Detumescence and analgesia compound preparation containing sodium aescinate and preparation method thereof

A technology of sodium aescinate and sodium aescinate fat, which is applied in the field of anti-tumor and analgesic compound preparation containing sodium aescinate and its preparation field, which can solve problems such as adverse reactions, reduce direct stimulation, and achieve good transdermal absorption The effect of reducing swelling and pain

Inactive Publication Date: 2021-03-26
黑龙江迪龙制药有限公司
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that the existing sodium aescinate dosage forms easily cause adverse reactions, the invention provides a compound preparation for reducing swelling and analgesia containing sodium aescinate and a preparation method thereof

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The present embodiment provides a kind of preparation method of sodium aescinate liposome, specifically comprises the following steps:

[0033] Step 1, prepare membrane material by the molar ratio of lecithin and cholesterol 5:2, prepare liposome raw material by the mass ratio of sodium aescinate and membrane material 1:30;

[0034] Step 2. Dissolve the sodium aescinate in purified water, dissolve the film material in an appropriate amount of absolute ethanol and slowly mix it with the obtained sodium aescinate aqueous solution, remove the solvent by rotary evaporation in a warm water bath at 40°C, and dry in vacuum overnight To obtain a lipid film, add DEPC physiological saline to dissolve and hydrate the lipid film. After hydrating on a shaker at 20°C for 2 hours, the resulting hydration system is ultrasonically treated to fully disperse the liposomes in the hydration system. The polycarbonate membrane with a pore size of 100 nm is used to process the hydration system...

Embodiment 2

[0036] This example provides a compound preparation for reducing swelling and analgesia containing sodium aescinate, including the following components by weight: 300 parts of sodium aescinate liposome, 5 parts of menthol, 20 parts of mugwort leaf oil, and The pharmaceutically acceptable excipient, wherein the mass percentage of sodium aescinate is 1-1.5%.

[0037]The preparation method of sodium aescinate liposome in the present embodiment comprises the steps:

[0038] Step 1, prepare membrane material by the molar ratio of lecithin and cholesterol 5:2, prepare liposome raw material by the mass ratio of sodium aescinate and membrane material 1:35;

[0039] Step 2. Dissolve the sodium aescinate in purified water, dissolve the film material in an appropriate amount of absolute ethanol and slowly mix it with the obtained sodium aescinate aqueous solution, remove the solvent by rotary evaporation in a warm water bath at 40°C, and dry in vacuum overnight To obtain a lipid film, a...

Embodiment 3

[0042] This example provides a compound preparation for reducing swelling and analgesia containing sodium aescinate, including the following components in parts by weight: 800 parts of sodium aescinate liposome, 10 parts of menthol, 30 parts of mugwort leaf oil, and The pharmaceutically acceptable excipient, wherein the mass percentage of sodium aescinate is 1-1.5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to a detumescence and analgesia compound preparation containing sodium aescinate and a preparation method thereof, and belongs to the technical field of pharmacy. In order to solve the problems that the dosage form of sodium aescinate can easily cause adverse reactions, the preparation method of sodium aescinate liposome is provided. The sodium aescinate is encapsulated in phospholipid membranes to relieve the stimulation generated when the sodium aescinate directly enters blood vessels, so that phenomenon such as swelling and pain and allergy can be reduced. In the compound preparation, the sodium aescinate liposome is compounded with menthol and artemisia argyi leaf oil, so that drug absorption can be promoted, and allergy can be further relieved. A gel preparationis provided and used for realizing detumescence and analgesia after wisdom tooth extraction, and has the effects of antibiosis and antiphlogosis and detumescence and analgesia after compounding honeysuckle flower and a dahurian angelica root extract. A cream preparation is also provided and used for achieving detumescence and analgesia after facial cosmetic surgery, and can have the effect of improving blood circulation and dispersing stasis, maintaining beauty and keeping young and preserving moisture and rejuvenating skins after compounding safflower oil and vitamin E.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a compound preparation for reducing swelling and relieving pain containing sodium aescinate and a preparation method thereof. Background technique [0002] Sodium aescinate is a triterpenoid saponin sodium salt extracted from the dried and ripe fruit of the traditional Chinese medicine Poluo. It has the functions of anti-inflammatory, anti-exudation, increasing venous tone, improving blood circulation and correcting brain dysfunction. It has an obvious protective effect on cerebral edema caused by carbon monoxide, and can be used to treat cerebral edema, swelling caused by trauma or surgery, and is also used for venous reflux disorders. [0003] Common dosage forms of sodium aescinate are intravenous injections, oral tablets, or topical gels. Adverse reactions such as local pain, swelling, and occasional allergies at the injection site may occur during intravenous i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K36/282A61K36/286A61K9/06A61K9/127A61K31/704A61K47/36A61K47/34A61K47/32A61P29/00A61K31/045A61K31/355
CPCA61K9/0014A61K9/06A61K9/127A61K31/045A61K31/355A61K31/704A61K36/232A61K36/282A61K36/286A61K36/355A61K47/32A61K47/34A61K47/36A61P29/00A61K2300/00
Inventor 董继胜杨久春于芳王永义胡俊
Owner 黑龙江迪龙制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap