29results about How to "Good hypoglycemic effect" patented technology

The invention discloses an ACE (Angiotensin Converting Enzyme) inhibition and DPP-IV (Dipeptidyl Peptidase-IV) inhibition bifunctional peptide as well as a design method and application thereof. The amino acid sequence of the bifunctional peptide fragment is Trp-Ala-Leu-Val-Ala-Pro or Trp-Pro-Leu-Val-Ala-Pro. According to the design method, hydrophobic amino acid replacement is carried out on most N-terminal first amino acid according to the characteristics of the DPP-IV inhibitory peptide, and N-terminal second amino acid is kept as proline Pro or alanine Ala. The difunctional peptide fragment obtained through the DPP-IV inhibitory activity optimization strategy has the effects of assisting in lowering blood pressure and lowering blood sugar at the same time and can be used for preparing functional food or health food with the functions of assisting in lowering blood pressure and lowering blood sugar, and the optimization strategy can be applied to improving the blood sugar lowering effect of the peptide fragment and has good market application prospects.

The invention discloses a preparation method of magnesium acetyltaurate and application of the magnesium acetyltaurate in preparation of hypoglycemic drugs or health care products, research finds that magnesium acetyltaurate has an obvious hypoglycemic effect, and results of repeated verification of mouse sugar tolerance animal experiments of single-time administration and multiple-time administration of magnesium acetyltaurate prove that the magnesium acetyltaurate has the obvious hypoglycemic effect. The magnesium acetyltaurate can reduce the blood sugar level of the mouse, basically has no influence on the weight of the mouse, can be used as a medicine for reducing the blood sugar, and has good development and application prospects. The preparation method disclosed by the invention is simple to operate and low in cost, and large-scale preparation of magnesium acetyltaurate can be realized.

The invention provides a formula for regulating hyperglycemia by probiotics and a preparation method of the formula, and relates to the technical field of the probiotics, the formula comprises two formulas, the formula I comprises the probiotics, hypoglycemic pepper, raw malt, burdock, snow pear and the like, and the formula II comprises the probiotics, the hypoglycemic pepper, the raw malt, the burdock, the snow pear and the like; and the formula II consists of inonotuso bliquus polysaccharide, schizophyllum commune, chromium yeast, soybean peptide powder and lactobacillus fermentation product powder. The two formulas can be taken independently, alternately or jointly, and are used for regulating the blood sugar level of patients with hyperglycemia or type 2 diabetes mellitus. The probiotic powder contains a plurality of strains with high activity and high viable count, and plays a role in digesting and absorbing basic metabolism. The natural components in the formula have a hypoglycemic effect, and play a role in improving the secretion function of pancreas islet beta cells, improving insulin sensitivity, delaying absorption of carbohydrates, helping produce saliva and slake thirst, diluting blood sugar and other mechanisms.

The invention discloses a brewing method of flavor vinegar, and relates to the technical field of table vinegar, the brewing method comprises the steps of crushing, size mixing, gelatinization, stirring of fermented grains, bilateral fermentation, aging of the fermented grains, smoking of the fermented grains, vinegar spraying, vinegar decocting, aging and the like, sorghum, tartary buckwheat and the like are adopted as raw materials, the taste and nutrition of the table vinegar are enriched, corn stigma is mixed with water for water extraction, cooking and gelatinization are performed, and then stirring of the fermented grains is performed. Alcohol extraction is carried out by virtue of alcohol fermentation of other raw materials, after two times of extraction, the table vinegar is rich in phenolic and flavonoid compounds, the phenolic and flavonoid compounds do not influence the quality of the table vinegar, and meanwhile, more pharmacological effects can be added to the table vinegar.

This invention discloses a meglumine-luteolin complex, its preparation method, and its applications, belonging to the interdisciplinary field of microbiome and drug delivery. Using luteolin as the main material, this invention employs a dual inclusion technique with hydroxypropyl-β-cyclodextrin and meglumine to synergistically prepare a meglumine-luteolin complex with colon-targeted delivery capabilities. This invention significantly improves the delivery efficiency and drug loading of luteolin in the colon through the dual inclusion technique. The preparation process is simple, and it exhibits excellent hypoglycemic effects and colon-targeted release characteristics in the treatment of diabetes and its complications.

