104 results about "Gastrointestinal tumors" patented technology

The invention discloses a gastrointestinal tumor microscopic hyper-spectral image processing method based on a convolutional neural network, comprising the following steps: reducing and de-noising the spectral dimension of an acquired gastrointestinal tissue hyper-spectral training image; constructing a convolutional neural network structure; and inputting obtained hyper-spectral data principal components (namely, a plurality of 2D gray images, which are equivalent to a plurality of feature maps of an input layer) as input images into the constructed convolutional neural network structure using a batch processing method, and by taking a cross entropy function as a loss function and using an error back propagation algorithm, training the parameters in the convolutional neural network and the parameters of a logistic regression layer according to the average loss function in a training batch until the network converges. According to the invention, the dimension of a hyper-spectral image is reduced using a principal component analysis method, enough spectral information and spatial texture information are retained, the complexity of the algorithm is reduced greatly, and the efficiency of the algorithm is improved.

The invention discloses a noninvasive and controllable miniature human lumen photodynamic therapy system, which is characterized by being mainly composed of an LED light source, a control magnet, a power supply circuit and a capsule-type medical mould shell. The LED light source is composed of two patch-type LEDs; the control magnet is one or more small magnet; the power supply circuit includes two modes, namely lithium battery power supply and wireless power supply, wherein in the lithium battery power supply mode, a lithium battery and a circuit board are arranged, and in the wireless power supply module, an LC resonance matching receiving coil, a rectifier and filter circuit, a voltage stabilizing module and a circuit board are arranged; and the capsule-type medical mould shell, which is made from a flexible high-light-transmission waterproof material, is a capsule-type shell provided with a vacuum interlayer. The miniature human lumen photodynamic therapy system disclosed by the invention, as a medical apparatus, has a great potential value in the field of treating gastrointestinal tumors, inflammations, dysbacteriosis and infection; and the photodynamic therapy system is broad in application scope, good in therapeutic effect, safe to use and low in cost.

The invention relates to the technical field of medical appliances, and particularly relates to a specific sampler for a gastrointestinal tumor biopsy tissue. The sampler comprises a battery cartridge, a rear tube head, a rubber tube and a front tube head, wherein a cap is arranged on the battery cartridge, and dry batteries are arranged inside the battery cartridge; the battery cartridge and the rear tube head are connected and fixed; front and rear ends of the rubber tube are respectively connected with the front tube head and the rear tube head; a micro-camera and an LED bead are arranged at the opening part of the front end of the front tube head; a sampling knife component is arranged on the side wall of the front tube head, and is provided with a pulling wire; and a pulling ring is fastened at the end part, extending out of the rear tube head, of the pulling wire. The sampler has reasonable structure design, a visual operation environment is provided by adopting combination of the rubber tube and the metal tube head with the micro-camera and the LED bead, and the opening and closing states of the sampling knife on the side wall can be controlled for sampling a tumor tissue in a narrow digestive tract. The sampler has the advantages of simple and convenient operation and time and labor saving, is safe and reliable, and can be used for improving the diagnosis efficiency of medical staff and reducing the pain of patients.

The invention belongs to the field of medicines and health products, and concretely relates to an application of Chimonanthus salicifolius total alkaloid extract and monomer compounds thereof in the preparation of medicines or health products for treating gastrointestinal tumor diseases. The Chimonanthus salicifolius total alkaloid extract and chimonanthine monomer compounds (1-4) are extracted and prepared from a Calycanthaceae Chimonanthus plant Chimonanthus salicifolius, and experiments prove that the Chimonanthus salicifolius total alkaloid extract can substantially inhibit proliferation of stomach cancer SGC-7901, colorectal carcinoma SW1116 and colorectal carcinoma HCT116 cells and induce cancer cell apoptosis, and the alkaloid monomer compounds have different inhibition effects on the stomach cancer SGC-7901, colorectal carcinoma SW1116 and colorectal carcinoma HCT116 cells. The Chimonanthus salicifolius extract and the monomer compounds thereof can be applied individually or together or be combined with a suitable excipient, can be processed through a routine method to prepare an oral or non-oral dosage form used for treatment or assisted treatment of gastrointestinal tumor diseases, and is especially suitable for being used to prepare medicines or health products for treating stomach cancer and colorectal carcinoma.

