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Preparation method of macroporous adsorbent resin for toxin substance adsorption

A pore adsorption and resin technology, which is applied in the field of preparation of macroporous adsorption resins, can solve the problems of undisclosed preparation methods of adsorbents, etc., and achieve the effects of enriching pore screening, large adsorption capacity, and improving blood compatibility

Active Publication Date: 2015-11-25
TIANJIN STANDARD BIOLOGICS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN103533830A Chinese invention patent publication also discloses the preparation method of the adsorbent composition whose blood compatibility surface is polyvinyl alcohol, but does not disclose the blood compatibility surface of the adsorbent poly(N-vinylpyrrolidone) preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Free radical polymerization:

[0040] Add 500mL of aqueous solution containing 1.5wt% gelatin and 3wt% NaCl to a 1000mL three-necked flask, add 4g of divinylbenzene, 3.28g of ethylstyrene, 42.72g of styrene, 65g of toluene, 40g of n-heptane, 0.5g of supernatant For the mixed oil phase of benzoyl oxidation, under mechanical stirring, heat up to 75°C for 6 hours, then heat up to 80°C for 5 hours, and then heat up to 87°C for 6 hours. After the reaction, evaporate the porogen and wash with water Until the washing solution is clarified, suction filter, dry, and sieve, select the resin with a particle size of 0.5-1.2 mm, that is, the obtained macroporous polystyrene-based resin.

[0041] (2) Chloromethylation reaction:

[0042] Add 20 g of the macroporous polystyrene resin matrix obtained above into a 500 mL three-necked flask, add 100 g of chloromethyl ether, and let stand at room temperature for 4 h; start the stirrer, add 15 g of anhydrous zinc chloride in two times,...

Embodiment 2

[0052] (1) Free radical polymerization:

[0053] Add 500mL of aqueous solution containing 1.5wt% gelatin and 3wt% NaCl to a 1000mL three-necked flask, add 7.5g divinylbenzene, 6.15g ethylstyrene, 36.35g styrene, 55g toluene, 45g200 # The mixed organic phase of gasoline and 0.5g benzoyl peroxide was heated to 75°C for 5 hours under mechanical stirring, then heated to 80°C for 5 hours, and then heated to 87°C for 6 hours. After the pore agent, wash with water until the washing solution is clear, filter with suction, dry, and sieve to select the resin with a particle size of 0.5-1.2 mm, which is the obtained macroporous polystyrene-based resin matrix.

[0054] (2) Chloromethylation reaction:

[0055] Add 20 g of the macroporous polystyrene resin matrix obtained above into a 500 mL three-necked flask, add 100 g of chloromethyl ether, and let stand at room temperature for 4 h; start the stirrer, add 15 g of anhydrous zinc chloride in two times, and heat up to React at 50°C for 20...

Embodiment 3

[0066] (1) Free radical polymerization:

[0067] Add 500mL of aqueous solution containing 1.5wt% gelatin and 3wt% NaCl to a 1000mL three-necked flask, add 10g of divinylbenzene, 8.18g of ethylstyrene, 31.82g of styrene, 50g of toluene, 40g of liquid paraffin, 0.5g of supernatant For the mixed organic phase of benzoyl oxidation, under mechanical stirring, heat up to 75°C for 4 hours, then heat up to 80°C for 4 hours, then heat up to 87°C for 6 hours, after the reaction, steam or extract the porogen Afterwards, washing with water until the washing solution is clear, suction filtering, drying, and sieving, and selecting resin with a particle size of 0.5-1.2 mm, that is, the obtained macroporous polystyrene-based resin matrix.

[0068] (2) Chloromethylation reaction:

[0069] Add 20 g of the macroporous polystyrene resin matrix obtained above into a 500 mL three-necked flask, add 100 g of chloromethyl ether, and let stand at room temperature for 4 h; start the stirrer, add 15 g o...

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PUM

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Abstract

The invention provides a preparation method of a macroporous adsorbent resin for toxin substance adsorption, which comprises the following steps: preparing a lower-crosslinking-degree macroporous styrene-divinylbenzene resin, crosslinking the lower-crosslinking-degree macroporous styrene-divinylbenzene resin by a Friedel-Crafts process to obtain an ultrahigh-crosslinked-structure macroporous adsorbent resin, and introducing acylation reaction and grafting reaction in the ultrahigh-crosslinked-structure macroporous adsorbent resin preparation process to successfully prepare the carboxylic-acid-group-containing polyvinylpyrrolidone-grafted ultrahigh-crosslinking-degree macroporous adsorbent resin for toxin substance adsorption. The resin has the advantages of huge specific area and abundant pore structure, contains part of carboxylic acid ion groups, and is grafted by the polyvinylpyrrolidone on the resin surface. Therefore, the adsorption capacity for paraquat, acetochlor and other toxin substances containing cations or basic groups can be enhanced by utilizing the potential energy effect caused by hydrophobicity and huge specific area of the particular polystyrene skeleton of the ultrahigh-crosslinking-degree adsorbent resin, the pore screening action of the abundant pore structure and the charge action of the carboxylic acid groups. Besides, the polyvinylpyrrolidone is grafted on the resin surface to enhance the compatibility of the resin with blood.

Description

technical field [0001] The invention belongs to the field of blood purification, and in particular relates to a preparation method of a macroporous adsorption resin used for the adsorption of toxin substances. Background technique [0002] Hemoperfusion technology has been widely used in the fields of poisoning first aid, kidney disease, liver disease and critical illness. The principle is that the blood is introduced into a container with a solid adsorbent by means of an extracorporeal circulation power device to absorb and remove exogenous or endogenous toxins in the blood. substance. Adsorbent is the core part of hemoperfusion technology. The quality of its adsorption performance directly affects the therapeutic effect, and the quality of blood compatibility directly affects the safety of treatment. With the wide application of hemoperfusion technology in clinical practice, the requirements for the effectiveness and safety of adsorbents are constantly increasing. Especia...

Claims

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Application Information

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IPC IPC(8): C08F290/00C08F257/02C08F226/10C08F212/08C08F212/12C08F212/36C08F2/20C08F8/46C08F8/24C08J9/28C08J9/26C08J3/24B01J20/26B01J20/30
Inventor 董凡邵柯
Owner TIANJIN STANDARD BIOLOGICS CO LTD
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