6 results about "Friability" patented technology

According to the technical scheme, the high-efficiency pharmaceutical friability tester is characterized by comprising a mounting table, a plurality of supporting columns are fixedly mounted on the top surface of the mounting table, a weighing disc is fixedly mounted on the top surfaces of the supporting columns, a distinguishing frame is fixedly mounted on one side of the weighing disc, and the distinguishing frame is fixedly mounted on the other side of the weighing disc; a transparent cover is fixedly installed on the top face of the weighing disc, a medicine feeding hopper is fixedly installed on the top face of the transparent cover, a medicine inlet hole is formed in the top face of the transparent cover, through cooperation of a first weighing sensor and a rough panel, weight recording before medicine testing is automatically completed, a real falling test is simulated, and through intermittent movement of a rotary medicine pushing plate, the medicine feeding hopper is fixedly installed on the top face of the transparent cover. The lifting and falling process of the medicine in the test shell is accurately controlled, the space is separated by utilizing the segmentation plate, multiple groups of experiments are allowed to be performed at the same time, the equipment utilization rate is improved, automatic weighing is performed after testing, automatic weighing of the medicine after testing is realized through the second weighing sensor and the weighing plate, and direct calculation of the friability is facilitated.

This invention discloses a block-shaped piroxicam crystal and its direct compression formulation method, relating to the field of pharmaceutical formulation technology. The block-shaped piroxicam crystal is prepared according to the following steps: crude piroxicam is dissolved in a solvent, an organic acid and polyvinylpyrrolidone are added, the mixture is cooled and crystallized, and then filtered, washed, and dried to obtain block-shaped piroxicam crystals. The solvent is acetonitrile or ethyl acetate; the organic acid is glutaric acid or citric acid. The active pharmaceutical ingredient powder prepared by this invention has an angle of repose ≤35°, good flowability, which ensures smooth material transportation, mixing, and tableting processes, resulting in small tablet weight differences and high content uniformity. The finished tablet has a hardness ≥90 kgf, high mechanical strength, and a friability ≤0.02%, exhibiting extremely strong wear and breakage resistance, making it less prone to damage during production, packaging, and transportation. The 15-minute dissolution rate ≥50% balances formability and dissolution, facilitating rapid drug release and improving in vivo bioavailability.

The application discloses a preparation method of a trazodone hydrochloride sustained-release tablet and a new tablet type. The sustained-release tablet is mainly composed of trazodone hydrochloride, a skeleton material, a pore forming agent, a binder and a lubricant and the like medicinal auxiliaries. In the application, a swing granulator is used to granulate and integrate the materials. The optimal aging condition of the trazodone hydrochloride sustained-release tablet is obtained through sample dissolution, the problems of high material loss and high equipment energy consumption in the prior art prepared by a fluidized bed are avoided, the tablet type is screened, the product stability is ensured, and the defect of high friability and easy breaking of the original research tablet type is avoided.

The invention discloses a diclofenac sodium sustained-release tablet and a preparation method thereof, the sustained-release tablet takes diclofenac sodium as an active ingredient, a waxy sustained-release framework material, a filler, an adhesive, a glidant, a lubricant and a coating material are supplemented, and 12-24 hours of stable release is realized by optimizing a hot melting granulation process; by expanding the selection range of auxiliary materials and simplifying the production steps, the product has good compressibility, hardness of 60-100N, friability of less than 0.6%, excellent dissolution performance, release of 25%-30% in one hour and release of more than or equal to 90% in 24 hours in a phosphate buffer solution with pH of 6.8, stability, acceleration of 6 months at 40 DEG C / 75% RH and long-term storage of 12 months at 25 DEG C / 60% RH, is consistent with in-vitro pharmaceutical characteristics of a control preparation, and is suitable for industrial production.

The utility model relates to the technical field of medicine, and discloses a medicine production friability inspection tester which comprises a first installation box and a second installation box, the first installation box is arranged at the end of the second installation box, a first installation cavity is formed in the first installation box, and a second installation cavity is formed in the second installation box. A moving mechanism is arranged in the first mounting cavity, through the arrangement of the moving mechanism, medicine is placed in the second mounting cavity, a servo motor is started, the servo motor drives a rotating shaft and a rotating disc on the outer side of the rotating shaft to rotate, a fixing column and a sliding groove are clamped in a sliding mode, a rotating block is driven to swing, and first teeth and second teeth are in meshing transmission; the servo motor drives the moving column to reciprocate and drives the extruding plate to extrude medicines, the extruding force of the extruding plate to the medicines is controlled by controlling the rotating speed of the servo motor, the servo motor has high-precision speed and position control capacity, fine adjustment can be achieved, and it is guaranteed that the extruding force of each time is consistent.

The invention discloses a trazodone sustained-release tablet and a preparation method thereof, and belongs to the field of pharmaceutical preparations, and the sustained-release tablet contains trazodone hydrochloride, a sustained-release framework material, a pore-foaming agent, an adhesive and other pharmaceutic adjuvants. The preparation method comprises the following steps: preparing sustained-release particles from trazodone hydrochloride, a skeleton sustained-release material and other necessary auxiliary materials by adopting a hot-melt extrusion granulation process, and then mixing and tabletting the sustained-release particles and the auxiliary materials to prepare the trazodone sustained-release tablet. The preparation process is simple, the production reproducibility is relatively good, the sustained release effect of the product is good, the release behavior of the product is relatively consistent with that of a foreign original sustained release preparation, and the problems that the original product is easy to break and high in friability are solved.