29results about How to "Good disintegration" patented technology

The invention provides anti-scattering water-guided laser cutting fluid as well as a preparation method and application thereof. The anti-scattering water-guided laser cutting fluid comprises the following components in parts by weight: 0.1-1 part of an anti-scattering agent; 0.01 to 0.1 part of a foam discharging agent; 1-5 parts of a refractive index regulator; and 80-99 parts of ultrapure water. The anti-scattering agent is a polymer; the foam removing agent is one or more of hydroxymethyl cellulose, hydroxy propyl cellulose, sodium lignin sulfonate, potassium lignin sulfonate and naphthalene sulfonic acid formaldehyde condensate sodium salt; the refractive index regulator is an iodine-containing compound and / or a fluorine-containing compound. According to the anti-scattering water-guided laser cutting fluid, light beam scattering and energy loss in the water-guided laser cutting process can be remarkably reduced, and the cutting precision and efficiency are improved. The anti-scattering water-guided laser cutting fluid has very good application prospects and large-scale industrial popularization potential in the field of water-guided laser cutting.

The invention relates to the technical field of nerve calming granules, and discloses sugar-free blood nourishing and nerve calming granules and a preparation method thereof.The sugar-free blood nourishing and nerve calming granules are composed of hairyvein agrimony, prepared rehmannia roots, vine of multiflower knotweed, yerbadetajo herbs, rehmannia roots, suberect spatholobus stems, cortex albiziae and sugar-free auxiliary materials; comprising microcrystalline cellulose, isomaltitol, mannitol, nano silicon dioxide, Arabic gum, hydroxypropyl methyl cellulose and polyvinylpyrrolidone. By optimizing the proportion and process conditions of the auxiliary materials and the synergistic effect of the medicinal material extract and the auxiliary materials, the humidity of the wet granules is controlled to be 30-35%, the granulation pressure is 3-6 MPa, the drying temperature is 50-55 DEG C, and finally the granules with the particle size of 200-400 microns are prepared. According to the invention, the problems of poor particle formability and insufficient disintegration performance caused by removal of sugar are overcome, rapid disintegration, good formability and stability of sugar-free particles are realized, the solubility and taste of the particles are improved, and the sugar-free granules are suitable for long-term administration by diabetics and sugar-sensitive people.

The invention belongs to the field of breeding of special aquatic products, and particularly relates to a bionic nutrient enrichment micro-capsule for jellyfish offspring seeds as well as a preparation method and application of the bionic nutrient enrichment micro-capsule. The capsule core is prepared from fish soluble powder, enzymolysis sea cucumber viscera powder, enzymolysis kelp powder, euphausia superba powder, scallop skirt powder, chlorella powder, schizochytrium limacinum powder, haematococcus pluvialis powder, diatomite, taurine, yeast wall-broken powder, disodium nucleotide, chondroitin sulfate, multivitamins and sodium carboxymethyl cellulose; the capsule wall consists of crab meat powder, fairy shrimp egg powder, L-glutamic acid, chitosan, sodium alginate, calcium glycinate, enzymolysis soybean protein and whey protein powder. According to the food intake requirements of the jellyfish offspring seeds, the superfine nutritional micro-capsules and the granular nutritional micro-capsules suitable for the jellyfish offspring seeds of different specifications are prepared.

The invention discloses a pharmaceutical composition containing an abelmoschus manihot flower extract and a preparation method, application and a preparation thereof, and belongs to the technical field of pharmaceutical preparations, the pharmaceutical composition is composed of the abelmoschus manihot flower extract, magnesium stearate and calcium hydrogen phosphate. Compared with the prior art, the pharmaceutical composition disclosed by the invention has better long-term stability, and the medicament prepared by applying the pharmaceutical composition is smaller in volume, so that the taking discomfort or swallowing difficulty of a patient is reduced, and the compliance is improved.

