanthin, blueberry powder, natural carotene, trehalose, D-mannitol and the like. The composition is used for preparing the pressed lutein candy, and the preparation method comprises the steps of embedding natural carotene and the like, mixing the natural carotene with remaining materials except trehalose and D-mannitol, and pulverizing and sieving the mixture to obtain powder; using the powder as a core material, coating the core material with a wall material solution, and conducting granulating, drying, tabletting and coating to obtain a final product. According to the method, specific components and content are combined together, and therefore the absorption dose demanded by the human body can be achieved; each component plays a good synergistic role in eye protection; through a specific technologicalprocess, the final product is stable and has a slow release function, correspondingly people can effectively and continuously absorb effective components, and the problem of absorption limitation is solved.

The invention relates to multi-vitamin calcium-zinc chewable tablets which are prepared from povidone K30, zinc gluconate, sucralose, calcium hydrogen phosphate, L-calcium lactate, D-mannitol, folic acid, vitamins, D-calcium pantothenate, lactose, nicotinamide, strawberry essence and magnesium stearate. More specifically, the multi-vitamin calcium-zinc chewable tablets provided by the invention are vitamin B tablets; compared with common vitamin B chewable tablets which are added with some trace elements that the human body lacks and need to be supplemented by food, a simple preparation can replace the preparations such as vitamin B, calcium tablets and zinc gluconate oral liquid while supplementing vitamin B, calcium and zinc; moreover, the preparation technology is simple and easy to implement, the product performance is stable, the production cost is relative low, and the effect of the product is relatively obvious.

The invention relates to a water-based flocking adhesive. The flocking adhesive is characterized by being prepared from the following raw materials, in parts by weight: 20-30 parts of a water-solubleterminal acrylate hyperbranched polyester, 5-10 parts of 3-chloro-2-hydroxypropyl acrylate ionized modified hyperbranched polyethyleneimine, 30-40 parts of hydroxyl terminated water-based polyurethane, 1-5 parts of a blocked isocyanate crosslinking agent, 1-3 parts of D-mannitol-1,6-bis(2-isocyano-3-methyl-2-butenoate), 0.5-1 part of a fluorine-containing trihydroxysilane compound, 2-5 parts of anemulsifying agent, 0.1-0.5 part of an initiator, and 50-60 parts of water. The invention also discloses a preparation method and use method of the water-based flocking adhesive. The water-based flocking adhesive disclosed by the invention has the advantages of excellent water resistance, wear resistance and weather resistance, high bonding strength, excellent stability, water resistance, hand feeling and air and moisture permeability, and safe, green and environmentally-friendly use.

The invention relates to a natural type oil-water compatible edible essence and a preparation method thereof. The natural type oil-water compatible edible essence has oil solubility and water solubility and is prepared by uniformly mixing and dissolving following components in parts by weight: 5-10 parts of limonene, 10-20 parts of glycerol, 5-10 parts of phospholipid, 1.5-2.5 parts of D-mannitol, 1-2 parts of polydextrose and 2-4 parts of maltitol. According to the product, the adopted main material limonene is produced from natural tangerine and orange peels and dreg, is natural, has no stimulation and has a lasting aroma; the raw materials are recyclable and renewable and wide in sources so that wastes are changed into valuable things. The edible essence has many functions, a sweet taste and good biological degradability; the manufacturing process is simple, the operation is convenient, the conditions of a production environment are not strict, and no pollution is caused; special equipment and a matched pollution discharging facility are not needed and the practical value and the economic benefit are obvious. The use amount of the product can be adjusted according to an actual production condition; the seasoning effect is very good and the quality guaranteeing time is long; the natural type oil-water compatible edible essence is convenient to transport and storage, can be widely applied to food processing fields of candies, bakery products, beverages and the like, and is convenient to use.

