29 results about "Guanidine derivatives" patented technology

The invention provides novel guanidine derivatives of tricyclic aryl compounds, and pharmaceutical compositions thereof and methods for treating diseases and disorders, such as various types of cancer.

To provide a factor Xa reagent.SOLUTION: Exemplary compositions include Factor Xa, a substrate, one or more guanidine derivatives, and in some cases heparin. An exemplary method of detecting an anticoagulant in a sample includes combining or contacting a composition with a sample and measuring factor Xa activity based on substrate status. The composition modulates the activity of factor Xa in the sample, and the modulation includes a reduction in the rate of clotting of the sample caused by factor Xa. The presence of an anticoagulant is based on the activity of factor Xa.SELECTED DRAWING: None

The invention provides a guanidyl-pyridine bridged porous organic polymer composite gas generating agent and a preparation method thereof, and the preparation method comprises the following steps: mixing a guanidyl derivative monomer, a pyridyl monomer and a first organic solvent, adding an organic alkali, and carrying out degassing treatment; degassing, and reacting at 120-150 DEG C to obtain a guanidyl-pyridine bridged porous organic polymer; dispersing in a second organic solvent, adding basic copper nitrate, stirring and carrying out ultrasonic treatment; and removing the second organic solvent to obtain powder, and tabletting and granulating to obtain the guanidyl-pyridine bridged porous organic polymer composite gas generating agent. A guanidyl functional group and a pyridine group are combined through a covalent bond to construct a porous organic polymer, integration of a fuel function and a coordination function is achieved, a solvent-pre-coordination strategy is combined, effective compounding of GBPOP and CuBN is achieved, and the prepared composite gas generating agent has high energy density and excellent combustion stability.

The present disclosure relates to biaryl aminoguanidine derivatives of Formula II or a pharmaceutically acceptable salt thereof and processes for their preparation. The present disclosure also relates to the use of such biaryl aminoguanidine derivatives for the treatment of diseases involving the melanocortin receptor or related systems, such as proopiomelanocortin-related diseases.

The invention discloses a multifunctional guanidine salt doped perovskite solar cell and a preparation method thereof. The cell comprises an ITO (indium tin oxide) conductive glass substrate layer, a hole transport layer (MeO-4PACz), a perovskite layer Cs0.05 (FA0.95 MA0.05) 0.95 Pb (I0.95 Br0.05) 3 doped with biguanide hydrochloride (BH), a [6, 6]-phenyl-C61-butyric acid isomethyl ester electron transport layer (PCBM), a 2, 9-dimethyl-4, 7-biphenyl-1, 10-phenanthrene hole blocking layer (BCP) and a metal Ag electrode layer from bottom to top. During preparation, by means of the strong chemical action of nitrogen atoms in BH and Pb < 2 + > ions, the crystallization direction of perovskite is changed, the defect state density is reduced, non-radiative recombination is inhibited, and the carrier separation and transmission efficiency is improved. According to the invention, BH is introduced into the perovskite active layer, so that the application of guanidine derivatives in perovskite photovoltaic materials is expanded, and a new way is provided for preparing stable and efficient perovskite solar cells.

The invention claimed herein relates to a dielectric polishing composition and a method thereof. The invention claimed herein particularly relates to a composition comprising: (A) surface-modified colloidal silica particles comprising negatively charged groups on the surface of the particles, wherein the surface-modified colloidal silica particles have a negative charge, a particle size of 60 nm to 200 nm, and a zeta potential of < -35 mV at a pH in the range of > 2.0 to < 6.0; (B) at least one corrosion inhibitor selected from at least one guanidine derivative; (C) at least one iron (III) oxidizing agent; (D) at least one buffering agent selected from at least one basic amino acid having an isoelectric point (pi) of > 6.5; (E) at least one stabilizer; and (F) an aqueous medium, wherein the pH of the composition is in the range of > 2.0 to < 4.3, and wherein the composition has a polyacrylamide content of < 1 ppm.

The invention discloses a pyridine cyano guanidine derivative or a pharmaceutically acceptable salt thereof, which can be used as an NAMPT inhibitor and can be used as a potential drug for chemical treatment of various NAD + expression abnormity related diseases. Nitrile guanidine combined piperazine or pyrrolidine is used as a main body, the main body is connected through an aliphatic chain in the middle, and aromatic ring formyl (or heterocyclic ring formyl) and pyridyl (or substituted pyridyl) are used as auxiliary materials on the side surface; the structure is derived from structural optimization of an efficient NAMPT inhibitor FK866, substituted formyl piperazine and substituted formyl tetrahydropyrrole are further optimized on the basis of FK866, interaction with NAMPT is enhanced, affinity with NAMPT is further enhanced by introduction of a nitrile guanidine structure, the defect of poor water solubility of the FK866 is overcome, and the NAMPT inhibitor has the advantages that the NAMPT inhibitor has a good application prospect. The subsequent medicine test is more facilitated.

A thermally expandable composition includes at least one epoxy-functional polymer, at least one endothermic chemical blowing agent, and at least one curative selected from the group made of a urea, urea derivatives, guanidine derivatives, amidine derivatives, and imidazoles. Further, a baffle and / or a reinforcement element for hollow structures includes the thermally expandable composition, a process manufactures the baffle and / or the reinforcement element, the baffle and / or the reinforcement element is used for sealing, baffling, or reinforcing of a cavity or a hollow structure, and a method seals, baffles and / or reinforces a cavity or hollow structure.

To provide a guanidine derivative (especially an amino acid compound having 4-guanidino group) which is produced at a low cost and hardly causes a waste liquid problem, to provide a method for producing the same, and to provide an intermediate used for the production.SOLUTION: A compound represented by formula (I), a tautomer thereof, an enantiomer thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof.SELECTED DRAWING: None

This application relates to the field of pharmaceutical technology, specifically disclosing a self-sampling mouthwash wash composition, a self-sampling mouthwash wash, and its application. The self-sampling mouthwash wash composition, based on the self-sampling mouthwash wash composition, comprises 0.1–2.5 wt% sodium hexadecyl sulfonate, 0.05–1.0 wt% guanidine derivative, and 0.05–1.0 wt% amino derivative. The raw materials of the self-sampling mouthwash wash include the self-sampling mouthwash wash composition. The application of the self-sampling mouthwash wash in oral self-collection of respiratory viruses. This application improves the elution ability of respiratory viruses, bacteria, and other pathogenic microorganisms in the oral cavity during self-sampling.

The invention discloses a liposome preparation prepared from a benzoyl guanidine derivative LY104 crystal form as well as a preparation method and application of the liposome preparation, and belongs to the technical field of medicines. The invention provides a liposome for inflammatory lung diseases, which takes LY104 and a novel crystal form thereof as active ingredients. The liposome prepared by the invention is good in stability, stable in membrane drug loading, and suitable for atomization drug delivery, and the particle size can be controlled to be 50-200nm. Meanwhile, the liposome preparation provided by the invention can delay drug release, prolong the onset time, improve the tolerated dose of single administration, reduce drug irritation, and can be used for treating inflammatory lung diseases, after being freeze-dried, the liposome preparation provided by the invention is dispersed in saline water to be atomized and inhaled, so that the bitter taste of the drug can be greatly covered, and the bioavailability of the drug is improved. The lipidosome preparation has the advantages that drug irritation is reduced, drug bioavailability is improved, patient compliance is improved, the lipidosome preparation can optimize the in-vivo metabolic process of the benzoyl guanidine derivative, the curative effect of the benzoyl guanidine derivative on treating inflammatory lung diseases is enhanced, and the application prospect is wide. The liposome preparation provided by the invention can be used for treating inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease and the like in a more targeted manner, and has a wide market application prospect.

Example compositions comprise Factor Xa, a substrate, one or more guanidine derivatives, and, in some cases, heparin. An example method for detecting an anticoagulant in a sample includes combining or contacting the sample with a composition and measuring the activity of factor Xa based on the status of the substrate. The composition modulates the activity of Factor Xa in a sample, wherein the modulation comprises reducing the rate of clotting in the sample caused by Factor Xa. The presence of an anticoagulant is based on the activity of factor Xa.

Provided is an ink composition for writing instruments having excellent light resistance and storage stability.　This ink composition for writing instruments is characterized by containing at least an azo iron dye represented by (α) below.　(In formula (α), R1 are the same or different and represent a hydrogen atom or an alkyl group having 1-12 carbon atoms; R2 and R3 are the same or different and represent an alkyl group having 3-10 carbon atoms; and A+ represents an ammonium ion of a guanidine derivative or a monovalent ammonium ion that has an alkyl group having 3-18 carbon atoms).

An example composition includes factor Xa, a substrate, one or more of guanidine derivatives, and, in some cases, heparin. An example method for detecting an anticoagulant in a sample includes combining or contacting the sample with the composition and measuring activity of the factor Xa based on a state of the substrate. The composition modulates the activity of the factor Xa in the sample, where modulation includes reducing a rate of coagulation of the sample caused by factor Xa. A presence of the anticoagulant is based on the activity of the factor Xa.

