33results about How to "Suitable for long-term use" patented technology

This utility model relates to the field of radar drone technology, specifically a multi-directional adjustable three-dimensional lidar drone bracket. The utility model provides such a bracket, including a support plate, a limiting plate, a base plate, adjusting rods, a top plate, an electric slide rail, and an electric slider. Limiting plates are slidably connected to the left and right sides of the bottom of the support plate. Adjusting rods are rotatably connected inside each limiting plate, and the base plate is threaded onto each of the two adjusting rods. The base plate is slidably connected to the limiting plates. The top plate is fixedly connected to the top of the support plate, and an electric slide rail is fixedly connected to the top of the top plate. An electric slider is slidably connected to the electric slide rail. This utility model achieves height adjustment through the threaded connection between the adjusting rods and the base plate, improving installation adaptability; simultaneously, the electric slide rail and electric slider achieve precise horizontal positioning, adapting to different application scenarios and showing good application prospects.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The invention discloses a muscle anti-aging composition with spermidine combined with a wolfberry aqueous extract and application of the muscle anti-aging composition, and belongs to the technical field of application of bioactive substances. The composition is prepared by compounding spermidine and a Chinese wolfberry aqueous extract according to a specific ratio, and the Chinese wolfberry aqueous extract is prepared by an optimized aqueous extraction process, so that core active ingredients are reserved to a greater extent. The optimal mass ratio of spermidine to the wolfberry aqueous extract is 1: 2. Through a synergistic effect mechanism, the antioxidant capacity of senescent muscle cells is remarkably improved, and the muscle cell oxidative stress and senescence process induced by D-galactose is effectively inhibited. The composition is simple in preparation process and safe in components, can be widely applied to the fields of food, health care products and medicines, and provides a new solution for developing efficient and natural muscle anti-aging products.

The application discloses prednisolone sodium phosphate oral solution and a normal-temperature preparation method thereof. The oral solution contains the following components per 1000ml: prednisolone sodium phosphate (calculated as prednisolone) 5.0g, maltitol 250-450g, sodium benzoate 1.0-3.0g, disodium edetate 0.5-2.0g, disodium hydrogen phosphate 2.0-8.0g, sodium dihydrogen phosphate 1.0-5.0g, essence 1.0-5.0g, and purified water is added to reach a constant volume, and the pH value is 7.0-8.0. The chemical stability of the preparation is significantly improved through the synergistic stabilizing effect of disodium edetate and phosphate buffer pair; the taste is significantly improved, and the drug compliance of children is improved through the optimization of maltitol as a child-friendly sweetener and the synergistic taste masking of essence; the destruction of active ingredients by high temperature is avoided, and the production process is simplified through the adoption of sodium benzoate and the normal-temperature preparation process. The preparation process is simple, the quality is stable, and the preparation is suitable for industrial production.

The invention provides a plant-derived active polypeptide and application thereof in prevention or treatment of Parkinson's syndrome, and belongs to the technical field of polypeptide bioengineering. The amino acid sequence of the active polypeptide is MKGASSIMYALG, and the active polypeptide is prepared from Fuding white tea raw materials through a directional two-step enzymolysis process. According to the polypeptide, the damage of 6-OHDA induced BZ555 nematode dopaminergic neurons can be remarkably reduced, and the dyskinesia of Parkinson's syndrome model animals can be remarkably improved; meanwhile, the expression level of proinflammatory factors such as IL-1beta and IL-18 in serum of a model mouse can be lowered, the content of dopamine in a nigra area of brain tissue of the model mouse can be increased, and the activity of monoamine oxidase B can be reduced. The results show that the Fuding white tea-derived active polypeptide has exact prevention and treatment effects on Parkinson's syndrome, and has important development value and wide application prospects in the field of medicines.

The invention discloses a traditional Chinese medicine composition for treating hypertension and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating hypertension is prepared from dracocephalum moldavica, leontopodium leontopodum, uncaria, corn stigma and Chinese dates. The traditional Chinese medicine composition is simple in medicine flavor, clear in medicine effect and capable of relaxing blood vessels and effectively reducing the blood pressure value of hypertensive rats, and all the medicines act together to promote hypertension treatment. The composition disclosed by the invention takes effect quickly and has an exact effect when being used for treating hypertension, and has a good clinical application prospect.

