65 results about "Polyvinylpolypyrrolidone" patented technology

The present disclosure relates to a procedure for the synthesis of polymers (homo and copolymers) of the poly (ionic liquid) (PIL) type. The homopolymers are derived from polyvinylimidazolium, polyvinylpyrrolidone or polyvinylpyridine and the copolymers from monomers of vinyl ionic liquids (ILs) are derived from imidazole and N-vinylpyrrolidone. The structural modification of these homopolymers and copolymers occurs by using strong inorganic acids such as sulfuric, chlorosulfonic and bromosulfonic, among others, and halide metallic salts such as AlCl3, FeCl3, CuCl, ZnCl2, and SnCl2. Also, these PILs are employed as catalysts in alkylation reactions between isoparaffins and olefins for producing alkylate gasoline.

The invention relates to a sodium propionate-containing hydrate inhibitor for guaranteeing flow of a carbon dioxide conveying pipeline, which comprises sodium propionate, glycine, polyvinyl pyrrolidone and methanol, and the sodium propionate, the glycine, the polyvinyl pyrrolidone and the methanol are mixed with a sodium chloride solution serving as a solvent, so that the sodium propionate, the glycine, the polyvinyl pyrrolidone and the methanol are mixed according to the molar percentage as follows: 1-15 mol% of the sodium propionate, 1-15 mol% of the glycine, 0.1-1 mol% of the polyvinyl pyrrolidone and 5-60 mol% of the methanol. The sodium propionate, the glycine, the polyvinyl pyrrolidone and the methanol are compounded for use, so that the effect of a single inhibitor is enhanced, the application range is wider, a better inhibition effect is achieved at a lower concentration, and the generation of carbon dioxide hydrate can be better inhibited. The mixed use reduces the cost of the inhibitor, reduces the use amount of the mixture, and weakens the toxicity and pollution of the inhibitor.

The invention relates to a preparation method of an artificial blood vessel, the artificial blood vessel is composed of a porous support layer, a biodegradation layer and an antithrombotic layer, and the method comprises the following steps: soaking an expanded polytetrafluoroethylene substrate with silver nitrate doped polyvinyl pyrrolidone-poly-N-isopropylacrylamide to obtain the porous support layer; and then assembling a biodegradable material and an antithrombotic material as a biodegradable layer and an antithrombotic layer. The invention also relates to the artificial blood vessel prepared by the method.

The invention belongs to the technical field of natural gas extraction, and particularly relates to an oil-resistant anti-freezing corrosion-inhibition foaming agent for a gas well as well as a preparation method and application of the oil-resistant anti-freezing corrosion-inhibition foaming agent. The oil-resistant anti-freezing corrosion inhibition type foaming agent for the gas well is prepared from the following components in parts by mass: 40 to 70 parts of sodium alpha-olefin sulfonate, 10 to 20 parts of cocamidopropyl dimethylamine oxide, 1 to 10 parts of modified nanoparticles, 20 to 40 parts of betaine zwitterionic surfactant, 5 to 15 parts of corrosion inhibitor, 1 to 15 parts of polyvinyl pyrrolidone and the balance of water. After the foaming agent is aged at the low temperature of-30 DEG C, the liquid carrying rate of the foaming agent can be up to 83.8% in the range that the condensate oil content is 10%-50%, the degree of mineralization resistance is up to 2 * 10 mg / L, and the corrosion inhibition rate in a composite sample solution containing 20 wt% of condensate oil, 20 wt% of methanol and saturated CO2 can be up to 75% or above; the requirements of extreme composite working conditions of high salinity, gas condensate pollution and acid gas corrosion in the middle and later periods of gas well development can be met, and the dual effects of drainage gas recovery and underground protection are achieved.

