Magnetic composite microsphere of molecular blot polymer and its preparing process by combination of reverse-phase emulsion polymerization with suspension polymerization

A technology of magnetic composite microspheres and inverse emulsion polymerization, which is applied in the fields of material science and engineering and biological separation engineering, can solve the problems of cumbersome, separation, and complexity in the operation process, and achieve the effect of simplifying the separation process

Inactive Publication Date: 2005-11-09
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Molecularly imprinted polymer microspheres currently used in the field of bioseparation engineering cannot be easily and conveniently separated by a magnetic field because they do not contain magnetic components, and can only be separated statically (D Wistuba, V Schurig. Enantiomer separation of chiral pharmaceuticals by capillaryelectrochromatography, Journal of Chromatography A, 2000, 875: 255-276); if dynamic separation is performed, SMIPs need to be separated by centrifugation and other processes, and the operation process is cumbersome and complicated

Method used

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  • Magnetic composite microsphere of molecular blot polymer and its preparing process by combination of reverse-phase emulsion polymerization with suspension polymerization
  • Magnetic composite microsphere of molecular blot polymer and its preparing process by combination of reverse-phase emulsion polymerization with suspension polymerization
  • Magnetic composite microsphere of molecular blot polymer and its preparing process by combination of reverse-phase emulsion polymerization with suspension polymerization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Inverse emulsion polymerization

[0038] (1) Dissolve 9g of acrylamide (AM) and 1g of N,N'-methylenebisacrylamide (Bis) in 20ml of water, and add 0.6g of Fe after dissolving 3 o 4 powder, stir to disperse;

[0039] (2) 0.1g potassium persulfate (K 2 S 2 o 8 ), 0.05g sodium bisulfite (NaHSO 3 ) is dissolved in 10ml of water;

[0040] (3) Add 100ml of toluene into a 250ml three-neck flask, add 1.0g of Span80 (Span80), stir well, add the mixture of (1) and (2), and continue stirring. Pass N 2 Oxygen removal, stirring control 300r / m, room temperature, reaction 2h. After standing for a certain period of time, the upper solvent was removed to obtain inverse emulsion A.

[0041] 2. Suspension polymerization

[0042] (1) Add 0.1g AIBN to 10ml trimethylolpropane triacrylate (TRIM), dissolve and add 10ml inverse emulsion A, and then disperse with ultrasonic waves for 5min to obtain inverse emulsion B.

[0043] (2) Add 130ml of water into a 250ml three-necked flask equ...

Embodiment 2

[0049] 1. Inverse emulsion polymerization

[0050] (1) Dissolve 9g of acrylamide (AM) and 1g of N,N'-methylenebisacrylamide (Bis) in 20ml of water, and add 0.8g of ground Fe 3 o 4 powder, stir to disperse;

[0051] (2) 0.1g ammonium persulfate ((NH 4 ) 2 S 2 o 8 ), 0.05g sodium bisulfite (NaHSO 3 ) is dissolved in 10ml of water;

[0052] (3) Add 100ml of toluene into a 250ml three-neck flask, add 1.2g of Span85 (Span85), stir well, add the mixture of (1) and (2), and continue stirring. Pass N 2 Oxygen removal, stirring control 300r / m, room temperature, reaction 2h. After standing for a certain period of time, the upper solvent was removed to obtain inverse emulsion A.

[0053] 2. Suspension polymerization

[0054] (1) Add 0.1g of benzoyl peroxide (BPO) into a mixture of 10ml of styrene (St) and 2ml of divinylbenzene (DVB), dissolve it and add 10ml of inverse emulsion A, then disperse it with ultrasonic waves for 5min to obtain Inverse emulsion B.

[0055] (2) Add ...

Embodiment 3

[0061] 1. Inverse emulsion polymerization

[0062] (1) Dissolve 9g of acrylamide (AM) and 1g of N,N'-methylenebisacrylamide (Bis) in 20ml of water, and add 0.6g of Fe after dissolving 2 0 3 powder, stir to disperse;

[0063] (2) 0.1g potassium persulfate (K 2 S 2 o 8 ), 0.05g sodium bisulfite (NaHSO 3 ) is dissolved in 10ml of water;

[0064] (3) Add 100ml of benzene into a 250ml three-neck flask, add 1.0g of Span60 (Span60) and 0.5g of Tween80 (Tween80), stir well, add the mixture of (1) and (2), and continue stirring. Pass N 2 Oxygen removal, stirring control 300r / m, room temperature, reaction 2h. After standing for a certain period of time, the solvent in the upper layer was separated to obtain inverse emulsion A.

[0065] 2. Suspension polymerization

[0066] (1) Add 0.1g of AIBN to 10ml of pentaerythritol triacrylate (PETRA), dissolve and add 10ml of inverse emulsion A, and then disperse with ultrasonic waves for 5min to obtain inverse emulsion B.

[0067] (2) ...

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Abstract

A composite magentic microsphere for molecular blot polymer, based on molecular blot technique, is prepared from different substances as template moleculae (blot moleculae), different monomers as function monomer and the mother material of polymer, and different powdered metals (or their oxides) as magnetic component through reversed-phase emulsion polymerization and suspension polymerization. It can be used for separating similar compound, chiral compound, by-product and trace compound with more precision and simple process.

Description

technical field [0001] The invention belongs to the fields of material science and engineering and bioseparation engineering, and particularly relates to a molecularly imprinted polymer magnetic composite microsphere and a composite preparation method thereof by inverse emulsion polymerization and suspension polymerization. Background technique [0002] Molecular imprinting technology has been widely and deeply researched in many fields, such as separation of similar compounds, antibody binding simulation, enzyme simulation, bioimitation sensors, etc. Molecularly imprinted polymers (MIPs) prepared by this technology have become the new century One of the most promising new materials. [0003] MIPs were prepared by bulk polymerization in the early days (Wulff G. Molecular recognition in polymers prepared by imprinting with template, polymeric reagents and catalysts, Am Chem Soc Sym Ser, 1986, 308(2): 186-200). Although the polymerization process of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/00C08F2/12C08F2/44C08K3/22
Inventor 成国祥陆书来庞兴收
Owner TIANJIN UNIV
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