104 results about "Gastrointestinal tumors" patented technology

The invention discloses a gastrointestinal tumor microscopic hyper-spectral image processing method based on a convolutional neural network, comprising the following steps: reducing and de-noising the spectral dimension of an acquired gastrointestinal tissue hyper-spectral training image; constructing a convolutional neural network structure; and inputting obtained hyper-spectral data principal components (namely, a plurality of 2D gray images, which are equivalent to a plurality of feature maps of an input layer) as input images into the constructed convolutional neural network structure using a batch processing method, and by taking a cross entropy function as a loss function and using an error back propagation algorithm, training the parameters in the convolutional neural network and the parameters of a logistic regression layer according to the average loss function in a training batch until the network converges. According to the invention, the dimension of a hyper-spectral image is reduced using a principal component analysis method, enough spectral information and spatial texture information are retained, the complexity of the algorithm is reduced greatly, and the efficiency of the algorithm is improved.

The invention discloses a noninvasive and controllable miniature human lumen photodynamic therapy system, which is characterized by being mainly composed of an LED light source, a control magnet, a power supply circuit and a capsule-type medical mould shell. The LED light source is composed of two patch-type LEDs; the control magnet is one or more small magnet; the power supply circuit includes two modes, namely lithium battery power supply and wireless power supply, wherein in the lithium battery power supply mode, a lithium battery and a circuit board are arranged, and in the wireless power supply module, an LC resonance matching receiving coil, a rectifier and filter circuit, a voltage stabilizing module and a circuit board are arranged; and the capsule-type medical mould shell, which is made from a flexible high-light-transmission waterproof material, is a capsule-type shell provided with a vacuum interlayer. The miniature human lumen photodynamic therapy system disclosed by the invention, as a medical apparatus, has a great potential value in the field of treating gastrointestinal tumors, inflammations, dysbacteriosis and infection; and the photodynamic therapy system is broad in application scope, good in therapeutic effect, safe to use and low in cost.

The invention relates to the technical field of medical appliances, and particularly relates to a specific sampler for a gastrointestinal tumor biopsy tissue. The sampler comprises a battery cartridge, a rear tube head, a rubber tube and a front tube head, wherein a cap is arranged on the battery cartridge, and dry batteries are arranged inside the battery cartridge; the battery cartridge and the rear tube head are connected and fixed; front and rear ends of the rubber tube are respectively connected with the front tube head and the rear tube head; a micro-camera and an LED bead are arranged at the opening part of the front end of the front tube head; a sampling knife component is arranged on the side wall of the front tube head, and is provided with a pulling wire; and a pulling ring is fastened at the end part, extending out of the rear tube head, of the pulling wire. The sampler has reasonable structure design, a visual operation environment is provided by adopting combination of the rubber tube and the metal tube head with the micro-camera and the LED bead, and the opening and closing states of the sampling knife on the side wall can be controlled for sampling a tumor tissue in a narrow digestive tract. The sampler has the advantages of simple and convenient operation and time and labor saving, is safe and reliable, and can be used for improving the diagnosis efficiency of medical staff and reducing the pain of patients.

The invention belongs to the field of medicines and health products, and concretely relates to an application of Chimonanthus salicifolius total alkaloid extract and monomer compounds thereof in the preparation of medicines or health products for treating gastrointestinal tumor diseases. The Chimonanthus salicifolius total alkaloid extract and chimonanthine monomer compounds (1-4) are extracted and prepared from a Calycanthaceae Chimonanthus plant Chimonanthus salicifolius, and experiments prove that the Chimonanthus salicifolius total alkaloid extract can substantially inhibit proliferation of stomach cancer SGC-7901, colorectal carcinoma SW1116 and colorectal carcinoma HCT116 cells and induce cancer cell apoptosis, and the alkaloid monomer compounds have different inhibition effects on the stomach cancer SGC-7901, colorectal carcinoma SW1116 and colorectal carcinoma HCT116 cells. The Chimonanthus salicifolius extract and the monomer compounds thereof can be applied individually or together or be combined with a suitable excipient, can be processed through a routine method to prepare an oral or non-oral dosage form used for treatment or assisted treatment of gastrointestinal tumor diseases, and is especially suitable for being used to prepare medicines or health products for treating stomach cancer and colorectal carcinoma.

