A preparation for detecting, diagnosing or evaluating prognosis of esophageal cancer, a drug for treating esophageal cancer and application of rnd2 gene

Abstract

The invention relates to a preparation for detecting, diagnosing or evaluating prognosis of esophageal cancer, a drug for treating esophageal cancer and application of RND2 gene, belonging to the technical field of tumor molecular biology. The esophageal cancer detection, diagnosis or prognosis evaluation preparation of the present invention includes a detection product of RND2 gene mRNA expression level, or a detection product of RND2 protein expression level; RND2 protein belongs to the Rnd subfamily in the Rho GTPase superfamily, the present invention For the first time, it was discovered that the expression of RND2 gene is related to esophageal cancer. By detecting the expression of RND2 in the esophageal tissue of the subject, it can be judged whether the subject has esophageal cancer, or whether the subject has the risk of esophageal cancer. By increasing the expression of RND2 protein and supplementing the lack or insufficiency of endogenous RND2 protein, the esophagus cancer caused by RND2 protein deficiency can be treated or alleviated.

Description

technical field [0001] The invention relates to a preparation for detecting, diagnosing or evaluating prognosis of esophageal cancer, a drug for treating esophageal cancer and application of RND2 gene, belonging to the technical field of tumor molecular biology. Background technique [0002] Esophageal cancer (Esophageal Carcinoma, EC) is one of the most common malignant gastrointestinal tumors in my country, ranking fifth in the death rate of various cancers. In the 2008 World Cancer Incidence and Death Report released by the International Agency for Research on Diseases, it was pointed out that China is a high incidence area of ​​esophageal cancer in the world, and more than half of the world's esophageal cancer occurs in China. [0003] However, corresponding to the grim epidemiological situation of esophageal cancer is the lack of early diagnosis of esophageal cancer. Most patients are already in the advanced stage of esophageal cancer when they see a doctor. The overal...

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Problems solved by technology

[0004] The publication number is CN105734159A Chinese invention patent application discloses a molecular marker of esophageal squamous cell carcinoma, which points out that the detection primer of CCKBR gene can be used as a diagnostic product for esophageal squamous cell carcinoma, but it only detects CCKBR in patients with esophageal squamous cell carcinoma. The low expression indicates that the CCKBR gene is related to the occurrence and development of esophageal squamous cell carcinoma, but the detection primers of CCKBR gene have not been used to evaluate and predict the survival of patients with esophageal squamous cell carcinoma, and there is no effective preparation for evaluating the prognosis of esophageal cancer

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