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Uncaria sustained-release tablet and preparation method thereof

A technology for sustained-release tablets and Uncaria, applied in the field of sustained-release tablets of Uncaria and preparation thereof, can solve the problems of lack of sustained-release effect, unfavorable storage of decoction, inability to control blood pressure stably and the like

Inactive Publication Date: 2010-10-20
贵州苗王金藤生物医药股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Chinese medicinal materials are usually decocted into decoctions, but decoctions are not conducive to storage, carrying and taking, and usually lack slow-release effects, and cannot control blood pressure stably, so the long-term efficacy is not good

Method used

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  • Uncaria sustained-release tablet and preparation method thereof
  • Uncaria sustained-release tablet and preparation method thereof
  • Uncaria sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: Take rhynchophylline or total alkaloids of rhynchophyllum 1g, 45g of hydroxypropyl methylcellulose, and 41.6g of lactose, mix well, add a concentration of 5%, containing 17g of polyvinylpyrrolidone ethanol solution, granulate, dry, The granules are processed to obtain sustained-release granules, and 0.5 g of magnesium stearate is added as a lubricant, and compressed into tablets to obtain sustained-release tablets.

Embodiment 2

[0070] Embodiment 2: Weigh 3 g of rhynchophylline or total alkaloids of rhynchophyllum, 45 g of polycarboxyethylene, and 50 g of lactose, mix evenly, add a 45% ethanol solution with a concentration of 7% and 10 g of hypromellose, granulate, and dry , granulate, to obtain sustained-release granules, add 1g of talcum powder as a lubricant, and compress into tablets to obtain sustained-release tablets.

Embodiment 3

[0071] Example 3: Weigh 5 g of rhynchophylline or total alkaloids of rhynchophyllum, 37 g of sodium alginate, 3 g of calcium alginate, and 46 g of lactose, mix well, add 15 g of absolute ethanol, granulate, dry, and granulate to obtain sustained-release granules , add 1.7g of magnesium stearate as a lubricant, and compress into tablets to obtain sustained-release tablets.

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Abstract

The invention discloses an uncaria sustained-release tablet and a preparation method thereof; the uncaria sustained-release tablet comprises the following components in parts by weight: 1 to 30 parts of rhynchophylline or uncaria alkaloid, 10 to 70 parts of sustained-release auxiliary materials and other auxiliary materials: 0.2 to 5 parts of pore-foaming agent, 10 to 45 parts of filler, 0.5 to 20 parts of adhesive, 5 to 15 parts of wetting agent, 0.1 to 2 parts of lubricant, 0 to 5 parts of solubilizer, 0 to 10 parts of emulsifier, 0 to 25 parts of membrane material, 0 to 15 parts of opacifying agent and 0 to 25 parts of solvent. The invention slowly releases the medicine through a sustained-release technology, can effectively reduce the fluctuation of plasma concentration, prevents the 'peak and valley' phenomenon of common preparation caused by frequency medication, improves the utilization rate of the medicine, reduces the medical expenses, reduces the direct stimulation of the medicine to the gastrointestinal tract so as to reduce the side effect, so that a patient is more tolerant, thereby facilitating long-termed curing and more facilitating the curing of hypertension.

Description

technical field [0001] The invention relates to an Uncaria sustained-release tablet and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] The new guidelines for the treatment of hypertension released by the World Health Organization to the world believe that with the changes in human life style and living environment, the proportion of hypertensive patients in the total population has become higher and higher, and heart disease caused or induced by hypertension Diseases of the brain, brain and kidney have become the number one killer that endangers human life and health. Hypertension is the most important risk factor leading to major diseases of human death such as coronary heart disease and cerebrovascular disease. The morbidity and mortality of cardiovascular and cerebrovascular diseases are closely related to the blood pressure level of patients. Therefore, all countries in the world attach great importance to the p...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/437A61K36/74A61K9/36A61K9/32A61P9/12
Inventor 黄文荣周方勇李江
Owner 贵州苗王金藤生物医药股份有限公司
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