Thrombolysis catheter

Abstract

The invention is suitable for the field of medical instruments, and provides a thrombolysis catheter which comprises a conveying pipe, a thrombolysis part, a pushing part and an adjusting part, one end of the pushing part is connected with the near end of the thrombolysis part, the adjusting part is arranged in the conveying pipe in a penetrating mode and used for driving the thrombolysis part to move in the axial direction of the conveying pipe, and the adjusting part is connected with the far end of the thrombolysis part and used for driving the thrombolysis part to move in the axial direction of the conveying pipe. The adjusting part is used for pulling the far end of the thrombolysis part so as to adjust the axial distance between the near end and the far end of the thrombolysis part. When the axial distance between the near end and the far end of the thrombolysis part is changed, the shape of the thrombolysis part is changed, so that the thrombolysis part can be adjusted, the spraying length of the thrombolysis part can also be adjusted, targeted adjustment and targeted medicine spraying can be performed according to the conditions of blood vessels and thrombus, medicine spraying can be more accurate, and the medicine spraying efficiency is improved. The medicine waste can be greatly reduced, the medicine irritation injury to the thrombus-free blood vessel part can be avoided to a great extent, and the probability of bleeding complications increased due to excessive medicine is reduced.

Description

Technical Field

[0001] The present invention belongs to the field of medical devices, and particularly relates to a thrombolytic catheter. Background Art

[0002] Lower extremity deep vein thrombosis is a common and frequently-occurring disease in clinic. Lower extremity deep vein thrombosis can cause swelling of the affected limb of the patient, dysfunction, and some can lead to serious complications such as pulmonary embolism, and the latter has a high mortality rate. At present, the main treatment method for lower extremity deep vein thrombosis is to introduce a thrombolytic catheter to administer thrombolytic drugs such as urokinase for drug thrombolysis treatment. However, for the existing thrombolytic catheters, their distal openings cause the thrombolytic liquid medicine to flow out from the distal openings, affecting the treatment effect.

[0003] In addition, the lengths of the thrombi encountered during local thrombolysis are mostly different, and the drug injection length of the existing thrombolytic catheters is fixed and unchanged, resulting in their inability to spray drugs specifically on the thrombi, causing drug waste and drug irritation damage to the blood vessel parts without thrombi. At the same time, too much drug will increase the probability of bleeding complications. Summary of the Invention

[0004] The purpose of the present invention is to provide a thrombolytic catheter, aiming to solve the problem that the injection length of the existing thrombolytic catheter is fixed and unchanged and it cannot spray drugs specifically on the thrombi.

[0005] The present invention is realized as follows: A thrombolytic catheter includes a thrombolytic part, a pusher, and an adjuster. The pusher is connected to the proximal end of the thrombolytic part, and the adjuster is connected to the distal end of the thrombolytic part. The adjuster is used to pull the distal end of the thrombolytic part to adjust the distance between the proximal end and the distal end of the thrombolytic part.

[0006] Optionally, the thrombolytic part includes a proximal part, a distal part, and a main body part. The two ends of the main body part are respectively connected to the proximal part and the distal part. At least part of the side wall of the main body part is recessed towards the radial inner side, and spraying holes are provided on the side wall of the main body part. The pusher is connected to the proximal part, and the adjuster is connected to the distal part.

[0007] Optionally, the thrombolytic part includes a plurality of thrombolytic tubes and a restraint. The proximal ends of the plurality of thrombolytic tubes are connected to form the proximal part, the distal ends of the plurality of thrombolytic tubes are connected to form the distal part, and the plurality of thrombolytic tubes are connected to the restraint to form the main body part. The maximum diameter of the proximal part or the maximum diameter of the distal part is greater than the maximum diameter of the main body part, and the spraying holes are provided on the thrombolytic tubes.

[0008] Optionally, the constraint member includes a tubular member located inside multiple thrombolysis tubes. The outer wall of the tubular member is connected to the multiple thrombolysis tubes, and the tubular member forms a channel between the multiple thrombolysis tubes.

[0009] Optionally, it further includes a flow blocking layer connected to the main body portion to form a channel inside the main body portion. A first through hole is provided on the proximal end portion, and a second through hole is provided on the distal end portion. The first through hole and the second through hole are respectively communicated with the channel. The flow blocking layer covers at least a part of the proximal end portion or the distal end portion, and the medicine spraying holes are provided on the outer side wall of the main body portion.

[0010] Optionally, the aperture diameter of each medicine spraying hole decreases from the proximal side to the distal side.

