124 results about "Domperidone" patented technology

The invention relates to a loach fry artificial breeding method which is characterized by including the steps of selecting healthy parental loaches above two winters old and conducting enrichment culture for 25-35 days; then conducting hybrid injection of HCG (human chorionic gonadotropin) and DOM (domperidone) for artificially hastening parturition; after 10-14 hours after parturition hastening, collecting fertilized eggs; and then conducting artificial incubation and larva breeding, thus obtaining the loach fry. In the invention, through the enrichment culture of the parental loaches, synchronous maturing is promoted and oogonium percentage is enhanced; with the parental loach parturition hastening technology, synchronous egg laying can be realized; with the hybrid injection method, the ovarian development and the egg laying effect of the loaches can be promoted, so that the synchronous egg laying rate of the parental loaches achieves 40%; and an inflation incubation way is adopted on the fertilized eggs, so that the incubation rate of the fertilized eggs can be greatly improved. Through enrichment culture, the survival rate of the loach fry can be enhanced remarkably.

The invention relates to an artificial intensive incubation method for cyprinus carpio koi fries. The method comprises the following steps of: injecting 1 to 3mg of oxytocic hormone domperidone and 2 to 5mu g of chorionic gonadotropin into every 1kg of parent fish of cyprinus carpio koi; filling water into a hybridization pool; putting a mixture of collected roe and semen into 1 to 3 percent physiological saline for insemination by an extrusion method; adhering oosperm to an artificial egg collector by using a brush and putting into an incubator in the hybridization pool for incubation, wherein the water temperature of the hybridization pool is 18 to 23 DEG C; treating by using 18 to 24 ppm saline solution for 15 to 30 minutes; and incubating the roe at the water temperature of between 15 and 25 DEG C for 5 to 7 days for membrane breaking and fry emergence. The method has the obvious advantages of improving the disease resistance of the fries, increasing the incubating rate and survival rate and forming the cyprinus carpio koi fry production technology of intensification, industrialization, mass production and high quality.

The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.

The invention is a Chinese traditional medicine compound for treating intestines functions disorder. The compound includes following ingredients: bupleurum root 6-18g, white peony root 6-30g, pseudostellaria root 3-18g, liquorice 6-15g. The method can be used in clinic directly without adding ingredients; it also can use the extract of above mentioned medicines as medicine; the extract is: a. extract the volatile oil for backup from above mentioned compound; b. carries on extraction with water, alcohol, or other organic solution to above mentioned volatile oil compound; c. purifies and separates: water extracting liquid, vacuum condensing, and alcohol depositing, resin absorbing and exchanging, high speed eccentric process, and cyclodextrin packaging method; d. the extracts in above steps are combined, and become medicine compound. There also can increase lagehead atractylodes, chuaniong rhizome, Tuckahoe, kudzu vine root, uncaria and other medicines; or some compounds such as shimida, and dopan ketone. The invention also provides a manufacturing method for above mentioned medicine.

The present invention relates to fast water-dispersible tablets containing domperidone for oral administration. The formulations comprise domperidone or pharmaceutically acceptable salts thereof, about 60-80% of a “auxiliary” granulate (w / w), and about 10-30% of microcrystalline cellulose (w / w), expressed in relation to the total weight of the tablets, a sweetener, a flavouring agent and a lubricant. The “auxiliary” granulate is obtained by wet granulation of D-mannitol and maize starch gum in a high shear granulator, it facilitates the flowability and the compressibility of the mixture and, because of its high solubility in water, contributes to the fast dispersion of the tablet. The formulations have an enhanced structural integrity, for instance having a friability lower than 1.0% and hardness values between 3 and 6 Kp, and are able to disperse in water within 3 minutes, preferably within 2 minutes and most preferably within 1 minute, to provide a dispersion that passes through a 710 μm diameter mesh size sieve and presents a pleasant taste and the absence of perceptible granules in the mouth. This invention also refers to the process for the preparation of said pharmaceutical preparations.

