21 results about "Free blood" patented technology

The invention discloses a magnetofluid-driven pump-free blood purification system, and belongs to the technical field of medical apparatuses and instruments. The system breaks through a traditional mechanical pump driving mode, magnetic nanoparticles are introduced into blood, the blood is driven to flow by means of magnetic force generated by a gradient magnetic field, and a pump-free blood purification system is constructed. Compared with a traditional blood purification system, the blood purification system has the advantages that damage of high shear force generated by a mechanical pump to blood cells is thoroughly avoided, and the hemolysis risk is effectively eliminated; continuous operation of a mechanical pump is not needed, and energy consumption is remarkably reduced; no mechanical part runs, so that the noise is greatly reduced; meanwhile, huge structures of a mechanical pump and a driving system thereof are eliminated, and miniaturization of equipment is facilitated. The system provides a brand new thought for blood purification treatment, has safety, high efficiency and convenience, is expected to bring a new change to the medical field, and meets the blood purification requirements in different scenes.

The invention discloses a method for evaluating fetal DNA concentration (cffDNA) in free blood of a pregnant female parent through a polymorphic site linkage region block. The method comprises the following steps: acquiring low-depth WGS sequencing data of a sample; obtaining a mapping relation between the point location and the linkage polymorphic relation; and according to the low-depth WGS sequencing data and the mapping relationship between the point locations and the linkage polymorphic relationship, performing concentration calculation by taking a plurality of sites forming the linkage polymorphic relationship as units. Wherein the mapping relation between the point location and the linkage polymorphism can be obtained by processing public genome WGS data, processing public linkage polymorphism region block data or processing a large amount of high-depth WGS measured data. Based on the low-depth WGS data, the cffDNA concentration in the free blood of the pregnant female parent can be directly calculated through the heterozygosity of the linkage SNP region blocks, the method is not affected by the gender of a fetus in NIPT practical application, a father sample and an additional experiment are not needed, the stability is high, the performance is high, and the cost is low.

The present subject matter relates to systems and methods for syringe-free blood return in a dialysis machine blood circuit. A three-way connector can include a first inlet configured to be connected to a patient arterial access line, a second inlet connected to a substitution fluid line, and an outlet connected to a machine arterial line. In this arrangement, the three-way connector is configured to selectively allow a flow of substitution fluid from the substitution line into the machine arterial line and / or into the patient arterial access line without changing the connections of tubing within the circuit.

The invention discloses an IVUS-based guide wire-free blood vessel center line identification and navigation method, and relates to the technical field of blood vessel intervention and image navigation. The method comprises the following steps: arranging an IVUS transducer at the front end of an instrument, and synchronously obtaining an IVUS frame sequence and a probe pose; through cavity wall segmentation, center point extraction and time sequence-space fusion processing, a three-dimensional center line of the main blood vessel is constructed, and a safety envelope is generated; for a branch artery, branch super-selection navigation is realized through candidate sector detection, direction estimation and center line generation and splicing; meanwhile, a mismatch rollback and failure protection mechanism is set, so that navigation safety is ensured; the virtual center line is used for replacing a solid guide wire, the risk that blood vessels are punctured and mistakenly enter a false cavity is reduced, the radiography frequency and radiation exposure are reduced, the operation time is shortened, and the method is suitable for complex intracavity treatment scenes of aorta trunks and branches.

A system for measurement of non-invasive and calibration-free blood pressure (BP) is disclosed. The system comprises a measurement probe (302) which is in contact with a person's skin. The measurement probe (302) comprises a first array of sensors (302-1) and a second array of sensors (302-2). The first array of sensors (302-1) determines a force exerted on skin (304) and the second array of sensors (302-2) determines a compression-decompression characteristics of the arteries through skin. The force exerted on skin and the compression-decompression characteristics of the arteries are used to determine indices indicative of the material properties of the vessel. Based on the indices indicative of the material properties of the vessel, blood pressure and continuous transmural pressure waveform may be determined.

The present invention discloses an ACE inhibitory peptide with DPP-IV inhibitory activity and its application, belonging to the field of active peptide biotechnology; its amino acid sequence is shown in SEQ ID NO.1. The present invention prepares and identifies an ACE inhibitory peptide with DPP-IV inhibitory activity from sea cucumber intestinal egg hydrolysate, which can significantly inhibit the activity of ACE through a competitive inhibition mode, tolerate the gastrointestinal digestive environment, and also has DPP-IV inhibitory activity, and has a mitigating effect on hypertension and type 2 diabetes. It has the characteristics of simple structure, safety, strong activity, etc., can play a role in nutrition and health care, and is expected to provide effective active ingredients for the development of food and side-effect-free blood pressure-lowering, blood sugar-lowering or blood pressure-lowering and blood sugar-lowering efficacy products, etc., and has broad application prospects.

