Fruit powder orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses a fruit powder orally disintegrating tablet and a preparation method thereof. The fruit powder orally disintegrating tablet comprises the following raw materials: 2-30 parts of fruit powder, 20-70 parts of a filler, 0-5 parts of an adhesive, 5-30 parts of a disintegrating agent, 0.1-2 parts of a flow aid and 0.1-2 parts of a lubricant. The fruit powder orally disintegrating tablets with a series of tastes are prepared, can be rapidly disintegrated in the oral cavity through saliva within 60 seconds, and are very friendly to people with dysphagia and children; and meanwhile, the selected filling agent is sugar substitute, so that the mouthfeel of the sugar is kept, the sugar substitute cannot be absorbed by a human body, the beverage is friendly to people with hyperglycemia, and decayed teeth cannot be caused.

Description

Technical Field

[0001] The invention belongs to the field of functional foods, and in particular relates to a fruit powder orally disintegrating tablet and a preparation method thereof. Background Art

[0002] According to the Chinese Nutrition Society's Balanced Diet Pagoda for Chinese Residents (2016), in order to maintain normal human metabolism, the recommended daily fruit intake is 200-350g. The "Research Report on Dietary Guidelines for Chinese Residents (2021)" pointed out that even urban residents with higher fruit intake have an average per capita intake of 55.7g / day, which is relatively low. The report also pointed out that increasing fruit intake can reduce the risk of cardiovascular disease and digestive tract tumors (gastric cancer, colorectal cancer, and esophageal cancer). Increasing fruit intake can reduce the risk of cardiovascular disease. In addition, randomized controlled trials using specific fruits or juices (high flavonoids fruits, kiwis, blueberries, blueberry powder and blueberry juice, orange juice, sour cherry juice, polyphenol berry juice, cranberry juice, red grape juice, and pomegranate juice) have shown that increasing the intake of fruits or juices can effectively regulate blood pressure levels and has a protective effect on cardiovascular disease. Increasing fruit intake can reduce the risk of colorectal cancer, esophageal cancer, and gastric cancer. A meta-analysis of 5 cohort studies and 17 case-control studies showed that fruit intake was significantly associated with a reduced risk of colorectal cancer, and every increase of 100g / day of fruit intake could reduce the risk by 6%.

[0003] At present, it is difficult for children, busy office workers and some people with dysphagia to consume a certain amount of fresh fruit every day, so new ways need to be developed to meet the intake of fruit. At the same time, in order to solve the problem of transportation and storage of fresh fruit, processing fresh fruit into fruit powder through a certain process has become a popular choice. Researchers are constantly improving the preparation process of fruit powder in order to retain the nutritional value of fruit to the greatest extent.

[0004] For processed fruit powder, researchers are constantly developing new forms to meet the needs of different groups of people. For example, Chinese patent CN 104824584 B has developed a passion fruit tablet and a preparation method thereof. The passion fruit tablet improves the medicinal and health value of the passion fruit tablet by complementing passion fruit and passion fruit flower powder. The addition of fresh fruit powder and sugar improves the taste of the passion fruit tablet, and the taste is diversified. The passion fruit tablet is not only easy to carry, but also easy to take; Chinese patent CN 108013399 A has developed a selenium-enriched kiwi fruit granule powder. The invention relates to a selenium-enriched kiwi fruit granule powder. The granule uses kiwi fruit powder as a main component. At the same time, selenium yeast tablet powder is added to the formula of the invention, so that the fruit powder contains rich selenium, which is beneficial for absorption after drinking; Chinese patent CN 103960603 A has developed a grape nutritional chewable tablet and a preparation method thereof. The grape nutritional chewable tablet of the invention is an all-natural grape nutritional chewable tablet with high nutritional value, unique flavor and taste, easy to carry, suitable for all ages, and can be taken and eaten anytime and anywhere.