Compositions of domperidone formulated for transmucosal delivery are provided. Also provided are methods for the treatment of nausea, vomiting, and gastrointestinal motility disorders, and methods for the enhancement of breast milk production. The methods utilize domperidone compositions formulated for transmucosal administration, administered to patients in an amount effective to treat nausea, vomiting, or gastrointestinal motility disorders, or to enhance breast milk production.

The invention discloses a culturing method for sex reversal of a female carp to a male carp. The culturing method comprises the following steps that A. squeezing an abdomen of a 10-11-month-old carp, and separating a male carp with out-flown semen and a carp with no out-flown semen; B. inserting a copper roe digging device in a genital pore of the carp from which semen can not be squeezed, and selecting the carp capable of obtaining roe particles to cultivate the carp in a cement pond; C. according to the weight of the carp, feeding the carp with dosing fodders containing 17 alpha- methyltestosterone every day, and mix-injecting domperidone, luteinizing hormone releasing hormone and carp pituitary gland in the thoracic cavity of the carp in each five days; and D. after continuously processing the test carp for 2 months, squeezing the abdomen of the carp, the test carp with out-flown milky white semen is the sex reversal carp which is a female on genotype and a male on physiology. The culturing method is easy and feasible and is convenient in operation, and can be used for sex reversing the female carp on genotype into a male carp on physiology. The growth speed of the filial generation cross bred by the sex reversal carp and the common carp is fast and the economic benefits are remarkable.

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make domperiodine dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.

A composite medicine for reflux of gastroesophageal and functional digestion is prepared from omeprazole and domperidone in the ratio of (2:1-3).

The invention discloses a method for batch breeding of loach fry, which notably improves catalytic production rate of the loach. The method comprises the steps of: a, selecting loach parent for breeding to perform prenatal strengthening cultivation; b, building a third-level filtering reservoir device for spawning and hatching; c, selecting composite of the maleic acid domperidone and the trout luteinizing hormone releasing hormone analogue as a catalyst to catalyze male and female loaches, wherein per kilogram of female loaches need 10-15mg of the catalyst; per kilogram of male loaches need 5-7.5mg of the catalyst; enabling the female loaches and the male loaches to spawn and inseminate in a net cage in the jar according to the ratio of the female loaches to the male loaches being 1:2; taking out the loaches, enabling the spawns to continuously hatch; producing loach fry in a large scale; d, feeding the initial feed, putting the loaches to the pond; according to organ development characteristic of the loach fry, controlling diet conversion time point, electing palatable bait, scientifically feeding the bait, and strengthening water quality and disease control and prevention.

The present invention provides a domperiodone oral disitegrant tablet preparation. Its composition includes medicine active component, filling agent, corrective, disitegrant, lubricating agent and glidant. Its medicin active component includes dopamine receptor antagonist and gastroprokinetic, and its disitegrant agent is selected from cross-linked polyvinylpyrrolidone, carboxymethyl starch sodium and microcrystal cellulose or their mixture, and corrective is selected from aspartame. Said invention adopts direct addition of disitegrant in theprescription so as to attain the effect of quick disitegration. Its preparation process is simple, and it is convenient for taking in.

The invention discloses a preparation method of domperidone particles. The method comprises the following steps: dispersing domperidone and dispersion aids into a solvent; adding an acid to dissolve to obtain a solution I; adding an alkali liquor to the solution I under an agitation condition, so as to obtain a mixture containing the domperidone particles; separating the domperidone particles, wherein the mean grain size of the obtained particles is smaller than 20mum, the particles have the specific surface area equivalent to over twice of those of common domperidone particles and are high in dissolution rate. The invention also discloses a preparation method of the preparation containing the domperidone particles. The method for preparing the domperidone particles is simple and convenient to operate, free of harsh process condition and equipment, low in cost and easy for realization of industrial production.

