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Aweto micropowder tablet and preparation method thereof

A Cordyceps micropowder and micropowder technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve sticking, de-powdering, splitting, falling blocks, loose flakes, loss of heat-sensitive components of Cordyceps sinensis, and tablets Uneven drug content and other problems, to achieve the effect of improving curative effect, clinical significance and resource utilization, and reducing the dosage

Active Publication Date: 2008-12-31
QINGHAI SPRING MEDICINAL RESOURCES TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the surface tension of micropowder with a particle size of 1-150 μm is very large, and the gaps between the powders are large. Usually, it is difficult for those skilled in the art to directly compress or granulate it, and it is necessary to add auxiliary materials to improve its fluidity and compressibility. tablet
And in the process of compressing tablets with Cordyceps micropowder, it is found that the conventional fluidized bed granulation or wet granulation process easily causes the loss of volatile components or heat-sensitive components in Cordyceps sinensis. If the moisture control is not good in wet granulation, It is prone to technical problems such as sticking, powdering, splitting, falling blocks, and loose tablets. To overcome the above defects, it is usually necessary to add auxiliary materials for shaping, improve the fluidity and water content of granules to ensure the quality of tableting
However, after adding excipients, there will be defects such as uneven mixing and uneven drug content in the tablet
[0005] In a word, there is no report about crushing Cordyceps sinensis into fine powder and then pressing it into tablets without adding any auxiliary materials.

Method used

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  • Aweto micropowder tablet and preparation method thereof
  • Aweto micropowder tablet and preparation method thereof
  • Aweto micropowder tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] (3) Preparation of the test solution: filter the filtrate obtained by measuring the total dissolution rate in the above test 1 with a microporous membrane (0.45 μm), and take the subsequent filtrate as the test solution.

[0025] (4) Linear relationship investigation

[0026] Precisely draw 5, 10, 15, 20, and 25 μl of the above-mentioned reference substance solution and inject them sequentially, measure according to the above-mentioned chromatographic conditions, take the concentration as the abscissa, and the integrated value of the peak area as the ordinate, draw a standard curve, and the regression equation is: Y=33.815 X-19.792r=0.9996. It shows that the linear relationship of adenosine is good in the range of 0.011~0.302μg.

[0027] The dissolution rate (%) of adenosine over time in the Cordyceps sinensis of different crushing grades in table 2

[0028]

[0029]The determination results of adenosine in Cordyceps sinensis of different crushed grades showed that...

Embodiment 1

[0082] Embodiment 1 micropowder direct powder tableting process

[0083] 1. Raw material: superfine powder of Cordyceps sinensis (particle size: D90=15-20 μm; moisture content about 9.5%).

[0084] 2. The speed of the tablet press is 15 / h, the pre-compression pressure is 0.8kN, and the pressure is 48kN.

[0085] 3. Adopt round rod type pulsator feeder (to increase the fluidity of powder).

[0086] 4. The ambient temperature is 23°C; the ambient humidity is 50%.

[0087] Under the above process conditions, the powder is directly compressed into tablets, the tablet specification is 0.25g / tablet, 100 tablets.

Embodiment 2

[0088] Embodiment 2 Micropowder secondary tableting process:

[0089] 1. Raw materials: superfine powder of Cordyceps sinensis with a particle size of D90=15-20 μm and a moisture content of about 9.5%.

[0090] 2. The speed of the tablet press is 15 / h, the pre-compression pressure of the first tablet compression is 28kN, and the main pressure is 28kN; the pre-compression pressure of the second tablet compression is 28kN, and the main pressure is 28kN.

[0091] 3. Adopt round rod type pulsator feeder (to increase the fluidity of powder).

[0092] 4. The ambient temperature is 23°C; the ambient humidity is 50%.

[0093] Under the above-mentioned process conditions, the first tablet is made into a first tablet with an average hardness of 2.57Kg (the specification of the first tablet is about 0.25g / tablet), and then crushed into a fine powder that can pass through a 100-mesh sieve. Tablets, ready to use, tablet specification 0.25g / tablet, 100 tablets.

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Abstract

The present invention relates to a cordyceps sinensis powder tablet and a preparation method thereof, which pertains to the field of medicines and health products. The technical problem the present invention aims at providing a tablet containing cordyceps sinensis medicinal powder and no auxiliary material; the appearance, shape and harness of the tablet is consistent with the tablet quality standard. The cordyceps sinensis powder tablet only adopts cordyceps sinensis powder with the water content of 8 to 18 percent and the granule diameter of 1 to 150mum; no auxiliary material is added in the preparation process and the cordyceps sinensis powder is the only component. The aim of direct tablet forming can be achieved by controlling the water of the powder or by the process of second tabletting or dry granule tabletting. The process ensures that the tablet appearance is good; pockmark surface rate and fracture rate are low; tablet harness, disintegration rate and friability are consistent with the tablet quality requirement; the harness can also ensure that the tablet can not fracture in the preparation process when coating and film covering is carried out in the later stage.

Description

technical field [0001] The invention relates to micropowder tablets of Cordyceps sinensis and a preparation method thereof, belonging to the field of medicine and health care products. Background technique [0002] Usually, when preparing tablets, those skilled in the art must first select appropriate excipients according to the properties of the drug and the requirements of clinical medication, and then mix and process them to make them have good fluidity and compressibility. (Chinese Medicine Pharmaceutics, China Press of Traditional Chinese Medicine, first edition in January 2003, p411, penultimate paragraph 2), the choice of excipients is extremely important during direct compression, the most important of which are fillers and binders, They are the key to tableting. The excipients in the direct compression tablet prescription, especially the role of fillers and binders, are more important in the wet granulation method (Chinese Medicine Pharmaceutics, China Traditional ...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K9/20A61P37/04
Inventor 马建滨张雪峰
Owner QINGHAI SPRING MEDICINAL RESOURCES TECHNOLOGY CO LTD
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