14 results about "Reflux esophagitis" patented technology

The invention discloses a traditional Chinese medicine composition for treating reflux esophagitis. The composition is prepared by extracting the following traditional Chinese medicine raw materials in parts by weight: 15-25 parts of gentian, 20-30 parts of selfheal, 18-22 parts of chrysanthemum, 20-30 parts of mint, 15-25 parts of scutellaria, 12-16 parts of gardenia, 15-25 parts of peony bark, etc. The composition can clear liver fire, clear stomach fire, soothe the liver and harmonize the stomach, promote blood circulation and soften the liver, strengthen the spleen and replenish qi, and reduce stomach qi and lung qi, thereby jointly treating reflux esophagitis of liver and stomach stagnation heat type with significant effect. The invention also discloses a preparation method thereof.

The application relates to a composition for treating reflux esophagitis and application thereof. The composition comprises the following components in parts by weight: 2-8 parts of scutellaria baicalensis, 3-7 parts of licorice, 5-10 parts of beeswax and 80-120 parts of vegetable oil. The composition for treating reflux esophagitis contains scutellaria baicalensis, licorice, beeswax and vegetable oil, and through mutual cooperation among the components, the drug prepared from the composition can significantly increase the plasma motilin level of a patient, further increase the pressure of the lower esophageal sphincter, promote gastric emptying and prevent acid reflux, promote the recovery of reflux esophagitis, the esophagus of the patient is obviously improved, and no adverse reaction is found; meanwhile, the content of lipid peroxide can be obviously reduced, the activities of superoxide dismutase and glutathione peroxidase are increased, the esophageal mucosa is protected and treated, the pathological changes of the esophagus are obviously improved, and the treatment effect is excellent.

This invention provides a traditional Chinese medicine composition for reflux esophagitis, relating to the field of traditional Chinese medicine pharmaceutical technology. The composition comprises rose, Lithospermum erythrorhizon, Sargentodoxa cuneata, Rabdosia rubescens, honeysuckle, licorice, Evodia rutaecarpa, pearl, Coix seed, and Salvia miltiorrhiza. This composition is obtained through rational combination based on the principles of traditional Chinese medicine syndrome differentiation and treatment, with synergistic effects among the various herbs. This invention's composition exhibits significant anti-inflammatory effects and demonstrates significant repair and improvement effects on damaged esophageal mucosa. It shows significant efficacy in treating reflux esophagitis, significantly improving the treatment effectiveness and cure rate, significantly alleviating patient discomfort and pain. This invention's composition is a pure traditional Chinese medicine preparation, with no toxic side effects and no drug resistance.

The invention discloses a composite solution for treating reflux esophagitis and a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations, the composite solution is formed by physically mixing drug-loaded microspheres and a gastric buoyant raft matrix solution; wherein the drug-loaded microspheres are solid particles which take thiolated pectin as a carrier, are crosslinked and cured through divalent metal ions and are coated with a periplaneta americana extract; the gastric buoyant raft matrix solution comprises a hydrophilic colloid, a component capable of generating gas when encountering acid and a stabilizer. The magnesium mercapto pectin microspheres provide excellent mucous membrane adhesion, and the acting time of the medicine on the esophageal focus is prolonged; the gastric buoyant raft substrate forms a physical barrier in a gastric acid environment to inhibit regurgitation of gastric contents. Through cooperation of the two, a dual treatment mechanism of local repair and source control is realized. The preparation can remarkably prolong the in-vivo residence time and effectively promote esophageal mucosa healing, and the curative effect is better than that of a pure periplaneta americana extract preparation.

The invention provides a hedyotis diffusa extract and a preparation method thereof, the hedyotis diffusa extract is prepared by taking a hedyotis diffusa medicinal material as a raw material, adding a 75-85% ethanol solution for extraction, and filtering; concentrating the filtrate until no alcohol smell exists, precipitating with water, and filtering; separating the filtrate by using macroporous resin, sequentially adding 1.5-2.5 BV of water and 3-4BV of 55-65% ethanol solution for elution, collecting 2BV-3BV sections at the tail end of ethanol eluent, and concentrating to obtain a finished product. The invention further provides application of the oldenlandia diffusa extract in preparation of drugs for preventing and / or treating acute gastric mucosal lesion, gastric ulcer and reflux esophagitis, and particularly, the acute gastric mucosal lesion caused by alcohol or acute alcoholic gastric mucosal lesion and the gastric ulcer caused by excessive gastric secretion are included. In addition, the invention also provides a preparation containing the oldenlandia diffusa extract. The oldenlandia diffusa extract provided by the invention has a better curative effect of resisting acute gastric mucosal lesion, the preparation process is green and environment-friendly, the preparation method is simple, and the oldenlandia diffusa extract is suitable for industrial popularization.

