Compound medicine contg. omeprazol and

A technology of omeprazole and domperidone, which is applied in the field of combined preparations of omeprazole and domperidone, can solve problems such as functional dyspepsia, achieve the effect of enhancing gastric peristalsis, prolonging the time, and reducing gastroesophageal reflux

Inactive Publication Date: 2006-01-25
张志生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] So far, the combination preparation of omeprazole and domperidone has not been seen in the prior art to jointly treat gastroesophageal reflux disease (or gastroesophageal reflux disease), functional dyspepsia, etc., especially for controlling a single Gastroesophageal reflux disease not effectively treated with PPIs or H2 receptor antagonists

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepare each enteric-coated tablet containing active ingredient omeprazole 20mg and domperidone 10mg, and its formula is:

[0036] Omeprazole 20g

[0037] Domperidone 10g

[0038] Mannitol 65g

[0039] Lactose 45g

[0040] Poloxamer 1g

[0041] PVP 6g

[0042] Magnesium stearate 8g

[0043] Talc powder 20g

[0044] Acrylic No. 2 Resin 5g

[0045] Appropriate amount of diethyl phthalate

[0046] Specific preparation method:

[0047] Put 20 g of omeprazole, 10 g of domperidone, 65 g of mannitol, and 45 g of lactose passed through a 100-mesh sieve into a KJz-10 type fast stirring granulator and mix at high speed for 2 minutes, and dissolve 1 g of poloxamer in 15 ml of 5% PVP in absolute ethanol solution as a binder, add, mix quickly for 3 minutes, granulate quickly for 2 minutes, take it out, put it in a vacuum drying oven for 4 hours, granulate with a 16-mesh sieve, add an appropriate...

Embodiment 2

[0049] Prepare each enteric-coated tablet containing active ingredient omeprazole 10mg and domperidone 10mg, and its formula is:

[0050] Omeprazole 10g

[0051] Domperidone 10g

[0052] Mannitol 65g

[0053] Lactose 45g

[0054] Poloxamer 1g

[0055] PVP 6g

[0056] Magnesium stearate 8g

[0057] Talc powder 20g

[0058] Acrylic No. 2 Resin 5g

[0059] Appropriate amount of diethyl phthalate

[0060] Preparation:

[0061] According to the preparation in the same manner as in Example 1, 1000 omeprazole-domperidone enteric-coated tablets were prepared, each containing 10 mg of omeprazole and 10 mg of domperidone.

Embodiment 3

[0063] Prepare every capsule containing active ingredient omeprazole 20mg and domperidone 10mg, its formula is:

[0064] Omeprazole 20g

[0065] Domperidone 10g

[0066] Mannitol 60g

[0067] Lactose 40g

[0068] Poloxamer 1.5g

[0069] PVP 6g

[0070] Magnesium stearate 8g

[0071]Talc powder 20g

[0072] Acrylic No. 2 Resin 5g

[0073] Appropriate amount of diethyl phthalate

[0074] Specific preparation method:

[0075] Preparation of omeprazole enteric-coated granules: 20 g of omeprazole, 60 g of mannitol and 40 g of lactose passed through a 100-mesh sieve were placed in a KJz-10 type fast stirring granulator and mixed at high speed for 2 minutes, and the poloxamer was about Dissolve 1g (poloxamer) in 15ml 5% PVP absolute ethanol solution as a binder, add, mix quickly for 3 minutes, granulate quickly for 2 minutes, take it out, dry it in a vacuum drying oven for 4 hours, and sieve the granules...

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PUM

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Abstract

A composite medicine for reflux of gastroesophageal and functional digestion is prepared from omeprazole and domperidone in the ratio of (2:1-3).

Description

technical field [0001] The invention relates to a medicine, in particular to a combined preparation of omeprazole and domperidone. Background technique [0002] Omeprazole is a proton pump inhibitor (PPI) that blocks gastric acid secretion from various causes. After PPI enters the human body, the action time can reach more than 24 hours, so PPI's acid suppression intensity is strong and lasts for a long time, and it can effectively relieve acid reflux, heartburn and other symptoms of gastroesophageal reflux disease clinically. [0003] In the prior art, a large number of technologies about omeprazole preparation form, compound form and the like are disclosed. For example, Chinese patent application 95194038.4 discloses a new oral pharmaceutical preparation containing omeprazole magnesium salt wrapped by one or more enteric coating layers and a preparation method of the preparation. [0004] Although omeprazole salt is an excellent gastric acid inhibitor, its clinical appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P1/04A61P1/14A61K31/4439
Inventor 刘春平康秋萍李绍安李云霞
Owner 张志生
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