The invention discloses an Omeprazole sodium and domperidone injection, wherein the active constituents include Omeprazole sodium and domperidone by the weight ratio of 4:1-2:3, the injection also comprises excipient and stabilizing agent. The injection can be used for treating gastric ulcer, duodenal ulcer, stomach and gullet reverse-current, and functional dyspepsia.

The invention relates to a complete artificial propagation method for acrossocheilus fasciatus. The method comprises: acquiring wild acrossocheilus fasciatus juvenile fishes for acclimation, culturing until sex matured, using exogenous parturifacient chorionic gonadotropin (HCG), lutropin releasing hormone analog (LHRH-A3) and domperidone (DOM), through a one-time injection method, to promote sexual gland of parent fishes of acrossocheilus fasciatus which is mature naturally to develop further, through dry insemination to obtain oosperms, and through a special hatching equipment, performing flowing hatching until hatching. Rate of inducing spawning of parent fishes reaches up to 85%, and fertility rate reaches above 85%, and hatchability is above 70%. The method solves problems of large-scale production of acrossocheilus fasciatus fries.

The invention provides a combined drug of pantoprazole and domperidone and in particular provides application of pantoprazole and domperidone to preparing combined injections for treating gastric ulcer, duodenal ulcer, gastro-esophageal reflux diseases or functional dyspepsia. The invention also provides the combined injections for treating gastric ulcer, duodenal ulcer, gastro-esophageal reflux diseases or functional dyspepsia, including different specifications of unit preparations, pantoprazole and domperidone for simultaneous, respective or successive administration and preparations prepared by pharmaceutically acceptable vectors. The weight ratio of pantoprazole and domperidone is 1:1-5:1, and the pantoprazole and domperidone contain excipients, stabilizing agents, etc. Through combined injection administration, the invention improves the bioavailability of pantoprazole and domperidone and ensures the treatment effects to be obviously better.

The invention discloses a domperidone orally disintergrating tablet and the preparation method. The domperidone orally disintergrating tablet of the invention contains effective dose of domperidone and pharmaceutical excipient which is capable of rapidly disintegrating and releasing medicine in the oral cavity. The preparation method adopts modern preparation technology and the product has stable quality. So the preparation method provides patients with a safe and effective domperidone orally disintergrating tablet which is absorbed rapidly.

The invention discloses a domperidone suspension, and each 1000ml of the suspension comprises the following components: 1g of domperidone, 6g-8g of sodium carboxymethyl cellulose, 8g-12g of microcrystalline cellulose, 0.3ml-0.7ml of polysorbate, 80g-120g of sorbierite, 1.5g-2.0g of methylparaben, 0.1g-0.3g of propylparaben, 0.1g-0.4g of saccharine sodium salt and the balance of water. The suspension is good in stability and redispersibility, has sweet flavor, can be preserved for 5 years, and is free of agglomeration.

The invention provides an artificial breeding method for wallago bleeker, and belongs to the technical field of aquaculture. The method comprises the steps that sexually mature female wallago bleeker and sexually mature male wallago bleeker are selected based on the ratio of 1:1, exogenous hormone is injected into chests to induce wallago bleeker gonadal maturation, 12 micrograms of luteinizing hormone-releasing hormone A2 (LRH-A2) and 6 mg of maleic acid domperidone (DOM) are injected to each kg of wallago bleeker two times for female wallago bleeker and one time for male wallago bleeker, then, the wallago bleeker is placed in a spawning pond with the bottom paved with an artificial fish spawning nest, the effect is achieved for 8 h at the temperature of 25-27 DEG C, the female wallago bleeker and the male wallago bleeker complete natural egg laying and fertilization on the fish spawning nest, the spawning nest with fertilized eggs in the spawning pond is fished out and placed into a flow water incubation grooves for incubation, and therefore wallago bleeker fry is obtained. The process of killing male wallago bleeker to obtain spermary for artificial fertilization is not needed, a large number of wallago bleeker fertilized eggs can be obtained, the fertilization rate is high, the incubation rate is high, the temperature adaptability is high, and the yield is high.

