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Domperidone orally disintegrating tablet

A technology of dipperidone orally disintegrating tablets and domperidone, which is applied to medical preparations of non-active ingredients, pill delivery, and the digestive system. Good taste effect

Inactive Publication Date: 2011-07-20
上海中邦斯瑞生物药业技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As is well known, these preparations must be taken orally as a whole when used, and there are defects such as inconvenient use and difficulty in swallowing for patients.
For patients who need to take medicine for a long time, there are obvious problems of medication compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Domperidone 20g

[0029] Lactose 140g

[0030] Crospovidone 10g

[0031] Hydroxypropyl Cellulose 10g

[0032] Magnesium Stearate 5g

[0033] Aspartame 10g

[0034] Micronized silica gel 5g

[0035] Poloxamer ethanol solution (50%) appropriate amount

[0036] Preparation: pass all raw and auxiliary materials through 80-100 mesh sieves, fully mix domperidone and other excipients, sieve through No. 14-18 sieves, add flow aid, compress into tablets, and pack after passing the inspection.

Embodiment 2

[0038] Domperidone 10g

[0039] Lactose 150g

[0040] Sodium Carboxymethyl Cellulose 10g

[0041] Hydroxypropyl Cellulose 10g

[0042] Magnesium Stearate 5g

[0043] Aspartame 10g

[0044] Micronized silica gel 5g

[0045] Poloxamer ethanol solution (50%) appropriate amount

[0046] Preparation: pass all raw and auxiliary materials through 80-100 mesh sieves, fully mix domperidone and other excipients, sieve through No. 14-18 sieves, add flow aid, compress into tablets, and pack after passing the inspection.

Embodiment 3

[0048] Domperidone 15g

[0049] Lactose 145g

[0050] Crospovidone 10g

[0051] Hydroxypropyl Cellulose 10g

[0052] Magnesium Stearate 5g

[0053] Aspartame 10g

[0054] Micronized silica gel 5g

[0055] Poloxamer ethanol solution (50%) appropriate amount

[0056] Preparation: pass all raw and auxiliary materials through 80-100 mesh sieves, fully mix domperidone and other excipients, sieve through No. 14-18 sieves, add flow aid, compress into tablets, and pack after passing the inspection.

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PUM

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Abstract

The invention provides a domperidone orally disintegrating tablet, which is characterized in that the tablet contains a physiologically effective amount of domperidone and a necessary pharmaceutically applicable excipient; the weight percent of domperidone in the orally disintegrating tablet is 5%-10%, and the pharmaceutically applicable excipient is a mixture of a plurality of agents selected from fillers, odor masking agents, disintegrants, surfactants, adhesives, lubricants, and glidants. The domperidone orally disintegrating tablet of the invention has the advantages of quick disintegration, excellent mouthfeel, stable quality, and reliable curative effects, and can improve the compliance of medicine taking for patients.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a domperidone orally disintegrating tablet and a preparation method thereof. Background technique [0002] Domperidone is a synthetic benzoimidazole derivative, structurally similar to propyl ketone phenyl. It is a dopamine receptor antagonist with anti-emetic effect, and it is not easy to enter the brain through the blood-brain barrier. Domperidone acts on the chemoreceptor trigger area outside the blood-brain barrier, so it hardly acts on the central nervous system; domperidone selectively blocks dopamine 2 (DA2) receptors and mainly acts on the peripheral nervous system. Since DA2 receptors are also the main receptors in the gastrointestinal tract, DA2 receptor antagonists reduce dopamine-mediated relaxation of gastric smooth muscle. In the gastrointestinal tract, domperidone, as a prokinetic drug, can increase the motility of the digestive tract and can be used ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/454A61K47/32A61K47/38A61P1/04A61P1/08
Inventor 杨岩
Owner 上海中邦斯瑞生物药业技术有限公司
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