The invention provides a colorectal-cancer joint detection evaluation kit through excrement hemoglobin, transferrin and PKM2 and a method thereof. The colorectal-cancer joint detection evaluation kit is based on a streaming fluorescence platform, and gastrointestinal tumors such as rectal cancer or colon cancer are evaluated and early diagnosed by quantitatively detecting excrement hemoglobin, transferrin and PKM2 markers.

The invention provides a disposable stool screening and collecting detection suit for gastrointestinal tumors, solving the technical problem that an existing stool screening and collecting detection suit for gastrointestinal tumors is tedious in flow and time- and labor-wasting, the environment is easily polluted and the effectiveness of a sample is easily affected as a reagent and the sample are in an open interflowing state with the environmental air all the way in the preparation and operation processes of the sample, and moreover, the detection is only performed in a special medical mechanism and is hard to popularize and apply in a large scope. The suit is provided with an inspection tube part and a feces sampling part. The feces sampling part comprises a feces sampling sleeve, a puncture needle is arranged in the middle of the feces sampling sleeve, a pressing end is arranged at the upper end of the puncture needle, a feces sampling sleeve connecting end is arranged in a part, close to the upper end surface, of the feces sampling sleeve, and the front end of the inspection tube part is connected to the connecting end of the feces sampling sleeve. The suit provided by the invention can be widely applied to collecting and detecting feces in screening gastrointestinal tumors in common families and quickly and accurately judging the detection result.

The invention relates to an application of rhizopus nigricans exopolysaccharides in preparation of a medicine for treating or preventing gastrointestinal tumors. The method for preparing the rhizopus nigricans exopolysaccharides comprises the following steps: (1) activating and performing fermental cultivation on rhizopus nigricans with a strain collection number of CGMCC NO.8436, and preparing fermentation liquor; (2) separating and purifying the fermentation liquor, and preparing a crude extracting solution; and (3) discoloring the crude extracting solution by resin columns, oscillating to remove proteins through a Seveage reagent, performing column chromatography purification on Sephadex G-50 sephadex, and preparing the rhizopus nigricans exopolysaccharides. An animal tumor model is established by utilizing the rhizopus nigricans exopolysaccharides, the tumor activity of an entity anti-alimentary system of the rhizopus nigricans exopolysaccharides is explored, the animal tumor experiment anti-tumor result proves that the rhizopus nigricans exopolysaccharides can obviously inhibit growth of tumor blocks of stomach cancer tumor mice and colon cancer tumor mice, and when the rhizopus nigricans exopolysaccharides are combined with modern chemotherapy drug cyclophosphamide, the anti-tumor curative effect is obviously higher than the anti-tumor effect of a single cyclophosphamide drug.