[0005] With the development of dosage forms, consumers have a wider range of choices, but at the same time, they have higher requirements for taste, ease of use, and healthiness. Some fruit powder preparations contain a large amount of natural sugars, such as fructose, sucrose, etc., which limit their use by people with low sugar needs; granules need to be used with water and are not convenient to use; some fruit powder chewable tablets contain cyclodextrin, etc., which results in a poor taste when used.

[0006] Therefore, how to develop new preparations that taste better, are more convenient to use, and are more in line with modern people's health concepts has become the development direction of deep processing of fruit powder. Summary of the invention

[0007] The purpose of this section is to summarize some aspects of embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and the invention title of this application to avoid blurring the purpose of this section, the specification abstract and the invention title, and such simplifications or omissions cannot be used to limit the scope of the present invention.

[0008] In view of the above problems and / or the problems existing in the prior art, the present invention is proposed.

[0009] Therefore, the object of the present invention is to overcome the deficiencies in the prior art and provide a fruit powder orally disintegrating tablet.

[0010] To solve the above technical problems, the present invention provides the following technical solution: a fruit powder orally disintegrating tablet, comprising fruit powder, a filler, a binder, a disintegrant, a glidant and a lubricant, wherein, by weight of the raw materials, the fruit powder is 2 to 30 parts, the filler is 20 to 70 parts, the binder is 0 to 5 parts, the disintegrant is 5 to 30 parts, the glidant is 0.1 to 2 parts, and the lubricant is 0.1 to 2 parts.

[0011] As a preferred embodiment of the orally disintegrating fruit powder tablet of the present invention, the fruit powder comprises one or more of fruit freeze-dried powder, fruit spray-dried powder, fruit microwave dried powder, fruit ultrafine pulverized powder and fruit hot air dried powder.

[0012] As a preferred embodiment of the fruit powder orally disintegrating tablet of the present invention, the filler is one or more of xylitol, mannitol, sorbitol and erythritol.

[0013] As a preferred embodiment of the fruit powder orally disintegrating tablet of the present invention, the binder is one or more of starch, pregelatinized starch, sucrose, glucose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, ethyl cellulose, povidone, gelatin, polyethylene glycol and sodium alginate.

[0014] As a preferred embodiment of the fruit powder orally disintegrating tablet of the present invention, the disintegrant is one or more of starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinylpyrrolidone, microcrystalline cellulose, alginic acid and sodium alginate.

[0015] As a preferred embodiment of the fruit powder orally disintegrating tablet of the present invention, the glidant is talcum powder or micro-powder silica gel.

[0016] As a preferred embodiment of the fruit powder orally disintegrating tablet of the present invention, the lubricant is one or more of stearate, stearic acid, sodium stearyl fumarate, talc, hydrogenated vegetable oil, polyethylene glycol, micro powder silica gel and lauryl sulfate.

[0017] Another object of the present invention is to overcome the deficiencies in the prior art and provide a method for preparing a fruit powder orally disintegrating tablet, comprising:

[0018] According to the mass proportions, the fruit powder, filler, binder, disintegrant and glidant are sieved and mixed evenly;

[0019] After adding the lubricant and mixing evenly, tabletting is performed to obtain the fruit powder orally disintegrating tablet; the sieving includes sieving through a 60-80 mesh sieve.

[0020] As a preferred embodiment of the preparation method of the present invention, the tableting pressure is 10 to 15 kN.

[0021] Beneficial effects of the present invention:

[0022] (1) The present invention applies orodisintegrating tablet technology to fruit powder for the first time, and proposes a fruit powder orodisintegrating tablet and a preparation method thereof. The filler used is mainly a sugar substitute auxiliary material, which retains the taste of natural sugar substances and is not absorbed by the human body. It will not change the blood sugar changes in the body of the user and avoid the occurrence of dental caries, which is conducive to improving the user's acceptance and greatly expanding the audience range of fruit powder. At the same time, the fruit powder orodisintegrating tablet prepared by the present invention can be quickly disintegrated in the mouth through saliva within 60 seconds, which is very friendly to people with dysphagia and children.