The invention discloses a cuff-free individual blood pressure estimation method based on age grouping fine tuning and two-stage integration. The method comprises the following steps of data collection and preprocessing; pre-training the model; finely adjusting the pre-training model; performing two-stage integrated learning to obtain an individual blood pressure estimation model; and calculating a final blood pressure prediction result based on the model. According to the cuff-free individual blood pressure estimation method based on age grouping fine tuning and two-stage integration, the blood pressure estimation performance of a traditional fine tuning normal form can be improved. The age grouping fine tuning emphasizes the matching age grouping fine tuning model to have better accuracy in cuff-free blood pressure estimation; the two-stage integrated learning unit comprises feature-level integration and result-level integration, the feature-level integration fuses encoder features and regression device weights of a plurality of fine tuning models based on age grouping fine tuning to construct an optimal blood pressure model, and the result-level integration can significantly reduce the uncertainty of selection of a plurality of blood pressure models and significantly improve the final blood pressure estimation precision.

The invention is suitable for the field of medical instruments, and provides a thrombolysis catheter which comprises a conveying pipe, a thrombolysis part, a pushing part and an adjusting part, one end of the pushing part is connected with the near end of the thrombolysis part, the adjusting part is arranged in the conveying pipe in a penetrating mode and used for driving the thrombolysis part to move in the axial direction of the conveying pipe, and the adjusting part is connected with the far end of the thrombolysis part and used for driving the thrombolysis part to move in the axial direction of the conveying pipe. The adjusting part is used for pulling the far end of the thrombolysis part so as to adjust the axial distance between the near end and the far end of the thrombolysis part. When the axial distance between the near end and the far end of the thrombolysis part is changed, the shape of the thrombolysis part is changed, so that the thrombolysis part can be adjusted, the spraying length of the thrombolysis part can also be adjusted, targeted adjustment and targeted medicine spraying can be performed according to the conditions of blood vessels and thrombus, medicine spraying can be more accurate, and the medicine spraying efficiency is improved. The medicine waste can be greatly reduced, the medicine irritation injury to the thrombus-free blood vessel part can be avoided to a great extent, and the probability of bleeding complications increased due to excessive medicine is reduced.

The embodiment of the application provides a kind of key and electronic equipment, belong to electronic technical field, the second shell of key can be pressed and move and rotate, when pressing second shell, elastic deformation piece occurs elastic deformation by second shell.Electronic device can be detected elastic deformation variable, obtain the first pressing force information on second shell, realize the quantitative detection of first pressing force.Using first pressing force information can meet the specific application scenario requirement of electronic device, such as in pressing, the physiological parameter information of pressing part can be detected, the physiological parameter information is the physiological parameter information of pressing part under extrusion force scene, combined with the physiological parameter information and first pressing force information, more accurate biological characteristic information can be obtained, and the accuracy of biological feature detection is improved.No need to additionally increase pressure device, high-precision biological feature detection can be realized, such as high-precision wristband-free blood pressure detection, which is beneficial to the miniaturization and convenience design of electronic device.

The invention discloses a quality control method and system for cuff-free blood pressure monitoring equipment, and relates to the technical field of medical equipment, and the quality control system comprises a multi-dimensional physiological signal database module in which a multi-dimensional crowd physiological signal database is stored; the dynamic signal output module is used for extracting real data samples and synchronously outputting physiological signals and waveforms; the multi-dimensional error analysis module is used for collecting a cuff-free blood pressure monitoring curve output by the detected cuff-free blood pressure monitoring equipment and carrying out function fitting analysis, integral error analysis and point-by-point statistical error analysis; and the quality control qualification judgment module is used for judging whether the quality control of the detected cuff-free blood pressure monitoring equipment is qualified or not in combination with a preset qualification standard. Dynamic changes of multiple physiological signals such as electrocardio and respiration can be simulated, real physiological signals and individual differences are matched, and it is ensured that an analysis result is matched with a change rule of real blood pressure through triple analysis of function fitting analysis, integral error analysis and point-by-point statistical error analysis.