The invention discloses a levonorgestrel tablet and a preparation method thereof. The levonorgestrel tablet is prepared from the following components: 0.75 part of levonorgestrel, 20 to 30 parts of lactose, 20 to 25 parts of corn starch, 0.8 to 1.0 part of corn starch slurry, 1 to 2 parts of colloidal silicon dioxide, 1 to 2 parts of talcum powder and 1 to 2 parts of magnesium stearate. The colloidal silicon dioxide provided by the invention can cooperate with the corn starch to help the tablet to be disintegrated more quickly in vivo, so that the release rate of the medicine is accelerated. The dissolution rate of the prepared levonorgestrel tablet reaches 65.6%-70.7% in 30 minutes, and the dissolution rate of the prepared levonorgestrel tablet reaches up to 86.0% in 60 minutes.

The invention discloses a special cleaning agent for a windshield of a vehicle body as well as a preparation method and application of the special cleaning agent. The cleaning agent comprises the following components in parts by weight: 20-25 parts of an emulsifier, 10-15 parts of a builder, 5-8 parts of a penetrant, 5-10 parts of a corrosion inhibitor and 50-65 parts of a solvent, wherein the emulsifying agent is selected from at least one of fatty alcohol polyoxyethylene 10 ether, isomeric alcohol polyoxyethylene ether and methyl stearate sodium sulfonate; the builder is selected from at least one of glycerol, coco fatty acid diethanol amide and sulfo-imidazoline betaine; the penetrant is selected from at least one of tetrasiloxane, isooctanol polyoxyethylene ether phosphate and alkylphenol polyoxyethylene ether; the corrosion inhibitor is selected from at least one of glycerol, sodium polyacrylate, benzotriazole, sodium tripolyphosphate and sodium gluconate. The cleaning agent has the advantages of being good in cleaning force, free of flash points, incombustible, free of corrosion to rubber base materials and the like.

The invention discloses a formula of blood-nourishing and tendon-nourishing pills, which is prepared from the following components in parts by weight: 7 to 9 parts of radix angelicae sinensis, 13 to 17 parts of caulis spatholobi, 30 to 35 parts of wine-fried radix polygoni multiflori, 13 to 17 parts of radix paeoniae rubra, 13 to 17 parts of radix dipsaci and 13 to 17 parts of herba taxilli. The modified dietary fiber and hydroxymethyl cellulose are added into the formula of the blood-nourishing and tendon-nourishing pill, so that the disintegration property and the acting effect on a patient of the blood-nourishing and tendon-nourishing pill are effectively improved, the sugar content of the blood-nourishing and tendon-nourishing pill is also reduced, and the excessive influence of the blood-nourishing and tendon-nourishing pill on the blood sugar of the patient is avoided.

The invention discloses a fruit powder orally disintegrating tablet and a preparation method thereof. The fruit powder orally disintegrating tablet comprises the following raw materials: 2-30 parts of fruit powder, 20-70 parts of a filler, 0-5 parts of an adhesive, 5-30 parts of a disintegrating agent, 0.1-2 parts of a flow aid and 0.1-2 parts of a lubricant. The fruit powder orally disintegrating tablets with a series of tastes are prepared, can be rapidly disintegrated in the oral cavity through saliva within 60 seconds, and are very friendly to people with dysphagia and children; and meanwhile, the selected filling agent is sugar substitute, so that the mouthfeel of the sugar is kept, the sugar substitute cannot be absorbed by a human body, the beverage is friendly to people with hyperglycemia, and decayed teeth cannot be caused.

The present application relates to a kind of converter tapping hole repair material and preparation method, including repair layer, glaze layer, the repair layer is composed of the following raw materials: pretreated high-purity magnesia, carboxymethyl cellulose, binder;The pretreatment of high-purity magnesia: high-purity magnesia is soaked in magnesium sulfate heptahydrate aqueous solution for 24 hours or more, take out and dry at 100~110 ℃ temperature;Glaze layer is composed of the following raw materials: glass powder, potassium feldspar powder, quartz powder, SiC fine powder, chromium oxide green, water.The advantage is: converter tapping hole repair material according to the need characteristics of use position and steel plant, use high-purity magnesia soaked in magnesium sulfate heptahydrate aqueous solution as main raw material, improve the disintegration of material, shorten the replacement tapping hole time.Repair layer disintegration is excellent, the added carboxymethyl cellulose or clay and binder effectively improve the volume stability of repair agent at high temperature.