[0023] (2) Compared with wet granulation and dry granulation, direct tableting requires less equipment and less energy consumption during the production process, and the resulting tablets have better disintegration effect.

[0024] (3) Different auxiliary materials can be added to the fruit powder orally disintegrating tablets prepared by the present invention during the preparation process to improve the taste of the tablets, making the taste of the tablets more diversified and suitable for the needs of different groups of people. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor. Among them:

[0026] Figure 1 This is a physical picture of the orally disintegrating tablet prepared in Example 2 of the present invention. DETAILED DESCRIPTION

[0027] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0028] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0029] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0030] The raw materials in the present invention are all common commercially available products.

[0031] Example 1

[0032] Compared with granulation followed by tableting (wet granulation), direct tableting requires less equipment and consumes less energy during the production process.

[0033] In order to compare the disintegration effects of tablets prepared by the two methods, this example investigates the disintegration effects of orally disintegrating tablets prepared by both wet granulation and direct compression methods. The specific formulas are shown in Table 1.

[0034] Table 1

[0035] Wet granulation Direct Compression Fruit powder 15 15 Sugar alcohols 67.5 67.5 Adhesives 1.0 1.0 Disintegrants 15.0 15.0 Glidants 0.5 0.5 Lubricants 1.0 1.0

[0036] Among them, the amount of each component in Table 1 is calculated by weight; the fruit powder in Table 1 is banana powder, the binder is povidone, the disintegrant is cross-linked povidone, the glidant is micro powder silica gel, and the lubricant is sodium stearyl fumarate.

[0037] The specific process of the wet granulation method is as follows: sugar alcohol, (1 / 2-2 / 3) disintegrant and binder are weighed in proportion, mixed evenly, 20 mL of water is added to make wet granules, the wet granules are sieved, dried, and granulated, and then fruit powder, the remaining disintegrant and glidant are added, mixed evenly, and then a lubricant is added, mixed evenly again, and a pressure of 15 kN is applied to obtain fruit powder tablets.

[0038] The specific process of direct tableting is as follows: fruit powder, sugar alcohol, disintegrant, binder and glidant are sieved through a 60-mesh sieve, then weighed in proportion, mixed evenly, and finally lubricant is added. After mixing evenly again, a pressure of 15 kN is applied to obtain orally disintegrating fruit powder tablets.

[0039] Results: The disintegration time of the orodisintegrating fruit powder tablets prepared by wet granulation method in 37℃ water was 70s, and the disintegration time of the orodisintegrating fruit powder tablets prepared by direct compression method was 50s.

[0040] It can be seen that the fruit powder orodisintegrating tablets prepared by direct compression have better disintegration effect.

[0041] Example 2

[0042] A strawberry fruit powder orally disintegrating tablet, the raw material ratio of which is shown in Table 2.

[0043] Table 2

[0044] raw material Dosage Strawberry powder 10.0 Sugar alcohols 69.5 Povidone 4.0 Crospovidone 15 Micro powder silica gel 0.5 Sodium stearyl fumarate 1.0

[0045] The unit of the numbers in the dosage column in the table is "g".

[0046] The preparation method is as follows:

[0047] The strawberry powder, sugar alcohol, povidone, cross-linked povidone and micro-powdered silica gel are passed through a 60-mesh sieve, then weighed in proportion and mixed evenly, and finally sodium stearyl fumarate is added, mixed evenly again, and tabletted to obtain fruit powder orally disintegrating tablets.

[0048] The above amount of raw materials was used to prepare 400 strawberry powder orally disintegrating tablets; the disintegration time of the prepared strawberry powder orally disintegrating tablets was 40s. Figure 1 .

[0049] Example 3

[0050] A strawberry fruit powder orally disintegrating tablet, the raw material ratio of which is shown in Table 3.

[0051] Table 3

[0052]

[0053]

[0054] The unit of the numbers in the dosage column in the table is "g".

[0055] The preparation method is the same as that in Example 3.