Disclosed herein are resuscitation fluids and compositions comprising NEFA free blood serum albumin and hemoglobulin (cell free or as lysed red blood cells) and methods of treating internal bleeding and hemorrhage.

The utility model discloses a primary screening article box for blood donation without repayment, which belongs to the technical field of medical instruments and comprises a box body, a box cover, a transverse plate, a partition frame, a placing plate, a box body, a handle, a plurality of partition plates, a placing component, two groups of fixing components and a lifting component, the transverse plate is fixedly connected with the box body, and the box body is divided into a first cavity and a second cavity by the transverse plate; the partition frame is fixedly connected with the box body and located in the first cavity, the containing plate is fixedly connected with the partition frame and provided with a plurality of containing holes, the box body penetrates through the box body and located in the second cavity, the partition plates are all fixedly connected with the box body, the box cover is hinged to the box body and located on the upper surface of the box body, and the containing assembly is arranged on the outer side of the box body. And the two fixing assemblies are symmetrically arranged on the two sides of the box body, and through the arrangement, screened objects and consumables can be conveniently classified and stored, so that the use convenience is improved.

The present invention relates to the field of medical device technology, and in particular to a suture-free blood vessel device, a suture-free artificial blood vessel, and a delivery system. The suture-free blood vessel device comprises a hoop and a skirt, one end of the skirt is fixedly mounted on the hoop, and a side edge of the skirt is provided with an incision for cutting the skirt along its axial direction, and a binding wire is provided at the incision for pulling the incision together and tightening it. The beneficial effect of the present invention is as follows: during surgery, a vascular blocking forceps is used to clamp the hoop, and the hoop and the skirt are inserted along the stump of the descending aorta and then sleeved on the outside of the descending aorta. Then, a stent graft is implanted into the inner wall of the descending aorta, and the binding wire is tightened. The stent graft and the skirt clamp the inside and outside of the descending aorta to achieve a suture-free effect, so that the descending aorta, the stent graft, and the artificial blood vessel can be quickly and tightly connected together, thereby greatly shortening the deep hypothermic circulatory arrest time during surgery and reducing surgical complications.

The invention discloses an anaesthesia-free blood sampling integrated deer restraint frame which comprises a bottom plate, supporting legs are fixed to the four corners of the bottom plate respectively, adjusting mechanisms are movably arranged on the two sides of the top of the bottom plate respectively, positioning mechanisms are fixedly arranged on the two sides of the top of the bottom plate respectively, and the adjusting mechanisms can slide in a reciprocating mode to change the distance between the adjusting mechanisms and the positioning mechanisms. According to the device, the distance between the device and the positioning mechanism can be flexibly adjusted through reciprocating sliding of the adjusting mechanism, and the device is adaptive to the body width of deer with different body types; the adjusting frame and the positioning frame can ascend and descend through the second sliding mechanism and can be matched with the angle-adjustable limiting rollers to be attached to the back contours and the body heights of different deer bodies, the limitation that a traditional fixing frame can only achieve foundation fixing is broken through, the multi-scene fixing requirements of antler collection, physical examination, treatment, reproduction assistance and the like can be met, and the practicability is high. And frequent equipment replacement or deer transfer is not needed.

The present subject matter relates to systems and methods for syringe-free blood return in a dialysis machine blood circuit. A three-way connector can include a first inlet configured to be connected to a patient arterial access line, a second inlet connected to a substitution fluid line, and an outlet connected to a machine arterial line. In this arrangement, the three-way connector is configured to selectively allow a flow of substitution fluid from the substitution line into the machine arterial line and / or into the patient arterial access line without changing the connections of tubing within the circuit.

The invention discloses a cuff-free blood pressure estimation method and device based on wearable equipment. The cuff-free blood pressure estimation method comprises the steps that PPG data and ECG data collected by the wearable equipment of a user are obtained; the PPG data and the ECG data are preprocessed; dividing according to a preset window length based on the preprocessed PPG data and the filtered ECG data to obtain a plurality of time slices; performing multi-layer wavelet decomposition on each time slice and performing wavelet statistical feature extraction to obtain statistical features; and combining the statistical features with user sign data to construct feature vectors, and inputting the feature vectors into a lightweight multi-resolution neural network model to output systolic pressure and diastolic pressure data of corresponding time slices, thereby obtaining a continuous blood pressure estimation result of the user. By means of the technical scheme, real-time estimation of systolic pressure and diastolic pressure is achieved under the condition that the end side calculation force is limited.