The utility model discloses an auxiliary treatment mattress for reflux esophagitis, and relates to the technical field of medical auxiliary instruments. The auxiliary treatment mattress for reflux esophagitis comprises a mattress body and an air pump, a self-adaptive bending groove is formed in the outer wall of the bottom of the mattress body, a protection pad is arranged on the upper portion of the mattress body, an angle adjusting air bag is arranged at the bottom of the mattress body, a connecting belt is fixedly connected to the outer wall of the angle adjusting air bag, and the connecting belt is fixedly connected to the outer wall of the angle adjusting air bag. The connecting belt is arranged on the outer side of the angle adjusting air bag in a surrounding mode, a first hidden buckle is fixedly connected to the inner side of the connecting belt, a second hidden buckle is fixedly connected to the outer wall of the mattress, and the first hidden buckle and the second hidden buckle are connected in a clamped mode. The angle adjusting air bag is inflated through the air pump, so that the mattress forms an inclined plane, the chest and the back of a patient are raised, the probability that gastric contents flow back to the esophagus is reduced through gravity, the sleep position suggestion of the reflux esophagitis patient is met, symptoms caused by gastric acid reflux at night of the patient can be effectively relieved, and the treatment effect is improved.

Omeprazole is used as a widely applied proton pump inhibitor and is mainly used for treating various diseases caused by hyperacidity, such as gastric ulcer, duodenal ulcer, reflux esophagitis and the like. The invention relates to a novel application of a commercially available medicine omeprazole, namely the omeprazole has remarkable anti-aging activity. The research on model organism caenorhabditis elegans finds that omeprazole can significantly prolong the life of nematodes. Specifically, when the nematodes are cultured in culture media containing 1.6 mg / mL omeprazole and 3.2 mg / mL omeprazole, the service lives of the nematodes are prolonged by 47.80% and 61.51% respectively, and the effect is extremely rare in current drug research.

Omeprazole, as a widely used proton pump inhibitor, is mainly used for the treatment of various diseases caused by excessive gastric acid, such as gastric ulcer, duodenal ulcer and reflux esophagitis. The present application relates to a new use of a commercially available drug omeprazole, i.e. it has significant anti-aging activity. The present application found that omeprazole can significantly prolong the life of nematodes through research using model organisms Caenorhabditis elegans. Specifically, when the nematodes are cultured in a medium containing 1.6 mg / mL and 3.2 mg / mL omeprazole, their life is prolonged by 47.80% and 61.51% respectively, which is extremely rare in current drug research.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating reflux esophagitis, and relates to the technical field of traditional Chinese medicine pharmacy. According to the traditional Chinese medicine composition, thunberg fritillary bulb, fructus evodiae and fingered citron serve as monarch drugs, inula flower, buckeye, rhizoma nardostachyos, clove, amomum tsao-ko and membrane of hen egg serve as ministerial drugs, nacre mother of pearl, cortex fraxini, felwort, sweet-scented osmanthus and reed rhizome serve as adjuvant drugs, licorice serves as conductant drugs, and all the drugs are combined to achieve the effects of soothing the liver and harmonizing the stomach, calming the adverse-rising energy, relieving acid and regulating cold and heat. The traditional Chinese medicine composition can significantly improve the esophagitis index of RE rats, has an obvious inhibition effect on inflammatory injury, can significantly improve the pathological morphology of esophageal tissues of the RE rats, and achieves good anti-inflammatory and therapeutic effects on the RE rats. Meanwhile, the traditional Chinese medicine composition can remarkably improve and relieve clinical symptoms such as sour regurgitation, heartburn, abdominal distension and belching of reflux esophagitis patients, and the attack frequency of the clinical symptoms is reduced. The traditional Chinese medicine composition disclosed by the invention is expected to be further developed and popularized as a medicine for treating reflux esophagitis.

The application discloses a magnetic particle chemiluminescence immunoassay kit for pepsin and a detection method thereof. The kit mainly comprises isothiocyanate fluorescein (FITC) labeled anti-PEP antibody 1 (R1), alkaline phosphatase (ALP) labeled anti-PEP antibody 2 (R2) and magnetic particles coated with sheep anti-FITC antibody (R3). Based on the double-antibody sandwich principle, the application realizes rapid and accurate quantitative detection of pepsin in a saliva sample by combining a sub-nanomolar high-affinity monoclonal antibody with a high-efficiency magnetic separation technology. The detection system has a linear range of 3.0-500.0 ng / mL, and the minimum detection limit reaches 3.0 ng / mL. The detection system has the advantages of high sensitivity, strong specificity, good repeatability and the like, and fully meets the clinical diagnosis requirements of gastroesophageal reflux related diseases such as reflux esophagitis.

