Uncaria sustained-release capsule preparation and preparation method thereof

A technology of sustained-release capsules and preparations, applied in the field of Uncaria sustained-release capsule preparations and its preparation, which can solve the problems of lack of sustained-release effect, poor curative effect, and inability to control blood pressure smoothly

Inactive Publication Date: 2015-11-25
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, total alkaloids of Uncaria can be used to treat hypertension, but Chinese herbal medicines are usually decocted into decoctions, but decoctions are not conducive to storage, carrying and taking, and usually lack slow-release effects, and cannot control blood pressure stably, so long-term efficacy poor

Method used

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  • Uncaria sustained-release capsule preparation and preparation method thereof
  • Uncaria sustained-release capsule preparation and preparation method thereof
  • Uncaria sustained-release capsule preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0065]Embodiment 3: first take by weighing 85g starch, 50g microcrystalline cellulose, 88g dextrin, sieve, mix uniformly, with 10g ethyl cellulose as wetting agent, make blank ball core in coating granulator, Dry and set aside. Then weigh 6.5g of rhynchophylline, 43g of starch, and 1.0g of sodium lauryl sulfate to pulverize and sieve respectively, place the blank ball core in the coating pan, add the mixture of rhynchophylline, starch and sodium lauryl sulfate The mixture is sprayed with ethyl cellulose, then the powder mixture is added, the ethyl cellulose is sprayed, and the operation is repeated until all the powders are added. After dosing, take it out and place it on a tray to dry. Finally, 5 g of hydroxypropyl methylcellulose was weighed and added to 200 ml of 70% ethanol, and left overnight. Add 15 g of diethyl phthalate and 1.0 g of titanium dioxide, and stir evenly to make a coating liquid. Put the above-mentioned vegetarian pills in the coating pot, then spray the...

Embodiment 2

[0066] Embodiment 4: First take by weighing 100g starch, 50g sodium carboxymethylcellulose, 77g dextrin, sieve, mix evenly, use polyvinylpyrrolidone and ethylcellulose mixture solution as wetting agent, in coating granulator Make a blank ball core, dry it, and set it aside. Then weigh 17g of total alkaloids of Uncaria, 52g of starch, and 10g of Tween, respectively pulverize and sieve, put the blank ball core in the coating pan, add the mixture of total alkaloids of Uncaria, starch and Tween, and spray into hydroxypropyl formazan. Base cellulose solution, then add the powder mixture, spray into the solution, repeat the operation until all the powder is added. After dosing, take it out and place it on a tray to dry. Finally, 12 g of hydroxypropyl methylcellulose was weighed and added to 250 ml of ethanol, and left overnight. Add 38 g of diethyl phthalate and 1.0 g of titanium dioxide, and stir evenly to make a coating liquid. Put the above-mentioned vegetarian pills in the co...

Embodiment 3

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Abstract

The invention discloses an uncaria slow release capsule preparation and a preparation method thereof. The preparation is prepared from 1 to 15 parts by weight of uncarine or uncaria rhomotoxine and 73.2 to 130.2 parts by weight of accessories, wherein the accessories comprise 65 to 85 parts of excipient, 3 to 15 parts of coating agent, 5 to 20 parts of wetting agent, 0.1 to 0.5 part of surface active agent, 0 to 9 parts of plasticizer and 0.1 to 0.7 part of sunscreen. Compared with the prior art, by a slow release technology of the invention, medicaments are slowly released; the fluctuation of the concentration of plasma medicaments is effectively reduced; a peak valley phenomenon caused by frequent administration of an ordinary preparation is avoided; the utilization rate of the medicaments is enhanced; the medical cost is reduced; and the direct stimulation of the medicaments for the gastrointestinal tract is reduced. Therefore, side effects are reduced; patients are easy to endure the medicaments; and the preparation is beneficial to long-term treatment and hypertensive treatment. In addition, the invention also simplifies the technology; the preparation process of a capsule is easier to operate and more convenient to carry and take; the problem of the prior art is solved; and the purpose of the invention is achieved.

Description

technical field [0001] The invention relates to an Uncaria sustained-release capsule preparation and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Hypertension belongs to the pain syndromes of dizziness, headache, liver yang and liver wind in traditional Chinese medicine. The main symptoms of the patient are dizziness, headache and elevated blood pressure. It can be caused by the imbalance of liver and kidney yin and yang due to heredity or long-term mental stress, depression, or addiction to fat, sweet, and excessive drinking. In severe cases, symptoms such as stroke and coma may occur. Hypertension is a common disease and the most important risk factor for major diseases such as coronary heart disease and cerebrovascular disease that lead to human death. The morbidity and mortality of cardiovascular and cerebrovascular diseases are closely related to the blood pressure level of patients. Therefore, all countrie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/437A61K36/74A61P9/12
Inventor 黄文荣周方勇李江
Owner GUIZHOU BAIHUA PHARMA
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