The application relates to the technical field of drug synthesis, and particularly discloses a diamino guanidine derivative, discloses a structural general formula of the derivative, and provides a preparation method and application of the derivative. The derivative has good inhibiting and killing effects on pseudomonas aeruginosa, the preparation method is simple, the reaction condition is mild, and the derivative has the possibility of being developed into a drug for inhibiting and killing pseudomonas aeruginosa and treating diseases caused by pseudomonas aeruginosa infection.

The application discloses antibacterial polyester fiber for safety shoes and a production method thereof, and comprises composite particles, PET polyester and an additive, wherein the composite particles are 0.01-0.1% by mass, the additive is 6-17% by mass, and the rest is PET polyester; the composite particles comprise 70-88% of copper powder, 10-25% of graphene oxide and 2-7% of guanidine derivative for sterilization; the inventor of the application integrates the copper powder, the graphene oxide and the guanidine derivative into one body based on an accident, finds that the antibacterial performance is greatly increased, the antibacterial requirement can be met by adding a small amount, and the influence on the performance of the polyester fiber is reduced.

The invention discloses an antibacterial polyester fiber for safety shoes and a production method, the antibacterial polyester fiber comprises, by mass, 0.01-0.1% of composite particles, 6-17% of an auxiliary agent, and the balance of PET, the composite particles comprise 70-88% of copper powder, 10-25% of graphene oxide, and 2-7% of guanidine derivatives for sterilization, and the auxiliary agent comprises, by mass, 0.01-0.1% of composite particles, 6-17% of auxiliary agent, and the balance of PET. On the basis that copper powder, graphene oxide and guanidine derivatives are accidentally compounded into a whole, it is found that the antibacterial performance is greatly improved, the antibacterial requirement can be met by adding a small amount, and the influence on the performance of polyester fibers is reduced.

A foamable sealing material comprising one or more polymeric materials, an azodicarbonamide as a blowing agent, a water-insoluble urea or guanidine derivative, and optionally a zinc carboxylate. The water-insoluble urea or guanidine derivative and the zinc carboxylate synergistically reduce the activation temperature of azodicarbonamide.

A thermally expandable composition comprising a thermoplastic polymer compound and / or an elastomer compound, at least one blowing agent including at least one dicarboxylic acid salt of an aminoguanidine compound, optionally at least one free radical initiator and / or a vulcanization system, and at least one guanidine derivative. The invention is also related to baffle and / or a reinforcement element for hollow structures including the thermally expandable composition, to a process for manufacturing the baffle and / or reinforcement element, to use of the baffle and / or reinforcement element for sealing, baffling, or reinforcing of a cavity or a hollow structure, and to a method for sealing, baffling and / or reinforcing a cavity or hollow structure.

The invention discloses an antibacterial lotion and a preparation method thereof. The antibacterial lotion comprises the following raw and auxiliary materials: an antibacterial component (comprising polyhexamethylene biguanide and a newly synthesized polyhexamethylene biguanide derivative single or compound component), a synergist, a skin care and repair component, a surfactant, a plant extract, an antioxidant, a film-forming agent and a PH buffer component. , essence, a thickening agent, sterile water and the like. The antibacterial lotion can effectively resist common pathogenic bacteria such as escherichia coli, staphylococcus aureus and candida albicans, has a good cleaning function on stains on the surface of skin, can resist bacteria, diminish inflammation and relieve itching by adding moisturizing, skin care and repairing components, has certain dirt-removing power, can also achieve skin care and multiple effects, is safe in selected components, and is free of toxic and side effects. No irritation is caused to skin and the use is convenient and safe.

The invention claimed herein relates to a dielectric polishing composition and method thereof. The invention claimed herein particularly relates to a composition comprising: (A) surface-modified colloidal silica particles comprising negatively charged groups on the surface of the particles, wherein the surface-modified colloidal silica particles have a negative charge, a particle size of 60 nm to 200 nm, and a zeta potential of < -35 mV at a pH in the range of > 2.0 to < 6.0; (B) at least one corrosion inhibitor selected from at least one guanidine derivative; (C) at least one iron (III) oxidizing agent; (D) at least one buffering agent selected from at least one acidic amino acid having an isoelectric point (pi) of < 5.0; (E) at least one stabilizer; and (F) an aqueous medium, wherein the pH of the composition is in the range of > 2.0 to < 4.3, and wherein the composition has a polyacrylamide content of < 1 ppm.

