Method for preparing novel compound anti-hypertension preparation

A compound preparation and high blood pressure technology, applied in the field of medicine, can solve the problems of inaccurate clinical drug dosage, influence drug efficacy, increase side effects, etc., and achieve the effects of improving antihypertensive efficacy, reducing adverse reactions, and neutralizing adverse reactions.

Inactive Publication Date: 2015-07-08
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The product of the present invention overcomes that when benidipine and hydrochlorothiazide are used clinically, the dosage of the drug is increased to ensure the curative effect when the drug is used alone, resulting in a significant increase in side effects; Inaccurate dosage of clinical medication, defects affecting drug efficacy

Method used

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  • Method for preparing novel compound anti-hypertension preparation
  • Method for preparing novel compound anti-hypertension preparation
  • Method for preparing novel compound anti-hypertension preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A compound preparation containing the following components:

[0032]

[0033] This embodiment can be made into compound benidipine-hydrochlorothiazide tablets, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

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PUM

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Abstract

The invention discloses a compound preparation for treating hypertension. The compound preparation comprises 1-10 mg of benidipine and 5-50 mg of hydrochlorothiazide. The novel compound preparation provided by the invention solves the problem that when benidipine and hydrochlorothiazide are clinically used at present, side effects are obviously increased by increase of drug dose since only one of benidipine and hydrochlorothiazide is put into use. According to the novel compound preparation, benidipine and hydrochlorothiazide are used together to achieve synergetic and complementary curative effects; and the novel compound preparation increases the tolerance of patients, improves the compliance, is reduced in dose to relieve adverse reaction, and is convenient to take and low in price.

Description

technical field [0001] The invention relates to the technical field of medicine, and discloses a preparation method of a new compound antihypertensive preparation. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. my country currently has about 100 million hypertensive patients. According to the epidemiological survey in 1991, the awareness rate of hypertension in my country's urban and rural areas was 36% and 13%, and the treatment rate was 17% and 5%, respectively. The form of hypertension prevention and treatment is quite severe. According to the forecast of WTO, by 2020, non-communicable diseases will account for 79% of the causes of death in my country, among which cardiovascular diseases will take the first place. [0003] Commonly used antihypertensive drugs include the angiotensin receptor antagonist irbesartan and the angiotensin converting enzyme inhibitor fosinopril. [0004] Benidi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61P9/12A61K31/4545
Inventor 高瑞银魏福荣陈进刘云峰
Owner JIANGSU JIBEIER PHARMA
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