The invention relates to the technical field of foods, and discloses tabletted sweets capable of alleviating asthenopia. The tabletted sweets comprise the following raw materials in parts by weight: 40-50 parts of blueberry fruit juice powder, 1-5 parts of chrysanthemum powder, 20-30 parts of Chinese wolfberry fruit powder, 1-5 parts of grape seeds, 0.1-1 part of xanthophyll, 5-10 parts of dietaryfibers, 10-20 parts of D-mannitol, 5-10 parts of maltodextrin and 0.1-1 part of magnesium stearate. The invention further discloses a preparation method of the tabletted sweets and an application ofthe tabletted sweets in the respect of alleviating asthenopia. The tabletted sweets have the beneficial effects of being comprehensive in nutrient components, an original ecology low-temperature processing technology is adopted, the tabletted sweets conform to the proportion of promoting blood circulation for removing blood stasis, nourishing liver and kidney and removing liver fire for improvingeyesight in traditional Chinese medicines, and nutrient components of the raw materials are guaranteed not to be destroyed, so that the efficacy of promoting blood circulation for removing blood stasis and removing liver fire for improving eyesight can be achieved.

The invention relates to the technical field of cosmetics, in particular to a skin-brightening freeze-drying powder containing oligopeptides and 3-O-ethyl ascorbic acid. The skin-brightening freeze-drying powder is prepared from, by weight, 85-95 parts of deionized water, 3-8 parts of D-mannitol, 2-7 parts of a vitamin C derivative, 0.7-1.4 parts of a sugar composition and 0.0008-0.0018 parts of oligopeptides. The oligopeptide refers to oligopeptide-5, the vitamin C derivative refers to 3-O-ethyl ascorbic acid, and the sugar composition includes trehalose and pullulan polysaccharide; the obtained freeze-drying powder can penetrate the skin rapidly, inhibit the tyrosinase activity, inhibit melanin formation, and can effectively enhance the skin brightness and effectively and continuously brighten the skin; the components in a raw material formula complement one another, the obtained freeze-drying powder has the synergistic effect and the synergistic effect is especially obvious in skinbrightness enhancing and brightening lasting.

The present invention relates to an effervescent tablet, and particularly relates to a vitamin C effervescent tablet. The invention belongs to the technical field of health food tablet formulation. Vitamin C, one of the essential vitamins of the human body, has a preventive effect on many diseases. Vitamin C can also be used in combination with many other drugs in the treatment of certain diseases. Effervescent tablet is a novel tablet developed and applied abroad in recent years, and the effervescent tablet is usually prepared by acid and alkali separate wet granulation, followed by being mixed with other raw materials for tablet compressing. In order to shorten the production process and further improve the product stability, the invention adopts the mixed use of alpha- and beta-crystalform D-mannitol, which reduces the fragility of the tablets on the basis of ensuring the effervescent effect of the tablets. The formula of the invention is suitable for the direct tablet compressingprocess, free of the addition of water or other wetting agents in the production process and capable of reducing the occurrence of material pollution, improving the production efficiency, reducing theprocess flow and decreasing and reducing the energy consumption. In addition, the addition of sodium caseinate can improve the effervescent effect of the tablets.

A pharmaceutical composition for administration to a mammal is disclosed. The composition includes a therapeutically effective amount of a peptide, such as a GLP-1 molecule, a PTH molecule, or a GRF molecule. The composition further includes a buffer including a weak acid having an acid dissociation constant value of greater than about 1×10⁻⁵, such as acetic acid. The composition also includes an excipient for making the composition generally isotonic, such as D-mannitol.

The invention relates to extinction type polyester resin for an HAA system. Terephthalic acid, tetrahydrophthalic acid, 2-amino-4,6-dihydroxypyrimidine, neopentyl glycol, 1,10-decanediol, diacetone-D-mannitol, 1,4,5,8-naphthalenetetracarboxylic dianhydride, 5-methyl isophthalic acid and trimethyl citrate are adopted as raw materials. All the components are matched with one another and have a synergistic effect so that the molecular weight distribution of the finally obtained polyester resin is not uniform and polybasic acids for end capping are different in type, and therefore, when the polyester resin with different end-capping functional groups and HAA are cured, the reaction activity difference is large, the curing process cannot be synchronously carried out, the cured coating surface shrinks, and the surface gloss is effectively low. Experimental data show that when the prepared extinction type polyester resin is used for preparing extinction type powder coating of an HAA system, acoating film with the glossiness smaller than 15% can be obtained, and excellent comprehensive performance is achieved.