The invention provides medicine containing toad venom lipid-soluble substances and a preparation method thereof. According to the toad venom lipid-soluble substances, the weight sum of bufalin, cinobufagin and resibufogenin is larger than 50% of the total weight of the toad venom lipid-soluble substances. The preparation method of the toad venom lipid-soluble substances includes the steps that toad venom herbs are smashed, then absolute ethyl alcohol is added, the amount of the absolute ethyl alcohol is 5-50 times that of the herbs, heating reflux is performed on the mixture for 1 h in a water bath of 60 DEG C, then the mixture is cooled to indoor temperature, suction filtration is performed, dry extract is obtained after filtrate is evaporated to dryness, purified water is added into the extract for ultrasonic suspending, the amount of the purified water is 5-30 times that of the extract, and extracting is performed through chloroform, wherein the amount of chloroform is 5-50 times that of the mixture. The invention further provides a medicine composite and a preparation method thereof. The medicine composite is a toad venom extract lipid microsphere oral solution and is used for treating gastrointestinal tumors.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating gastrointestinal tumors and provides a novel method for treating the tumors on account of defects of traditional Chinese medicine for treating the tumors in the prior art. Growth of the tumors can be effectively controlled. According to a technical scheme for solving the problem, the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 0.01-0.03 parts of venenum bufonis, 5-6 parts of scorpions, 9-15 parts of rhizoma pinelliae, 3-5 parts of trogopterus dung (ground into powder with liquor), 8-10 parts of rhizoma atractylodis macrocephalae, 2-3 parts of pericarpium citri reticulatae, 2-3 parts of fructus amomi, 2-3 parts of radix aucklandiae, 8-10 parts of rhizoma cyperi, 5-7 parts of Szechwan Chinaberry fruits, 6-8 parts of pollen typhae (fried), 12-15 parts of bulbus fritillariae thunbergii, 6-8 parts of radix glehniae, 10-12 parts of radix angelicae sinensis, 10-12 parts of radix rehmanniae recens and 4-5 parts of radix liquiritiae. The traditional Chinese medicine has the advantages that toxic and side effects are small, treatment is convenient, treatment cost is low, and the treatment cost is only one-fifth to one-tenth of the cost of the chemotherapy and surgery when the same curative effect is achieved.

The invention provides a pharmaceutical composition of a quinoline derivative and a PD-1 monoclonal antibody. The pharmaceutical composition comprises a tyrosine kinase inhibitor and an immune checkpoint inhibitor. The tyrosine kinase inhibitor is a compound as shown in formula I or a pharmaceutically acceptable salt thereof. The pharmaceutical composition has good anti-tumor activity against gastrointestinal tumors, urologic neoplasms or neuroendocrine carcinomas.

The invention discloses a blood vessel protection belt and a preparation method and application thereof. The blood vessel protection belt is coiled by a long-strip-shaped collagen thin film or a long-strip-shaped collagen composite thin film. The blood vessel protection belt is applied to isolation of blood vessels and tissue liquid, the blood vessels are subjected to skeletonization dissection, and the tissue liquid is abdominal pus or digestive juice after radical excision surgery of hepatic-biliary-pancreatic malignant tumors. For the first time, it is proposed that the strip-shaped collagen film and the strip-shaped collagen composite film are used as the blood vessel protection belt, and the blood vessel protection belt is used for the radical excision surgery of gastrointestinal tumors, especially the hepatic-biliary-pancreatic malignant tumors, is wound around the arteriovenous blood vessels subjected to skeletonization lymphatic tissue dissection, conducts isolation protectionon the blood vessels, and prevents the abdominal pus or the digestive juice leaking from anastomotic stoma from corroding the blood vessels and then causing hemorrhage.

The invention discloses an oxaliplatin folic acid targeted lipidosome and an application thereof. The raw materials of the oxaliplatin folic acid targeted lipidosome comprise oxaliplatin, phospholipids, cholesterol acid, folic acid- polyethylene glycol monostearate and poloxamer F68. The structure of the folic acid- polyethylene glycol monostearate is demonstrated as follows, wherein n is equal to 45 to 136. The oxaliplatin folic acid targeted lipidosome which is prepared by the invention can be applied to preparing medicine for treating gastrointestinal tumors. Compared with the prior art, the obtained oxaliplatin folic acid targeted lipidosome has the advantages of small grain size, high entrapment efficiency, improving pharmacokinetic behavior, good targeting and enhancing antineoplastic efficacy. In addition, the cost of raw materials is low and the process is simple.

