30 results about "Esophageal Tissue" patented technology

A system for stapling tissue comprises a flexible endoscope and an operative head including a pair of opposed, curved tissue clamping jaws sized to pass through an esophagus, the jaws being moveable with respect to one another between an open tissue receiving configuration and a closed tissue clamping configuration, a first one of the curved jaws including a stapling mechanism and a second one of the jaws including a staple forming anvil surface, the stapling mechanism including staple slots through which staples are fired arranged in a row extending from a proximal end of the first jaw to a distal end thereof in combination with a control handle which, when the operative head is in an operative position within one of a patient's stomach and esophagus, remains outside the patient, the control handle including a first actuator for moving the jaws relative to one another and a second actuator for operating the stapling mechanism.

A system and method for automatically analyzing impedance and pH data from an esophageal probe includes a data collection system that collects and stores the output from the sensors for a certain period of time to locate reflux episodes in the waveforms. The data analysis system uses wavelet analysis to assist in locating bolus entry and exit points in the waveforms and to smooth waveforms for additional analysis. It also distinguishes between candidate acid reflux episodes and candidate non-acid reflux episodes for determining actual acid reflux episodes and non-acid reflux episodes, and it distinguishes between, and provides different signal processing for, signals from patients that have healthy esophageal tissue and those that have diseased esophageal tissue.

The invention relates to a preparation technique of a biochemically emulated tissue engineering gullet, which is a bio-active molecule adopts electrical weaving method to weave biodegradalbe polyester polymer for a second time, thus obtaining basement membranes of epithelium similar with gullet and an asymmetric porous nano fiber structure arranged in sequence and similar with muscular layer structure, and the fiber is chemically modified to ingraft the surface of the biochemically emulated tissue engineering gullet and facilitate the growth of cells. The porous nano fiber similar with the basement membranes can support the growth of gullet epithelium, while the oriented fiber arranged in sequence is helpful for inducing the oriented growth of gullet smooth muscle cells, and the porous nano fiber can is cultured for 3 to 4 weeks in DMEM wholly culture medium, thus preparing a biochemically emulated tissue engineering gullet with both epithelium and muscular layer. The gullet of the invention completely simulates the normal gullet tissue of human body in microstructure causing the man made gullet constructed in vitro to be much closer to human gullet in structure and functions, andthe ingrafted bio-active molecules are beneficial for retaining the original form and bio-functions of the body cells for the cells ingrafted to the bio-active molecules, and can be used for the restoration and construction of diseased gullet.

The invention discloses an automatic segmentation method and a system of an esophageal endoscopic OCT image hierarchy structure. The method comprises the following steps: image preprocessing, whereinan image is filtered and searched, and pixel values are complemented; image planarization, wherein the whole esophageal tissue in the image is straightened and corrected; segmentation of an image organization layer, wherein a current segmentation layer is used as a reference and the searching area of a next layer to be segmented is obtained in a mode of translating certain pixels downward and segmentation layer by layer is performed; image unplanarization, wherein the segmented image is inversely translated to obtain the final segmentation result. The invention provides a scheme for respondingto interference of a probe protective film, tissue liquid and the like, so as to avoid subsequent influences on tissue layer segmentation. The invention combines the Canny edge detection with the gradient operator, and proposes a new image segmentation method weight design scheme. The scheme uses the Canny operator to improve the precision of edge detection, and uses the gradient operator to compensate the missing edge in the Canny operator. The accuracy of segmentation is improved by combining the two operators.

The invention discloses a CHKA gene that can function as a molecular marker for early diagnosis of esophageal cancer. Experiments prove that compared with normal esophageal tissues, the CHKA gene in esophageal cancer tissues has significantly increased expression, and RNA interference experiments prove that CHKA can affect proliferation of esophageal cancer cells. According to study results herein, it is possible to develop medicine to inhibit CHKA gene expression so as to clinically prevent and treat the esophageal cancer.