37results about How to "Improve antihypertensive effect" patented technology

The invention discloses a compound preparation of calcium antagonist and timishatan for reducing blood pressure and its use. The inventive compound preparation is composed of following components by weight portion: 10-160 portion of timishatan, 0.5-50 protion of calcium antagonist. The calcium antagonist expands blood vessel to induce reflex sympathetic nerve excitement and the timishatan antagonizes neurohormone activity which is able to release from the sympathicus over-activation in the CCB blood pressure reduction, reduce the adverse effect induced by CCB treatment, provide all-around protection of the target organ such as heart, brain and kidney. The association of two acts synergistic effect to reduce blood pressure.

The invention relates to a pharmaceutical composition containing atenolol, amlodipine, or folic acid compounds and application thereof. The pharmaceutical composition contains an officinal dosage of the atenolol, an officinal dosage of the amlodipine or levamlodipine, an officinal dosage of the folic acid compounds, and a pharmaceutical acceptable carrier. The dosage of the atenolol is between 5 and 50 milligrams, the dosage of the amlodipine or the levamlodipine is between 0.5 and 5.0 milligrams, and the dosage of the folic acid type compounds is between 0.2 and 1.6 milligrams. The pharmaceutical composition has the following advantages: the pharmaceutical composition enhances the hypertension curative effect through multi-target synergistic hypotensive action, and reduces the taking dosage of the amlodipine simultaneously, that is, just about one fourth of the original dosage can achieve the same hypotensive effect and reduce the side effects and medical expenses; and more importantly, the pharmaceutical composition can effectively prevent and treat or delay various complications of high blood pressure cardiovascular and cerebrovascular diseases such as cerebrovascular disorder and the like through dual targets (Hcy and blood pressure) on the basis of reducing toxic side effects. Besides, the pharmaceutical composition ensures that patients can take medicine conveniently.

The invention provides a risk assessment method and device based on literature data and a server. The method comprises: acquiring all article abstract data of a biomedical literature database; establishing an abstract database of articles related to adverse reactions of certain antihypertensive drugs through limiting a medical subject heading; establishing a data index for measuring article quality related to the adverse reactions of the certain antihypertensive drugs; extracting information of articles, authors, journals, publication types and adverse reactions of the certain antihypertensive drug in each article related to the certain antihypertensive drugs according to the abstract database; and constructing a weighting heterogeneous graphic according to the extracted information and data and sorting to obtain ranking information of the adverse reactions of the certain antihypertensive drugs. The method provided by the invention can recommend the ranking information of the adverse reactions of all types of the antihypertensive drugs, so that the use risk of the antihypertensive drugs is evaluated, the cognition on the risks of the antihypertensive drugs by low-experience and grass-roots doctors and patients is improved, adverse events are reduced and the antihypertensive curative effect is improved.

The invention discloses a preparation method of burdock blood pressure reduction tea. The method comprises the following steps of: dicing burdock, so that the burdock is easily dissolved in water to improve the utilization rate of tea; adopting a cooking machine processing technology, so that the original taste of the burdock is effectively changed to be the mellow taste accepted by common people; heating and controlling temperature and a pH value by using a 40% ethanol solution; alcoholizing chlorogenic acid of burdock dices in the burdock and stabilizing the content of the chlorogenic acid in the tea, wherein the chlorogenic acid is mainly used for blood pressure reduction, the content of burdock is 0.86g per 100g, the burdock is difficultly volatilized, and the blood pressure reduction efficiency is improved; drying the burdock after the special process under the condition that the air pressure is 0.5Pa and the temperature is controlled to be below 25-30 DEG C according to the characteristic of the chlorogenic acid in the burdock so that the content of the chlorogenic acid in the burdock is further stabilized; and frying the burdock at a low temperature to obtain the burdock blood pressure reduction tea.

The invention relates to a preparation technology of a drug and aims at providing an application method of a drug for treating high blood pressure. The preparation technology comprises the following steps: taking radix paeoniae alba, grinding into powder, carrying out alcohol extraction and carrying out water extraction treatment on residues subjected to the alcohol extraction; respectively concentrating an extracting solution and then combining; adding accessories according to a conventional pharmaceutical processing method to obtain a drug dosage form for treating the high blood pressure. According to the preparation method disclosed by the invention, an extract obtained by an alcohol-water extracting method of the radix paeoniae alba has an outstanding curative effect of treating the high blood pressure: after the drug is administrated, the lowering speed of blood pressure is remarkably increased recently, the lowering amplitude is significantly improved, and the antihypertensive effect of the drug can exceed that of western medicine irbesartan. Compared with conventional water extraction, the application method disclosed by the invention has the advantages that the component loss is reduced, further the effectiveness is improved, the radix paeoniae alba is promoted to be completely utilized by a human body through oral medication, and the curative effect is improved. The drug selectively adjusts patients with the high blood pressure and has no influence on normal blood pressure.