This invention relates to the field of medical tape technology and discloses a medical tape and its preparation method, comprising the following steps: mixing polyvinylpyrrolidone, polyvinyl alcohol, antibacterial filler, glycerin and deionized water, stirring to obtain an antibacterial adhesive; coating the antibacterial adhesive onto the surface of a nonwoven fabric, drying to obtain an adhesive layer; and bonding a fabric substrate to the adhesive layer to obtain the medical tape. The antibacterial filler contains a composite antibacterial material with a multilayered antibacterial structure, exhibiting excellent antibacterial activity. Furthermore, the composite black phosphorus nanosheets are adhered between the layers, forming a composite layered material with high oxygen barrier properties, preventing black phosphorus from easily oxidizing upon contact with oxygen in the air, thus avoiding the loss of antibacterial activity of the medical tape. The formed composite layered material also possesses good mechanical properties, can weaken the stress in the tensile test of the medical tape, thereby distributing pressure, and has good flexibility.

The application discloses a rain night type road marking paint. The road marking paint is prepared from the following raw material components in parts by weight: modified acrylic emulsion 50-80 parts, polyvinylpyrrolidone 30-50 parts, curing agent 8-15 parts, wear-resistant agent 5-8 parts, glass microbead 30-50 parts, potassium feldspar powder 10-20 parts, antioxidant 3-5 parts, dispersing agent 3-6 parts, anti-sedimentation agent 3-5 parts, drying catalyst 1-3 parts, and toughening agent 2-5 parts. The road marking paint prepared by the application has good reflection performance in rain night and daytime; the combination use of the glass microbead and the potassium feldspar powder improves the retroreflective coefficient of the material; the combination use of the adipic dihydrazide and 3,3',4,4'-benzophenonetetracarboxylic dianhydride reduces the drying time; and the combination use of (3,3,3-trifluoropropyl)trimethoxysilane and potassium hexatitanate whisker improves the wear resistance of the material.

The invention discloses a preparation method for prolonging the validity period of erythromycin ethylsuccinate orally disintegrating tablets. The preparation method comprises the following steps: sequentially putting low-substituted hydroxypropyl cellulose, microcrystalline cellulose, aspartame, carboxymethyl starch sodium and polyvinylpolypyrrolidone into a wet granulation mixer, covering with a cover, starting equipment, carrying out low-speed dry mixing for 3 minutes, slowly adding low-concentration hydroxypropyl methylcellulose slurry from a feed port of a pot cover, and carrying out low-speed wet mixing for 3 minutes; stopping the machine, opening the cover, scraping powder on the inner surface of the pot cover and the periphery of the inner side of the pot by using a clean scraper, adding erythromycin ethylsuccinate raw materials, covering the cover, starting equipment, carrying out low-speed wet mixing for 3 minutes, and carrying out high-speed wet mixing for 2 minutes. By improving the medicine production process, the stability and durability of the medicine are improved, so that the validity period of the medicine is prolonged, and meanwhile, the effectiveness and safety of the medicine can still be kept within the prolonged validity period.

The application provides a palladium-zinc-bismuth oxide catalyst and a preparation method and application thereof in beta-hydroxy ester oxidation, and the preparation steps of the catalyst comprise the following steps: dissolving a bismuth salt and an alkali into water, adding carbon powder to be ultrasonically dispersed, then heating to reflux to perform reaction, and then performing filtration and drying to obtain Bi2O3 / C; dissolving a palladium salt, a zinc salt, L-ascorbic acid and polyvinyl pyrrolidone into water, adding Bi2O3 / C to be ultrasonically dispersed, then heating to reflux to perform reaction, and then performing filtration, drying and calcination to obtain the palladium-zinc-bismuth oxide catalyst. The obtained catalyst can be used in beta-hydroxy ester oxidation reaction, and beta-keto ester products can be obtained with high yield and high selectivity. The catalyst has novel structure, simple preparation process, can efficiently catalyze beta-hydroxy ester oxidation to obtain beta-keto ester products, has the advantages of fast reaction speed, high raw material conversion rate and high product selectivity, and has important application prospect.