[0011] Optionally, the side wall of the main body portion bulges towards the radially outer side, and the maximum diameters of the proximal end portion and the distal end portion are smaller than the maximum diameter of the main body portion.

[0012] Optionally, the thrombolysis portion further includes a support wire connected to the main body portion, and the support wire is used to support the main body portion.

[0013] Optionally, it further includes a delivery tube. The pusher and the adjuster are both disposed inside the delivery tube. One end of the pusher away from the thrombolysis portion is located outside the delivery tube, and one end of the adjuster away from the thrombolysis portion is located outside the delivery tube.

[0014] Optionally, multiple thrombolysis portions are provided, and the multiple thrombolysis portions are spaced along the axial direction of the pusher.

[0015] The thrombolysis catheter provided by the embodiment of the present invention includes a delivery tube, a thrombolysis portion, a pusher, and an adjuster. One end of the pusher is connected to the proximal end of the thrombolysis portion. The adjuster is disposed inside the delivery tube and is used to drive the thrombolysis portion to move along the axial direction of the delivery tube. The adjuster is connected to the distal end of the thrombolysis portion, and the adjuster is used to pull the distal end of the thrombolysis portion to adjust the axial distance between the proximal end and the distal end of the thrombolysis portion. When the axial distance between the proximal end and the distal end of the thrombolysis portion changes, the shape of the thrombolysis portion will change, so that the thrombolysis portion can be adjusted, and the spraying length of the thrombolysis portion can also be adjusted to make targeted adjustments according to the conditions of blood vessels and thrombus and perform targeted medicine spraying. It can spray medicine more accurately, greatly reduce drug waste, and to a large extent avoid causing drug irritation damage to blood vessel parts without thrombus, and reduce the probability of increasing bleeding complications due to excessive drugs. Description of the Drawings

[0016] Figure 1It is a schematic diagram when the thrombolytic part of the thrombolytic catheter provided in the first embodiment of the present invention is in a blood vessel;

[0017] Figure 1a It is a schematic structural diagram of the control handle and the delivery tube of the thrombolytic catheter provided in the first embodiment of the present invention;

[0018] Figure 2 It is a schematic diagram when the thrombolytic area length of the thrombolytic part is relatively long (the concave degree of the main body part is relatively small) in the first embodiment of the present invention;

[0019] Figure 2a It is a schematic diagram when the restraint sleeve is sleeved on the thrombolytic tube of the thrombolytic part in the first embodiment of the present invention;

[0020] Figure 3 It is a schematic axonometric structural diagram of a local part (including the thrombolytic part, the delivery tube, the pusher, and the adjuster) of the thrombolytic catheter provided in the first embodiment of the present invention;

[0021] Figure 3a It is a schematic structural diagram of an embodiment in which the thrombolytic part is provided with a flow blocking layer in the first embodiment of the present invention;

[0022] Figure 4 It is Figure 3a A side view schematic diagram of the thrombolytic part of the embodiment;

[0023] Figure 5 It is a schematic diagram of an embodiment in which the thrombolytic part includes a tubular member in the first embodiment of the present invention;

[0024] Figure 6 It is a schematic diagram of the tubular member controlling the curvature and the injection angle of the thrombolytic tube of the thrombolytic part in the first embodiment of the present invention;

[0025] Figure 7 It is Figure 5 A side view schematic diagram of the thrombolytic part of the embodiment;

[0026] Figure 8 It is Figure 5 A partial cross-sectional view schematic diagram of the thrombolytic catheter of the embodiment;

[0027] Figure 9 It is a schematic diagram of an embodiment when a single thrombolytic tube of the thrombolytic part is straightened in the first embodiment of the present invention;

[0028] Figure 10 It is a schematic diagram of another embodiment when a single thrombolytic tube of the thrombolytic part is straightened in the first embodiment of the present invention;

[0029] Figure 11 It is a three-dimensional schematic diagram of the thrombolytic part provided in the second embodiment of the present invention;

[0030] Figure 12 It is a schematic structural diagram of the thrombolytic catheter provided in the second embodiment of the present invention;

[0031] Figure 12a It is an enlarged schematic diagram of the thrombolytic part provided in the second embodiment of the present invention;

[0032] Figure 13 It is a schematic structural diagram of the thrombolytic catheter during thrombolysis provided in the second embodiment of the present invention.