The invention discloses an application of chalcone derivative psoralen B in preparation of a GPR84 receptor antagonist and a medicine for treating GPR84 receptor related diseases. Cell experiments show that the compound is an antagonist of GPR84 and has concentration dependence; animal experiments show that the compound has a remarkable drug effect on a Crohn disease colitis model induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS), and can relieve colon shortening caused by the TNBS and improve the weight loss degree. The compound can be used for preparing a GPR84 antagonist and preventing and treating GPR84 related diseases such as Crohn's disease, non-alcoholic fatty liver disease, reflux esophagitis and the like.

The invention provides a novel guanidino cyclohexane derivative as shown in a formula I, a preparation method of the novel guanidino cyclohexane derivative and application of a pharmaceutical preparation containing the novel guanidino cyclohexane derivative in drugs for treating gastric mucosal lesions. The compound has a medicine development prospect for preventing and treating reflux esophagitis by adjusting the influence of nitric oxide synthase (NOS) and anti-inflammatory activity on microcirculation.

The invention belongs to the field of traditional Chinese medicine compositions, and relates to a traditional Chinese medicine composition and traditional Chinese medicine granules for treating liver-stomach disharmony type reflux esophagitis, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of pericarpium citri reticulatae viride, 6-12 parts of pericarpium citri reticulatae, 6-12 parts of moutan bark, 5-10 parts of cortex magnoliae officinalis and 6-12 parts of cortex fraxini. The traditional Chinese medicine is prepared from 5-10 parts of calcined concha arcae, 5-10 parts of cuttle bone, 3-9 parts of ginger, 5-10 parts of sandalwood, 8-15 parts of salvia miltiorrhiza, 8-15 parts of calcined oyster, 5-10 parts of immature bitter orange, 5-9 parts of oven earth and 8-15 parts of concha meretricis seu cyclinae. The traditional Chinese medicine composition takes green tangerine peel, immature bitter orange, calcined concha arcae and cuttle bone as monarch drugs; pericarpium citri reticulatae, cortex magnoliae officinalis, calcined oyster shell, concha meretricis seu cyclinae, sandalwood, cortex moutan and cortex fraxini are taken as Salvia miltiorrhiza, oven earth and ginger are used as adjuvant drugs. The traditional Chinese medicine composition treats reflux by soothing liver-qi stagnation and regulating qi and harmonizing stomach to regulate qi activity and calming adverse-rising energy and controlling acid, is assisted by clearing heat and dispersing blood stasis to remove heat stasis and blood stasis, can warm middle and harmonize stomach and protect mucous membrane, can achieve a good treatment effect by single medication, and has the advantages of quick response, stable curative effect, high total effective rate, low recurrence rate and the like.

This invention belongs to the field of traditional Chinese medicine compositions, and relates to a traditional Chinese medicine composition and granules for treating reflux esophagitis of the liver-stomach disharmony type. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 6-12 parts green tangerine peel, 6-12 parts dried tangerine peel, 6-12 parts peony bark, 5-10 parts magnolia bark, 6-12 parts fraxinus bark, 5-10 parts calcined oyster shell, 5-10 parts cuttlebone, 3-9 parts fresh ginger, 5-10 parts sandalwood, 8-15 parts salvia miltiorrhiza, 8-15 parts calcined oyster shell, 5-10 parts immature bitter orange, 5-9 parts hearth soil, and 8-15 parts clam shell. This traditional Chinese medicine composition uses green tangerine peel, immature bitter orange, calcined oyster shell, and cuttlebone as the principal herbs; tangerine peel, magnolia bark, calcined oyster shell, clam shell, sandalwood, peony bark, and fraxinus bark as the assistant herbs; and salvia miltiorrhiza, calcined clay, and ginger as adjuvant herbs. The entire formula works by soothing the liver and relieving depression, regulating qi and harmonizing the stomach to regulate the fundamental qi mechanism, reducing reflux and neutralizing acid to treat the symptoms of reflux, and supplementing with heat-clearing and blood-stasis-removing to eliminate the transformation of stagnant heat and blood stasis. At the same time, it also takes into account warming the middle and harmonizing the stomach and protecting the mucosa. It can achieve good therapeutic effects when used alone, and has the advantages of rapid onset of action, stable efficacy, high total effective rate, and low recurrence rate.