[0056] A total of 400 strawberry powder orodisintegrating tablets were prepared with the above amounts of raw materials; the disintegration time of the prepared strawberry powder orodisintegrating tablets was 45 s.

[0057] Example 4

[0058] A blueberry fruit powder orodisintegrating tablet, the raw material ratio of which is shown in Table 4.

[0059] Table 4

[0060] raw material Dosage Blueberry Powder 10 Sugar alcohols 66.5 Povidone 2.0 Microcrystalline Cellulose 20.0 Micro powder silica gel 0.5 Sodium stearyl fumarate 1.0

[0061] The unit of the numbers in the dosage column in the table is "g".

[0062] The preparation method is as follows:

[0063] Blueberry powder, sugar alcohol, povidone, microcrystalline cellulose and micro-powdered silica gel are passed through a 60-mesh sieve, then weighed in proportion and mixed evenly, and finally sodium stearyl fumarate is added, mixed evenly again, and tabletted to obtain blueberry fruit powder orally disintegrating tablets.

[0064] A total of 400 blueberry powder orodisintegrating tablets were prepared with the above amounts of raw materials; the disintegration time of the prepared blueberry powder orodisintegrating tablets was 50s.

[0065] Example 5

[0066] A cherry fruit powder orally disintegrating tablet, the raw material ratio of which is shown in Table 5.

[0067] Table 5

[0068]

[0069]

[0070] The unit of the numbers in the dosage column in the table is "g".

[0071] Cherry powder, sugar alcohol, povidone, microcrystalline cellulose and micro-powdered silica gel are passed through a 60-mesh sieve, then weighed in proportion and mixed evenly, and finally sodium stearyl fumarate is added, mixed evenly again, and tabletted to obtain cherry fruit powder orally disintegrating tablets.

[0072] A total of 400 cherry powder orodisintegrating tablets were prepared with the above amounts of raw materials; the disintegration time of the prepared cherry powder orodisintegrating tablets was 40s.

[0073] Example 6

[0074] A pitaya powder orodisintegrating tablet, the raw material ratio of which is shown in Table 6.

[0075] Table 6

[0076] raw material Dosage Dragon fruit powder 15.0 Sugar alcohols 67.5 Povidone 1.0 Crospovidone 15.0 Micro powder silica gel 0.5 Sodium stearyl fumarate 1.0

[0077] The unit of the numbers in the dosage column in the table is "g".

[0078] The preparation method is as follows:

[0079] Pass pitaya powder, sugar alcohol, povidone, cross-linked povidone and micro-powder silica gel through a 60-mesh sieve, then weigh them according to proportion, mix them evenly, finally add sodium stearyl fumarate, mix them evenly again, and press them into tablets to obtain mango fruit powder orally disintegrating tablets.

[0080] A total of 400 pitaya powder orally disintegrating tablets were prepared with the above-mentioned amounts of raw materials; the disintegration time of the prepared pitaya powder orally disintegrating tablets was 20 s.

[0081] Example 7

[0082] A peach powder orodisintegrating tablet, the raw material ratio of which is shown in Table 7.

[0083] Table 7

[0084] raw material Dosage Peach powder 15.0 Sugar alcohols 67.5 Povidone 1.0 Croscarmellose Sodium 15.0 Micro powder silica gel 0.5 Sodium stearyl fumarate 1.0

[0085] The unit of the numbers in the dosage column in the table is "g".

[0086] Peach powder, sugar alcohol, povidone, cross-linked sodium carboxymethyl cellulose and micro-powder silica gel are passed through a 60-mesh sieve, then weighed in proportion and mixed evenly, and finally sodium stearyl fumarate is added, mixed evenly again, and tabletted to obtain peach powder orally disintegrating tablets.

[0087] The above amounts of raw materials were used to prepare 400 peach powder orodisintegrating tablets in total; the disintegration time of the prepared peach powder orodisintegrating tablets was 40s.

[0088] Example 8

[0089] Under the experimental conditions of Example 2, the formula was optimized (unit: "g"), see Table 8.