The invention provides a colorectal-cancer joint detection evaluation kit through excrement hemoglobin, transferrin and PKM2 and a method thereof. The colorectal-cancer joint detection evaluation kit is based on a streaming fluorescence platform, and gastrointestinal tumors such as rectal cancer or colon cancer are evaluated and early diagnosed by quantitatively detecting excrement hemoglobin, transferrin and PKM2 markers.

The invention provides a disposable stool screening and collecting detection suit for gastrointestinal tumors, solving the technical problem that an existing stool screening and collecting detection suit for gastrointestinal tumors is tedious in flow and time- and labor-wasting, the environment is easily polluted and the effectiveness of a sample is easily affected as a reagent and the sample are in an open interflowing state with the environmental air all the way in the preparation and operation processes of the sample, and moreover, the detection is only performed in a special medical mechanism and is hard to popularize and apply in a large scope. The suit is provided with an inspection tube part and a feces sampling part. The feces sampling part comprises a feces sampling sleeve, a puncture needle is arranged in the middle of the feces sampling sleeve, a pressing end is arranged at the upper end of the puncture needle, a feces sampling sleeve connecting end is arranged in a part, close to the upper end surface, of the feces sampling sleeve, and the front end of the inspection tube part is connected to the connecting end of the feces sampling sleeve. The suit provided by the invention can be widely applied to collecting and detecting feces in screening gastrointestinal tumors in common families and quickly and accurately judging the detection result.

The invention relates to an application of rhizopus nigricans exopolysaccharides in preparation of a medicine for treating or preventing gastrointestinal tumors. The method for preparing the rhizopus nigricans exopolysaccharides comprises the following steps: (1) activating and performing fermental cultivation on rhizopus nigricans with a strain collection number of CGMCC NO.8436, and preparing fermentation liquor; (2) separating and purifying the fermentation liquor, and preparing a crude extracting solution; and (3) discoloring the crude extracting solution by resin columns, oscillating to remove proteins through a Seveage reagent, performing column chromatography purification on Sephadex G-50 sephadex, and preparing the rhizopus nigricans exopolysaccharides. An animal tumor model is established by utilizing the rhizopus nigricans exopolysaccharides, the tumor activity of an entity anti-alimentary system of the rhizopus nigricans exopolysaccharides is explored, the animal tumor experiment anti-tumor result proves that the rhizopus nigricans exopolysaccharides can obviously inhibit growth of tumor blocks of stomach cancer tumor mice and colon cancer tumor mice, and when the rhizopus nigricans exopolysaccharides are combined with modern chemotherapy drug cyclophosphamide, the anti-tumor curative effect is obviously higher than the anti-tumor effect of a single cyclophosphamide drug.

