Preparation method of pellet-type formula granules

A formula granule and micro-pill type technology, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, pill delivery, etc. It can solve the problems of rough surface, uneven size and irregular shape of granules.

Inactive Publication Date: 2018-03-02
GUANGDONG LUOFUSHAN SINOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During packaging, especially when subpackaging by the intelligent blending system, due to the irregular shape of the granules, the rough surface of the granules, the uneven size, and the poor fluidity, there are problems of large differences in the filling volume, and powder is easily produced during the subpackaging and metering process. Adhering to metering equipment and pipelines, causing cross-contamination and drug mixing, especially particles with certain toxicity, such as aconite, aconitum and other particles; at the same time, Chinese medicine formula particles are easy to absorb moisture, and there is stability sexual problems

Method used

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  • Preparation method of pellet-type formula granules
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  • Preparation method of pellet-type formula granules

Examples

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Embodiment 1

[0076] An embodiment of the method for preparing pellet-shaped formula granules of the present invention, the Chinese medicinal material used in this embodiment is Clematis clematis, and the preparation method described in this embodiment includes the following steps:

[0077] (1) Take the medicinal material of Clematis clematis, add water to decoct, add 8 times the amount of water to the medicinal material, decoct twice, each time for 1 hour, after decoction, filter the decoction and concentrate it into a clear paste, dry, and obtain pretreatment Material;

[0078] (2) Mix the pretreated materials and auxiliary materials (preferably dextrin, lactose, microcrystalline cellulose) (clear cream powder: auxiliary materials = 5:0~3:2), add them to the boiling granulator, and use 40~95 Use % ethanol as a wetting agent to prepare pellet cores, set the air inlet temperature at 90-110°C, and start granulation. During granulation, control the material temperature at 50-70°C. When the mo...

Embodiment 2

[0081] An embodiment of the method for preparing pellet-shaped formula granules of the present invention, the Chinese medicinal material used in this embodiment is Huajuhong, and the preparation method described in this embodiment includes the following steps:

[0082] (1) Take the orange red medicinal material, add water to decoct, add 12 times of the medicinal material, decoct 2 times, each time for 2 hours, after decoction, filter the decoction and condense it into a clear paste, dry to obtain the pretreatment material ;

[0083] (2) Mix the pretreated materials and auxiliary materials (preferably starch, hydroxypropyl cellulose) (clear paste powder: auxiliary materials = 5:0~3:2), add to the boiling granulator, and mix with 5-10% starch Slurry is used as a binder to prepare pellet cores. Set the air inlet temperature at 110-130°C and start granulation. During granulation, control the material temperature at 40-60°C. When the moisture content of the granules is ≤8%, the pel...

Embodiment 3

[0087] An embodiment of the method for preparing pellet-shaped formula granules of the present invention, the Chinese medicinal material used in this embodiment is motherwort, and the preparation method described in this embodiment includes the following steps:

[0088] (1) Take the motherwort medicinal material, add water to decoct, add 12 times the amount of water as the medicinal material, decoct 2 times, 3 hours each time, filter the decoction after decoction and condense it into a clear paste, dry to obtain the pretreatment material;

[0089] (2) Mix the pretreated materials and auxiliary materials (one or more of dextrin, lactose, and sodium carboxymethyl starch) (clear cream powder: auxiliary materials = 1:2~3:2), and add them to the dry granulator During granulation, the feeding frequency is controlled to be 20-50HZ, the tableting frequency is 10-50HZ, the granulation frequency is 20-50HZ, the pressure is 35-65Pa, and the pellet core particle size is 60-120 mesh;

[00...

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Abstract

The invention discloses a preparation method of pellet-type formula granules. The method comprises the following steps: (1) selecting at least one of the traditional Chinese medicinal materials; (2) respectively extracting the medicinal materials selected in step (1) for obtaining extracts, or respectively grinding the medicinal materials, or respectively carrying out partial extraction and partial grinding, thus obtaining pretreated materials; and (3) preparing the pretreated materials obtained in step (2) into pellets, thus obtaining the pellet-type formula granules. According to the preparation method provided by the invention, on the basis of the prior art, the preparation process of the formula granules is innovated, the formula granules are innovated into pellets, the fluidity and moisture absorption resistance are good, the friability is small, the shape is round and uniform as well as regular, the content uniformity is small, and the divided dose is accurate.

Description

technical field [0001] The invention relates to a preparation method of traditional Chinese medicine, in particular to a preparation method of pellet-shaped formula granules. Background technique [0002] Traditional Chinese medicine formula granules (formerly known as granular decoction pieces) refer to granules made from traditional single-flavor Chinese medicine decoction pieces that meet the processing specifications and processed by modern pharmaceutical technologies such as extraction or crushing. Traditional Chinese medicine formula granules maintain the characteristics of traditional decoction pieces and decoctions in the preparation process. Except for the varieties that are traditionally used as powder, other varieties are prepared by modern dry or wet granulation technology after decoction. For varieties containing volatile oil, the volatile oil is first extracted and then decocted, and finally the volatile oil is sprayed to retain the volatile components of the C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61J3/06A61K36/716A61K36/752A61K36/533A61K36/185A61K36/284A61K9/36
CPCA61J3/06A61K9/2059A61K9/2095A61K9/2866A61K36/185A61K36/284A61K36/533A61K36/716A61K36/752
Inventor 叶耀良张清民廖志钟滕云霞
Owner GUANGDONG LUOFUSHAN SINOPHARM
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