The invention relates to the technical field of microorganisms and biological medicines, in particular to triple probiotics as well as a preparation method and application thereof, and the triple probiotics comprise at least one probiotic of bacillus, lactobacillus acidophilus and bifidobacterium longum. The triple probiotics provided by the invention form an'oxygen consumption-enzyme production-acid production 'synergistic chain, and through synergistic degradation of uric acid, inhibition of excessive growth of conditioned pathogens and enhancement of intestinal barrier functions, the blood uric acid level of patients with asymptomatic hyperuricemia is reduced, the alpha-diversity of intestinal tracts is improved, the abundance of butyric acid producing bacteria is improved, and the content of the butyric acid producing bacteria is improved. The ratio of escherichia coli to shigella is reduced; sIBO is effectively relieved or reversed, and digestive tract symptoms such as abdominal distension and exhaust are reduced. In addition, the triple probiotics avoid liver and kidney toxicity caused by chemical drugs, and are suitable for long-term administration.

The invention belongs to the field of medicine, and provides a spray for treating rhinitis and a preparation method thereof, the spray comprises the following raw materials by weight: 5-20 parts of dahurian angelica root, 20-40 parts of Ligusticum wallichii, 10-20 parts of sea-buckthorn, 10-30 parts of Chinese angelica, 10-20 parts of cinnamon, 10-30 parts of wrinkled gianthyssop herb, 10-20 parts of cocklebur fruit, 10-20 parts of magnolia flower, 20-30 parts of chrysanthemum, 5-12 parts of mint, 6-15 parts of purple perilla and 5-20 parts of notopterygium root. When the spray is prepared, the raw materials are fully extracted according to the characteristics of the raw materials, so that effective components in the raw materials are extracted to the maximum extent, the drug effect of the product is improved, the nasal mucosa of a patient can be protected from drug stimulation by adding the nasal mucosa protective agent into the spray, and meanwhile, the effect is good. By controlling the range of the pH value of the spray in the preparation process of the spray, the stability and activity of the medicine can be maintained, meanwhile, stimulation and damage to nasal mucosa are reduced, and the safety and curative effect of the product are improved.

The invention discloses a traditional Chinese medicine formula for softening hyperplasia scars and a preparation method thereof. The formula is composed of manis pentadactyla, salvia miltiorrhiza, safflower, leech, peach kernel, ligusticum wallichii, pseudo-ginseng, frankincense, myrrh, curcuma zedoary, rhizoma sparganii, golden head centipede, lucid ganoderma, quick lime, white mulberry root-bark, cocklebur fruit, wahlenbergia marginata, malva verticillata, sedum sarmentosum, mazus japonicus, selfheal, mature vinegar, alcohol and other medicinal materials. Through accurate proportioning and scientific preparation, the formula can effectively soften hyperplastic scars and promote repair and regeneration of skin tissues, and has the characteristics of mildness, no irritation and no obvious side effects. The preparation method comprises the steps of raw material preparation, material mixing, forming, preparation and the like. The traditional Chinese medicine composition has remarkable superiority in the aspects of softening scars, relieving pruritus and improving skin texture, is suitable for repairing various types of scars after operation, burn and the like, and has a wide application prospect.

This invention relates to the field of traditional Chinese medicine (TCM) composition technology. It discloses a TCM formula for treating gout using a warming and dampness-eliminating approach. The TCM composition is made from the following raw materials: kudzu root, yam, cinnamon twig, dioscorea hypoglauca, corydalis rhizome, poria cocos, atractylodes macrocephala, cistanche deserticola, morinda officinalis, and licorice root. Cistanche deserticola and morinda officinalis are the principal herbs to warm and tonify kidney yang, while poria cocos and atractylodes macrocephala are the assistant herbs to strengthen the spleen and eliminate dampness. This warming and dampness-eliminating TCM formula for gout breaks through the limitations of traditional heat-clearing and dampness-eliminating methods, focusing on the pathogenesis of spleen and kidney yang deficiency and internal dampness, treating both the root cause and symptoms, and significantly reducing the recurrence of gout attacks. The entire formula is warming without being drying, does not harm spleen and kidney yang, has high safety, and is suitable for long-term use. The formula is carefully formulated, quickly relieving pain and lowering uric acid, while improving yang deficiency symptoms, with side effects far lower than Western medicine. It has various dosage forms, simple processing, and is easy to produce and promote, providing a safe and effective new solution for gout treatment.