The invention provides medicine containing toad venom lipid-soluble substances and a preparation method thereof. According to the toad venom lipid-soluble substances, the weight sum of bufalin, cinobufagin and resibufogenin is larger than 50% of the total weight of the toad venom lipid-soluble substances. The preparation method of the toad venom lipid-soluble substances includes the steps that toad venom herbs are smashed, then absolute ethyl alcohol is added, the amount of the absolute ethyl alcohol is 5-50 times that of the herbs, heating reflux is performed on the mixture for 1 h in a water bath of 60 DEG C, then the mixture is cooled to indoor temperature, suction filtration is performed, dry extract is obtained after filtrate is evaporated to dryness, purified water is added into the extract for ultrasonic suspending, the amount of the purified water is 5-30 times that of the extract, and extracting is performed through chloroform, wherein the amount of chloroform is 5-50 times that of the mixture. The invention further provides a medicine composite and a preparation method thereof. The medicine composite is a toad venom extract lipid microsphere oral solution and is used for treating gastrointestinal tumors.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating gastrointestinal tumors and provides a novel method for treating the tumors on account of defects of traditional Chinese medicine for treating the tumors in the prior art. Growth of the tumors can be effectively controlled. According to a technical scheme for solving the problem, the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 0.01-0.03 parts of venenum bufonis, 5-6 parts of scorpions, 9-15 parts of rhizoma pinelliae, 3-5 parts of trogopterus dung (ground into powder with liquor), 8-10 parts of rhizoma atractylodis macrocephalae, 2-3 parts of pericarpium citri reticulatae, 2-3 parts of fructus amomi, 2-3 parts of radix aucklandiae, 8-10 parts of rhizoma cyperi, 5-7 parts of Szechwan Chinaberry fruits, 6-8 parts of pollen typhae (fried), 12-15 parts of bulbus fritillariae thunbergii, 6-8 parts of radix glehniae, 10-12 parts of radix angelicae sinensis, 10-12 parts of radix rehmanniae recens and 4-5 parts of radix liquiritiae. The traditional Chinese medicine has the advantages that toxic and side effects are small, treatment is convenient, treatment cost is low, and the treatment cost is only one-fifth to one-tenth of the cost of the chemotherapy and surgery when the same curative effect is achieved.

The invention provides a pharmaceutical composition of a quinoline derivative and a PD-1 monoclonal antibody. The pharmaceutical composition comprises a tyrosine kinase inhibitor and an immune checkpoint inhibitor. The tyrosine kinase inhibitor is a compound as shown in formula I or a pharmaceutically acceptable salt thereof. The pharmaceutical composition has good anti-tumor activity against gastrointestinal tumors, urologic neoplasms or neuroendocrine carcinomas.

The invention discloses a blood vessel protection belt and a preparation method and application thereof. The blood vessel protection belt is coiled by a long-strip-shaped collagen thin film or a long-strip-shaped collagen composite thin film. The blood vessel protection belt is applied to isolation of blood vessels and tissue liquid, the blood vessels are subjected to skeletonization dissection, and the tissue liquid is abdominal pus or digestive juice after radical excision surgery of hepatic-biliary-pancreatic malignant tumors. For the first time, it is proposed that the strip-shaped collagen film and the strip-shaped collagen composite film are used as the blood vessel protection belt, and the blood vessel protection belt is used for the radical excision surgery of gastrointestinal tumors, especially the hepatic-biliary-pancreatic malignant tumors, is wound around the arteriovenous blood vessels subjected to skeletonization lymphatic tissue dissection, conducts isolation protectionon the blood vessels, and prevents the abdominal pus or the digestive juice leaking from anastomotic stoma from corroding the blood vessels and then causing hemorrhage.

The invention relates to a three-dimensional porous graphene assembled drug temperature controlled chemotherapy and thermotherapy gastrointestinal tumor device, which comprises a three-dimensional porous graphene assembled drug multi-temperature-controlled chemotherapy and thermotherapy tumor instrument, wherein the tumor instrument comprises a three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus, a telescopic multi-beam optical fiber rod and a dimming chamber; the three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus, the dimming chamber and the telescopic multi-beam optical fiber rod form an integrated controllable telescopic structure together which can generate actions such as linkage extensionand retraction in the whole device; the three-dimensional porous graphene assembled drug multi-temperature-controlled therapeutic apparatus comprises a three-dimensional porous graphene assembled multi-temperature-controlled drug releasing chamber; the three-dimensional porous graphene assembled multi-temperature-controlled drug releasing chamber comprises three-dimensional porous graphene and assembled drugs; and different types of drugs can be released for multiple times under different temperature control conditions. The device in the embodiment of the invention can also be applicable to chemotherapy and thermotherapy for tumors at the throat and tumors in the skin of the human body.

