8results about How to "Good hypoglycemic effect" patented technology

This invention discloses a meglumine-luteolin complex, its preparation method, and its applications, belonging to the interdisciplinary field of microbiome and drug delivery. Using luteolin as the main material, this invention employs a dual inclusion technique with hydroxypropyl-β-cyclodextrin and meglumine to synergistically prepare a meglumine-luteolin complex with colon-targeted delivery capabilities. This invention significantly improves the delivery efficiency and drug loading of luteolin in the colon through the dual inclusion technique. The preparation process is simple, and it exhibits excellent hypoglycemic effects and colon-targeted release characteristics in the treatment of diabetes and its complications.

This invention discloses an octapeptide derived from soybean protein with the function of lowering blood pressure, blood sugar, and cholesterol, as well as its preparation and application, belonging to the field of small molecule peptide technology. The octapeptide sequence is YEGNWGPL, which can be obtained artificially or by targeted enzymatic hydrolysis of soybean protein isolate. Functional verification in a hyperlipidemia model shows that the octapeptide YEGNWGPL has the function of lowering blood lipids; functional verification in a hyperglycemia model shows that the octapeptide YEGNWGPL has the function of lowering blood sugar, with a significantly better effect than the drug metformin; functional verification in a hypertension model shows that the octapeptide YEGNWGPL has the function of lowering blood pressure, with a significantly better effect than the antihypertensive drug captopril; moreover, food-derived bioactive peptides have high biosafety, therefore, they can be applied to the development of related products for lowering blood pressure, blood sugar, and cholesterol or assisting in lowering blood pressure, blood sugar, and cholesterol, with good market prospects and application potential.

The application discloses a neokotalanol derivative with a structural formula I and a preparation method and application thereof, designs a brand-new synthesis method, uses cheap and easily-obtained benzyl glucoside as raw material, successfully constructs a seven-ring glycoside intermediate with the same chiral center as the side chain of a natural product through five steps of reaction, uses the key seven-ring glycoside intermediate as raw material, and goes through a series of reactions to construct a coupling precursor with trifluoromethylsulfonyl as a leaving group, reacts with a benzyl-protected sulfur sugar, and goes through deprotection, reduction and other reactions to synthesize the neokotalanol and the derivative thereof, and the method completes the total synthesis of the neokotalanol and the synthesis of the derivative at a yield of 17%, which is 8.5 times of the highest yield reported.

This invention relates to an extraction method for enhancing the hypoglycemic activity of mulberry leaf peptides. Freshly harvested mulberry leaves are washed, crushed, and then water and alkaline protease are added for extraction. After extraction, the enzyme is inactivated to obtain the mulberry leaf peptide extract. The extract is then filtered through a plate and frame filter to obtain a clear liquid and a residue. The clear liquid is further fractionated using ultrafiltration and nanofiltration membranes to obtain components with different molecular weight ranges. These components are then concentrated, sterilized using filter cartridges, and spray-dried to obtain products with different molecular weight ranges. This invention utilizes a fractionation and purification technology in the mulberry leaf peptide extraction process, resulting in different grades of mulberry leaf peptide products suitable for various hypoglycemic cases and scenarios.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating upper digestion type diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 25 to 35 parts of herba eupatorii, 25 to 35 parts of radix codonopsis, 25 to 35 parts of radix rehmanniae recen, 25 to 35 parts of radix puerariae, 25 to 35 parts of radix trichosanthis, 20 to 30 parts of radix ophiopogonis, 15 to 25 parts of rhizoma coptidis, 15 to 25 parts of radix adenophorae, 15 to 25 parts of rhizoma anemarrhenae, 15 to 25 parts of rhizoma polygonati, 15 to 25 parts of poria with hostwood, 15 to 25 parts of corn stigma, 15 to 25 parts of folium mori, 5 to 15 parts of fructus schizandrae and 5 to 10 parts of liquorice root. The traditional Chinese medicine composition provided by the invention can be used for effectively treating the upper-digestion diabetes mellitus on the basis of the main pathogenesis of the upper-digestion diabetes mellitus according to medication experience and traditional Chinese medicine theories.

The invention provides a composition containing medicinal and edible astragalus polysaccharide and application of the composition in reducing blood sugar. The composition provided by the invention consists of astragalus polysaccharide, tremella polysaccharide, lycium barbarum polysaccharide and angelica polysaccharide. The mass ratio of the raw materials is (1-3): (1-3): (1-3): (1-3). The hypoglycemic effect of the plant polysaccharide and the composition thereof is proved through a hyperglycemia mouse model, it is shown that the four plant polysaccharides can reduce the blood sugar of mice, after the four plant polysaccharides are compounded, the obvious synergistic interaction effect is shown, and the effect is obviously better than that of other schemes that every two plant polysaccharides are combined or combined in a stacked mode. Clinical medical manifestations of polydipsia, polyphagia, diuresis and weight loss of diabetes mellitus are slowed down and improved after polysaccharide combination treatment, a positive effect on reduction of hyperglycemia is achieved, the adopted plant polysaccharide is safe and non-toxic, blood sugar can be effectively reduced, and the diabetes mellitus health-care product has a good health-care effect on diabetes mellitus. The traditional Chinese medicine composition can also prevent acute complications caused by hyperglycemia, such as diabetic ketoacidosis, hyperglycemia syndrome and the like.

The invention discloses a 2, 3-substituted physalis alkekengi sugar ester compound as well as a preparation method and application thereof. The compound has a structural general formula as shown in a formula (1), in the formula (1), R1 and R2 are-CH3 or-(CH2) XCH3, and X is 1-7. The preparation method comprises the following steps: with calyx seu fructus physalis as a raw material, carrying out ethanol extraction, silica gel column chromatography and thin-layer chromatography separation, recrystallization and the like. In-vitro alpha-glucosidase inhibition experiments show that the compound has significant inhibition activity, the IC50 of the physalis alkekengi sugar ester A1 is 2.06 + / -0.03 mu g / mL, and the activity is superior to that of acarbose. In an STZ-induced diabetic mouse model, the physalis alkekengi glycoester A1 (30 mg / kg) can significantly reduce fasting blood-glucose to a near-normal level, and the effect is superior to that of a positive control. A series of specific compounds (physalis alkekengi sugar esters A1-A8) with the structural characteristics of the general formula (1) are separated and identified from the physalis alkekengi, and specific substances with the hypoglycemic efficacy of the physalis alkekengi are defined.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine composition for treating diabetic nephropathy and application thereof. The traditional Chinese medicine composition is prepared from the following ten medicinal materials according to a specific ratio: radix rehmanniae recen, astragalus membranaceus, golden cypress, coptis chinensis, gastrodia elata, cicada slough, salvia miltiorrhiza, chinaroot greenbrier, rosa laevigata michx and motherwort. Systematic animal experiments and clinical researches prove that the Zuogui blood-glucose-reducing kidney-pleasing formula can effectively reduce fasting blood-glucose of diabetic nephropathy model mice, improve lipid metabolism disorder, remarkably reduce the levels of urea nitrogen, creatinine and uric acid and the ratio of urine protein to creatinine, and can be used for treating diabetic nephropathy by inhibiting expression of fibrosis-related factors such as TGF-beta and alpha-SMA. The renal fibrosis process is delayed. Compared with the prior art, the pharmaceutical composition provided by the invention has remarkable advantages in the aspects of improving renal functions, inhibiting renal tissue fibrosis and delaying the development of diabetic nephropathy.