The invention belongs to the field of agricultural fertilizers, and provides a micro-mineral activator and an application thereof in improving the fertilizer efficiency of a bio-organic fertilizer. According to the invention, epoxy silane coupling modified potassium feldspar powder is adopted as a core to construct a two-phase collaborative design of humic acid coated core-shell composite powder IM-X and metal ion crosslinked microgel powder IM-Y; the balance between the compressive strength of the particles and the rapid disintegration and dispersion performance when encountering water is realized, the consideration of a high-solid-content low-water-adding-amount granulation process window and the rheological stability of a humic acid cross-linked network is considered, and the unification of moisture absorption and caking resistance during storage and transportation and water absorption and retention ion response regulation and control functions after application is realized; the mineral-organic composite additive solves the performance coupling contradiction of natural conflicts in physical and chemical mechanisms of the existing mineral-organic composite additive, has the advantages of good processing controllability, excellent storage and transportation stability and remarkable fertilizer efficiency improvement effect, and has wide application value in the field of bio-organic fertilizer synergism.

The invention relates to the technical field of deer blood tablets, in particular to a deer blood tablet and a preparation method thereof.The deer blood tablet is prepared from, by weight, 150-160 parts of deer blood powder, 70-80 parts of American ginseng powder, 70-80 parts of fructus lycii powder, 75-85 parts of disintegrating agent, 2.5-4 parts of magnesium stearate and 2.5-3.5 parts of carboxymethyl chitosan; wherein the disintegrating agent is a mixture of croscarmellose sodium and microcrystalline cellulose, and the mass ratio of croscarmellose sodium to microcrystalline cellulose is (8-12): 70; the deer blood tablet has the advantage of reducing the disintegration time of the deer blood tablet.

The invention relates to a preparation process of a pitavastatin calcium tablet, and belongs to the technical field of drug synthesis, the pitavastatin calcium tablet comprises a tablet core and a coating, the tablet core comprises the following components in parts by weight: 1-2 parts of pitavastatin calcium, 40-75 parts of a filler, 4-30 parts of a disintegrating agent, 0.5-1.5 parts of an adhesive, 0.4-0.75 part of a lubricant, 2-5 parts of a stabilizer and 1-2 parts of a solubilizer; the preparation method comprises the following steps: weighing pitavastatin calcium, sieving, and uniformly mixing with the stabilizer to obtain a mixture A; sieving the filling agent and the disintegrating agent, and uniformly mixing to obtain a mixture B; uniformly mixing the mixture A and the mixture B according to an equal increment method to obtain a mixture C; adding an adhesive into the mixture C, and sieving twice to prepare wet particles; placing the wet particles in a drying oven for forced air drying to obtain dry particles; and adding a lubricant and the like into the dry granules, uniformly mixing, tabletting, and coating to obtain the pitavastatin calcium tablet. The whole tablet has the advantages of high tablet stability, good content uniformity and high disintegration and absorption efficiency.

The invention relates to the technical field of capsules, in particular to a compound soft capsule and a preparation method thereof. The compound soft capsule comprises a capsule content and a capsule shell prepared from capsule liquid, and the capsule content is prepared from the following raw materials in parts by weight: 5-12 parts of calcium carbonate and 10-20 parts of a compound extract. The compound soft capsule product prepared by the invention has excellent storage stability, antibacterial property, good disintegration performance and high bioavailability.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a compound pharmaceutical preparation based on spray lactose and a preparation method thereof. The compound pharmaceutical preparation comprises the following components in parts by weight: active drug 10-15 parts, spray lactose 27-33 parts, mannitol 30-35 parts, modified microcrystalline cellulose 13-16 parts, disintegrating agent 3-5 parts, lubricant 1-2 parts, and flavoring agent 1-3 parts. The compound pharmaceutical preparation has the characteristics of high hardness, low friability, rapid disintegration, good content uniformity, excellent taste masking effect and good taste.

