The invention discloses a health product having an anti-fatigue effect. According to statistics, the incidence rate of a sub-health state is 70% of the total population, and the sub-health state greatly affects the quality of human life and consumes human life costs. The health product is prepared by taking pearls, hippocampus, syngnathus, sea snakes, sea shrimps, sea cucumber, oysters and other seafood as main ingredients and combining a part of medicine and food dual-purpose traditional Chinese medicines; through providing high-quality proteins, polypeptides, amino acids, zinc, iron, selenium, magnesium, calcium, phosphorus and other minerals, the health product make a human body supplemented, can eliminate fatigue, thereby adjusting the sub-health state of the human body. After the heath product is made into a liquid agent, a mouse anti-fatigue test is performed; and results show that compared with a control group, the average time of 5 groups of mice to sink into water is 45 minutes, while the average time of the control group to sink into water is 25 minutes. Therefore, the results show that the health product can significantly improve the swimming ability of the mice, and reveal that the health product has the anti-fatigue effect.