30 results about "Esophageal Tissue" patented technology

The present invention includes a device and a method for preventing injury of the esophagus during thermal ablation of the left atrium. The device has an esophageal probe with a balloon tip for insertion into the esophagus of a patient. During usage, coolant passes into the esophageal probe and then fills its balloon. The coolant, when circulating through the balloon and an external cooling machine, protects the esophageal tissue in contact with the esophageal probe from thermal damage during ablation of the posterior wall of the left atrium of the heart, or other procedure.

A system for stapling tissue comprises a flexible endoscope and an operative head including a pair of opposed, curved tissue clamping jaws sized to pass through an esophagus, the jaws being moveable with respect to one another between an open tissue receiving configuration and a closed tissue clamping configuration, a first one of the curved jaws including a stapling mechanism and a second one of the jaws including a staple forming anvil surface, the stapling mechanism including staple slots through which staples are fired arranged in a row extending from a proximal end of the first jaw to a distal end thereof in combination with a control handle which, when the operative head is in an operative position within one of a patient's stomach and esophagus, remains outside the patient, the control handle including a first actuator for moving the jaws relative to one another and a second actuator for operating the stapling mechanism.

A medical device for treating esophageal tissue comprises a catheter, a balloon, placeable within the esophagus of the patient, and a refrigerant. The refrigerant is deliverable into the interior of the balloon so to place the balloon into an expanded, cooled state so that the balloon can press against and cool esophageal tissue. In other examples the medical device may include means for limiting radial expansion of the balloon.

A system includes an implantable polymer for increasing the dimensions of layers of tissue. In one embodiment, the implantable polymer is delivered transorally using a scope and injection needle. The system allows for visualization and injection of polymer into the lower esophageal sphincter. Methods of treating gastroesophageal reflux disease include insertion of the distal portion of the injection needle into the esophageal tissue and injection of a polymer liquid to enlarge tissue dimensions. The polymer can be injected at several sites to distribute localized pressures and attain better distribution of the tissue bulking effect.

The invention relates to a preparation for detection, diagnosis or prognostic evaluation of an esophageal cancer, a medicament for treating the esophageal cancer and an application of an RND2 gene, and belongs to the technical field of tumor molecular biology. The preparation for detection, diagnosis or prognostic evaluation of the esophageal cancer disclosed by the invention comprises a detectionproduct for the mRNA (messenger Ribonucleic Acid) expression level of the RND2 gene, or a detection product for the expression amount of an RND2 protein; the RND2 protein belongs to the Rnd subfamilyof the Rho GTPase superfamily. The situation that the expression of the RND2 gene is related to the esophageal cancer is discovered by the invention for the first time. By detecting the expression ofthe RND2 in the esophageal tissue of a subject, whether the subject suffers from the esophageal cancer or not or whether the subject is at risk of suffering from the esophageal cancer or not can be judged. By improving the expression of the RND2 protein and supplementing the missing or deficiency of the endogenous RND2 protein, the esophageal cancer caused by lack of the RND2 protein can be treated or alleviated.

The invention belongs to the field of biomedical engineering and specifically relates to an esophageal tissue constructed by tissue engineering. A tissue-engineered esophagus containing an epithelial layer and a dermal layer is consisted of scaffold materials and seed cells according to the basic principles and methods of tissue engineering. Vascular endothelial cells in the dermal layer directly participate in the establishment of a capillary network, and two revascularization methods are used to quickly communicate the capillary network in the dermal layer with the blood supply channel of a receptor, thus providing blood to the epithelium of the tissue-engineered esophagus. The esophageal tissue of the invention changes a former therapeutic mode of repairing damage by damage, and can be used for simplifying esophagectomy and one-stage reconstruction of digestive tracts, thus reducing medical trauma and benefiting the majority of patients with esophageal diseases.

The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of esophageal tissue and/or organoids formed from differentiated definitive endoderm.

The invention discloses a CHKA gene that can function as a molecular marker for early diagnosis of esophageal cancer. Experiments prove that compared with normal esophageal tissues, the CHKA gene in esophageal cancer tissues has significantly increased expression, and RNA interference experiments prove that CHKA can affect proliferation of esophageal cancer cells. According to study results herein, it is possible to develop medicine to inhibit CHKA gene expression so as to clinically prevent and treat the esophageal cancer.

This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.