[0033] Reference numerals:

[0034] 100, thrombolytic catheter;

[0035] 10, delivery tube;

[0036] 20, thrombolytic part; 201, channel; 202, thrombolytic area; 21, proximal end part; 211, proximal convergence point; 22, main body part; 23, distal end part; 231, distal convergence point; 24, thrombolytic tube; 241, medicine spraying hole; 242, first imaging point; 243, second imaging point; 25, flow blocking layer; 26, tubular member; 28, restraining member;

[0037] 30, pushing member; 31, pushing tube;

[0038] 40, adjusting member;

[0039] 50, control handle; 51, drug injection port; 52, adjusting member control assembly;

[0040] 70, support wire;

[0041] 90, blood vessel; 91, thrombus; Detailed implementation manners

[0042] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0043] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as "connected to" another element, it can be directly connected to the other element or there may be an intermediate element at the same time.

[0044] It should also be noted that the terms of orientation such as left, right, up, and down in this embodiment are only relative concepts to each other or are referenced based on the normal use state of the product, and should not be considered restrictive.

[0045] For the thrombolytic catheter of the present application, the end close to the outside of the human body or for the operator is defined as the proximal end, and the end located inside the human body close to the thrombus or away from the operator is defined as the distal end.

[0046] Embodiment 1

[0047] As Figure 1 and Figure 1a shown, the figures are schematic diagrams related to the thrombolytic catheter 100 provided by Embodiment 1 of the present invention. The thrombolytic catheter 100 includes a delivery tube 10, a thrombolytic part 20, a pusher 30, and an adjuster 40.

[0048] Referring to Figure 1 and Figure 1a , one end of the pusher 30 is connected to the proximal end of the thrombolytic part 20. The pusher 30 is disposed inside the delivery tube 10 and can move axially inside the delivery tube 10. The pusher 30 is connected to the proximal end of the thrombolytic part 20 and can drive the thrombolytic part 20 to move axially along the delivery tube 10. For example, in one embodiment, when it is necessary to load the thrombolytic part 20, the pusher 30 can pull the thrombolytic part 20 to move towards the proximal side, and the thrombolytic part 20 can be squeezed by the delivery tube 10 and contracted into the delivery tube 10. When it is necessary to perform thrombolysis on the part to be thrombolyzed, the pusher 30 can push the thrombolytic part 20 to move towards the distal side, and the thrombolytic part 20 can be pushed to the distal side of the delivery tube 10, and then the release of the thrombolytic part 20 is achieved.

[0049] Referring to Figure 1a and Figure 2 , the pusher 30 is fixedly connected to the proximal end of the thrombolytic part 20. The pusher 30 is communicated with the thrombolytic part 20. The pusher 30 is also used to deliver thrombolytic liquid medicine into the thrombolytic part 20. A plurality of medicine spraying holes 241 are formed on the thrombolytic part 20, and the liquid medicine sprays out from the medicine spraying holes 241 to dissolve the thrombus. In one embodiment, the pusher 30 includes a pusher tube 31. A medicine injection port 51 is provided at the proximal end of the pusher tube 31, and thrombolytic liquid medicine can be injected into the pusher tube 31 through the medicine injection port 51. The medicine injection port 51 can be communicated with an external high-pressure fluid source, and the high-pressure fluid source can be a syringe, a perfusion pump, etc. Through the pushing of the high-pressure fluid source, a certain pressure impact can be formed on the thrombus 91 physically, so as to achieve the dual thrombolytic effects of physical thrombus fragmentation and agent thrombolysis, and the thrombolytic effect is better.

[0050] Referring to 1a, Figure 2 and Figure 2a , the adjuster 40 is connected to the distal end of the thrombolytic part 20. The adjuster 40 is used to pull the distal end of the thrombolytic part 20 to adjust the axial distance between the proximal end and the distal end of the thrombolytic part 20. The adjuster 40 can be disposed inside the thrombolytic part 20, or can be located outside the thrombolytic part 20 and disposed inside the delivery tube 10.

[0051] The adjusting member 40 can reciprocate along the axial direction of the delivery tube 10. The adjusting member 40 is fixedly connected to the distal end of the thrombolysis part 20. During the process of the adjusting member 40 reciprocating along the axial direction of the delivery tube 10, it can pull the distal end of the thrombolysis part 20 to move, so as to adjust the axial distance between the proximal end and the distal end of the thrombolysis part 20. The adjusting member 40 can be filamentous or tubular. The proximal end of the adjusting member 40 is connected to the control handle 50 of the thrombolysis catheter 100. An adjusting member control assembly 52 is provided on the control handle 50. Through the control of the adjusting member control assembly 52, the adjusting member 40 can be controlled to reciprocate along the axial direction of the delivery tube 10, thereby driving the distal end of the thrombolysis part 20 to move axially, so as to change the axial distance between the proximal end and the distal end of the thrombolysis part 20. When the axial distance between the proximal end and the distal end of the thrombolysis part 20 changes, the shape of the thrombolysis part 20 will also change accordingly, so that the length of the thrombolysis part 20 can be adjusted. Correspondingly, the effective thrombolysis length of the thrombolysis part 20 can also be adjusted, so that the thrombolysis part 20 can adapt to embolized areas of different lengths, and thus drug irritation damage to blood vessel parts without thrombus can be avoided.