This invention discloses an octapeptide derived from soybean protein with the function of lowering blood pressure, blood sugar, and cholesterol, as well as its preparation and application, belonging to the field of small molecule peptide technology. The octapeptide sequence is YEGNWGPL, which can be obtained artificially or by targeted enzymatic hydrolysis of soybean protein isolate. Functional verification in a hyperlipidemia model shows that the octapeptide YEGNWGPL has the function of lowering blood lipids; functional verification in a hyperglycemia model shows that the octapeptide YEGNWGPL has the function of lowering blood sugar, with a significantly better effect than the drug metformin; functional verification in a hypertension model shows that the octapeptide YEGNWGPL has the function of lowering blood pressure, with a significantly better effect than the antihypertensive drug captopril; moreover, food-derived bioactive peptides have high biosafety, therefore, they can be applied to the development of related products for lowering blood pressure, blood sugar, and cholesterol or assisting in lowering blood pressure, blood sugar, and cholesterol, with good market prospects and application potential.

The invention discloses a tartary buckwheat compound with a blood sugar reducing effect and a preparation method and application thereof, tartary buckwheat is used as a main raw material and is subjected to water extraction, and an amino acid surfactant is added in the water extraction process, so that the permeability of cell walls can be effectively improved; flavonoid compounds, polyphenol compounds and proteins in cells are effectively dissolved out, and the extraction rate of active ingredients in the tartary buckwheat is increased; then the leach liquor is fermented by compounding Witzia ciliaris and Aspergillus niger, so that the content of active ingredients in the leach liquor is increased, and the effect of reducing blood sugar is further improved; the tartary buckwheat residues are subjected to combined treatment by adopting shearing homogenization and enzymolysis, and are further treated by adopting carboxymethyl cellulose, so that the viscosity of dietary fiber components is increased, the diffusion movement of glucose and amylase is favorably bound, and the auxiliary blood sugar reducing effect of the tartary buckwheat residues is further improved.

The present invention discloses a preparation method and application of heptadecanoic acid with hypoglycemic effect, belonging to the field of biology and medicine. The present invention uses Grifola frondosa as a raw material, and obtains heptadecanoic acid by two-phase solvent extraction and silica gel column chromatography separation. The present invention has the advantages of simple method, high product purity and high yield. After testing, the purity of the heptadecanoic acid prepared by the present invention is greater than 95%, the yield is 3.25%, and its inhibitory ability (IC 50 value is 106.91 μg / mL) is stronger than acarbose (IC 50 value is 216.42 μg / mL), which can be used as a potential active ingredient for lowering blood sugar and is conducive to industrial application.

The application discloses a neokotalanol derivative with a structural formula I and a preparation method and application thereof, designs a brand-new synthesis method, uses cheap and easily-obtained benzyl glucoside as raw material, successfully constructs a seven-ring glycoside intermediate with the same chiral center as the side chain of a natural product through five steps of reaction, uses the key seven-ring glycoside intermediate as raw material, and goes through a series of reactions to construct a coupling precursor with trifluoromethylsulfonyl as a leaving group, reacts with a benzyl-protected sulfur sugar, and goes through deprotection, reduction and other reactions to synthesize the neokotalanol and the derivative thereof, and the method completes the total synthesis of the neokotalanol and the synthesis of the derivative at a yield of 17%, which is 8.5 times of the highest yield reported.

This invention relates to an extraction method for enhancing the hypoglycemic activity of mulberry leaf peptides. Freshly harvested mulberry leaves are washed, crushed, and then water and alkaline protease are added for extraction. After extraction, the enzyme is inactivated to obtain the mulberry leaf peptide extract. The extract is then filtered through a plate and frame filter to obtain a clear liquid and a residue. The clear liquid is further fractionated using ultrafiltration and nanofiltration membranes to obtain components with different molecular weight ranges. These components are then concentrated, sterilized using filter cartridges, and spray-dried to obtain products with different molecular weight ranges. This invention utilizes a fractionation and purification technology in the mulberry leaf peptide extraction process, resulting in different grades of mulberry leaf peptide products suitable for various hypoglycemic cases and scenarios.

