The invention relates to a preparation for detection, diagnosis or prognostic evaluation of an
esophageal cancer, a medicament for treating the
esophageal cancer and an application of an RND2
gene, and belongs to the technical field of tumor
molecular biology. The preparation for detection, diagnosis or prognostic evaluation of the
esophageal cancer disclosed by the invention comprises a detectionproduct for the mRNA (
messenger Ribonucleic Acid) expression level of the RND2
gene, or a detection product for the expression amount of an RND2
protein; the RND2
protein belongs to the Rnd subfamilyof the Rho
GTPase superfamily. The situation that the expression of the RND2
gene is related to the esophageal
cancer is discovered by the invention for the first time. By detecting the expression ofthe RND2 in the
esophageal tissue of a subject, whether the subject suffers from the esophageal
cancer or not or whether the subject is at risk of suffering from the esophageal
cancer or not can be judged. By improving the expression of the RND2
protein and supplementing the missing or deficiency of the endogenous RND2 protein, the esophageal cancer caused by lack of the RND2 protein can be treated or alleviated.