[0052] In some embodiments, also referring to Figure 2 and Figure 2a , the thrombolysis part 20 includes a proximal part 21, a distal part 23 and a main body part 22. The two ends of the main body part 22 are respectively connected to the proximal part 21 and the distal part 23. The side wall of the main body part 22 is recessed towards the radial center direction of the delivery tube 10. The adjusting member 40 is connected to the distal part 23. A plurality of medicine spraying holes 241 are formed on the side wall of the main body part 22. The medicine spraying holes 241 are arranged towards the radial outside of the main body part 22. The curvature of the side wall of the main body part 22 is adapted to increase under the pulling action of the adjusting member 40. The proximal part 21 or the distal part 23 of the thrombolysis part 20 is adapted to expand towards the radial outside of the delivery tube 10 under the pulling action of the adjusting member 40.

[0053] The main body part 22 is located between the proximal part 21 and the distal part 23, and the side wall of the main body part 22 is recessed towards the radial inside. A plurality of medicine spraying holes 241 are formed on the side wall of the main body part 22, and the plurality of medicine spraying holes 241 can be arranged towards the radial outside of the main body part 22. A thrombolysis area 202 is formed at the recessed part of the main body part 22. When the axial distance between the proximal end and the distal end of the thrombolysis part 20 changes, the curvature and length of the main body part 22 will both change. For example, in one embodiment, as Figure 2 shown, when the length of the embolized area is relatively long, the axial distance between the proximal part 21 and the distal part 23 is adjusted to be l1 by the adjusting member 40, so that the axial distance between the proximal part 21 and the distal part 23 is relatively long, the curvature of the side wall of the main body part 22 is relatively small, the concave degree of the main body part 22 is relatively small, the spraying holes on the main body part 22 are relatively scattered, and the diameters of the proximal part 21 and the distal part 23 are relatively small. At this time, the effective thrombolysis length of the main body part 22 is relatively long. As Figure 2aAs shown, when the length of the embolization region is short, the distance between the proximal end portion 21 and the distal end portion 23 in the axial direction can be adjusted to l2 by the adjusting member 40, where l2 < l1, so that the distance between the proximal segment portion 21 and the distal end portion 23 in the axial direction is short, the curvature of the main body portion 22 is large, the degree of depression of the main body portion 22 is large, and the injection holes 241 on the main body portion 22 are relatively concentrated.

[0054] Thus, by the side wall of the main body portion 22 being recessed toward the radially inner side of the main body portion 22, the main body portion 22 can enclose the thrombus 91 within the concave region formed by the main body portion 22. Then, by a plurality of medicine injection holes 241 being provided on the side wall of the main body portion 22, all the medicine injection holes 241 can face the center of the thrombolysis region 202, so that the plurality of medicine injection holes 241 can inject medicine concentratedly toward the center of the thrombolysis region 202, thereby increasing the thrombolysis efficiency. On the other hand, during the process of shortening the distance between the two axial ends of the main body portion 22, the curvature of the side wall of the main body portion 22 can also be increased correspondingly, making the plurality of medicine injection holes 241 more concentrated, thereby further improving the thrombolysis efficiency.

[0055] In some embodiments, referring to Figure 2 and Figure 2a as shown, the thrombolysis portion 20 includes a plurality of thrombolysis tubes 24 and a constraining member 28. Each thrombolysis tube 24 is arranged in an array around the axis of the adjusting member 40. The proximal ends of each thrombolysis tube 24 are convergently connected to form the proximal end portion 21, the distal ends of each thrombolysis tube 24 are convergently connected to form the distal end portion 23, each thrombolysis tube 24 is connected to the constraining member 28 to form the main body portion 22, the maximum diameter of the proximal end portion 21 or the maximum diameter of the distal end portion 23 is greater than the maximum diameter of the main body portion 22, and injection holes 241 are provided on the thrombolysis tube 24.

