The invention discloses weight losing plaster which is prepared from transdermal patch, liquid medicine and medicine powder, wherein the liquid mechanism is prepared by extracting the following traditional Chinese medicine in parts by weight: 10 to 25 weight parts of poria cocos, 10 to 40 weight parts of radix puerariae and 20 to 45 weight parts of semen coicis, and the medicine powder is preparedfrom 10 to 25 weight parts of poria cocos and 15 to 30 weight parts of basil seed. According to the weight losing paste disclosed by the invention, the poria cocos is utilized as monarch drug and hasthe effects of clearing damp, promoting diuresis, eliminating dampness and phlegm, promoting urination and relaxing bowels to lose weight; the radix puerariae is utilized as ministerial drug to helpproduce saliva and slake thirst and reduce blood glucose and lipid to help enhance damp clearing and diuresis promoting effects of the monarch drug; the semen coicis is utilized as adjuvant drug to tonify spleen, remove damp, clear heat and discharge pus; the basil seed is utilized as conductant drug to moderate the medicinal materials and has a relaxing bowel effect. As all the medicinal materials are in compatibility, the weight losing plaster can treat diseases of obesity, metabolic syndrome, fatty liver and the like caused by depressed liver, deficient spleen, phlegmatic hygrosis, middle impedance, liver-kidney yin deficiency, liver-stomach heat accumulation and the like from the root; treating effects of activating collaterals, reducing lipid, tonifying spleen, eliminating damp, losing weight and reducing lipid are achieved jointly.