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses a retroauricular administration type sleep-promoting traditional Chinese medicine compound composition and a preparation method thereof. The retroauricular administration type sleep-promoting traditional Chinese medicine compound composition is prepared from pericarpium citri reticulatae, fingered citron, agastache rugosus, liquorice, lily, fried spina date seed, processed polygala tenuifolia, schisandra chinensis, poria with hostwood, platycladi seed, acanthopanax, cortex albiziae, rhizoma acori graminei, rhizoma anemarrhenae, albizia flower and pseudo-ginseng according to a specific mass ratio. According to the preparation method disclosed by the invention, the dissolution rate and the transdermal absorption efficiency of active ingredients in the medicinal materials are remarkably improved by carrying out cell wall breaking pretreatment on the prepared polygala tenuifolia and / or the schisandra chinensis, including modes of enzymolysis, bacterium-enzyme synergistic fermentation and plasma-assisted wall breaking. According to the preparation method, an ethanol-water mixed solution is used for extraction and centrifugal separation, and a medicine extracting solution is obtained. The composition can quickly and efficiently play a role in promoting sleep in a retroauricular administration manner, and has the comprehensive effects of soothing the nerves, stabilizing the mind, soothing the liver, relieving depression and promoting the circulation of heart and kidney.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for treating rosacea, its preparation method, and its application. This invention provides a traditional Chinese medicine composition for treating rosacea, comprising dandelion, purslane, sophora flavescens, sophora japonica flower, and rhubarb. The traditional Chinese medicine composition of this invention has the effects of clearing heat and detoxifying, reducing inflammation and antibacterial properties, cooling blood and promoting blood circulation, and repairing the skin barrier. It can be used to treat erythematous rosacea, relieving erythema, telangiectasia, papules, itching, and burning sensation on the skin, and reducing the risk of recurrence.

The invention belongs to the technical field of daily cosmetics, and particularly relates to an anti-hair loss composition containing a curcuma zedoary extract as well as a preparation method and application of the anti-hair loss composition. The anti-hair loss composition comprises a curcuma zedoary extract, a minoxidil analogue and a tea extract, the mass ratio of the curcuma zedoary extract to the minoxidil analogue to the tea extract is 1: (0.2-5): (0.01-1). According to the anti-hair loss composition containing the curcuma zedoary extract, only three main raw materials are compounded and supplement each other to achieve an obvious synergistic effect, the obvious anti-hair loss and hair growth effects are finally achieved, meanwhile, the anti-hair loss composition has the advantages of being mild, suitable for being used for a long time and capable of rapidly taking effect, the scalp environment can be improved, and the hair loss is reduced. Therefore, the hair conditioner has important application potential in the aspects of hair loss prevention and hair growth.

This invention belongs to the field of biomedical technology and relates to an ultrasound-responsive microneedle for acne treatment, specifically a PVDF / curcumin hyaluronic acid microneedle for ultrasound-responsive acne treatment and its preparation method. It is prepared by mixing sodium hyaluronate, PVDF, and curcumin. The PVDF in the microneedle triggers the targeted release of curcumin under ultrasound stimulation, increasing the drug concentration at the lesion site; the antibacterial and anti-inflammatory effects of curcumin synergistically enhance the therapeutic effect of acne treatment with the repair function of hyaluronic acid; the hyaluronic acid matrix reduces skin irritation, making it suitable for long-term use; the preparation process is simple, reproducible, and easy to scale up.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for adjuvant treatment of gradual freezing, which comprises a prescription I used in winter and a prescription II used in summer. According to the prescription disclosed by the invention, through elaborately blended herbal medicine components and reasonable decocting and taking methods, various types of gradual freezing diseases can be effectively treated in an auxiliary manner. Meanwhile, due to the composition of the natural herbal medicines, the treatment method is safer and milder, is suitable for long-term administration, and is a method for treating the gradual freezing disease, which is worthy of popularization and application.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a Qi-invigorating and blood-activating granule for heart pain and its preparation method, comprising the following raw materials in parts by weight: 25-35 parts of raw Astragalus membranaceus, 10-20 parts of Angelica sinensis, 5-15 parts of ginseng, 4-8 parts of Panax notoginseng, 10-20 parts of Ligusticum chuanxiong, 8-12 parts of earthworm, and 2-4 parts of leech. This invention precisely targets the core pathogenesis of Qi deficiency and blood stasis syndrome, which is "Qi deficiency as the root and blood stasis as the manifestation," selecting raw Astragalus membranaceus and ginseng as the core Qi-invigorating components, and Panax notoginseng, leech, Ligusticum chuanxiong, Angelica sinensis, and earthworm as the core blood-activating components. The formulation follows the traditional Chinese medicine principle of "invigorating Qi to promote blood circulation without harming the body's vital energy." The dosage of each raw material has been optimized through systematic experiments to form a specific range of parts by weight, solving the technical problems of poor targeting and insufficient synergy in existing formulations.