[0056] The thrombolytic tube 24 is an elongated tubular member with a lumen. The thrombolytic solution can be accommodated in the lumen of the thrombolytic tube 24. The pusher 30 is in communication with each thrombolytic tube 24, and the thrombolytic solution can be pushed into each thrombolytic tube 24 through the pusher 30. The thrombolytic tube 24 is a flexible tube with a certain hardness and can be made of a polymer material, such as a copolymer or mixture of one or more of polyetheretherketone (PEEK), acrylonitrile-butadiene-styrene plastic (ABS), polyethylene (PE), polypropylene (PP), polyether block polyamide (PEBAX), polycarbonate (PC), polyurethane (PU), nylon, polyvinyl chloride (PVC), polytetrafluoroethylene (PTFE), or polybutene (PB). The thrombolytic tube 24 can also be made of a biocompatible metal material, such as nitinol. The proximal end portion 21 and the distal end portion 23 are in an umbrella-like structure. The proximal ends of the proximal end portion 21 converge and connect to form a proximal convergence point 211. The distal end of the proximal end portion 21 is connected to the proximal end of the main body portion 22. The distal ends of the distal end portion 23 converge and connect to form a distal convergence point 231. The proximal end of the distal end portion 23 is connected to the distal end of the main body portion 22. The proximal end portion 21 and the distal end portion 23 can be used to block the thrombus 91 in the recess formed by the main body portion 22. The medicine spraying holes 241 on the thrombolytic tube 24 are used to spray the thrombolytic solution on the thrombus 91.

[0057] The restraining member 28 can be a tubular member or a ring-shaped member. For example, Figure 2a as described above, when the restraining member 28 is a ring-shaped member, the restraining member 28 can be sleeved on the outside of all the thrombolytic tubes 24, so that the restraining member 28 can form a restraint on the multiple thrombolytic tubes 24, thereby causing the thrombolytic tubes 24 to be recessed in the direction of the radial center to form the main body portion 22. It can be understood that in other embodiments, when the restraining member 28 is a tubular member, all the thrombolytic tubes 24 adhere to the outer wall of the tubular member, so that the thrombolytic tubes 24 are recessed in the direction of the radial center of the pusher 30 to form the main body portion 22.

[0058] In this embodiment, each thrombolytic tube 24 is fixedly connected to the restraining member 28. The restraining member 28 is used to restrain each thrombolytic tube 24. When the distal ends of the multiple thrombolytic tubes 24 are pulled and the thrombolytic tubes 24 are deformed, the multiple thrombolytic tubes 24 can be restrained by the restraining member 28, thereby avoiding the multiple thrombolytic tubes 24 from being entangled with each other and causing the misalignment of the medicine spraying holes 241 on different thrombolytic tubes 24.

[0059] In a further embodiment, refer to Figure 3 , Figure 3a and Figure 4 . The thrombolysis part 20 further includes a blocking layer 25. The blocking layer 25 is connected to the main body part 22 to form a channel 201 inside the main body part 22. Through holes are formed in the proximal end part 21 and the distal end part 23. The through holes on the proximal end part 21 and the distal end part 23 are both communicated with the channel 201 of the main body part 22. The blocking layer 25 covers at least part of the proximal end part 21 or the distal end part 23. The medicine spraying holes 241 are formed on the outer side wall of the main body part 22.

[0060] In this embodiment, the blocking layer 25 is connected to the side walls of multiple thrombolysis tubes 24 close to the center side of the main body part 22. The blocking layer 25 encloses to form a channel 201 inside the main body part 22. The blocking layer 25 can isolate the radially inner side and the radially outer side of the main body part 22. The blocking layer 25 can also extend to the proximal end part 21 or the distal end part 23. The blocking layer 25 can be made of materials such as polytetrafluoroethylene, polyester, polyethylene terephthalate, polyurethane, etc. It can be understood that in other embodiments, the blocking layer 25 can also be connected to the side walls of the thrombolysis tubes 24 far from the center side of the main body part 22, and a plurality of avoiding holes are formed on the blocking layer 25. The positions of the plurality of avoiding holes are arranged corresponding to the positions of the medicine spraying holes 241.

[0061] The medicine spraying holes 241 are formed on the outer side wall of the main body part 22. The medicine spraying holes 241 are formed on the side wall of the thrombolysis tube 24 far from the blocking layer 25. A first through hole 212 is formed at the axial proximal end of the proximal end part 21. The first through hole 212 is communicated with the channel 201. Two adjacent thrombolysis tubes 24 on the proximal end part 21 are arranged at intervals to form the first through hole 212. A second through hole 232 is formed at the axial distal end of the distal end part 23. The second through hole 232 is communicated with the channel 201. Two adjacent thrombolysis tubes 24 on the distal end part 23 are arranged at intervals to form the second through hole 232. In one embodiment, after the thrombolysis part 20 intervenes in the part to be thrombolyzed of the blood vessel, the blood flow can sequentially pass through the first through hole 212, the channel 201 and the second through hole 232 to pass through the thrombolysis part 20.

