133 results about "Molecular network" patented technology

The present invention provides a gelatin product that is shelf stable at room temperatures, completely vegetable-based, nutritionally beneficial to the consumer, able to meet restrictive religious dietary requirements, convenient and enjoyable to eat. The gelatin consists water held in a molecular network of carrageenan polysaccharide chains, cross-linked by ions in solution with the water. An iota form of carrageenan is particularly suitable for the gel formulation. Calcium ions are also particularly suitable for the gel formulation.

The present invention relates to systems and methods for biomedical drug research, addressing major molecular, cell biological and biochemical information management issues within drug discovery and basic biomedical science. The invention allows scientists to enter biological, chemical, and / or molecular data into a central database, analyze the data entries according to entry attributes, and graphically view the results. A group of web-enabled researchers can enter, share and analyze molecular and cellular data and information from the resources using standardized vocabularies and ontologies. This application describes in detail components of the databasing system, including but not limited to annotation modules, reference managers, advanced search algorithms, ontology browsers, molecular network builders, and text processing scripts. Ultimately, the information gathered, viewed, and analyzed by this relational databasing system is relevant to research ranging from basic researchers to advanced research in applied technologies within pharmaceutical development and biotech fields.

The present invention relates an absorbent material consisting of a molecular network of starch molecules, the starch molecules comprising an amylopectin content of at least 90% (w / w). The molecular network can either be comprised of self-entangled starches or cross-linked starches.

A computer system and methods are provided for mapping genotypes to phenotypes. The system includes a molecular network model and an optimizer. Functions of the molecular network model called trait functions are implemented to compute simulated phenotypes of the network. Simulated phenotypes are numerical properties of the molecular network that correspond to observed phenotypes which are observable properties of the biological system represented by the molecular network model. The optimizer optimizes the network to fit simulated phenotypes to observed phenotypes. The genotype to phenotype mapping system is useful in prediction of phenotypes, identification of phenotypic differences among polymorphic genotypes, determination of environmental effects on phenotypic development, determination of differences in patient response to a therapeutic agent due to genetic polymorphism, and genetic engineering of a target phenotype. Also provided are computer program products implementing the disclosed computer systems, computer data structures representing genotypic and phenotypic data, and computer readable media capable of storing such data structures.

The invention belongs to the field of application of liquid crystal materials and provides a method for utilizing polymer stable liquid crystal material to prepare a light brightness enhancement film. The method comprises the following steps of: mixing nematic liquid crystals, chiral compounds, ultraviolet polymerizable liquid crystal monomers, ultraviolet polymerizable siloxane and photoinitiators uniformly according to a certain mass proportion, injecting the mixture into pretreated film materials combined by PSLC substrate, carrying out diffusion from the high-concentration substrate to the low-concentration substrate by the chiral compounds, generating chiral nematic liquid crystals with continuous and different screw pitches, carrying out ultraviolet radiation on the film material, leading the ultraviolet polymerizable liquid crystal monomer molecules to occur polymerization reaction, forming a high-molecular network, leading the planar texture of the liquid crystal molecules to be stabilized and finally obtaining the PSLC material with wide wave reflection characteristics. The film material can reflect circularly polarized light with the reflection wavelength of 300 to 1500nm and the range of the reflected wave width can be precisely controlled. According to the differences of the reflection wavebands, the film material can be applied to the field of light brightness enhancement films and infrared ultraviolet light screen films of liquid crystal displays and the like.

A method and composition for polymer-reinforced composite cementitious construction materials is described. In one embodiment, a crosslinking component is mixed with a high molecular weight strengthening component and an inorganic cementitious material. The addition of the mixture to water causes a crosslinked molecular network to form within the hydrated, composite cementitious construction material. Both enhanced flexural strength and improved nail-pull resistance are shown, allowing a reduction in weight of the composite cementitious construction material compared to cementitious construction materials made according to other known methods.

The invention discloses preparation methods of mineralized hydrogel and a biomimetic mineralized bone repair material. The mineralized hydrogel is prepared by using a photoactivated biomacromoleculesand a photoactivated phosphatase as raw materials; hydrogel is formed by initiating cross-linking by means of light irradiation or initiating polymerization cross-linking by means of a radical initiator; when the hydrogel is put into mineralized liquid, phosphatase can promote the uniform deposition of phosphate in the gel, so that the uniformly mineralized hydrogel is obtained. Phosphoprotein-like molecules are added during the preparation of the hydrogel; the phosphoprotein-like molecules can promote the uniform deposition of phosphate along a molecular network of biomacromolecules, so thatthe high-strength mineralized hydrogel can be obtained. When the phosphoprotein-like molecules and cells are added during the preparation of the hydrogel, the in-situ loading of the cells can be realized, and the enzyme in a process of bone physiological mineralization can be simulated so as to promote a phosphate mineralization process, so that the biomimetic mineralized bone repair material withhigh strength can be obtained, and the personalized customization of the bionic mineralized bone repair material can be realized; therefore, the preparation methods have a broad application prospectin the field of bone tissue engineering.