The invention relates to a three-dimensional porous graphene assembled drug temperature controlled chemotherapy and thermotherapy gastrointestinal tumor device, which comprises a three-dimensional porous graphene assembled drug multi-temperature-controlled chemotherapy and thermotherapy tumor instrument, wherein the tumor instrument comprises a three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus, a telescopic multi-beam optical fiber rod and a dimming chamber; the three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus, the dimming chamber and the telescopic multi-beam optical fiber rod form an integrated controllable telescopic structure together which can generate actions such as linkage extensionand retraction in the whole device; the three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus comprises a three-dimensional porous graphene assembled multi-temperature-controlled drug releasing chamber; the three-dimensional porous graphene assembled multi-temperature-controlled drug releasing chamber comprises three-dimensional porous graphene and assembled drugs; and different types of drugs can be released for multiple times under different temperature control conditions. The device in the embodiment of the invention can also be applicable to chemotherapy and thermotherapy for tumors at the throat and tumors in the skin of the human body.

The invention discloses a matrine magnetic slow-releasing capsule for treating gastrointestinal tumors through oral administration, and a preparation method of the matrine magnetic slow-releasing capsule. The content of the matrine magnetic slow-releasing capsule is matrine magnetic slow-releasing particles; the matrine magnetic slow-releasing capsule comprises drug carried magnetic particles and a slow-releasing coating film; the drug carried magnetic particles of the content include matrine, magnetic substance (ferroferric oxide) nanoparticles, microcrystalline cellulose and chitosan in the slow-releasing coating film; and the mass ratio of the matrine, the magnetic substance (ferroferric oxide) nanoparticles, the microcrystalline cellulose and the chitosan is 1 : 0.5-2 : 1-8: 0.1-3 . Through oral administration and being guided by the magnetic field, the matrine magnetic slow-releasing capsule not only can target the gastrointestinal tumor cells, but also can delay the release speed of the main drug; the adverse effects, complications and adverse reactions of the drug can be expected to be reduced; the drug administration frequency is reduced; the compliance of the patients is increased; and the clinical treatment effect of the drug is enhanced.

The invention provides a tumor microsatellite instability detection kit based on a second-generation sequencing probe capture technology. The detection kit adopts the second-generation sequencing probe capture technology, and reagents of the detection kit comprise a quality control product, a library building reagent and an RNA probe; the quality control products comprise a negative quality control product and a positive quality control product; the negative quality control product is a negative sample dissolved in TE, and the positive quality control product is a plasmid containing an MSI site dissolved in TE; an NGS technology is selected on the basis of an MSI experimental method; the kit has the advantages that detection sites are many, up to 40 microsatellite sites are covered after screening, the microsatellite coverage area is wide, the uniformity is good after RNA probe adjustment, good medication guidance can be provided for patients, and the kit is suitable for multiple tumors such as colorectal cancer, endometrial cancer and gastrointestinal tumor.

The invention discloses an oxaliplatin chitosan nanoparticle and an application thereof. The preparation materials of the oxaliplatin chitosan nanoparticle comprise oxaliplatin, chitosan, sodium tripolyphosphate and an acetic acid aqueous solution. The oxaliplatin chitosan nanoparticle disclosed by the invention can be applied to preparing a drug for treating gastrointestinal tumors. Compared with the prior art, the oxaliplatin chitosan nanoparticle disclosed by the invention is small in grain size, high in encapsulation efficiency, low in material price and simpler in process.

The invention provides a traditional Chinese medicinal composition for treating tumors, early and mid-term cancers and a preparation method of the traditional Chinese medicinal composition, relates to traditional Chinese medicinal herbal compositions, and particularly relates to medicaments for treating tumors, early and mid-term cancers. The traditional Chinese medicinal composition comprises the following components in parts by weight: 10-16 parts of patrinia scaniosaefolia, 1-4 parts of rhodiola rosea, 10-15 parts of sargentgloryvine stem, 2-6 parts of Chinese angelica, 10-18 parts of official magnolia flower and 1-3 parts of gastrodia elata. The traditional Chinese medicinal composition has the functions of eliminating tumors, activating blood circulation to remove stasis, diminishing inflammation and relieving pain, cooling blood and healing sore, and has quick response and high cure rate when being used for treating early and mid-term esophagus cancer, gastric cancer and other gastrointestinal tumor diseases.