The invention discloses an oxaliplatin chitosan nanoparticle and an application thereof. The preparation materials of the oxaliplatin chitosan nanoparticle comprise oxaliplatin, chitosan, sodium tripolyphosphate and an acetic acid aqueous solution. The oxaliplatin chitosan nanoparticle disclosed by the invention can be applied to preparing a drug for treating gastrointestinal tumors. Compared with the prior art, the oxaliplatin chitosan nanoparticle disclosed by the invention is small in grain size, high in encapsulation efficiency, low in material price and simpler in process.

The invention provides a traditional Chinese medicinal composition for treating tumors, early and mid-term cancers and a preparation method of the traditional Chinese medicinal composition, relates to traditional Chinese medicinal herbal compositions, and particularly relates to medicaments for treating tumors, early and mid-term cancers. The traditional Chinese medicinal composition comprises the following components in parts by weight: 10-16 parts of patrinia scaniosaefolia, 1-4 parts of rhodiola rosea, 10-15 parts of sargentgloryvine stem, 2-6 parts of Chinese angelica, 10-18 parts of official magnolia flower and 1-3 parts of gastrodia elata. The traditional Chinese medicinal composition has the functions of eliminating tumors, activating blood circulation to remove stasis, diminishing inflammation and relieving pain, cooling blood and healing sore, and has quick response and high cure rate when being used for treating early and mid-term esophagus cancer, gastric cancer and other gastrointestinal tumor diseases.

The invention discloses a disposable gastrointestinal tumor feces screening, collecting and detecting set. The disposable gastrointestinal tumor feces screening, collecting and detecting set comprisesa first connecting tube, a second connecting tube and a detecting box which are sequentially arranged from top to bottom, wherein a connecting passage is arranged at the top part of the detecting boxand is communicated with the interior of the detecting box; the first connecting tube and the second connecting tube are fixedly connected by a connecting lug; a rotary ring is rotationally connectedbetween the corresponding side walls of the first connecting tube and the second connecting tube; the interiors of the first connecting tube, the second connecting tube and the rotary ring are rotationally connected with a collecting tube; a first convex structure and a second convex structure are respectively arranged at the opposite outer walls of the first connecting tube and the second connecting tube; the second convex structure is connected with the interior of the connecting passage by threads; the center of the inner wall of the top part of the detecting box is rotationally connectedwith a rotary rod. The disposable gastrointestinal tumor feces screening, collecting and detecting set has the advantages that a sample can be conveniently sampled by the collecting tubes; the samplecan be sampled for multiple times; the testing accuracy is improved.

The invention relates to the field of a biomedicine, in particular to a gastrointestinal tumor marker and an application thereof. The marker is WNT4. The gastrointestinal malignant tumor is human gastrointestinal malignant tumor tissue, including gastric cancer and colorectal cancer. The marker is used for preparing a reagent for early diagnosis of gastrointestinal malignant tumor, a fluorescencequantitative PCR primer pair of WNT4 is used, a cDNA of a sample to-be-tested is used as a template for performing a quantitative PCR reaction, and a CT value of WNT4 amplification is measured, and the CT value of an internal reference gene beta-actin is used for standardization correction to identify the sample to-be-tested. Through a reliable fluorescent quantitative PCR method, the expression level of WNT4 in the gastrointestinal malignant tumor tissue is significantly reduced through screening. The method has high sensitivity and strong specificity, and the marker can be used for early diagnosis of gastrointestinal malignant tumors.

The invention discloses a novel application of a Xianglian (coptidis rhizoma and radix aucklandiae) pill product in preventing or treating helicobacter pylori, gastrointestinal tumors, atrophic gastritis, cardiovascular and cerebrovascular diseases and the like. The invention solves the problems that the treatment effect of Xianglian pills is always limited to dysentery caused by damp-heat of large intestines, and the symptoms are purulent and bloody stool, tenesmus, fever and abdominal pain, enteritis and bacillary dysentery, and the new treatment effect is not developed all the time. The Xianglian pill product has the effect of resisting helicobacter pylori Hp, and the safety of the Xianglian pill product is higher than that of coptidis rhizoma and coptidis rhizoma extract; the Xianglian pill product can also be used for treating gastrointestinal tumors; and in addition, the Xianglian pill product also has the effect of preventing cardiovascular and cerebrovascular diseases including atherosclerosis.