[0062] Thus, by connecting the blocking layer 25 to the inner sidewall of the main body portion 22, the blocking layer 25 can isolate the two radial sides of the main body portion 22, so that the thrombolysis area outside the main body portion 22 is isolated from the channel 201 inside the main body portion 22. Then, by opening the medicine spraying holes 241 on the outer sidewall of the main body portion 22, the liquid medicine sprayed from the medicine spraying holes 241 can be isolated from the channel 201, thereby preventing the thrombolysis liquid from flowing away along with the blood in the channel 201 and causing damage to the embolized blood vessel area. At the same time, it can also avoid the small-sized thrombi formed during the thrombolysis process from flowing away along with the blood and causing blockage of the terminal blood vessels. By forming the channel 201 inside the main body portion 22 and connecting the through holes on the proximal end portion 21 and the distal end portion 22 to the channel 201 respectively, the blood flow can pass through the through holes on both sides of the channel 201 and the channel 201 in sequence, so as to realize the conduction of the blood flow on both sides of the thrombolysis portion 20, and thus the blood flow can pass through while isolating the thrombolysis area, promoting blood circulation. After expansion, the proximal end portion 21 or the distal end portion 23 can also abut against the inner wall of the blood vessel, so that the proximal end portion 21 and the distal end portion 23 can expand the inner wall of the blood vessel to make the blood vessels on both sides of the main body portion 22 bulge outward, and at the same time, the blocking layer 25 on the proximal end portion 21 and the distal end portion 23 can be attached to the inner wall of the blood vessel, increasing the sealing performance of the thrombolysis area 202 between the blocking layer 25 and the inner wall of the blood vessel.

[0063] In some embodiments, referring to Figures 5 to 7 , the restraining member 28 further includes a tubular member 26. The tubular member 26 is disposed inside the main body portion 22. The outer wall of the tubular member 26 is connected to each thrombolysis tube 24. The tubular member 26 is used to restrain a plurality of thrombolysis tubes 24, and the tubular member 26 is used to form the channel 201 inside the main body portion 22.

[0064] The tubular member 26 is located inside the main body portion 22, and its length can be shorter than that of the main body portion 22. Each thrombolysis tube 24 can be fixed to the outer sidewall of the tubular member 26 by means such as pasting or welding. The adjusting member 40 passes through the inner cavity of the tubular member 26. Thus, by connecting the outer wall of the tubular member 26 to the thrombolysis tubes 24, the tubular member 26 can form a restraint inside the plurality of thrombolysis tubes 24. During the deformation of the main body portion 22, the tubular member 26 can form a restraint on the plurality of thrombolysis tubes 24, avoiding the blocking of the channel 201 caused by the mutual abutment of the plurality of thrombolysis tubes 24. By forming the channel 201 for blood flow through the inside of the tubular member 26, the channel 201 can retain the blood flow path, ensuring the blood flow in the distal blood vessels.

[0065] Furthermore, referring to Figure 5 shown, the tubular member 26 can be located at the center position of the main body portion 22, so that the tubular member 26 can restrain each thrombolysis tube 24 at the center of the main body portion 22, so that each thrombolysis tube 24 can deform uniformly, thereby forming a balanced thrombolysis area 202 in the circumferential direction and improving the thrombolysis efficiency.

[0066] In some embodiments, referring to Figure 8 , one end of the pusher 30 is in communication with each of the plurality of thrombolytic tubes 24 of the thrombolytic part 20, and the other end of the pusher 30 passes through the delivery tube 10 and is located outside the tubular member 26.

[0067] The pusher 30 may include a pusher tube 31. The pusher tube 31 is a long tubular structure. The distal end of the pusher 30 is in communication with the proximal ends of the respective thrombolytic tubes 24 of the thrombolytic part 20, that is, the distal end of the pusher tube 31 is in communication with the proximal ends of the respective thrombolytic tubes 24 of the thrombolytic part 20. Through the pusher 30, thrombolytic liquid medicine can be introduced into each thrombolytic tube 24, and the thrombolytic liquid medicine in the thrombolytic tube 24 has a certain pressure and can form a thrombolytic spray column when sprayed out through the medicine spraying holes 241 on the thrombolytic tube 24. The proximal end of the pusher 30 is disposed through the delivery tube 10, and through the delivery tube 10, the pusher 30, the thrombolytic part 20, etc. can be transported to the embolism area.

