7 results about "Domperidone" patented technology

The application provides a use of a combination of metoclopramide and latanoprost for preparing an anticoagulant drug, and belongs to the technical field of biological medicines. It is accidentally found that the anticoagulant effect of patients with deep vein thrombosis combined with high intraocular pressure is improved after long-term continuous oral administration of metoclopramide. Thanks to this beneficial discovery, the application realizes good anticoagulant effect by applying the latanoprost liniment in a topical manner on the basis of oral administration of metoclopramide. The application is convenient to administer, has definite and sustained curative effect, and is safe and reliable. The application expands the optional range of anticoagulant drugs, and realizes better curative effect at the same time, and has outstanding technical advantages and wide popularization prospect.

The present application provides the application of torreya grandis inner seed coat extract in preparing a product for treating constipation, wherein the torreya grandis inner seed coat extract is obtained by stripping the black coat of torreya grandis after roasting, and then extracting the black coat with water or 50% ethanol, and drying the extract obtained by vacuum concentration; and the prepared torreya grandis inner seed coat extract is used in preparing various dosage forms of drugs for treating constipation and products for lubricating intestines and defecating. The prepared torreya grandis inner seed coat extract powder has the effect of promoting intestinal propulsion, can improve the small intestinal propulsion function, and can achieve good lubricating intestines and defecating effect, and can be used for treating constipation. The torreya grandis inner seed coat powder can be used for preparing food with the effect of lubricating intestines and defecating, so that the function of treating and conditioning constipation can be achieved through diet therapy, and the side effects of the commonly used drugs such as magnesium sulfate, castor oil, cisapride, loperamide, domperidone and bisacodyl can be overcome, and the resource utilization rate of torreya grandis is increased, and the economic benefits are increased.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a domperidone impurity detection method. According to the domperidone impurity detection method, the impurity A, the impurity B, the impurity C, the impurity D + E, the impurity F, the impurity H, the impurity I and the impurity J in domperidone can be detected, the separation degree of each impurity peak is high, and the content of each impurity can be measured at the same time. The detection method disclosed by the invention is good in specificity, high in sensitivity and good in experimental verification results such as linearity, repeatability, solution stability and accuracy inspection. The result provides a new method for impurity detection of domperidone, and provides guarantee for preparation of domperidone tablets and other preparations.

The disclosure provides pharmaceutical formulations comprising d4-domperidone of the formula (I):or a pharmaceutically acceptable salt thereof. The formulations also contain (i) a glyceryl stearate, and a medium chain triglyceride; or (ii) a stearoyl polyoxyl glyceride, a nonionic poly(ethylene oxide) polymer, and a medium chain triglyceride; or (iii) a nonionic poly(ethylene oxide) polymer, and a polyethylene glycol. The disclosure also provides methods for treating a disorder that is gastroparesis, nausea apart from gastroparesis, vomiting apart from gastroparesis, nausea associated with gastroparesis, vomiting associated with gastroparesis, gastroesophageal reflux disease, insufficient lactation, or a combination thereof in a patient, comprising administering to the patient a formulation described herein. In some aspects, the disorder is gastroparesis. In other aspects, the disorder is gastroesophageal reflux disease. In further aspects, the disorder is insufficient lactation.

The invention discloses an application of domperidone in preparation of a pharmaceutical preparation for treating inflammatory skin diseases. The domperidone disclosed by the invention can be used as an active ingredient for inhibiting the P2Y14 receptor and is applied to preparation of the medicine for treating the inflammatory dermatitis, a new application of the domperidone is developed, and a new choice is provided for treatment of psoriasis and atopic dermatitis. The domperidone disclosed by the invention has good P2Y14 receptor inhibition activity, and the domperidone has no obvious influence on cell activity under the dosage of 15 mu M; after domperidone intragastric administration is carried out on a mouse with psoriasis and atopic dermatitis, the skin thickness is remarkably reduced, and inflammatory cell infiltration is relieved. According to the application, the effect of domperidone on improving inflammatory skin diseases (psoriasis and atopic dermatitis) by inhibiting P2Y14 receptors is found and verified for the first time through in-vivo and in-vitro experiments, the domperidone has the potential of preparing novel anti-inflammatory drugs, and meanwhile, the domperidone is low in clinical application risk as an FDA approved marketing drug.

The invention discloses a preparation method of an imitated oral solution for lactulose Dumishan. The preparation method comprises the following steps: step 1, pretreating raw materials; 2, preparing a buffer system; step 3, dissolving and mixing core components; step 4, adjusting flavor and optimizing taste; step 5, osmotic pressure regulation; step 6; step 7, carrying out sterile treatment; step 8, constant-temperature curing and stability regulation and control; and step 9, quality detection and packaging. According to the invention, beta-cyclodextrin is adopted to carry out clathration treatment on lactulose, and the composite wall material can effectively protect the molecular structure of lactulose, so that the lactulose is prevented from being hydrolyzed and degraded in the preparation and storage processes; meanwhile, a citric acid-sodium citrate composite buffer pair and EDTA disodium have a synergistic effect, so that the pH value of the system is stabilized, metal ions are chelated, the degradation of lactulose is further inhibited, and the validity period of the preparation is prolonged. The sweetness is adjusted through the sucralose and maltitol compound sweetening agent, and the sweet greasy feeling of a single sweetening agent is avoided.

The invention provides a method for detecting the dissolution rate of domperidone tablets, and relates to the technical field of analytical chemistry. According to the method, high performance liquid chromatography is adopted for determination, mobile phases comprise a mobile phase A and a mobile phase B, the mobile phase A is methanol-ionic liquid, the mobile phase B is an acetonitrile-glacial acetic acid solution, a gradient elution procedure is adopted, effective separation of domperidone and a large number of other auxiliary materials and impurities is achieved, the number of main peak theoretical plates of domperidone is larger than 3000, and the detection wavelength is 250nm. The domperidone component is exclusively and precisely measured, the quality evaluation of the dissolution rate of the domperidone tablet is greatly improved, and the detection method has high specificity and high sensitivity, and meanwhile, meets the green and environment-friendly requirements.