The invention provides a triazole thiazolinone compound containing multiple halogen atoms and a preparation method of the triazole thiazolinone compound. The invention relates to a preparation method of a triazole thiazolinone compound containing multiple halogen atoms. The triazole thiazolinone compound contains dicarboxylic acid, an aminoguanidine derivative, halogenated benzaldehyde, mercaptoacetic acid and other raw materials. The preparation process of the triazole thiazolinone compound containing the multiple halogen atoms comprises the following steps: preparing a 3-amino-1, 2, 4-triazole compound from dicarboxylic acid and an aminoguanidine derivative; the preparation method comprises the following steps: preparing a Schiff base compound from a 3-amino-1, 2, 4-triazole compound and halogenated benzaldehyde; cyclizing the Schiff base compound and mercaptoacetic acid to prepare a triazole thiazolinone compound containing multiple halogen atoms; the invention provides a new thought for design and preparation of the triazole thiazolinone compound.

The invention discloses an application of a benzoylguanidine derivative in preparation of a medicine for treating and / or preventing chronic inflammatory diseases. According to the invention, the benzoylguanidine derivative is prepared into a hydrogel dosage form, and the hydrogel dosage form acts on a psoriasis affected part in a smearing manner, so that psoriasis-like skin lesion symptoms such as skin scales, erythema and epidermis thickening can be relieved, skin inflammatory cell infiltration and epidermis thickness can be relieved, spleen inflammatory cell infiltration can be relieved, and abnormal activity of a hair growth center can be improved; the traditional Chinese medicine composition reduces inflammatory reactions such as spleen index, reduces the level of inflammatory factors in plasma and spleen, and shows a good psoriasis treatment effect. Therefore, the benzoylguanidine derivative and the hydrogel preparation thereof have the remarkable advantages of safety, few toxic and side effects and no pollution of drug residues, and have a remarkable treatment effect and potential for realizing medical transformation.

The invention provides a triazolo imidazole compound containing multiple halogen atoms and a preparation method of the triazolo imidazole compound. According to the preparation method of the triazolo-imidazole compound containing the multiple halogen atoms, the triazolo-imidazole compound contains dicarboxylic acid, an aminoguanidine derivative, halogenated acetophenone and other raw materials; the preparation process of the triazole imidazole compound containing the multiple halogen atoms comprises the following steps: preparing a 3-amino-1, 2, 4-triazole compound from dicarboxylic acid and an aminoguanidine derivative; halogenating the halogenated acetophenone to prepare a-halogenated halogenated acetophenone; the preparation method comprises the following steps: carrying out cyclization on alpha-halogenated acetophenone and a 3-amino-1, 2, 4-triazole compound to prepare a triazole imidazole compound containing multiple halogen atoms; the invention provides a new thought for design and preparation of the triazolo imidazole compound.

The invention provides an application of a benzoylguanidine derivative in preparation of a medicine for preventing and treating nervous system diseases or cardiovascular system diseases. The benzoyl guanidine derivative comprises a compound ML-1, a compound ML-2, a compound ML-3, a compound ML-4, a compound ML-5, a compound ML-6, a compound ML-7 and a compound ML-8, and has the following structural formula. The benzoyl guanidine derivative with the novel structure is simple in preparation method, can protect nerve cells, myocardial cells and vascular endothelial cells, and is good in safety, so that the benzoyl guanidine derivative with the novel structure has important development significance.

Provided are: a black resin particle dispersion having excellent light resistance, blackness, and storage stability; and an aqueous ink composition for writing implements.　A black resin particle dispersion according to the present disclosure is characterized in that at least resin particles encapsulating an azo iron dye are dispersed in water.　The azo iron dye is preferably represented by formula (α). (In formula (α) the R1 groups are the same or different and represent a hydrogen atom or an alkyl group having 1-12 carbon atoms; the R2 groups and R3 groups are the same or different and represent an alkyl group having 3-10 carbon atoms; and A+ represents a monovalent ammonium ion that has an alkyl group having 3-18 carbon atoms or an ammonium ion of a guanidine derivative.)

In one aspect, the application relates to sulfonyl chalcogenide urea derivatives of Formula II, including sulfonyl thioureas and sulfonyl selenoureas, and methods of making the same, wherein the methods can be carried out under mild conditions and do not require the use of malodorous reagents. In one aspect, the methods are one-pot, two-step reactions wherein an intermediate imidoyl chloride is treated with a compound having formula M2X2O3 or M2XJO3 (where X and J can independently be Se, S, and / or Te) or a hydrate thereof, forming a Bunte salt which quickly decomposes to form the sulfonyl chalcogenide urea derivatives. The application also relates to substituted sulfonyl chalcogenide urea derivatives of Formula V and a method for their preparation from sulfonyl chalcogenide urea derivatives of Formula II, to a method for synthesizing a substituted guanidine from a sulfonyl chalcogenide urea of Formula II as well as to substituted guanidine derivatives thus prepared.

The present invention relates to benzylidene aminoguanidine derivatives as NR2B selective NMDA receptor antagonists and therapeutic uses thereof.