The invention discloses a compound preparation for treating hypertension, which comprises 5-30mg of nifedipine and 12.5-75mg of atenolol. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the nifedipine and the atenolol are clinically used at present and one medicament is singly used, and provides a new compound preparation. The nifedipine and the atenolol are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.

The invention discloses a compound preparation for curing hypertension. The invention contains ingredients with following day doses: 0.5-2.5mg of indapamide and 1.25-5mg of piaster. The pressure relief effect is excellent than one single medicine with a large dose, and it can eliminate the bad reaction caused by one single medicine, prevents the compensation reaction caused by using one single medicine to relief blood pressure, upgrades the patience of sufferer, upgrades the compliance.

The invention discloses a complex preparation for curing hypertension. The preparation comprises 2.5 to 50mg of felodipine and 2 to 40mg of candesartan. The preparation overcomes the defect that obviously increased side effects caused by increasing the medicament dosage to ensure the curative effect in single medicament when the felodipine and the candesartan are used clinically, and provides the novel complex preparation. Combination of the felodipine and the candesartan has synergic and complementary curative effect. The complex preparation increases tolerance of patients, improves compliance, reduces dosage, lightens adverse reactions, is convenient for taking, and has low price.

The present invention discloses one kind of hypertension treating compound preparation. The compound preparation contains Indapamide in 0.5-2.5 mg and Olmesartan in 2.5-40 mg as daily dosage. Compared with the single component hypertension treating medicine with relatively great dosage, the present invention has superior blood pressure lowering effect, no negative effect caused by some one medicine component, no compensated reaction, increased patient's tolerance and raised compliance.

The invention discloses a compound preparation for curing hypertension, which includes 2-10mg of felodipine and 5-50mg of metoprolol. The invention provides a novel compound preparation which solves the problem that when only one of felodipine and metoprolol is used clinically, in order to ensure the curative effect, the dosage of the drug is increased, which leads to obvious increase of the side effects. Felodipine and metoprolol are used together, so synergic and complementary curative effect can be produced. The novel antihypertensive drug enhances the tolerance of the patient, improves the compliance and reduces the dosage and the adverse reaction, and is convenient to take and cheap in price.

The invention provides a burdock tea cake with a health care function and a preparation method thereof. The preparation method comprises the steps that fresh burdock which is not damaged by worms areselected and refrigerated in a refrigeration house, the refrigerated burdock is cleaned and peeled in clear water and then put into a disinfected container for standby, the burdock is naturally cooledat room temperature, and the cooled burdock is sliced and ground into powder by using a pulverizer, so that the burdock powder is easily dissolved into water. By using a boiling machine processing technology, the original taste of the burdock is effectively changed, the tea cake has a mellow taste which can be accepted by most people, the burdock is heated and alcoholized with 30% ethyl alcohol solution under the conditions that the temperature and the pH value are controlled, and chlorogenic acid elements rich in the burdocks are extracted. The product prepared by using the method is not contaminated by dust in the indoor and outdoor environments, the refrigerated burdock can be saccharified, and the burdock tea cake prepared by using the method is fragrant, sweet and mellow.

The invention discloses a compound blood pressure reducing pharmaceutical composition. The compound blood pressure reducing pharmaceutical composition comprises the following components of amlodipineor pharmaceutical salts thereof, amiloride or an inorganic acid salt or an organic acid salt of the amiloride, and hydrochlorothiazide or an inorganic acid salt or an organic acid salt of the hydrochlorothiazide. According to the compound blood pressure reducing pharmaceutical composition provided by the invention, the medication dosage of single medicines can be reduced, and the number of medicines practically taken by a patient can be reduced, so that side reactions of medicines can be reduced, and the compliance that the patient takes medicines can be increased.

The invention discloses a compound preparation used for treating hypertension, particularly a novel compound anti-hypertensive drug which comprises 5-20 mg of nitrendipine and 5-50 mg of metoprolol. The novel compound anti-hypertensive drug solves the problem that when nitrendipine and metoprololare are clinically used at present, side effects are obviously increased to guarantee the curative effect by increase of drug dose since only one of nitrendipine and metoprololare is put into use. According to the novel compound preparation, nitrendipine and metoprololare are used together to achieve synergetic and complementary curative effects; and the novel compound anti-hypertensive drug increases the tolerance of patients, improves the compliance, is reduced in dose to relieve adverse reaction, and is convenient to take and low in price.

The invention discloses a compound preparation containing benidipine hydrochloride and benazepril hydrochloride, as well as application thereof, wherein preparation containing benidipine hydrochloride and benazepril hydrochloride serve as effective components of the medicament. According to the compound preparation, the defects of large dose and high side effect of single drug are overcome, and the compound preparation disclosed by the invention is obtained by compounding the benidipine hydrochloride and benazepril hydrochloride. Oral preparations with different forms can be prepared by the preparation, due to synergic and complementary effects of medicaments, the compound preparation has reinforced treatment effect, the medicament dose is reduced in clinical application, adverse reaction of a patient is lightened, and the compound preparation can be accepted easily. The compound preparation has remarkable treatment effect in mild and severe hypertension, and is suitable for hypertension patient with cardiovascular remodeling, and patients with renal hypertension, hypertension with renal damage or with diabetic renal damage. Furthermore, the compound preparation has low price, simple preparation and easy popularization and application.

