6 results about "Levamlodipine" patented technology

The utility model discloses a levamlodipine besylate tablet crusher, and particularly relates to the technical field of tablet processing, the levamlodipine besylate tablet crusher comprises a crushing cavity, the top of the crushing cavity is provided with a sealing cover in a threaded manner, the bottom of the crushing cavity is provided with a charging box in a threaded manner, the sealing cover is fixedly provided with a crushing motor, and the output end of the crushing motor is fixedly provided with a rotating shaft; a first smashing cutter and a second smashing cutter are arranged at the bottom of the rotating shaft, the second smashing cutter is located at the bottom of the first smashing cutter, a dust absorption structure is arranged on the surface of the sealing cover and located on one side of the smashing motor, the dust absorption structure comprises a treatment box, and the treatment box is located on one side of the smashing cavity. According to the levamlodipine besylate tablet crushing device, levamlodipine besylate tablets can be well crushed, generated dust can be absorbed and filtered in the crushing process, the situation that dust escapes in the environment and affects operators is avoided, and the whole levamlodipine besylate tablet crushing device is convenient to disassemble, assemble and maintain.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a levoamlodipine folic acid compound tablet and a preparation process thereof, and the preparation process comprises the following steps: mixing microcrystalline cellulose with vitamin C, and enabling nitrite in the microcrystalline cellulose to be in full contact with the vitamin C to obtain a first mixture; mixing folic acid with part of the first mixture to obtain a second mixture; mixing levamlodipine besylate with the remaining first mixture to obtain a third mixture; and uniformly mixing the second mixture, the third mixture and other auxiliary materials, and tabletting to obtain the tablet. The method comprises the following steps: reacting microcrystalline cellulose with vitamin C to consume nitrite in the microcrystalline cellulose so as to prevent the nitrite from reacting with secondary amino in levamlodipine to generate nitrosamine impurities with genetic toxicity;

According to the tablet containing the arginine perindopril and the levamlodipine besylate and the preparation method of the tablet, the pregelatinized starch and microcrystalline cellulose colloidal silicon dioxide co-treated substance is used as a filling agent, and the proportion of the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide co-treated substance is controlled, so that the tablet containing the arginine perindopril and the levamlodipine besylate is prepared. The problem that the fluidity of the tablet is poor in preparation is solved, the stability is remarkably improved, the tablet has the advantages of being simple in preparation method, low in cost, good in fluidity, good in compressibility and the like, meanwhile, the tablet shows rapid disintegration, dissolution and stability, and the tablet is suitable for large-scale industrial production.

The present invention relates to a composition comprising levamlodipine besylate hydrate and its production, pharmaceutical preparations and use, especially the composition of (S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylic acid-3-ethyl ester, 5-methyl ester benzenesulfonic acid hydrate and its production method and use. The composition of levamlodipine besylate crystallized in pure water and dried is easy for industrial production, has no organic solvent residue, good thermal stability and good dissolution amount in solid-form preparations.

The invention belongs to the technical field of raw material crystal forms, and particularly relates to a L-amlodipine maleate crystal form and a preparation method thereof. Cu-K alpha radiation is used, and X-ray diffraction represented by a 2 theta angle (degree) has peaks at the following positions: 4.5 + / -0.2 degrees, 8.8 + / -0.2 degrees, 11.8 + / -0.2 degrees, 13.2 + / -0.2 degrees, 13.5 + / -0.2 degrees, 15.7 + / -0.2 degrees, 17.6 + / -0.2 degrees, 18.4 + / -0.2 degrees, 22.2 + / -0.2 degrees, 22.6 + / -0.2 degrees, 23.2 + / -0.2 degrees, 24.8 + / -0.2 degrees, 26.4 + / -0.2 degrees, 29.1 + / -0.2 degrees, 30.3 + / -0.2 degrees, 35.4 + / -0.2 degrees and The purity and the stability of the novel crystal form are better than those of an original product, the operation is simpler, the salt is directly formed, refining is not needed, the yield is higher, and the batch is not limited any more.

The invention relates to the technical field of pharmaceutical preparation preparation processes, in particular to a compound bisoprolol and levamlodipine tablet and a preparation method thereof. According to the bisoprolol and bisoprolol fumarate bisoprolol double-layer tablet provided by the invention, the bisoprolol raw material is prepared into core particles by adopting wet granulation, and then the bisoprolol fumarate raw material is wrapped, so that the bisoprolol fumarate raw material is prevented from being in contact with the levamlodipine besylate raw material, and the growth speed of impurities formed by adding the bisoprolol and the bisoprolol fumarate into the impurities is obviously reduced. The levoamlodipine layer adopts a mode of dry granulation after mixing, the content of main drugs in the prepared granules is uniform, the layering risk in the tabletting process is reduced, and finally, the two layers of granules are pressed into double-layer tablets by adopting a double-layer tablet press, so that the contact of the two main drugs is avoided. The bisoprolol and levoamlodipine double-layer tablet provided by the invention has better stability, the levoamlodipine content uniformity is better, and the dissolution curve is closer to that of contrast drugs such as a bisoprolol fumarate tablet (Kinapi) and an amlodipine besylate tablet (Heishi).