The invention relates to the technical field of medical biological materials, and discloses a hydrogel microneedle dressing as well as a preparation method and application thereof. The hydrogel microneedle dressing comprises a substrate and a hydrogel needle tip positioned on the substrate, the hydrogel needle tip is prepared from the following raw materials in parts by weight: 20 to 40 parts of oxidized hyaluronic acid, 20 to 40 parts of carboxymethyl chitosan, 2 to 16 parts of iron-loaded ZIF-8 nanoparticles, 1 to 2 parts of glucose oxidase and 402 to 457 parts of water. The preparation method comprises the following steps: carrying out Schiff base reaction on carboxymethyl chitosan and oxidized hyaluronic acid to prepare hydrogel; loading the iron-loaded ZIF-8 nanoparticles and glucose oxidase on the hydrogel to obtain a needle tip precursor solution; and preparing the hydrogel microneedle dressing from the needle tip precursor solution and the substrate precursor solution through a hydrogel microneedle dressing forming process. The hydrogel microneedle dressing is used for preparing medical skin wound dressing, and the antibacterial effect under response of the internal environment is achieved.

The invention discloses a mineral-derived non-water-soluble medium element fertilizer and a preparation method thereof, and belongs to the technical field of mineral fertilizers, the mineral-derived non-water-soluble medium element fertilizer comprises granulated electric furnace phosphorus slag powder and molasses; the mass fraction of the molasses is 1%-10%. The invention has the advantages that: the integrity of the fertilizer granules can reach 70% or more, the fertilizer granules are easy to disintegrate when encountering water and easy to absorb, and the surfaces of the fertilizer granules cannot be hardened even if the fertilizer granules are stored for a long time.

The invention relates to the technical field of anti-rheumatism medicines, in particular to an anti-rheumatism traditional Chinese medicine preparation as well as a preparation method and application of the anti-rheumatism traditional Chinese medicine preparation. 8-12 parts of Chinese angelica; 8-12 parts of ligusticum wallichii; 5-8 parts of safflower; 10 to 15 parts of fructus liquidambaris; 12 to 18 parts of coix seeds; 10 to 15 parts of radix astragali seu hedysari; through reasonable compatibility of the medicinal materials such as the garden balsam stem, the angelica sinensis and the ligusticum wallichii, a multi-element anti-inflammatory network is formed. Active components in the medicinal materials, such as gallic acid, ferulic acid, hydroxysafflor yellow A and the like, have a synergistic effect, so that the anti-inflammatory and analgesic effects of the preparation are remarkably enhanced. Experimental results show that the effect of the preparation in the aspect of inhibiting inflammatory factors such as TNF-alpha and IL-6 is improved by 50% or above compared with that of a single medicine extract.

The invention relates to the technical field of pharmaceutical preparations, discloses a disintegration performance optimization method for eslicarbazepine acetate tablets, and solves the problems that when an existing eslicarbazepine acetate tablet disintegrant is used, the efficiency is low during timed and quantitative release of drugs and disintegration of drug tablets, the efficient release of the drugs is greatly influenced, and the disintegration performance of the drugs is influenced. And the eslicarbazepine acetate is not easy to absorb by a user. The disintegration efficiency of the medicine tablets can be improved, and efficient dilution of the medicine is greatly improved.

The invention discloses an exosome freeze-drying protective agent and application of the exosome freeze-drying protective agent in an oral soluble film. The protective agent is prepared from the following solid matters in parts by weight: 1 to 20 parts of zwitterionic polymer containing choline phosphate side groups, 10 to 80 parts of polyoxazoline polymer and 1 to 20 parts of volatile ammonium salt. The zwitterionic polymer containing the choline phosphate side group forms zwitterionic pair interaction through charge arrangement complementation between a choline phosphate group and a phosphatidylcholine head group on the surface of an exosome membrane, so that directional protection is provided for the exosome membrane structure; after the polyoxazoline polymer is freeze-dried, a glassy state curing matrix is formed to embed and support the exosome; the volatile ammonium salt is decomposed and volatilized in the freeze-drying secondary drying stage, and a communicated pore channel is formed in the membrane body. The invention also provides an application of the protective agent in preparation of an exosome freeze-drying preparation or an exosome oral soluble film, and the obtained oral soluble film can be rapidly disintegrated, can maintain the structural stability of the exosome, and is suitable for normal-temperature storage and rapid administration.