The invention discloses a composition for preventing and treating acnes and application thereof, and the composition for preventing and treating acnes comprises the following components in parts by mass: 6-12 parts of a peach leaf-eucommia ulmoides compound extract, 1-3 parts of vitamin E, 8-15 parts of aloe vera gel and 70-85 parts of hydrogen-rich water. The peach leaf-eucommia ulmoides compound extract, the vitamin E, the aloe vera gel and the hydrogen-rich water are compounded, all the components supplement one another, the functions of resisting oxidation, resisting inflammation, preserving moisture and the like are comprehensively exerted, acne can be effectively prevented and treated, skin healing and repairing can be promoted, and the skin care effect is good. Different components form a multi-layer synergistic effect by inhibiting bacteria, reducing inflammation, protecting skin cells and enhancing a skin barrier function.

The invention provides a medicinal and edible composition with gastrointestinal regeneration and a preparation method thereof, and relates to the field. The medicinal and edible composition capable of regenerating intestines and stomach comprises the following raw materials: 10-30 parts of cordyceps sobolifera, 10-30 parts of Chinese yam, 10-25 parts of hericium erinaceus, 8-20 parts of poria cocos, 8-18 parts of gordon euryale seed, 5-15 parts of Chinese date, 5-15 parts of lotus seed, 5-12 parts of sea-buckthorn, 3-10 parts of hawthorn, 10-30 parts of honey, 5-10 parts of American ginseng extract, 3-6 parts of wolfberry extract, 2-4 parts of astragalus extract and 1-3 parts of xylooligosaccharide. Through the scientific and reasonable raw material ratio, the synergistic interaction effect of all the components is exerted, gastrointestinal mucosa repair and tissue regeneration are promoted, the gastrointestinal digestion and absorption functions are improved, and the gastrointestinal immunity is enhanced; the invention also provides a preparation method of the composition, so that the product quality is stable, and the effective components are fully reserved.

The present application relates to the technical field of traditional Chinese medicine extraction, and discloses a water chestnut peel extract and application thereof in preparation of a medicine for treating chloasma; during preparation of the extract, low-temperature extraction is carried out by using an acid-alcohol mixed solvent, and enrichment is carried out by using macroporous resin purification, so that the water chestnut peel extract with high purity of active ingredients and complete retention can be prepared, the utilization rate of active ingredients in the water chestnut peel is effectively improved, and resource waste is reduced. The water chestnut peel extract provided by the present application can effectively inhibit tyrosinase activity, and shows excellent treatment potential for chloasma, a pigment deposition disease, thereby providing a solution to the current situation that chloasma is difficult to treat.

The application relates to the field of ethylene cracking, and discloses an alloy furnace tube and a treatment method and application thereof. The method comprises the following steps: (1) performing first heat treatment on the alloy furnace tube in the presence of a reducing atmosphere to obtain a pretreated alloy furnace tube; and (2) performing second heat treatment on the pretreated alloy furnace tube in the presence of a low-oxygen partial pressure atmosphere to obtain an alloy furnace tube with an oxidation film on the inner surface; wherein the content of oxygen in the reducing atmosphere is 0 ppm; and the dew point of the low-oxygen partial pressure atmosphere is-40 DEG C to 40 DEG C. By performing heat treatment on the alloy furnace tube in the presence of the reducing atmosphere and the low-oxygen partial pressure atmosphere, a dense and stable oxidation film can be formed on the inner surface of the furnace tube, catalytic coking is inhibited or slowed down, the degree of carburization of the furnace tube is reduced, and the service life of the furnace tube is prolonged. The cracking furnace tube provided by the application for a hydrocarbon cracking device can adapt to various hydrocarbon raw materials, and the operation cycle of the cracking furnace is significantly prolonged compared with the prior art.