The invention relates to the technical field of lithium battery diaphragms, in particular to a low-moisture and high-heat-resistance solution type acrylic acid binder and a preparation method thereof. Through the synergistic effect of the protective colloid composite cross-linking monomer, the low moisture content is achieved in a breakthrough mode. Wherein the steric hindrance effect of the polyvinyl alcohol in the protective colloid mixture inhibits exposure of hydrophilic groups, the polyvinyl pyrrolidone improves the dispersion stability, and the polyether polyol enhances the film-forming flexibility; hydroxyethyl acrylamide and diacetone methacrylamide in the crosslinking monomer mixture construct a dual crosslinking network, so that the covalent bond density between molecular chains is remarkably enhanced, and cyano groups of acrylonitrile further reduce the moisture adsorption path and improve the interface anchoring force through strong polarity and hydrophobicity; the three components cooperate with each other to achieve a heat-resistant effect which can only be achieved by a high addition amount in the prior art under a low addition amount, and meanwhile, the problem of diaphragm deformation caused by high-temperature long-time reaction is avoided.

The invention provides purpureocillium lilacinum for preventing and treating root rot and soil nematode diseases of food crops, a microbial inoculum and application of the purpureocillium lilacinum and the microbial inoculum. The name of the Purpureocillium lilacinus is Purpureocillium lilacinus HN-17, the Purpureocillium lilacinus HN-17 is classified and named as Purpureocillium lilacinus, the Purpureocillium lilacinus HN-17 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.41954. The Purpureocillium lilacinus HN-17 can be used for preparing the Purpureocillium lilacinus. Research results show that the antibacterial effect of the purpureocillium lilacinum HN-17 on 9 kinds of plant pathogenic bacteria such as fusarium oxysporum reaches 60.42%-83.33%; the indoor nematode killing effect on wheat cyst nematode and tomato root-knot nematode reaches 100%; the optimized binder, the optimized wetting agent, the optimized stabilizer and the optimized disintegrating agent are polyvinyl pyrrolidone, lauryl sodium sulfate, CaCO3 and AlCl3 respectively; the field control effects of wheat root rot and soybean root rot are 61.08% and 80.95% respectively after seed dressing and broadcasting, the field cyst decline rates of wheat cyst nematode and soybean cyst nematode are 54.61% and 66.67% respectively, and the application value is high.

Disclosed is a solid dispersion of a rifamycin-quinazolinone conjugated molecule, which comprises a rifamycin-quinazolinone conjugated molecule shown in formula (I) and a polymer carrier. The polymer carrier comprises one or a combination of more of hydroxypropyl methylcellulose acetate succinate (HPMCAS), hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl cellulose (HPC), polypropylene resin, and polyvinyl pyrrolidone (PVP). FIG. 1: AA%%%Formula (I)

The invention relates to the technical field of medical instrument coatings, and particularly provides a hydrophilic lubricating coating and a preparation process thereof, the hydrophilic lubricating coating comprises the following components by weight: 3%-10% of polyvinyl pyrrolidone, 5%-15% of composite bonding resin, 1%-5% of a cross-linking agent, 1%-5% of an initiator, 0.1%-1% of a leveling agent, 0.1%-0.5% of an antifoaming agent, 0.2%-2% of a nanometer reinforcing filler, and 60%-80% of a mixed solution; the preparation process comprises the following steps: preparing a presol, preparing a coating liquid, coating the coating liquid, carrying out thermocuring and carrying out UV photocuring. According to the invention, through collaborative design of the composite bonding resin and a gradient cross-linking system, strong adhesive force and lasting lubricity of the coating on a PVC substrate are realized; the mechanical strength and sterilization resistance of the coating are remarkably improved by introducing the nano reinforcing filler and the PVP with controllable molecular weight; according to the scheme, a dual-curing process is creatively used, and the forming quality of the hydrophilic lubricating coating is improved.