The application discloses a PHA water-based coating paper pulp molding seedling raising container with functions of air preservation, root guidance and disintegration promotion, and a preparation method and application thereof, and belongs to the technical field of green agriculture and biomaterials. The application innovatively constructs an air preservation, root guidance and disintegration promotion synergistic zone, and solves the pain point that traditional paper-based containers are difficult to balance water resistance and air permeability by using differential coating technology. Compared with the traditional scheme which needs to greatly increase the coating thickness to maintain the wet strength, the application realizes better wet stability and root zone air permeability by synergistic effect of structure and material with only a very low coating amount, and gives the container the functions of intelligent root guidance penetration and directional cracking after transplanting. The product supports pot-free planting and significantly reduces the comprehensive seedling raising cost, and is in line with the future development direction of full biodegradation.

The application discloses cilostazol dextrophan sublingual tablets and a preparation method thereof. The application effectively solves the technical bottleneck that cilostazol cannot be quickly dissolved due to poor solubility by optimizing the types and proportions of excipients; and by creatively adding sodium bicarbonate and citric acid, the dual technical targets of 'fast dissolution + high hardness' are unexpectedly achieved, the bioavailability of cilostazol is significantly improved, and the drug effect of cilostazol can be quickly exerted within the golden treatment period of acute cerebral stroke. Meanwhile, the drug composition process is good in feasibility, the prepared sublingual tablets are excellent in disintegration performance, can adapt to the drug administration needs of patients with dysphagia, completely meet the clinical application and pharmaceutical quality standards, and have significant clinical value and industrialization potential.

The present invention relates to the technical field of solid waste resource utilization, and a method for preparing a sinter-free high-reflectivity ceramsite with solidified heavy metals is provided, and the specific steps are as follows: slag, fly ash, carbide slag powder, sludge powder, shell powder and titanium dioxide are placed in a dry powder mixing and stirring machine in sequence to obtain a dry powdered mixture; a certain amount of dry powdered mixture is taken and placed in a disc granulator, and a mixed solution is sprayed on a ball core, and a dry powdered mixture and a mixed solution are repeatedly added to the disc granulator to obtain a spherical raw material; the spherical raw material is placed on a rolling disc, and an anti-radiation coating is sprayed to obtain a raw material ball with a spray thickness of 0.4-0.8mm; a super-hydrophobic surface with a thickness of 0.4-0.8mm is sprayed on the raw material ball to obtain ceramsite; ceramsite is cured in a water bath curing box and a curing room in sequence to obtain sinter-free ceramsite. The present invention excites slag and shell powder by physical activation, saline-alkali activation and thermal activation to prepare sinter-free ceramsite with solidified heavy metals and high reflectivity.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an oral rapidly disintegrating tablet composition containing a sustained-release pellet core, a preparation method and a method for effectively improving the hardness of tablets. The invention provides a method for improving the hardness of tablets, which comprises the following steps of: granulating and tabletting raw materials containing maltose and / or maltitol in an environment with the humidity of 40-70%, and placing in an environment with the relative humidity of below 10% for 12-96 hours. According to the method, the hardness of the tablet containing one or more functional coating layers can be improved under the condition of low-pressure tabletting through a simple environment control means, and the functional coating layers are not damaged. The method can be achieved only by controlling the environment humidity in the production process, redundant operation steps are reduced, and the production efficiency is improved. The invention further provides a tamsulosin hydrochloride orally disintegrating sustained-release tablet and a preparation method thereof. The tamsulosin hydrochloride orally disintegrating sustained-release tablet is simple to prepare, the process is stable and controllable, and the hardness can be well improved.

The invention relates to grass carp and black carp overwintering feed and a production method thereof, and belongs to the technical field of fish feed. According to the overwintering feed for the grass carps and the black carps, the food calling performance, the nutrition performance and the functionality of the overwintering feed are greatly improved through winter nutrition adaptation, health-care factor addition and a microbial fermentation technology, physical recovery and physique enhancement of the overwintering fishes are facilitated, and therefore the prevention effect on the overwintering syndromes is achieved; the problems that an existing overwintering feed cannot effectively provide nutrition and energy for overwintering fishes and is not easy to digest and absorb are solved, and the feed is particularly suitable for overwintering feeding of grass carps and black carps.