The invention discloses a disposable gastrointestinal tumor feces screening, collecting and detecting set. The disposable gastrointestinal tumor feces screening, collecting and detecting set comprisesa first connecting tube, a second connecting tube and a detecting box which are sequentially arranged from top to bottom, wherein a connecting passage is arranged at the top part of the detecting boxand is communicated with the interior of the detecting box; the first connecting tube and the second connecting tube are fixedly connected by a connecting lug; a rotary ring is rotationally connectedbetween the corresponding side walls of the first connecting tube and the second connecting tube; the interiors of the first connecting tube, the second connecting tube and the rotary ring are rotationally connected with a collecting tube; a first convex structure and a second convex structure are respectively arranged at the opposite outer walls of the first connecting tube and the second connecting tube; the second convex structure is connected with the interior of the connecting passage by threads; the center of the inner wall of the top part of the detecting box is rotationally connectedwith a rotary rod. The disposable gastrointestinal tumor feces screening, collecting and detecting set has the advantages that a sample can be conveniently sampled by the collecting tubes; the samplecan be sampled for multiple times; the testing accuracy is improved.

The invention relates to the field of a biomedicine, in particular to a gastrointestinal tumor marker and an application thereof. The marker is WNT4. The gastrointestinal malignant tumor is human gastrointestinal malignant tumor tissue, including gastric cancer and colorectal cancer. The marker is used for preparing a reagent for early diagnosis of gastrointestinal malignant tumor, a fluorescencequantitative PCR primer pair of WNT4 is used, a cDNA of a sample to-be-tested is used as a template for performing a quantitative PCR reaction, and a CT value of WNT4 amplification is measured, and the CT value of an internal reference gene beta-actin is used for standardization correction to identify the sample to-be-tested. Through a reliable fluorescent quantitative PCR method, the expression level of WNT4 in the gastrointestinal malignant tumor tissue is significantly reduced through screening. The method has high sensitivity and strong specificity, and the marker can be used for early diagnosis of gastrointestinal malignant tumors.

The invention discloses application of a composition of an avirulent toxoplasma strain and a traditional Chinese medicine polysaccharide adjuvant, and a vaccine and a preparation method thereof. The traditional Chinese medicine polysaccharide adjuvant can be cooperated with the immune activation effect of toxoplasma via immune synergism for multi-target high-efficiency activation of certain specific anti-tumor immunoregulation pathways, especially anti-tumor immunoregulation pathways related to immune activation of cytotoxic T-cells. The composition can be used for treating tumors and preparing biological drugs used for treating tumors, especially for treatment of gastrointestinal tumors; and in particular, the composition has substantial treatment effect on bile duct carcinoma.

The invention relates to gastrointestinal tumor-targeted magnetic doxorubicin-albumin nanoparticles prepared by a compression-vibration wrapping method. The high polymer coating layer on the surface of magnetic doxorubicin albumin nanoparticles is uneven, and the surface of a single magnetic doxorubicin albumin nanoparticle is partially coated with a polymer coating layer, and some parts are not coated with a polymer polymer In the production process of the above magnetic doxorubicin albumin nanoparticles, the magnetic doxorubicin albumin nanoparticles powder is uniformly dispersed and laid on a flat, smooth surface with sufficient surface strength and surrounded by a circle. On the plane, another flat, smooth and hard enough circular surface is pressed on the magnetic doxorubicin albumin nanoparticle powder for pre-pressurization, the two circular planes have equal areas, and the upper surface is embedded in the lower surface circle; Then vibrate, pressurize to the required pressure while vibrating, and then drop the solution of high molecular polymer drop by drop around the magnetic doxorubicin albumin nanoparticle powder. .