The Chinese medicine gastric dynamia medicine is Chinese medicine preparation with aucklandia Weitai extracted from aucklandia as the main material, and aucklandia Weitai contains total aucklandia lactone in 50-90 wt%. Animal test shows that the Chinese medicine gastric dynamia medicine has the effect of promoting gastric dynamia and remitting gastric adynamia similar to that of Domperidone, the analgetic effect superior to Domperidone and has no side effect of Domperidone. In addition, it has small dosage and low cost.

The invention provides a domperidone orally disintegrating tablet, which is characterized in that the tablet contains a physiologically effective amount of domperidone and a necessary pharmaceutically applicable excipient; the weight percent of domperidone in the orally disintegrating tablet is 5%-10%, and the pharmaceutically applicable excipient is a mixture of a plurality of agents selected from fillers, odor masking agents, disintegrants, surfactants, adhesives, lubricants, and glidants. The domperidone orally disintegrating tablet of the invention has the advantages of quick disintegration, excellent mouthfeel, stable quality, and reliable curative effects, and can improve the compliance of medicine taking for patients.

Disclosed are methods of terminating acute episodes of cardiac arrhythmia, such as atrial fibrillation or ventricular fibrillation, in a mammal, such as a human, by administering to that mammal an amount of domperidone, or a pharmaceutically acceptable salt, derivative or metabolite thereof, effective to terminate an acute episode of cardiac arrhythmia and / or restore normal sinus rhythm or heart rate. Also disclosed are methods of maintaining normal sinus rhythm or heart rate in a mammal, such as a human, and preventing a recurrence of an episode of cardiac arrhythmia in a mammal, by administering an amount of domperidone, or a pharmaceutically acceptable salt, derivative or metabolite thereof, effective to maintain normal sinus rhythm or heart rate in a mammal that has experienced at least one prior episode of cardiac arrhythmia. Pharmaceutical compositions for use in these methods are also disclosed.

The present invention relates to a domperidone gel preparation for curing reflux esophagitis. Said preparation includes active component and matrix, in which the active component includes the solution made up by using domperidone, polyvinylpyrrolidone and water. Its taste is good, and its stability is better.

The invention provides a domperidone tablet and a preparation method thereof. The domperidone tablet is prepared by carrying out direct powder compression on powder, a production is simple, a production cycle is shortened, equipment cost and operational cost are reduced, the prepared domperidone tablet is excellent in appearance, a technological process is smooth, operability is good, dissolution rate of the domperidone tablet product is high, content uniformity is qualified, and good bioavailability in a human body can be realized, so that good curative effect is realized.

The invention discloses a domperidone oral disintegrating tablet, and a method for preparing the same and a method for quality control. The domperidone oral disintegrating tablet is prepared from domperidone and auxiliary materials, and the quality thereof is controllable and stable. The domperidone oral disintegrating tablet is a peripheral dopamine receptor agonist which is safe and effective. Compared with the prior art, the domperidone oral disintegrating tablet has the advantages of rapid disintegration, convenient taking, no vomiting, rapid effect, and low side effect.

The invention discloses an artificial breeding method of Barbatula nuda. The artificial breeding method comprises the following steps: firstly, collecting parent fishes: harvesting from a natural water area to select healthy wild fishes, and starting to collect parent Barbatula nuda in early March; secondly, stocking and breeding the parent fishes: putting the selected parent fishes into a temporary cement pond; after the parent fishes enter the pond, enabling the parent fished to stay in the pond for 1 to 2 days and then starting to feed bait; thirdly, preparing a parturifacient: mixing and proportioning 1000 international units of gonadotropin, 2mu g of luteinizing hormone releasing hormone No.2 and 1mg of domperidone for each kilo of female fish chorionic vill; fourthly, hastening spawning: injecting the parturifacient prepared in the third step into base muscle of dorsal fins of the parent fishes; fifthly, artificially inseminating: performing dry inseminating to obtain fertilized ova; sixthly, incubating, thus obtaining Barbatula nuda fries after 7 days. The developmental maturities of sexual glands of the parent fishes are basically consistent. A parent fish population centrally spawns, so that the induced spawning rate and the fertilization rate are improved. The whole technical process is performed within a controllable range, is little influenced by an external environment, and is convenient and reliable to operate.