The invention relates to the technical field of medical adhesive tapes, and discloses a medical adhesive tape and a preparation method thereof.The preparation method comprises the following preparation steps that polyvinyl pyrrolidone, polyvinyl alcohol, antibacterial filler, glycerin and deionized water are mixed and stirred, and an antibacterial adhesive is obtained; coating the antibacterial adhesive on the surface of a non-woven fabric material, drying to obtain an adhesive layer, and adhering a fabric base material to the surface of the adhesive layer to obtain the medical adhesive tape. The composite antibacterial material in the antibacterial filler contains an antibacterial multilayer structure and shows excellent antibacterial activity, and the composite black phosphorus nanosheet is adhered between layers, so that the formed composite layered material has relatively high barrier property to oxygen, and the situation that black phosphorus is in contact with oxygen in the air and is easy to oxidize, resulting in failure of the antibacterial activity of the medical adhesive tape, is avoided, and the service life of the medical adhesive tape is prolonged. The formed composite layered material has good mechanical properties, can weaken the stress of the medical adhesive tape in a tensile test so as to disperse the pressure, and has good flexibility.

The invention discloses a dapagliflozin-propylene glycol monohydrate pharmaceutical composition and a preparation method thereof, and relates to the technical field of medicine preparation, the pharmaceutical composition is composed of dapagliflozin-propylene glycol monohydrate, microcrystalline cellulose, lactose anhydrous, polyvinylpolypyrrolidone, silica, magnesium stearate and a coating agent; in the preparation process, firstly, the raw material medicines are sieved by a 120-mesh sieve, so that the in-vitro dissolution capacity is fully improved, and then granulation and coating are performed; the dapagliflozin propylene glycol monohydrate has the advantages that the coating rate of the prepared dapagliflozin propylene glycol monohydrate is high and reaches 95% or above through the unique ingredient proportion of the auxiliary materials and the coating agent, the disintegration time is short under various pH medium conditions, the dapagliflozin propylene glycol monohydrate can be completely disintegrated within 30 seconds, and the dissolution rate in 15 minutes reaches 85% or above. The sample content is uniform and reaches 100%; the prepared dapagliflozin and propylene glycol monohydrate composition has better stability under the conditions of high temperature, high humidity and illumination, and meanwhile, the tablet surface is smooth, so that the compliance of a patient can be improved.

The invention belongs to the field of food, and particularly relates to direct drinking powder which comprises but is not limited to the following raw materials in parts by weight: 5-10 parts of coenzyme Q10 microcapsule powder, 1-3 parts of a white kidney bean probiotic fermentation extract, 2-5 parts of a pseudo-ginseng extract, 30-40 parts of a sweetening agent, 3-5 parts of polyvinylpolypyrrolidone, 1-2 parts of silicon dioxide, 1-2 parts of an acidity regulator and 0.5-1 part of edible essence. The instant powder disclosed by the invention has the characteristics of melting within 3 seconds in the mouth, no need of being taken after being mixed, fine and fresh in mouth feel, high in bioavailability and strong in stability, not only effectively solves the problems of solubility and stability of fat-soluble active ingredients, but also realizes dual absorption of the fat-soluble active ingredients in oral mucosa and gastrointestinal tracts, and improves the nutritional and health-care effects of the instant powder.

The invention discloses a preparation method of hypercrosslinked macroporous adsorption resin for removing cytokines in blood purification. Macroporous styrene-divinylbenzene resin with low crosslinking degree is prepared from styrene and divinylbenzene, then secondary crosslinking is performed on the macroporous styrene-divinylbenzene resin with the low crosslinking degree by utilizing a Friedel-Grafts method to prepare the hypercrosslinked adsorption resin, residual chloromethyl reacts with enamine to generate dangling double bonds, and then the hypercrosslinked adsorption resin is prepared. And then, polyvinyl pyrrolidone and poly (hydroxyethyl methacrylate) are grafted. The hypercrosslinked adsorption resin prepared by the invention has a huge specific surface area and abundant pore channels, and has superstrong adsorption performance on cell factors represented by TNF-alpha and IL-6, and in addition, polyvinyl pyrrolidone and poly (hydroxyethyl methacrylate) are grafted on the surface of the resin, so that the blood compatibility is improved.