There is provided system for monitoring spontaneous breathing of a mechanically ventilated target individual, comprising: a feeding tube for insertion into a distal end of an esophagus of the individual, sensor(s) disposed on the feeding tube at a location such that the sensor(s) is located at the distal end of the esophagus of the individual when the feeding tube is in use, wherein the sensor(s) is positioned for sensing values by contact with the tissue of the esophagus including a lower esophageal sphincter (LES) and/or tissue in proximity to the LES, and code for computing an indication of a frequency band of diaphragm movement of the individual according to an analysis of values sensed by the sensor(s), and for adjustment of parameter(s) of a mechanical ventilator for mechanically ventilating the individual, wherein the instructions for adjustment are computed while the feeding tube is in use.

An airway management device (10) for a human or animal subject (20) includes an airway tube (101) having a first end for disposal external to the subject (20) and a second end (102) for disposal in a portion of an airway of the subject (20). A light emitting element (108) and a photo-sensing element (109) may be disposed at the second end (102) of the airway tube (101). The light emitting element (108) may be configured to transmit light to tissue adjacent to the light emitting element (108). The photo-sensing element (109) may be configured to receive reflectance spectra (204) from the tissue. The location of the second end (102) of the airway tube (101) may be determined from characteristics of the reflectance spectra (204) of the tissue.

The invention provides a tissue clamp assembly and clamp forceps, wherein the tissue clamp assembly comprises a tissue clamp and a traction magnet, the tissue clamp comprises a first clamping arm, a second clamping arm and a spring body, and the first clamping arm and the second clamping arm are hinged to each other; a first clamping part and a second clamping part are formed at the front end of the first clamping arm and the front end of the second clamping arm respectively, the first clamping part is provided with a first tooth-shaped chuck, the second clamping part is provided with a second tooth-shaped chuck, and the two ends of the spring body are connected with the first clamping arm and the second clamping arm respectively; corresponding clamping holes are formed in the rear end of the first clamping arm and the rear end of the second clamping arm; the traction magnet is connected with the tissue clamp through a connecting ring; the first tooth-shaped chuck and the second tooth-shaped chuck clamp human tissues under the action of the spring body; and the traction magnet is used for pulling the human tissues through the tissue clamp under the action of the attraction force of the external anchoring magnet. Therefore, when a single-hole thoracoscope operation is carried out, lung or esophageal tissue can be effectively pulled, and other surgical instruments cannot be collided or interfered.

The invention discloses a decellularized small intestinal submucosa/polylactic acid-glycolic acid copolymer composite scaffold as well as a preparation method and application thereof, and relates to the technical field of tissue repair. The shape of the composite scaffold is similar to a layered structure of laryngeal pharynx and neck esophageal tissues. In the composite scaffold, the amount of residual DNA of the decellularized small intestinal submucosa is small, the composite scaffold has low immunogenicity and high biological activity, the polylactic acid-glycolic acid copolymer is arranged in a nanofiber mode and can promote migration and growth of mucosa cells, and the composite scaffold has good mechanical properties. Through verification, interaction between cells and each layer of the scaffold is good, ideal cell proliferation and cell phenotypes are shown, and it is proved that the composite scaffold has a good tissue repair function.

The invention provides a florescent real-time quantitative PCR kit for detecting the amplification of the TERC (Telomerase RNA (Ribonucleic Acid) Component) gene of the esophageal cancer, wherein the reference sequence of the TERC gene is as follows: NR_001566.1. The florescent real-time quantitative PCR kit comprises the following primers: (1) a forward primer for the amplification of the TERC gene: 5'-AACCCTAACTGAGAAGGGCG-3', (2) a reverse primer for the amplification of the TERC gene: 5'-TAGAATGAACGGTGGAAGGC-3', (3) a forward primer for the reference gene GAPDH (Glyceraldehyde-Phosphate Dehydrogenase):5'-CCAGGTGGTCTCCTCTGACTT-3', and (4) a reverse primer for the reference gene GAPDH: 5'-GTTGCTGTAGCCAAATTCGTTGT-3'. The florescent real-time quantitative PCR kit provided by the invention is used for detecting rRNA (ribosomal RNA) of the TERC gene in an esophageal tissue specimen to determine whether the TERC gene is amplified or not. Compared with a method for detecting the amplification of the TERC gene by an FISH (Fluorescence In Situ Hybridization) technology, the method provided by the invention has the advantages of short detection period and reduced cost.