The present invention relates to the field of food technology, and in particular to a health food that helps maintain healthy blood sugar levels and blood lipid levels and a preparation method thereof. The following components are included in weight: 30-90 parts of sheep skim milk powder, 0.1-7 parts of coffee extract, 0.5-19 parts of mulberry leaf extract, 0.1-7 parts of plant sterol esters, 0.1-15 parts of Gynostemma pentaphyllum extract, 2-30 parts of resistant dextrin, 0.01-1.8 parts of compound vitamins, 0.01-1.2 parts of vitamin C, 0.001-0.005 parts of chromium compounds, and 0.5-10 parts of theaflavins. The preparation method includes first mixing sheep skim milk powder and resistant dextrin with water, and then shearing the plant sterol esters and the dissolved chromium compounds to obtain an emulsion 1; then dissolving the compound vitamins and shearing and mixing them with the emulsion 1, adding water to the fixed volume, homogenizing, and drying to obtain dry powder; mixing the dry powder with coffee extract, mulberry leaf extract, Gynostemma pentaphyllum extract, theaflavins compounds and vitamin C. Continuous consumption of the health food prepared by the present invention helps maintain healthy blood sugar levels and healthy blood lipid levels, improves impaired glucose tolerance, and does not cause side effects such as liver and kidney damage.

The invention is applicable to the technical field of biology, and provides application of a Mup3 recombinant protein in treatment of type 2 diabetes mellitus, and the amino acid sequence of the Mup3 recombinant protein is shown as SEQ ID NO.1 in a sequence table; the Mup3 recombinant protein provided by the invention is small in side effect, and the mechanism of the Mup3 recombinant protein playing a role is to directly inhibit the gluconeogenesis gene and enhance the insulin sensitivity, so that the hypoglycemic effect is obvious. The compound can play a role in treatment of type 2 diabetes mellitus, and can be further applied to prevention and treatment of other related diseases by deep research on enhancement of an insulin signal channel.

The invention provides the hypoglycemic pharmaceutical composition of the compound A and / or the pharmaceutically acceptable salt thereof and the dapagliflozin and / or the pharmaceutically acceptable salt thereof with pharmaceutical prospects, and the pharmaceutical composition can reduce the risk of urinary tract infection of diabetic patients, is beneficial to improving the hypoglycemic effect, and reduces adverse drug reactions.

The invention relates to the technical field of medical biological materials, and discloses a hydrogel microneedle dressing as well as a preparation method and application thereof. The hydrogel microneedle dressing comprises a substrate and a hydrogel needle tip positioned on the substrate, the hydrogel needle tip is prepared from the following raw materials in parts by weight: 20 to 40 parts of oxidized hyaluronic acid, 20 to 40 parts of carboxymethyl chitosan, 2 to 16 parts of iron-loaded ZIF-8 nanoparticles, 1 to 2 parts of glucose oxidase and 402 to 457 parts of water. The preparation method comprises the following steps: carrying out Schiff base reaction on carboxymethyl chitosan and oxidized hyaluronic acid to prepare hydrogel; loading the iron-loaded ZIF-8 nanoparticles and glucose oxidase on the hydrogel to obtain a needle tip precursor solution; and preparing the hydrogel microneedle dressing from the needle tip precursor solution and the substrate precursor solution through a hydrogel microneedle dressing forming process. The hydrogel microneedle dressing is used for preparing medical skin wound dressing, and the antibacterial effect under response of the internal environment is achieved.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition and a preparation method and application thereof, in particular to a traditional Chinese medicine composition and a preparation method thereof and application in preparation of medicines for treating diabetes mellitus, especially diabetes mellitus complicated with metabolism-related fatty liver diseases. The traditional Chinese medicine composition is prepared from the following raw materials: 920 to 1200 parts of fructus crataegi, 240 to 400 parts of radix bupleuri, 580 to 700 parts of radix salviae miltiorrhizae, 240 to 400 parts of radix curcumae, 352 to 500 parts of semen cassiae, 240 to 400 parts of rhizoma pinellinae praeparata, 352 to 500 parts of rhizoma alismatis and 240 to 400 parts of pericarpium citri reticulatae. Furthermore, the mass ratio of hawthorn to radix bupleuri to salvia miltiorrhiza to radix curcumae to semen cassiae to rhizoma pinellinae praeparata to rhizoma alismatis to pericarpium citri reticulatae is (3-4): (1-2): (2-3): (1-2): (1-3): (1-2): (1-3): (1-2). The composition is prepared by the following steps: respectively removing impurities and dust from hawthorn, radix bupleuri, salvia miltiorrhiza, radix curcumae, semen cassiae, rhizoma pinellinae praeparata, rhizoma alismatis and pericarpium citri reticulatae, drying, respectively grinding, and mixing in proportion. The composition disclosed by the invention not only has an obvious effect of reducing blood sugar, but also has an effect of reducing blood fat, and is better for diabetes mellitus complicated with fatty liver.