The application relates to a sodium propionate hydrate inhibitor containing sodium propionate for carbon dioxide conveying pipeline flow guarantee, which comprises sodium propionate, glycine, polyvinyl pyrrolidone and methanol, and the molar percentage of the four after being mixed with a sodium chloride solution as a solvent is as follows: 1-15mol% of sodium propionate, 1-15mol% of glycine, 0.1-1mol% of polyvinyl pyrrolidone and 5-60mol% of methanol. In the application, the composite use of sodium propionate, glycine, polyvinyl pyrrolidone and methanol enhances the effect of a single inhibitor, the use range is more extensive, better inhibiting effect can be achieved at a lower concentration, and the generation of carbon dioxide hydrate can be better inhibited. The mixed use reduces the cost of the inhibitor, reduces the use amount of the mixture and weakens the toxicity and pollution of the inhibitor.

The invention relates to the technical field of biomedicine, and particularly discloses a nano-material protective agent for cell preservation and a preparation method. The nanomaterial protective agent is prepared from the following raw materials in parts by weight: 0.5 to 2 parts of functionalized graphene oxide nanosheets, 0.3 to 1.5 parts of an amphiphilic block copolymer, 4 to 6 parts of trehalose, 1 to 3 parts of poly (vinyl pyrrolidone), 0.2 to 0.5 part of glutathione, 2 to 4 parts of polyethylene glycol and 83 to 92 parts of a phosphate buffer solution. The functionalized graphene oxide nanosheet is a graphene oxide nanosheet of which the surface is grafted with polyvinyl alcohol. The nano-material protective agent can reduce cell damage caused by reagents in the cell preservation process and improve the cell survival rate.

The present disclosure provides coated optical articles that exhibit anti-fog properties. The coated article comprises: (1) an optical substrate; and (2) a coating applied as a topmost layer over the surface of the substrate. The coating is formed from a treatment composition comprising: (A) a polymer comprising a carboxylic acid group, a pyrrolidone group, and an alkoxysilane group; (B) an alkoxysilane containing an amino functional group, an ammonium functional group, an epoxy functional group, or an ethylenically unsaturated group; and (C) polyvinyl pyrrolidone.

The invention discloses an immune probe for orderly immobilizing a biological enzyme and an antibody as well as a preparation method and application of the immune probe. The method comprises the following steps: S1, adding 2-methylimidazole and a metal salt solution into a polyvinyl pyrrolidone and cysteine mixed solution containing bio-enzyme, and aging at room temperature; after aging, centrifuging to obtain a precipitate, washing and dispersing to obtain a signal generating element suspension; s2, slowly dropwise adding an antibody solution into a 2-methylimidazole solution, then adding the signal generation element suspension prepared in the step S1, then adding a metal salt solution, and carrying out vortex oscillation; and finally, centrifugally collecting precipitates, washing and dispersing to obtain the immune probe integrating the dual functions of antibody recognition and signal generation. The method of the present invention shows an ordered, efficient strategy of synthetase-antibody conjugates that not only loads a large amount of enzymes to generate amplification signals, but also protects encapsulated proteins from denaturation conditions.

The application provides a method for preparing an ultralubricating coating by a "in situ transplanting method", which coats a natural rubber medical catheter with a synthetic polyisoprene solution. Since the synthetic polyisoprene has the same composition as the natural rubber, the interface of the two is firmly combined and the coating does not fall off. An azo initiator opens the double bond in the polyisoprene molecule under ultraviolet light irradiation, and further initiates the polymerization of a vinyl pyrrolidone monomer, so that polyvinyl pyrrolidone side chain molecular brushes grow on the polyisoprene molecular chain, like seedlings growing in a field. The polyvinyl pyrrolidone molecular brushes with ultralubricating effect are firmly combined on the surface of the natural rubber medical catheter, and the purpose of ultralubricating and drag reduction is achieved. The method can prevent the allergic reaction caused by trace amounts of protein in the natural rubber, and can effectively increase the lubricity of the natural rubber medical catheter and reduce the surface friction.

