The invention discloses a preparation method of a premixed reinforced asphalt mixture. During the production process of the mixture, soft asphalt and mineral materials are premixed, so that the mixture is good in construction and usability, natural asphalt powder is used for re-mixing, so as to enhance the pavement performance, on one hand, the soft asphalt is high in grade and low in viscosity, the soft asphalt is uniformly mixed with aggregate at a relatively low temperature and the fluidity is good; on the other hand, hard natural asphalt containing a large amount of minerals is selected in the re-mixing process, so that the high-temperature performance, the anti-aging performance and the anti-stripping performance of the mixture can be remarkably improved, thus the pavement performance of the asphalt mixture is improved, and the service life is prolonged. In addition, the natural asphalt is high in hardness, is dispersed in the mixture after being remixed, and plays a role of filling, extruding and reinforcing ribs and cooperates with fibers to improve the low-temperature performance of the asphalt mixture; the premixed reinforced asphalt mixture preparation and construction process is simple, so that expensive additives such as warm mixing agents are avoided, and the road performance is improved at the same time.