The invention discloses a GLP-1 and PYY twin drug and a preparation method and application thereof, the structure of the GLP-1 and PYY twin drug is shown in the following general formula (I), n is a natural number, and n is greater than or equal to 1 and less than or equal to 8. The GLP-1 and PYY twin drug can play the activities of GLP-1 and PYY at the same time to generate a synergistic effect. The GLP-1 and PYY twin drug disclosed by the invention is obtained by coupling a GLP-1 analogue and a PYY analogue through a pegylation scheme. The GLP-1 and PYY twin drugs can effectively reduce blood sugar and weight, and can be used for treating related diseases such as diabetes and obesity. # imgabs0 #

The invention discloses a waltheria indica extract with a blood sugar reducing effect as well as a preparation method and application of the waltheria indica extract. The preparation method comprises the following steps: uniformly mixing and stirring waltheria indica powder and an ethanol water solution, and performing ultrasonic-assisted extraction to obtain a waltheria indica extracting solution; performing macroporous resin column chromatography on the waltheria indica extracting solution, collecting eluent, and performing freeze drying to obtain the waltheria indica extract with the blood sugar reducing effect. The preparation method is simple and convenient to operate, excellent in yield, green, environment-friendly and suitable for industrial production and large-scale extraction. The invention discovers that the waltheria indica extract has a blood sugar reducing function for the first time, and is suitable for preparing the blood sugar reducing preparation.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating upper digestion type diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 25 to 35 parts of herba eupatorii, 25 to 35 parts of radix codonopsis, 25 to 35 parts of radix rehmanniae recen, 25 to 35 parts of radix puerariae, 25 to 35 parts of radix trichosanthis, 20 to 30 parts of radix ophiopogonis, 15 to 25 parts of rhizoma coptidis, 15 to 25 parts of radix adenophorae, 15 to 25 parts of rhizoma anemarrhenae, 15 to 25 parts of rhizoma polygonati, 15 to 25 parts of poria with hostwood, 15 to 25 parts of corn stigma, 15 to 25 parts of folium mori, 5 to 15 parts of fructus schizandrae and 5 to 10 parts of liquorice root. The traditional Chinese medicine composition provided by the invention can be used for effectively treating the upper-digestion diabetes mellitus on the basis of the main pathogenesis of the upper-digestion diabetes mellitus according to medication experience and traditional Chinese medicine theories.

The invention relates to the technical field of biological medicines, and particularly discloses a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of medicines for treating depression. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: radix curcumae, poria cocos, polygala tenuifolia, andrographis paniculata and schisandra chinensis. Furthermore, the traditional Chinese medicine composition further comprises rhizoma corydalis and rhizoma coptidis. The traditional Chinese medicine composition disclosed by the invention has the effect of treating depression; therefore, the traditional Chinese medicine composition serving as an active ingredient has important application value in preparation of the medicine for treating depression.