The invention belongs to the technical field of pigments, and particularly relates to a special super-weather-resistant waterproof pigment for murals and a preparation method thereof.The special super-weather-resistant waterproof pigment for the murals is prepared from, by weight, 100 parts of distilled water, 70-75 parts of phthalocyanine blue, 15-20 parts of modified nano materials, 20-25 parts of polyvinyl alcohol, 5-10 parts of sodium bicarbonate, 7-12 parts of talcum powder and 3-5 parts of polytetrafluoroethylene powder. 4-8 parts of polyvinyl pyrrolidone, 2-3 parts of sodium citrate and 5-8 parts of a mixed surfactant. The prepared special pigment for the wall painting is good in weather resistance, fire resistance and water resistance, high in storage stability and extremely high in use value.

The present invention relates to solid oral care compositions, such as tablets, comprising a binder system. In certain aspects, the present invention relates to solid oral care compositions comprising a binder system, wherein the binder system comprises polyvinylpyrrolidone and hydroxyethylcellulose, as well as tablets, to the use of these compositions and to methods of manufacturing these compositions.

The invention provides a remegapam sulfate orally disintegrating tablet and a preparation method thereof, and the remegapam sulfate orally disintegrating tablet is prepared from an active component remegapam sulfate orally disintegrating tablet, a filler mannitol and microcrystalline cellulose, a disintegrating agent polyvinylpolypyrrolidone, an adhesive low-substituted hydroxypropyl cellulose, a flavoring agent sucralose and a lubricant magnesium stearate. The problems of poor material flowability, sticking, easy cracking during tabletting and the like during tabletting are solved, the tablet has the advantages of rapid disintegration, rapid dissolution, better compressibility, better stability, good taste, simple preparation method and the like, is more suitable for patients with dysphagia, especially the old and children, has great clinical significance, and is worthy of popularization and application. The method is suitable for large-scale industrial production.

The invention discloses a method for efficiently extracting polyphenol substances in olive juice by recycling PVPP (Polyvinyl Pyrrolidone). The method comprises the following steps: 1) adding water into the pulp of fresh olive fruits, pulping, and adding pectinase and cellulase for enzymolysis; (2) squeezing the olive pulp subjected to enzymolysis to obtain juice, filtering, centrifuging, and collecting crude olive extract supernate; (3) adding the crude olive extract supernatant into the swollen PVPP until the final concentration of the PVPP is 5%, stirring, adsorbing, standing, centrifuging, and discarding the supernatant to obtain PVPP precipitate adsorbed with olive polyphenol; 4) carrying out desorption on the PVPP precipitate adsorbed with the oleuropein by using an elution solvent, and separating used PVPP and a desorption solution containing the oleuropein; according to the method, the PVPP is recycled to extract the polyphenols, the polyphenol substances are obtained through desorption, adsorption and purification, clarified fruit juice is obtained at the same time, and waste recycling is achieved.