The invention discloses a compound preparation used for treating hypertension, and particularly relates to an anti-hypertensive preparation. The anti-hypertensive preparation comprises 0.5-5 mg of amlodipine and 5-100 mg of irbesartan. In order to solve the problem that at present, when either amlodipine or irbesartan is clinically used, the drug dose is increased to guarantee the curative effect, and accordingly, side effects are remarkably increased, the invention provides a novel compound preparation in which amlodipine and irbesartan are used together to take a collaborative and complementary curative effect. Therefore, the tolerance of a patient is increased, the compliance is improved, the dosage is reduced to further reduce adverse reaction, and the anti-hypertensive preparation is convenient to take and low in price.

The invention discloses a compound preparation for treating hypertension, which comprises 1-10mg of felodipine and 10-100mg of telmisartan. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the felodipine and the telmisartan are clinically used at present and one medicament is singly used, and provides a new compound preparation. The felodipine and the telmisartan are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.

The invention discloses a compound preparation containing benidipine hydrochloride and valsartan and an application thereof, wherein benidipine hydrochloride and valsartan are used as effective medicinal components of the preparation. Prepared by combination of drugs, the compound preparation for reducing pressure has good curative effects, less side effect and high cost performance, is taken once a day, is convenient to take, and can be used to raise drug compliance of patients. The preparation provided by the invention can be made into different oral dosage forms. Due to synergy and complementation of drugs, the treatment effect of the compound preparation is enhanced. The preparation provided by the invention has an obvious effect of treating hypertension and also can be applied to treat angina pectoris and protect kidney function. The preparation can be routinely used for patients with hypertension, myocardial infarction, heart failure, proteinuria, diabetes and the like, and is especially suitable for patients who are not tolerant to ACE inhibitor. The preparation is cheap, is simple to prepare, and is convenient for popularization and application.

The invention discloses a compound antihypertensive drug tablet. The compound antihypertensive drug tablet is prepared from the following components amlodipine or a pharmaceutical salt of the amlodipine, amiloride or an inorganic acid salt or an organic acid salt of the amiloride and hydrochlorothiazide or an inorganic acid salt or an organic acid salt of the hydrochlorothiazide. According to thecompound antihypertensive drug tablet, the dosage of a single drug is reduced, the number of drugs actually taken by patients is further reduced, and thus the side effects of the drugs are reduced, and the compliance of the patients to take the drugs is increased.

The invention discloses a compound preparation for treating hypertension, which comprises 10-100mg of metoprolol and 5-50mg of hydrochlorothiazide. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the metoprolol and the hydrochlorothiazide are clinically used at present and one medicament is singly used, and provides a new compound preparation. The metoprolol and the hydrochlorothiazide are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.

The invention discloses a novel compound antihypertensive preparation which comprises 50-200mg of irbesartan and 5-30mg of fosinopril. Aiming at solving the problem that currently when only one of irbesartan and fosinopril is used clinically, in order to ensure the curative effect, the dosage of the drug is increased, which leads to obvious increase of the side effects, the invention provides a novel compound preparation. Irbesartan and fosinopril are used together, so synergic and complementary curative effect can be produced. The novel compound antihypertensive preparation enhances the tolerance of the patient, improves the compliance and reduces the dosage and the adverse reaction, and is convenient to take and cheap in price.

The invention discloses strawberry drink with a pressure reducing function. The strawberry drink is prepared from concentrated strawberry juice, purple perilla seeds, flax seeds, alfalfa and other components through processing. The processing method comprises the following steps: (1) preparing the concentrated juice, namely, pulping strawberry; adding water; heating; and ultrasonically oscillating; (2) extracting with ethyl alcohol, namely, crushing purple perilla seeds, flax seeds and alfalfa; then soaking into 70% ethyl alcohol in a pressure increase manner; digesting with medium fire; and washing twice with absolute ethyl alcohol; (3) extracting germ, namely, soaking wheat in water; accelerating germination at normal temperature; soaking with table water; then moving out and pulping; adding water; and stirring at high speed; (4) extracting liquid, crushing hawthorn, lycium barbarum, folium ginkgo and broad bean flower; then adding water and sodium chloride; and correspondingly ionizing and performing protease hydrolyzing; and (5) mixing, namely, mixing the concentrated strawberry juice, the alcohol-extracted powder, the wheat germ extractive and the extracting solution; adding pectinase; stirring at high speed; sterilizing; and then canning to obtain the pressure-reduction drink.