The invention belongs to the technical field of preparation of soil conditioners, and particularly relates to a granular acid soil conditioner as well as a preparation method and application thereof. The granular acid soil conditioner prepared by taking wastes such as the plant ash, the ground phosphate rock and the alcohol production concentrated waste liquid as preparation raw materials and mixing bentonite, lime and the disintegrating agent according to a specific proportion is easy to disintegrate, can effectively improve acid soil, and has a quick-acting and lasting acid adjusting effect. Meanwhile, the granular acid soil conditioner can supplement medium trace elements in soil and promote plant growth. Furthermore, the granular soil conditioner is easier to realize mechanical operation in the application process, is more portable and is lower in cost. In addition, industrial and agricultural wastes can be fully utilized, resource utilization is realized, nutrient returning to the field is facilitated, and nutrient cyclic utilization is realized.

The invention belongs to the technical field of tunnels and underground engineering, and particularly relates to an advanced-small-conduit-free excavation method for an old loess stratum tunnel. For an old loess tunnel with the span smaller than 12 m, advanced small pipe supporting and radial anchor rod reinforcing measures are omitted, a three-step excavation mode that an upper step is provided with a temporary cross brace is adopted, the temporary cross brace is installed on the upper step along with excavation during three-step excavation, the temporary cross brace is dismantled along with excavation of a middle step, and single-side staggered excavation of the middle step and a lower step is achieved; the three-step excavation technology without advanced small guide pipes and 2.4 m short steps is researched and developed, the disturbance influence of pre-supporting is reduced, the construction period is shortened, the novel three-step excavation mode that the upper step is provided with the temporary transverse support is adopted, the working efficiency is improved by 12% compared with an original three-step temporary inverted arch method, the maximum accumulated settlement deformation of the vault is 35 mm, the maximum accumulated settlement deformation is reduced by 50% compared with similar tunnel construction, and the construction period is shortened. The size is obviously reduced.

The invention discloses a brain glioma targeted gamma-polyglutamic acid / chitosan core-shell nanoparticle, which is characterized in that the gamma-polyglutamic acid / chitosan core-shell nanoparticle takes a cation nanoparticle as an inner core, and the cation nanoparticle is formed by caffeic acid grafted chitosan-copper-curcumin through coordination driving self-assembly; phenylboronic acid modified gamma-polyglutamic acid is used as an anion shell, and gamma-polyglutamic acid / chitosan core-shell nanoparticles are formed through electrostatic interaction and mutual combination of pH-sensitive boric acid ester bonds. Then, lactoferrin is further modified on the surface of the nanoparticle through electrostatic adsorption, and the glioma targeted gamma-polyglutamic acid / chitosan core-shell nanoparticle is constructed.

The invention discloses an empagliflozin orally disintegrating tablet and a preparation method thereof. The empagliflozin orally disintegrating tablet comprises empagliflozin, a skeleton supporting agent, an adhesive, a suspending aid, a bitterness covering agent, edible essence and a flavoring agent. Through the specific empagliflozin orally disintegrating tablet components and the preparation method thereof, the dosage form of empagliflozin is expanded, auxiliary material components are optimized by removing a wetting agent and a disintegrating agent, the disintegration speed, the dissolution rate and the taste of the empagliflozin orally disintegrating tablet are improved, and the empagliflozin orally disintegrating tablet is suitable for oral administration. And the effects of complete and full tablet shape, uniform color, good taste, rapid disintegration and uniform content are achieved.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a halite four-ingredient granule formula and an extraction and concentration method thereof. The halite four-ingredient granule formula comprises halite, fructus piperis longi, fructus chebulae and rhizoma zingiberis; through scientific compatibility of the medicinal materials such as the halite, the fructus piperis longi, the fructus chebulae and the rhizoma zingiberis, the traditional Chinese medicine composition has the remarkable functions of warming the stomach, promoting digestion and detoxifying, can effectively relieve the symptoms such as gastrectasia, stomachache and belching caused by dyspepsia, can regulate the gastrointestinal physiological functions at multiple targets, such as enhancing gastrointestinal motility, promoting gastric secretion and inhibiting the growth of harmful bacteria; therefore, the gastrointestinal tract environment is comprehensively improved, and digestive absorption is promoted.