The invention relates to the technical field of tooth socket cleaning, in particular to a cleaning composition for effectively removing tooth socket calcification deposits and a preparation method of the cleaning composition. The cleaning composition is prepared from the following raw materials in parts by weight: 80-90 parts of citric acid, 20-30 parts of potassium peroxymonosulfate, 10-20 parts of sodium phytate, 10-20 parts of sodium pyrophosphate, 10-20 parts of polyvinylpolypyrrolidone, 15-25 parts of sorbitol, 5-7 parts of a foaming agent, 2-4 parts of a coloring agent, 1-2 parts of a bitter agent, 8-12 parts of a bactericide and 2-4 parts of a lubricating agent. In the invention, glycerol, sodium hydroxide and deionized water are treated to generate an alkaline environment to play a role in activating a material, a porous carrier can be formed after furfural residue and silicone oil are subsequently added for treatment, and formic acid treatment can expand a pore structure by etching and enhance the adsorption capacity of the carrier, so that the adsorption capacity of the carrier is improved in subsequent copper chloride solution treatment. The cleaning composition can continuously release low-concentration copper ions to interfere with the enzyme activity of bacteria, so that an efficient antibacterial effect is achieved.

Provided is a current collector for a power storage device for obtaining a low-resistance power storage device. A current collector for a power storage device, characterized by having a coating layer formed on one or both surfaces of a sheet-shaped conductive substrate, the coating layer containing a powdered carbon material, acid-modified poly(1,1-difluoroethylene), and polyvinylpyrrolidone, the content of the polyvinylpyrrolidone in the coating layer being 0.099 to 5.0 mass%, and the content of the powdered carbon material in the coating layer being 15.0 to 45.0 mass%.

The invention discloses a transition metal-nitrogen-carbon defect piezoelectric material and a preparation method and application thereof.The preparation method comprises the steps that Zn (NO3) 2.6 H2O, FeSO4. 7H2O, polyvinyl pyrrolidone and 2-methylimidazole are dissolved in a methanol solution to be fully stirred and react to obtain a mixed material, then the mixed material is subjected to centrifugal treatment, and ZnFe-ZIF nanocrystals are obtained; and dispersing the ZnFe-ZIF nanocrystals in a methanol solution, adding tannic acid, carrying out fixed-time etching to obtain a reaction product, carrying out high-temperature calcination on the reaction product in a nitrogen atmosphere, and cooling to obtain the piezoelectric material with the carbon defect structure. The piezoelectric material with the carbon defect structure is used for sewage catalytic treatment. The catalyst is simple in preparation method, low in cost, convenient to operate and good in repeatability, the obtained material can effectively achieve piezoelectric catalytic degradation of organic pollutants, and a green, efficient and feasible scheme is provided for water environment pollution treatment.

The invention provides a melogabalin besylate sustained release preparation. The melogabalin besylate sustained release preparation is prepared from the following components: melogabalin besylate, polyoxyethylene, polyvinylpolypyrrolidone, sodium alginate and microcrystalline cellulose, the mass ratio of the melogabalin besylate to the polyoxyethylene to the polyvinylpolypyrrolidone to the sodium alginate to the microcrystalline cellulose is (0.5-8): (20-40): (5-15): (20-40): (6-35). The sustained release preparation can ensure that melogabalin besylate is continuously released and absorbed in vivo, so that the drug effect is improved, the adverse reaction is reduced and the treatment effect is enhanced while the administration frequency is reduced.

The invention provides PRP gel poor in leucocyte and low in pro-inflammatory risk as well as a preparation method and application of the PRP gel, and belongs to the field of PRP gel. The method comprises the following steps: S1, under a high vacuum condition, mixing acrylate resin, a surface modified nano silicon dioxide composite material, polyether modified polysiloxane and polyvinyl pyrrolidone to obtain PRP separation gel; s2, collecting peripheral blood by using a vacuum blood collection tube with a built-in PRP (platelet rich plasma) separation gel, and centrifuging to obtain platelet rich plasma on an interface of the PRP separation gel; s3, mixing and activating the platelet-rich plasma and an initiator to obtain the PRP gel. The precise density gradient is constructed by customizing the thixotropic separation gel, efficient layered isolation of platelets, pro-inflammatory leukocytes and erythrocytes is achieved, the high-concentration platelets are accurately enriched, meanwhile, the leukocyte content is greatly reduced, and therefore PRP products with controllable components and stable effects are achieved, and the repairing requirements of sensitive environments such as uterine cavities are met.