The invention belongs to the technical field of cosmetics and skin external preparations, and discloses antioxidant brightening essence of a dual-molecular-weight PDRN composition and a preparation method of the antioxidant brightening essence. The antioxidant brightening essence of the dual-molecular-weight PDRN composition comprises a first poly (deoxyribonucleotide) component of which the average molecular weight is enriched in a range of 50-200kDa and a second poly (deoxyribonucleotide) component of which the average molecular weight is enriched in a range of 600-1000kDa, the weight ratio of the first poly-deoxyribonucleotide component to the second poly-deoxyribonucleotide component is 1: (1-10); through scientific compounding of double-molecular-weight PDRN, perfect combination of instant anti-oxidation brightening and long-acting repair anti-wrinkle is realized, and the efficacy coverage is comprehensive.

This invention provides a plant-derived bioactive polypeptide and its use in the prevention or treatment of Parkinson's syndrome, belonging to the field of polypeptide bioengineering technology. The amino acid sequence of the bioactive polypeptide is MKGASSIMYALG, and it is prepared from Fuding white tea raw materials through a directed two-step enzymatic hydrolysis process. This polypeptide can significantly alleviate 6-OHDA-induced damage to dopaminergic neurons in BZ555 nematodes and significantly improve motor dysfunction in Parkinson's syndrome model animals. Simultaneously, it can downregulate the expression levels of pro-inflammatory factors such as IL-1β and IL-18 in the serum of model mice, upregulate dopamine content in the substantia nigra region of brain tissue in model rats, and reduce monoamine oxidase B activity. These results indicate that the Fuding white tea-derived bioactive polypeptide of this invention has definite preventive and therapeutic effects on Parkinson's syndrome, and has significant development value and broad application prospects in the pharmaceutical field.

This invention provides a bactericidal and disinfectant gel and its preparation method, composed of plant-based active ingredients and excipients. The plant-based active ingredients consist of alkaloids, flavonoids, polyphenols, and polysaccharides. This invention, through the scientific formulation of flavonoids, alkaloids, polyphenols, and polysaccharides, not only achieves highly effective killing of common pathogens causing fungal skin diseases, but also possesses anti-inflammatory, antioxidant, and tissue repair-promoting functions, solving the technical problem of limited efficacy in existing fungal skin disease products.

The invention provides a transdermal composition with whitening and freckle removing effects and a preparation method thereof, and belongs to the technical field of cosmetics. The transdermal composition comprises whitening and freckle-removing functional components. The whitening and freckle-removing functional components comprise nicotinamide, arbutin, glycerol and water, and further comprise a plant extract and a fermentation extract. The plant extract comprises a silybum marianum extract, a sarcandra glabra extract and a radix paeoniae rubra extract. The fermentation extract is obtained by fermenting a soybean seed coat extract, a sargassum pallidum extract and a red bean extract through a compound fermentation inoculant. And the compound fermentation inoculant comprises bacillus alvei, lactobacillus rhamnosus and streptomyces olivaceus. The transdermal composition prepared by the invention not only has good whitening and freckle-removing effects and transdermal property, but also can keep the appearance state when the external temperature changes.

The invention discloses application of silkworm chrysalis in preparation of medicines and foods for preventing and treating complications of apnea syndrome, and belongs to the technical field of biological medicines. The medicine or food composition provided by the invention can effectively relieve various complication symptoms caused by diseases, including muscle strength decline, vascular dysfunction such as abnormal increase of endothelin (ET-1) level, lung injury manifestations such as lung function decline, lung edema, alveolar wall thickening or fracture, and eye injury such as retinal layer arrangement looseness. In addition, the composition also has the advantages of wide raw material source and low cost, has good safety when being used as a food or pharmaceutical composition, and is suitable for long-term use.