The invention discloses a novel application of a Xianglian (coptidis rhizoma and radix aucklandiae) pill product in preventing or treating helicobacter pylori, gastrointestinal tumors, atrophic gastritis, cardiovascular and cerebrovascular diseases and the like. The invention solves the problems that the treatment effect of Xianglian pills is always limited to dysentery caused by damp-heat of large intestines, and the symptoms are purulent and bloody stool, tenesmus, fever and abdominal pain, enteritis and bacillary dysentery, and the new treatment effect is not developed all the time. The Xianglian pill product has the effect of resisting helicobacter pylori Hp, and the safety of the Xianglian pill product is higher than that of coptidis rhizoma and coptidis rhizoma extract; the Xianglian pill product can also be used for treating gastrointestinal tumors; and in addition, the Xianglian pill product also has the effect of preventing cardiovascular and cerebrovascular diseases including atherosclerosis.

The invention discloses an oxaliplatin folic acid targeted lipidosome and an application thereof. The raw materials of the oxaliplatin folic acid targeted lipidosome comprise oxaliplatin, phospholipids, cholesterol acid, folic acid- polyethylene glycol monostearate and poloxamer F68. The structure of the folic acid- polyethylene glycol monostearate is demonstrated as follows, wherein n is equal to 45 to 136. The oxaliplatin folic acid targeted lipidosome which is prepared by the invention can be applied to preparing medicine for treating gastrointestinal tumors. Compared with the prior art, the obtained oxaliplatin folic acid targeted lipidosome has the advantages of small grain size, high entrapment efficiency, improving pharmacokinetic behavior, good targeting and enhancing antineoplastic efficacy. In addition, the cost of raw materials is low and the process is simple.

The invention discloses gastrointestinal tumor postoperative auxiliary rehabilitation equipment. The equipment comprises a bed body, wherein supporting legs are mounted on one side of the bottom of the bed body; a medicated bath assembly is mounted in the center of the top of the bed body; a left-right displacement assembly is fixed to the center of the outer wall of the bed body; a vertical plateis fixed to the left-right displacement assembly; a control panel is mounted on the outer wall of the vertical plate; a microwave nursing assembly is installed at the top of the vertical plate; the control panel is electrically connected with the left-right displacement assembly, the microwave nursing assembly and the medicated bath assembly; the microwave nursing assembly comprises a connectingframe, a rotating motor, a speed reducer, a nursing box, a microwave generator, a microwave transmitting probe, a rotating disc and a bearing; and the nursing box is fixed to the top of the vertical plate. The equipment is novel in structure and ingenious in conception, can help a patient to carry out nursing after a tumor treatment operation, relieves the pain of the patient, improves the rehabilitation effect, and relieves the workload of medical staff.

The invention discloses a gastrointestinal tumor biopsy sampling device, including a sampling pipe (1). The bottom of the sampling pipe (1) is provided with a puncturing cone (2), the upper top of thesampling pipe (1) is provided with an end cover (3) matched with the sampling pipe in a rotary mode, the sampling pipe (1) is of a hollow pipe-shaped structure integrally, one side of the sampling pipe (1) is axially provided in a penetrating mode with a sampling groove (4) which concurrently is a guide sliding groove, the sampling pipe (1) is internally provided with a piston top (5), and the upper part of the piston top (5) is provided with a piston rod (6) fixedly and rotatably connected with the piston top. According to the gastrointestinal tumor biopsy sampling device, the structure is simple, an integral sampling from bottom to top in entire tumour can be achieved, and growth and tissue distribution conditions of the tumour are convenient to understand by medical workers.