The invention provides the compound hypoglycemic pharmaceutical composition of the compound A and / or the pharmaceutically acceptable salt thereof and empagliflozin, and the pharmaceutical composition can reduce the risk of urinary tract infection of diabetic patients, is beneficial to improving the hypoglycemic effect, and reduces the adverse drug reaction.

The embodiment of the present invention relates to a strain of Lactobacillus reuteri B1-10 and its application, which belongs to the field of microorganisms and has a deposit number of CGMCC NO.26166. The Lactobacillus reuteri in the present invention is isolated from fresh and healthy breast milk, has good blood sugar lowering ability and prebiotic properties, and has certain potential for relieving enteritis, allergic rhinitis, and weight loss. It has strong acid and bile salt resistance and good heat resistance. Therefore, the bacteria has the potential to develop functional foods.

The invention relates to the technical field, and provides a raw material blood glucose reducing method in a lycopene production process, which combines resin adsorption and fermentation technologies, and remarkably improves the blood glucose reducing effect and the production efficiency by monitoring and optimizing the blood glucose reducing process in real time. The method comprises the following specific steps: substituting tomato clear juice powder data into a resin adsorption sugar-reducing model, determining the type and quantity of required resin, carrying out mixed adsorption, setting, monitoring and adjusting fermentation parameters in real time to obtain an optimal sugar-reducing effect, carrying out sterilization, drying and quality detection after fermentation, and finally comparing actual quality with predicted quality to obtain a sugar-reducing result. According to the method, the blood glucose reducing model is continuously optimized, the blood glucose reducing effect and the production stability are improved, the production efficiency is improved, the product is more suitable for diabetics, in addition, the method has the self-learning and optimizing capacity, and the blood glucose reducing effect can be continuously optimized along with accumulation of production data.

The present invention relates to a pharmaceutical combination comprising a PCSK9 inhibitor and a GLP-1 receptor agonist; The invention also relates to the use of the pharmaceutical combination in preparing drugs for treating hyperglycemia, diabetes, obesity and / or cholesterol related diseases.

The invention discloses a hypoglycemic composition and a preparation method and application thereof, belonging to the technical field of hypoglycemic drugs. The hypoglycemic composition comprises raw materials in parts by weight: 15-20 parts of pine mushroom polysaccharide, 10-15 parts of schisandra extract, 3-5 parts of lotus root extract, 1-2 parts of lotus leaf extract, 1-3 parts of lotus seed embryo extract, 8-10 parts of sargassum polysaccharide, 8-10 parts of cordyceps polysaccharide, 5-8 parts of tuckahoe polysaccharide, 2-5 parts of ganoderma lucidum polysaccharide, and 3-5 parts of sargassum polysaccharide. The hypoglycemic composition can improve the hypoglycemic effect of pine mushroom polysaccharide from different action pathways, and hypoglycemia is more efficient, and can repair pancreatic islet β cells and improve the hypoglycemic effect of type I diabetes.

The invention provides a composition containing medicinal and edible astragalus polysaccharide and application of the composition in reducing blood sugar. The composition provided by the invention consists of astragalus polysaccharide, tremella polysaccharide, lycium barbarum polysaccharide and angelica polysaccharide. The mass ratio of the raw materials is (1-3): (1-3): (1-3): (1-3). The hypoglycemic effect of the plant polysaccharide and the composition thereof is proved through a hyperglycemia mouse model, it is shown that the four plant polysaccharides can reduce the blood sugar of mice, after the four plant polysaccharides are compounded, the obvious synergistic interaction effect is shown, and the effect is obviously better than that of other schemes that every two plant polysaccharides are combined or combined in a stacked mode. Clinical medical manifestations of polydipsia, polyphagia, diuresis and weight loss of diabetes mellitus are slowed down and improved after polysaccharide combination treatment, a positive effect on reduction of hyperglycemia is achieved, the adopted plant polysaccharide is safe and non-toxic, blood sugar can be effectively reduced, and the diabetes mellitus health-care product has a good health-care effect on diabetes mellitus. The traditional Chinese medicine composition can also prevent acute complications caused by hyperglycemia, such as diabetic ketoacidosis, hyperglycemia syndrome and the like.