The invention relates to the technical field of anti-hair-loss shampoo, and discloses anti-hair-loss and anti-dandruff shampoo and a preparation method thereof.The anti-hair-loss and anti-dandruff shampoo is prepared from, by weight, 3%-10% of anti-hair-loss agents, 15%-30% of surfactants, 2%-8% of anti-dandruff agents, 5%-15% of humectants, 2%-6% of conditioners, 0.5%-2% of thickening agents, 0.1%-0.5% of preservatives, 0.1%-0.3% of essence and the balance water. The whole formula adopts various mild components, has no irritation to scalp and hair, and is suitable for long-term use. The preparation method disclosed by the invention is reasonable in process, the raw materials can be ensured to be fully and uniformly mixed and play the best effect, the produced shampoo is good in stability and not easy to layer and deteriorate in the storage and use processes, an efficient, safe and stable anti-hair-loss and anti-dandruff shampoo solution is provided for consumers, and the anti-hair-loss and anti-dandruff shampoo is worthy of popularization and application. Wide market application prospects and good social benefits are realized.

The utility model relates to the technical field of stinky bean curd, concretely to a stinky bean curd washing equipment, including base, the base lower surface fixed mounting has antiskid block, the antiskid block is four, connect device and factory power supply, the motor is the product on sale after starting through control switch, the output end drives fixed link rotation, fixed link slides in the rectangular groove of telescopic cylinder, simultaneously drives telescopic cylinder synchronous rotation, the convex axle of telescopic cylinder side slides in the annular inclined slide groove of fixed cylinder inner wall, is guided under the action of slide groove inclination angle, telescopic cylinder does up and down reciprocating motion along fixed cylinder inner wall in the rotation process, the synchronous movement of telescopic cylinder is driven support and wash frame through telescopic link, makes stinky bean curd in wash frame in the water in the basin continuously up and down and rotates and overturns, the water flow passes through the metal grating outside wash frame and goes in and out, washes the surface of stinky bean curd, realizes the washing purpose of removing impurity, and the sewage after washing can be discharged through the water outlet pipe.

The present application relates to a kind of medicine food for treating acne, preparation method, composition and application, medicine food is by sweet almond, Chinese yam, wax gourd seed, lily, fuzilong, jasmine, lotus seed, prepared wumei flesh, safflower, cypress seed, sweet leaf chrysanthemum and prepared yuzi, which are safe medicine of food and medicine composition;Preparation method is to be ground into fine powder, stir-fried, mixed to obtain;Composition includes medicine food for treating acne and peroxide benzoyl;The above medicine food is applied to the preparation of medicine food for treating acne;The medicine food for treating acne of the present application is more explicit than the curative effect of traditional Chinese medicine, more suitable in taste, more harmonious in nature and taste, convenient to serve, more suitable for long-term use.

This invention belongs to the field of energy carbohydrates and nutrition, and special medical foods. Specifically, it relates to a functional hydrolyzed starch, its preparation method, and its applications. This invention provides an application of functional hydrolyzed starch in intestinal mucosal barrier protection and as an adjunct intervention for inflammatory bowel disease (IBD) / chemoradiotherapy-induced intestinal mucosal inflammation. This hydrolyzed starch exhibits significant biological effects by regulating multiple key targets, including but not limited to upregulating the expression of genes such as ADORA2A. The starch hydrolysate of this invention improves energy supply to the intestinal epithelium and inhibits oxidation and inflammatory responses, thereby providing potential adjunctive protection against inflammatory bowel disease (IBD) and chemoradiotherapy-induced intestinal mucosal inflammation.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine composition for treating diabetic nephropathy and application thereof. The traditional Chinese medicine composition is prepared from the following ten medicinal materials according to a specific ratio: radix rehmanniae recen, astragalus membranaceus, golden cypress, coptis chinensis, gastrodia elata, cicada slough, salvia miltiorrhiza, chinaroot greenbrier, rosa laevigata michx and motherwort. Systematic animal experiments and clinical researches prove that the Zuogui blood-glucose-reducing kidney-pleasing formula can effectively reduce fasting blood-glucose of diabetic nephropathy model mice, improve lipid metabolism disorder, remarkably reduce the levels of urea nitrogen, creatinine and uric acid and the ratio of urine protein to creatinine, and can be used for treating diabetic nephropathy by inhibiting expression of fibrosis-related factors such as TGF-beta and alpha-SMA. The renal fibrosis process is delayed. Compared with the prior art, the pharmaceutical composition provided by the invention has remarkable advantages in the aspects of improving renal functions, inhibiting renal tissue fibrosis and delaying the development of diabetic nephropathy.