The invention discloses a gastrointestinal tumor biopsy sampling device and belongs to the technical field of medical instrument equipment. The device comprises a lifting assembly, a rotating assembly, a sampling assembly, an expansion assembly, a dirt sucking assembly and a moving assembly, wherein the moving assembly is vertically arranged; the rotating assembly is arranged on the moving assembly and is rotationally connected with the moving assembly; the lifting assembly is arranged at the top of the rotating assembly; the sampling assembly is arranged at the lifting end of the lifting assembly; the sampling assembly comprises a sliding part and two sampling parts; the lifting part is arranged at the lifting end of the lifting assembly; the two sampling parts are symmetrically arrangedat the moving end of the sliding part; the expansion assembly is arranged at the lifting end of the lifting assembly; and the dirt sucking assembly is arranged at the lifting end of the lifting assembly and is positioned at the other end of the sampling assembly. By adopting the device, scraping and sampling operation on a tumor part of a patient is implemented in all direction in multiple anglesthrough swinging of a sampling blade, so that samples of different parts of a tumor of the patient can be obtained.

The invention discloses a medicine with the functions of regulating the liver and kidneys and improving the immunities and a preparation method. The medicine comprises 20-70wt% of coriolus versicolor polysaccharides, 15-60wt% of pachymaran and 10-40wt% of garlic polysaccharides. The preparation method is characterized by firstly extracting coriolus versicolor polysaccharides, pachymaran and garlic polysaccharides respectively and preparing the medicine in proportion. The medicine is low in cost, does not have any toxic or side effect, has the functions of regulating the liver and kidneys, improving the immunities, diminishing inflammation, resisting viruses, tumors, radiation and ulcers, easing pains, enhancing the fertility and prolonging the lives, and has obvious effects on gynecological inflammations, gynecological and gastrointestinal tumors and ulcer diseases. 2-3 granules of the medicine are taken by the adults every day, 1-2 granules each time, and the medicine can be taken for a long term.

The invention provides a high-activity tumor inhibitor as well as a preparation method and an application thereof. To be specific, a key binding site of YAP protein and TEAD is obtained, polypeptides with the best YAP inhibition activity are screened out and modified, for example, amino acid is subjected to substitution, deletion and / or addition (for example, addition of cell penetration segments) by adding disulfide bonds, and a series of polypeptides having a YAP protein activity inhibition effect and good stability are final screened out. Experiments indicate that the polypeptides can effectively inhibit the binding activity of YAP protein with TEAD, thereby having a good treatment effect on gastrointestinal tumors, particularly liver cancers.

The embodiment of the invention discloses a hydroxybenzene derivative detection reagent and a preparation method thereof, and a tumor detection reagent. According to the volume ratio, the hydroxybenzene derivative detection reagent comprises the components: 1 of a solution A; 0.3-0.5 of a solution B; 0.16-0.18 of a solution C; 0.2-0.6 of a solution D; and 0.07-0.08 of a solution E, wherein the solution A is a dilute solution obtained after mercury is dissolved in concentrated nitric acid; the solution B is a 230-250 g / L mercurous nitrate nitric acid solution; the solution C is a 3-5 g / L paradimethylaminobenzaldehyde sulfuric acid solution; the solution D is a 0.001-0.004 g / L sodium nitrite solution; and the solution E is a 300-500 g / L nickel nitrate solution. The hydroxybenzene derivativedetection reagent is simple and convenient in preparation process, and is suitable for conventional production and manufacturing. In addition, the hydroxybenzene derivative detection reagent not onlyhas a high detection rate for most benign tumors, but also has a high detection effect on gastrointestinal tumors and some high-attack non-gastrointestinal tumors, such as bladder cancer, cervical cancer and breast cancer.

The invention discloses a benzimidazole amide compound as well as pharmaceutically acceptable salts and a preparation method thereof. The compound is used for tumors relevant to the continuous activation of hedgehog (Hh) signaling pathways, such as skin basal cell carcinoma, brain tumors, medulloblastoma, lung cancer, gastrointestinal tumors, breast cancer or pancreatic cancer, and illnesses relevant to the Hh signaling pathways.