[0090] Table 8

[0091]

[0092] The inspection indicators and results are shown in Table 9.

[0093] Table 9

[0094] Test 1 Test 2 Test 3 Test 4 Test 5 Appearance Smooth and beautiful Smooth and beautiful Smooth and beautiful Smooth and beautiful Smooth and beautiful Weight Difference Comply with regulations Comply with regulations Comply with regulations Comply with regulations Comply with regulations Disintegration time(s) 40 36 38 32 34

[0095] It can be seen from Table 9 that the orodisintegrating tablets of strawberry fruit powder prepared by the present invention can meet the requirements; at the same time, it can be seen from Experiment 1 and Experiment 2 that when orodisintegrating tablets are prepared using strawberry powder as a raw material, when hydroxypropyl cellulose is selected, the disintegration time is shorter than that when povidone is added;

[0096] It can be seen from Experiment 2, Experiment 3, Experiment 4 and Experiment 5 that the disintegration time of the product prepared by compounding cross-linked polyvinylpyrrolidone and cross-linked sodium carboxymethyl cellulose is better. It is possible that in the fruit powder orally disintegrating tablet system, cross-linked polyvinylpyrrolidone and cross-linked sodium carboxymethyl cellulose have a synergistic effect on the disintegration of the orally disintegrating tablet.

[0097] The invention prepares a fruit powder orodisintegrating tablet to improve the user's acceptance and the utilization rate of the effective components of the fruit powder. The orodisintegrating tablet preparation has the advantages of good taste and rapid disintegration time, is convenient for people with dysphagia to take, and has good patient compliance.

[0098] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the present invention.

Claims

1. A fruit powder orally disintegrating tablet, characterized in that: Includes fruit powder, fillers, binders, disintegrants, glidants and lubricants; Wherein, according to the mass proportion of raw materials, the fruit powder is 2 to 30 parts, the filler is 20 to 70 parts, the binder is 0 to 5 parts, the disintegrant is 5 to 30 parts, the glidant is 0.1 to 2 parts, and the lubricant is 0.1 to 2 parts.

2. The orodisintegrating fruit powder tablet according to claim 1, characterized in that: The fruit powder includes one or more of fruit freeze-dried powder, fruit spray-dried powder, fruit microwave-dried powder, fruit ultrafine powder and fruit hot-air dried powder.

3. The orodisintegrating fruit powder tablet according to claim 1 or 2, characterized in that: The filler is one or more of xylitol, mannitol, sorbitol and erythritol.

4. The orodisintegrating fruit powder tablet according to claim 3, characterized in that: The binder is one or more of starch, pregelatinized starch, sucrose, glucose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, ethyl cellulose, povidone, gelatin, polyethylene glycol and sodium alginate.

5. The orodisintegrating fruit powder tablet according to claim 4, characterized in that: The disintegrant is one or more of starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinylpyrrolidone, microcrystalline cellulose, alginic acid and sodium alginate.

6. The orodisintegrating fruit powder tablet according to claim 5, characterized in that: The glidant is talcum powder or micro-powder silica gel.

7. The orodisintegrating fruit powder tablet according to any one of claims 1, 2 or 4 to 6, characterized in that: The lubricant is one or more of stearate, stearic acid, sodium stearyl fumarate, talc, hydrogenated vegetable oil, polyethylene glycol, micro powder silica gel and lauryl sulfate.

8. The method for preparing the orally disintegrating fruit powder tablet according to any one of claims 1 to 7, characterized in that: include, According to the mass proportions, the fruit powder, filler, binder, disintegrant and glidant are sieved and mixed evenly; After adding the lubricant and mixing evenly, tableting is performed to obtain the fruit powder orally disintegrating tablet.

9. The preparation method according to claim 8, characterized in that: The screening includes screening through a 60-80 mesh sieve.

10. The preparation method according to claim 9, characterized in that: The tableting pressure is 10 to 15 kN.

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