The invention discloses a domperidone tablet and a preparation process thereof. The preparation process comprises the following steps: dissolving domperidone in alcohol, adding hydrophilic auxiliary materials, dispersing, drying under reduced pressure to remove alcohol, adding tertiary butanol suspension of polacrilin potassium, volatilizing to remove tertiary butanol to obtain drug-containing solid sediment; and uniformly mixing with other pharmaceutically acceptable auxiliary materials and tabletting. The domperidone tablet disclosed by the invention can be dissolved out quickly; and the preparation process is simple and suitable for industrial production.

The invention discloses an infantile domperidone orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet is prepared from the following raw materials in parts by mass: 10 to 30 parts of domperidone, 10 to 30 parts of fatty glyceride, 5 to 10 parts of tween 80, 900 to 2700 parts of white sugar, 2 to 5 parts of crospovidone, 10 to 30 parts of mannitol, 0.01 to 0.05 part of essence, 0.2 to 0.5 part of magnesium stearate and 0.2 to 0.5 part of aerosil. According to the infantile domperidone orally disintegrating tablet and the preparation method thereof, an orally disintegrating tablet medicament is prepared by using the domperidone as an effective component of the medicament and through an innovative process. By using the domperidone orally disintegrating tablet prepared by the invention, the problems that the dissolution rate of the medicament is low, the medicament has a bitter taste, and the like, are solved successfully; the infantile domperidone orally disintegrating tablet has a favorable effect on infantile functional dyspepsia.

The invention relates to an artificial propagating method of semilabeo obscurus and belongs to the technical field of fish product culture. According to the method, domperidone and lutein releasing hormone A2 are injected in gonadosomatic semilabeo obscurus according to a dosage that 1mg of domperidone and 1mug of lutein releasing hormone A2 are injected for each kilogram of body weight, the injection dosage is reduced to a half for milters, and the artificial wet process fertilization is carried out at the effect time of 22 hours and at the water temperature being 21 DEG C; ova and sperms of the gonadosomatic semilabeo obscurus are extruded into a container, 21-DEG C clean water is immediately poured into the container, and the water quantity is proper when the ova and sperms are immersed; then, the ova and sperms are slightly stirred for 30 seconds by chicken feather, and next, the incubation is prepared after the washing by clean water for three times; firstly, the fertilized ova are placed into 0.15ppm Tuzet water solution to be soaked for 15 minutes for sterilization and are then placed into large basins containing 60kg water, 3000 ova with the ovum diameter being 2.2 to 2.5 mm are placed into each basin, oxygenation is carried out through an oxygenation pump, the water temperature is 21 to 22 DEG C, the pH is 7.8 to 8.5, the incubation lasts 36 hours, the complicated reticular yolk system and the well developed somite and blood vessels can be clearly seen, and the semilabeo obscurus fry is obtained after 72-hour hatching. The artificial propagating method has the advantages that the cost is low, the operation is simple and convenient, the hatching rate is high, and the artificial propagating method can be put into production and practical use.

The invention discloses a pediatric domperidone suspension and a preparation method thereof. The suspension comprises domperidone, an antibacterial agent, a corrective, a suspending agent, a masking agent and a diluent, wherein the suspending agent and the masking agent both are montmorillonite, the average particle size of the montmorillonite is 8 to 27 [mu]m, and the dosage of the montmorillonite is 0.22% to 4.34% (w / w) of the total amount of the formula. According to the invention, the suspension is prepared by processes of preparing the domperidone with montmorillonite hydrogels, hydrogel microparticles with a rapid diffusion controlled drug release mechanism, a drug-containing suspension and the like, so that the problems of low drug dissolution rate, bitterness and the like are successfully solved to greatly improve the medication compliance and provide a good effect for functional dyspepsia of children.