[0068] In some embodiments, referring to Figure 9 and Figure 10 , the thrombolytic part 20 includes a plurality of thrombolytic tubes 24. Medicine spraying holes 241 are formed in the side walls of the respective thrombolytic tubes 24 of the main body part 22, and the openings of the respective medicine spraying holes 241 are arranged facing the radially outer side of the main body part 22.

[0069] A plurality of medicine spraying holes 241 may be formed to form a medicine spraying hole array, and the openings of the respective medicine spraying holes 241 face the radially outer side of the main body part 22. As the curvature of the side wall of the main body part 22 increases, the medicine spraying holes 241 can be concentrated towards the thrombus 91, increasing the thrombolytic efficiency. During thrombolysis, the medicine spraying holes 241 on both sides of the main body part 22 can be concentrated to spray medicine towards the center of the thrombolytic area 202, that is, both the left and right sides of the thrombus 91 can be sprayed with the thrombolytic liquid medicine, thereby improving the thrombolytic efficiency. The respective medicine spraying holes 241 are arranged at intervals, and their sizes may be the same or different. The medicine spraying holes 241 are mainly distributed on the main body part 22.

[0070] In a further embodiment, referring to Figure 10 , the aperture diameters of the respective medicine spraying holes 241 may gradually decrease from the proximal end to the distal end. The distal end of the pusher 30 is in communication with the proximal ends of the respective thrombolytic tubes 24. In the case where the pipe diameters of the respective thrombolytic tubes 24 and the sizes of the medicine spraying holes 241 are the same, the pushing pressure of the thrombolytic tube 24 will gradually decrease from the proximal end to the distal end. Therefore, the aperture diameters of the respective medicine spraying holes 241 gradually decrease from the proximal end to the distal end, and by decreasing the aperture diameter, the change in pressure is compensated. In this way, it can be ensured that the spraying pressures of the respective medicine spraying holes 241 on the thrombolytic tube 24 are uniform, so that the thrombolytic liquid medicine sprayed by the respective medicine spraying holes 241 has the same height and the thrombolysis is more balanced.

[0071] In this embodiment, the aperture diameter of the medicine spraying hole 241 is between 0.15 mm and 0.08 mm. Specifically, the aperture diameter of the medicine spraying hole 241 can be 0.08 mm, 0.10 mm, 0.11 mm or 0.15 mm.

[0072] In some embodiments, a first imaging point 242 is provided at a position on the thrombolytic tube 24 close to the medicine spraying hole 241 at the nearest end, and a second imaging point 243 is provided at a position on the thrombolytic tube 24 close to the medicine spraying hole 241 at the farthest end. Through the positions of the first imaging point 242 and the second imaging point 243, the operator can adjust the position of the spraying hole 241 of the thrombolytic part 20 through the positions of the first imaging point 242 and the second imaging point 242, so as to facilitate the positioning of the thrombolytic area. The materials used for the first imaging point 242 and the second imaging point 243 can be materials that do not penetrate X-rays, such as metals or alloy materials such as gold, platinum, and tantalum, or can also be high molecular materials that do not penetrate X-rays, such as PTFE films. It can be understood that in some other embodiments, for the main body part 22 of the thrombolytic part 20, the first imaging point 242 and the second imaging point 243 can be arranged at the maximum diameter of the main body part 22. In this way, the thrombolytic area 202 can be positioned more conveniently.

[0073] Embodiment Two

[0074] The difference between this embodiment and Embodiment One lies in that, referring to Figures 11 to 13 , the side wall of the main body part 22 of the thrombolytic part 20 bulges towards the radially outer side, and the maximum diameters of the proximal end part 21 and the distal end part 23 are smaller than the maximum diameter of the main body part 22.

[0075] The thrombolytic part 20 includes a plurality of thrombolytic tubes 24, and medicine spraying holes 241 with openings facing the radially outer side are provided on each thrombolytic tube 24. The plurality of medicine spraying holes 241 can be arranged along the axial direction of the thrombolytic tube 24 to form a larger thrombolytic area 202. The distal end of the adjusting member 40 is connected to the distal end of the thrombolytic part 20. By pulling the distal end of the thrombolytic part 20 through the adjusting member 40, the axial distance between the proximal end and the distal end of the thrombolytic part 20 can be adjusted, so that the thrombolytic part 20 can adapt to embolism areas of different lengths.

