Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Infantile domperidone orally disintegrating tablet and preparation method thereof

A technology for perperidone orally disintegrating tablets and domperidone is applied in the field of medicine and can solve the problems of low drug dissolution rate, drug bitterness and the like

Active Publication Date: 2016-05-11
SHANDONG SBOND PHARMA +1
View PDF7 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the deficiencies of the prior art, the present invention provides a domperidone orally disintegrating tablet for children and a preparation method thereof. Through innovative selection of excipients, optimized ratio of excipients and innovative preparation process, the low dissolution rate of the drug and the bitterness of the drug are successfully solved. question

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Infantile domperidone orally disintegrating tablet and preparation method thereof
  • Infantile domperidone orally disintegrating tablet and preparation method thereof
  • Infantile domperidone orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0176] Embodiment 1, a kind of preparation method of orally disintegrating tablet of domperidone for children

[0177] 1. A domperidone orally disintegrating tablet for children is made of the following raw materials in parts by mass:

[0178]

[0179] 2. The preparation method is as follows:

[0180] (1) Domperidone is pulverized and passed through a 150-mesh sieve to obtain an average particle size of 28-32 μm, which is set aside;

[0181] (2) pulverize the white sugar and polyvinylpolypyrrolidone of proportioning amount, cross 110 mesh sieves, and set aside;

[0182] (3) Melt fatty acid glycerides at 60-80°C, add the proportioning amount of Tween 80 and mix well, then weigh the proportioning amount of domperidone, then add the proportioning amount of 1 / 3 (W / W) white sugar, After cooling and solidifying, pulverize through a 15-mesh sieve;

[0183] (4) Dissolving mannitol in deionized water to prepare a 55% (W / W) mixed solution, then adding the materials in step (3), fu...

Embodiment 2

[0186] Embodiment 2, a kind of preparation method of children's domperidone orally disintegrating tablet

[0187] 1. A domperidone orally disintegrating tablet for children is made of the following raw materials in parts by mass:

[0188]

[0189]

[0190] 2. The preparation method is as follows:

[0191] (1) Domperidone is pulverized and passed through a 160-mesh sieve to obtain particles with an average particle diameter of 21-24 μm for subsequent use;

[0192] (2) Pulverize white sugar and polyvinylpolypyrrolidone of proportioning amount, cross 100 mesh sieves, and set aside;

[0193] (3) Melt the fatty acid glyceride at 60-80°C, add the proportioning amount of Tween 80 and mix well, then weigh the proportioning amount of domperidone, then add the proportioning amount of 1 / 3 (W / W) white sugar, After cooling and solidifying at room temperature, pulverize through a 20-mesh sieve;

[0194] (4) dissolving mannitol in deionized water to prepare a mixed solution of 60% (...

Embodiment 3

[0197] Embodiment 3, a kind of preparation method of children's domperidone orally disintegrating tablet

[0198] 1. A domperidone orally disintegrating tablet for children is made of the following raw materials in parts by mass:

[0199]

[0200] 2. The preparation method is as follows:

[0201] (1) Domperidone is pulverized and passed through a 155-mesh sieve to obtain particles with an average particle diameter of 24-28 μm for subsequent use;

[0202] (2) Pulverize the white sugar and polyvinylpolypyrrolidone of proportioning amount, cross 120 mesh sieves, and set aside;

[0203] (3) Melt the fatty acid glyceride at 60-80°C, add the proportioning amount of Tween 80 and mix well, then weigh the proportioning amount of domperidone, then add the proportioning amount of 1 / 3 (W / W) white sugar, After cooling and solidifying at room temperature, pulverize through a 10-mesh sieve;

[0204] (4) dissolving mannitol in deionized water to prepare a mixed solution of 50% (W / W), th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses an infantile domperidone orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet is prepared from the following raw materials in parts by mass: 10 to 30 parts of domperidone, 10 to 30 parts of fatty glyceride, 5 to 10 parts of tween 80, 900 to 2700 parts of white sugar, 2 to 5 parts of crospovidone, 10 to 30 parts of mannitol, 0.01 to 0.05 part of essence, 0.2 to 0.5 part of magnesium stearate and 0.2 to 0.5 part of aerosil. According to the infantile domperidone orally disintegrating tablet and the preparation method thereof, an orally disintegrating tablet medicament is prepared by using the domperidone as an effective component of the medicament and through an innovative process. By using the domperidone orally disintegrating tablet prepared by the invention, the problems that the dissolution rate of the medicament is low, the medicament has a bitter taste, and the like, are solved successfully; the infantile domperidone orally disintegrating tablet has a favorable effect on infantile functional dyspepsia.

Description

technical field [0001] The invention relates to a drug for gastrointestinal motility, in particular to an orally disintegrating tablet of domperidone for children and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Domperidone is a synthetic benzoimidazole derivative, it is a dopamine receptor antagonist with anti-emetic effect, and it is difficult to enter the brain through the blood-brain barrier. Domperidone acts on the chemoreceptor trigger area outside the blood-brain barrier, so it hardly acts on the central nervous system; domperidone selectively blocks dopamine 2 (DA2) receptors and mainly acts on the peripheral nervous system. Since DA2 receptors are also the main receptors in the gastrointestinal tract, DA2 receptor antagonists reduce dopamine-mediated relaxation of gastric smooth muscle. In the gastrointestinal tract, domperidone acts as a prokinetic agent, increasing the motility of the digestive tract. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/454A61K47/14A61K47/26A61P1/14
CPCA61K9/0056A61K9/2013A61K9/2018A61K9/2027A61K31/454
Inventor 乔敏袁武杰
Owner SHANDONG SBOND PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com