The invention discloses a 2, 3-substituted physalis alkekengi sugar ester compound as well as a preparation method and application thereof. The compound has a structural general formula as shown in a formula (1), in the formula (1), R1 and R2 are-CH3 or-(CH2) XCH3, and X is 1-7. The preparation method comprises the following steps: with calyx seu fructus physalis as a raw material, carrying out ethanol extraction, silica gel column chromatography and thin-layer chromatography separation, recrystallization and the like. In-vitro alpha-glucosidase inhibition experiments show that the compound has significant inhibition activity, the IC50 of the physalis alkekengi sugar ester A1 is 2.06 + / -0.03 mu g / mL, and the activity is superior to that of acarbose. In an STZ-induced diabetic mouse model, the physalis alkekengi glycoester A1 (30 mg / kg) can significantly reduce fasting blood-glucose to a near-normal level, and the effect is superior to that of a positive control. A series of specific compounds (physalis alkekengi sugar esters A1-A8) with the structural characteristics of the general formula (1) are separated and identified from the physalis alkekengi, and specific substances with the hypoglycemic efficacy of the physalis alkekengi are defined.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine composition for treating diabetic nephropathy and application thereof. The traditional Chinese medicine composition is prepared from the following ten medicinal materials according to a specific ratio: radix rehmanniae recen, astragalus membranaceus, golden cypress, coptis chinensis, gastrodia elata, cicada slough, salvia miltiorrhiza, chinaroot greenbrier, rosa laevigata michx and motherwort. Systematic animal experiments and clinical researches prove that the Zuogui blood-glucose-reducing kidney-pleasing formula can effectively reduce fasting blood-glucose of diabetic nephropathy model mice, improve lipid metabolism disorder, remarkably reduce the levels of urea nitrogen, creatinine and uric acid and the ratio of urine protein to creatinine, and can be used for treating diabetic nephropathy by inhibiting expression of fibrosis-related factors such as TGF-beta and alpha-SMA. The renal fibrosis process is delayed. Compared with the prior art, the pharmaceutical composition provided by the invention has remarkable advantages in the aspects of improving renal functions, inhibiting renal tissue fibrosis and delaying the development of diabetic nephropathy.

The invention discloses a low-calorie tremella aurantialba beverage with a blood sugar reducing effect and a preparation method thereof.According to the tremella aurantialba beverage, tremella aurantialba is combined with fructo-oligosaccharide and mogroside, the synergistic interaction effect is achieved, the blood sugar reducing performance is further improved, the product meets the sweet taste requirement, meanwhile, calorie is remarkably reduced, and the taste of the beverage is improved. The beverage has the functions of improving blood sugar and managing body weight, effectively meets the diet requirements of diabetic patients and hyperglycemia people on low calorie, health and sweetness, is healthier and safer, and shows remarkable advantages in the aspects of improving intestinal health and controlling blood sugar level.

The invention relates to the technical field of active ingredient extraction and application, and discloses a preparation method of a traditional Chinese medicine preparation for reducing blood sugar, which comprises the following steps: filtering and centrifugally separating papaya milk cut from papaya green fruits, and collecting supernatant liquid to obtain pretreated papaya milk; enabling the pretreated papaya milk to pass through an ultrafiltration membrane system with the molecular weight of 40000-55000Dal, and collecting milk penetrating through an ultrafiltration membrane; enabling the milk to pass through an ultrafiltration membrane system with the molecular weight of 15000-30000 Dal, and collecting the milk intercepted by an ultrafiltration membrane; performing multi-stage freeze drying on the ultrafiltration membrane milk to obtain milk powder, and preparing capsules, tablets or granules from the milk powder to obtain the traditional Chinese medicine preparation for reducing blood sugar. The milk powder with high hypoglycemic activity is prepared from the papaya milk as the raw material through filtration, centrifugation and two-stage ultrafiltration membrane treatment, and the milk powder is high in quality and can improve the hypoglycemic effect of the traditional Chinese medicine preparation when being used for preparing the hypoglycemic traditional Chinese medicine preparation.