The invention discloses an esophageal cancer serum detection method which comprises the following steps: 1, sample collection and pretreatment: blood collection requirements: on the day of admission of a patient and on the morning of the day of physical examination of a control group, extracting 5ml of vein blood by using an RNA enzyme-free blood collection tube (such as PAXgeneBloodRNATube) on an empty stomach, and then carrying out blood pretreatment: standing the blood in a kit for 30 minutes, centrifuging the blood at the temperature of 4 DEG C at the speed of 600 * g for 10 minutes, separating serum, and collecting the blood by using a blood collection tube (such as PAXgeneBloodRNATube); the accuracy of the serum detection result of the combination of the miR-134 and the miR-149 is obviously higher than the accuracy of the detection result of AUC (Z = 4.017 and P < 0.001) independently diagnosed by the miR-134 and the accuracy of the detection result of AUC (Z = 4.319 and P < 0.001) independently diagnosed by the miR-149, the expression level of the miR-134 in the serum of an esophageal cancer patient is increased, the expression level of the miR-149 in the serum of the esophageal cancer patient is reduced, and the combined detection of the miR-134 and the miR-149 has a relatively high prediction value on the esophageal cancer. The accuracy of esophageal cancer detection results is greatly improved, and the purpose of early diagnosis and early treatment is achieved.

1. The name of the design product: blood sampling pen without removing cap. 2. The use of the design product: instrument for collecting blood sample. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention provides a blood pressure monitoring method and device for a target user, electronic equipment, a medium and a product, and relates to the technical field of blood pressure monitoring. The method comprises the steps that a photoplethysmography signal set of the target user is obtained based on at least two photoplethysmography sensors; the photoplethysmography signal set comprises photoplethysmography signals correspondingly acquired by every two photoplethysmography sensors; determining a waveform feature point set according to each photoplethysmography signal in the photoplethysmography signal set; determining the pulse wave velocity of the target user according to the waveform feature point set; acquiring static physiological parameters of the target user; determining a blood pressure monitoring result of the target user according to the pulse wave speed and the static physiological parameters. According to the technical scheme, the pulse wave speed is determined through the at least two photoplethysmography sensors, the blood pressure monitoring result is determined based on the pulse wave speed and the static physiological parameters, and non-invasive, cuff-free and electrocardiogram-free blood pressure dynamic monitoring is achieved.

The utility model relates to the technical field of blood collection bag transportation, in particular to a temporary transportation tool for a blood collection bag for no-payment blood donation, which comprises a box body, a box cover is arranged at the top of the box body, a refrigeration shell is arranged at the bottom of the box body, and supporting legs are arranged at four corners of the bottom of the refrigeration shell. The bottom of the inner side of the box body is provided with a cold penetration groove hole, the bottom of the inner side of the refrigeration shell is provided with a cooling fan, a semiconductor refrigeration sheet is arranged on the inner side of the refrigeration shell and located above the cooling fan, and the inner side wall of the box body is provided with a temperature sensor. A blood collection bag is independently placed at the position between the two sets of concave clamping plates, then the corresponding two-way air cylinders are started to drive the concave clamping plates to move in the same direction to clamp the blood collection bag, and the blood collection bag can be independently fixed under the cooperation of the auxiliary telescopic rods, so that the stability is improved; and the buffering pads on the two sides can also reduce impact force generated by shaking.

The invention discloses a needleless blood sampling device. According to the needleless blood sampling device, an inner flow tube and a sliding block are arranged in a main body shell, the first end of the inner flow tube penetrates through the first end of the main body shell to be connected with an indwelling needle, and the second end of the inner flow tube is connected with a blood collecting device through the sliding block; the blood state acquisition module is electrically connected with the first end of the control module through the first flexible circuit and the second flexible circuit, and the blood state acquisition module is used for acquiring state information of blood flowing into the internal flow tube in real time and transmitting the state information of the blood to the control module; the second end of the control module is electrically connected with the alarm module through the second flexible circuit and the third flexible circuit, and the control module is used for comparing the state information of the blood with preset blood threshold information and controlling the working state of the alarm module according to a comparison result. The catheter blockage condition of the indwelling needle is judged according to the state information of the blood flowing into the inner flow tube, and different state reminding is carried out according to the catheter blockage condition.