The invention discloses a gastrointestinal tumor biopsy sampling device, including a sampling pipe (1). The bottom of the sampling pipe (1) is provided with a puncturing cone (2), the upper top of thesampling pipe (1) is provided with an end cover (3) matched with the sampling pipe in a rotary mode, the sampling pipe (1) is of a hollow pipe-shaped structure integrally, one side of the sampling pipe (1) is axially provided in a penetrating mode with a sampling groove (4) which concurrently is a guide sliding groove, the sampling pipe (1) is internally provided with a piston top (5), and the upper part of the piston top (5) is provided with a piston rod (6) fixedly and rotatably connected with the piston top. According to the gastrointestinal tumor biopsy sampling device, the structure is simple, an integral sampling from bottom to top in entire tumour can be achieved, and growth and tissue distribution conditions of the tumour are convenient to understand by medical workers.

The invention discloses a medicine with the functions of regulating the liver and kidneys and improving the immunities and a preparation method. The medicine comprises 20-70wt% of coriolus versicolor polysaccharides, 15-60wt% of pachymaran and 10-40wt% of garlic polysaccharides. The preparation method is characterized by firstly extracting coriolus versicolor polysaccharides, pachymaran and garlic polysaccharides respectively and preparing the medicine in proportion. The medicine is low in cost, does not have any toxic or side effect, has the functions of regulating the liver and kidneys, improving the immunities, diminishing inflammation, resisting viruses, tumors, radiation and ulcers, easing pains, enhancing the fertility and prolonging the lives, and has obvious effects on gynecological inflammations, gynecological and gastrointestinal tumors and ulcer diseases. 2-3 granules of the medicine are taken by the adults every day, 1-2 granules each time, and the medicine can be taken for a long term.

The invention provides a high-activity tumor inhibitor as well as a preparation method and an application thereof. To be specific, a key binding site of YAP protein and TEAD is obtained, polypeptides with the best YAP inhibition activity are screened out and modified, for example, amino acid is subjected to substitution, deletion and/or addition (for example, addition of cell penetration segments) by adding disulfide bonds, and a series of polypeptides having a YAP protein activity inhibition effect and good stability are final screened out. Experiments indicate that the polypeptides can effectively inhibit the binding activity of YAP protein with TEAD, thereby having a good treatment effect on gastrointestinal tumors, particularly liver cancers.

The embodiment of the invention discloses a hydroxybenzene derivative detection reagent and a preparation method thereof, and a tumor detection reagent. According to the volume ratio, the hydroxybenzene derivative detection reagent comprises the components: 1 of a solution A; 0.3-0.5 of a solution B; 0.16-0.18 of a solution C; 0.2-0.6 of a solution D; and 0.07-0.08 of a solution E, wherein the solution A is a dilute solution obtained after mercury is dissolved in concentrated nitric acid; the solution B is a 230-250 g/L mercurous nitrate nitric acid solution; the solution C is a 3-5 g/L paradimethylaminobenzaldehyde sulfuric acid solution; the solution D is a 0.001-0.004 g/L sodium nitrite solution; and the solution E is a 300-500 g/L nickel nitrate solution. The hydroxybenzene derivativedetection reagent is simple and convenient in preparation process, and is suitable for conventional production and manufacturing. In addition, the hydroxybenzene derivative detection reagent not onlyhas a high detection rate for most benign tumors, but also has a high detection effect on gastrointestinal tumors and some high-attack non-gastrointestinal tumors, such as bladder cancer, cervical cancer and breast cancer.

The invention discloses a benzimidazole amide compound as well as pharmaceutically acceptable salts and a preparation method thereof. The compound is used for tumors relevant to the continuous activation of hedgehog (Hh) signaling pathways, such as skin basal cell carcinoma, brain tumors, medulloblastoma, lung cancer, gastrointestinal tumors, breast cancer or pancreatic cancer, and illnesses relevant to the Hh signaling pathways.