[0076] In some embodiments, referring to Figure 12 and Figure 12a , the thrombolytic part 20 further includes a support wire 70. The support wire 70 is fixedly connected to the inner side of the main body part 22. The support wire 70 can be fixedly connected to the inner side of the main body part 22 entirely or partially. The support wire 70 is used to support the main body part 22. The hardness of the support wire 70 is greater than the hardness of the thrombolytic tube 24, so that the support wire 70 can support the thrombolytic tube 24, avoiding excessive deformation of the thrombolytic tube 24 during the process of adjusting the distance between the proximal end and the distal end of the main body part 22, resulting in an ineffective thrombolytic area, and making the main body part 22 more controllable.

[0077] In some embodiments, with reference to Figure 13 , a plurality of thrombolysis parts 20 may be provided. The plurality of thrombolysis parts 20 are arranged at intervals along the axial direction, so that a thrombolysis area 202 can also be formed between two adjacent thrombolysis parts 20, thereby improving the thrombolysis efficiency. At the same time, it also adapts to the embolized blood vessels with a longer length and meets the thrombolysis requirements of thrombi with a longer length.

[0078] In some other embodiments, the thrombolysis tubes 24 on adjacent thrombolysis parts 20 are communicated with each other. In this way, by connecting the pusher 30 with the thrombolysis part 20 at the nearest end, thrombolysis liquid medicine can be simultaneously delivered to a plurality of thrombolysis parts 20.

[0079] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements or improvements made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A thrombolytic catheter, characterized in that, It includes a thrombolysis part, a pusher and an adjuster. The pusher is connected to the proximal end of the thrombolysis part, and the adjuster is connected to the distal end of the thrombolysis part. The adjuster is used to pull the distal end of the thrombolysis part to adjust the interval distance between the proximal end and the distal end of the thrombolysis part.

2. The thrombolytic catheter according to claim 1, wherein, The thrombolysis part includes a proximal end part, a distal end part and a main body part. The two ends of the main body part are respectively connected to the proximal end part and the distal end part. At least part of the side wall of the main body part is recessed towards the radial inner side, and spraying holes are formed in the side wall of the main body part. The pusher is connected to the proximal end part, and the adjuster is connected to the distal end part.

3. The thrombolytic catheter according to claim 2, wherein, The thrombolysis part includes a plurality of thrombolysis tubes and a restraint. The proximal ends of the plurality of thrombolysis tubes are connected to form the proximal end part, the distal ends of the plurality of thrombolysis tubes are connected to form the distal end part, and the plurality of thrombolysis tubes are connected to the restraint to form the main body part. The maximum diameter of the proximal end part or the maximum diameter of the distal end part is greater than the maximum diameter of the main body part, and the spraying holes are formed in the thrombolysis tubes.

4. The thrombolytic catheter according to claim 3, wherein The restraint includes a tubular part. The tubular part is located inside the plurality of thrombolysis tubes, and the outer wall of the tubular part is connected to the plurality of thrombolysis tubes. The tubular part forms a channel between the plurality of thrombolysis tubes.

5. The thrombolytic catheter according to claim 2, wherein, It further includes a flow blocking layer. The flow blocking layer is connected to the main body part to form a channel inside the main body part. A first through hole is formed in the proximal end part, and a second through hole is formed in the distal end part. The first through hole and the second through hole are respectively communicated with the channel. The flow blocking layer covers at least part of the proximal end part or the distal end part, and the spraying holes are formed in the outer side wall of the main body part.

6. The thrombolytic catheter according to claim 2, characterized in that, The aperture diameter of each of the spraying holes decreases from the proximal side to the distal side.

7. The thrombolytic catheter according to claim 2, wherein The side wall of the main body part bulges towards the radial outer side, and the maximum diameters of the proximal end part and the distal end part are smaller than the maximum diameter of the main body part.

8. The thrombolytic catheter according to claim 7, wherein, The thrombolysis part further includes a support wire. The support wire is connected to the main body part, and the support wire is used to support the main body part.

9. The thrombolytic catheter according to claim 1, wherein It further includes a delivery tube. The pusher and the adjuster are both disposed inside the delivery tube. One end of the pusher away from the thrombolysis part is located outside the delivery tube, and one end of the adjuster away from the thrombolysis part is located outside the delivery tube.

10. The thrombolytic catheter according to claim 1, characterized in that, A plurality of the thrombolysis parts are provided, and the plurality of thrombolysis parts are spaced apart along the axial direction of the pusher.

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