The invention discloses a method for preparing crosslinked porous cassavastarch, which is to regulate the concentration of cassavastarch suspension to a diluter range from 20 to 34.8 weight percent for facilitating cross-linking reaction, achieving high degree of crosslinking and ensuring the quality uniformity of the crosslinked starch and creating a favorable condition for subsequent enzymolysis. The prepared crosslinked porous cassavastarch has a compact molecular shell structure, is stable in structure, enzymolysis resistant, chemically stable, free from collapse, safe, nontoxic, biodegradable and widely applicable and allows the size of the aperture of the molecular network to be adjusted by processes. In the preparation method, the production process is simple, the raw material cassavastarch is rich, cheap and readily available, the production cost is low, the production scale can be adjusted flexibly and the adaptability is high. The method is applicable to common fine starch manufacturers, chemically modified starch manufactures and common food, medicine, industrial, farm chemical, pesticide manufacturers and other manufacturers.

The method for preparing proton exchange membrane includes the following steps: dissolving membrane matrix high-molecular polymer in solvent, adding inorganic matter to form suspended substance, breaking said suspended substance by using nano breaking technology to obtain uniformly-dispersed mixture, using pouring method to make membrane with compact structure. The membrane has good stability andhigh application temperature, can make pile have good electrochemical stability and reliability, and can raise specific power of fuel cell.

The invention discloses a reverse type electric-control liquid-crystal light adjusting film and a preparation method thereof. The liquid-crystal light adjusting film comprises a high-molecular network skeleton and nematic-phase liquid-crystal molecules, wherein the high-molecular network skeleton consists of polymer-dispersed liquid-crystal network structure and a polymer-stabilized liquid-crystal network structure; the high-molecular network skeleton comprises a high-molecular matrix containing mesh holes which are internally provided with vertically-arranged high-molecular networks; the nematic-phase liquid-crystal molecules are dispersed in the high-molecular network skeleton and are nematic-phase liquid-crystal molecules with negative dielectric anisotropy. The reverse type electric-control liquid-crystal light adjusting film and the preparation method disclosed by the invention have the advantages that the bonding strength between two substrates of the prepared reverse type electric-control liquid-crystal light adjusting film is higher 5N / cm<2>, and the driving voltage threshold of the liquid-crystal film is 5V-100V; the light transmittance of the film can be adjusted between 0.3% and 82% by adjusting the level of voltage.

The provided preparation method for polymer dispersed liquid crystal film comprises: mixing the organic polymonomer with secondary cross-linking capacity and the liquid crystal by mass ratio as 50%:50%~10%:90%; adding light initiator and thermal initiator to stir and coat between two tin indium oxide conductive films; radiating with UV light for 1-30min at -10~50Deg to promote cross-linking reaction of light cross-linking groups and form macro molecular network; heating to 50-200Deg and holding for cross-linking reaction of thermal cross-linking groups; finally, natural cooling. This invention improves product stability and electric-photo property.

The invention discloses hydrogel system nano-scale phase change-based temperature-sensitive intelligent glass. The intelligent glass can produce a transition between a transparent appearance and an opaque appearance at a critical temperature. The intelligent glass is composed of glass sheets and temperature responsive hydrogel with an interpenetrating network structure, wherein the hydrogel is arranged between two of the glass sheets at least. The hydrogel is composed of a water-soluble cross-linked polymer network, temperature responsive polymers and water or inorganic salt aqueous solution, wherein the temperature responsive polymers run through the water-soluble cross-linked polymer network. The hydrogel can form a homogeneous system at a temperature below a critical temperature, and the temperature responsive polymers and the water-soluble cross-linked polymer network carry out a nano-scale phase separation at a temperature above the critical temperature. In the invention, temperature responsive polymers run through a cross-linked polymer network to form an interpenetrating network structure thus a molecular-scale uniform distribution is realized. Through a hydrogel system nano-scale phase change produced through a solubility change of temperature responsive polymers, a transition from a transparent appearance to an opaque appearance is realized, wherein the solubility change is produced when temperature changes.

The invention discloses a method for preparing micro-capsulized superfine red phosphorus, boiling the superfine red phosphorus with vitriol, sodium cyanide solution and sodium hydroxide solution, separately, filtering, eliminating impurities, and drying, and storing by sealing; blending and dissolve metal compound, depositing with ammonia, centrifuging and adding water to dilute, raising temperature, dropping in aluminum nitrate, vitriol or HCl and making metal hydroxide sol; mixing propylene acylamide monomers and N, Ní»-methylene dipropylene acylamide with ammonium persulphate, raising temperature and reacting to form high molecular network gel; adding the high molecular network gel into the metal hydroxide sol, raising the temperature and reacting to form high molecular network gel of metal hydroxide, mixing the high molecular network gel of metal hydroxide with the processed superfine red phosphorus, blending and placing still so that the sol takes the red phosphorus as the center to make surface absorption to form gel and coating a layer of colloid membrane on the red phosphorus surface, so as to obtain the micro-capsulized superfine red phosphorus. The advantages of the invention: it improves the stability, invariability and surface activity of the red phosphorus, improving processing property.

The invention discloses an inverse electrically-controlled light-adjusting film capable of adjusting transmittance rate of near-infrared light. The light-adjusting film comprises a macromolecule network framework, double-frequency nematic-phase liquid crystal molecules and vanadium dioxide nanoparticles. The macromolecule network framework is composed of a polymer dispersed liquid crystal networkstructure and a polymer stabilized liquid crystal network structure. The macromolecule network framework comprises a high-molecular matrix with meshes. The interiors of the meshes are equipped with vertically-arrayed high-molecular networks. The double-frequency nematic-phase liquid crystal molecules are dispersed into the interior of the macromolecule network framework. The vanadium dioxide nanoparticles are dispersed between the framework and the liquid crystal molecules. The invention also discloses the preparation method for the inverse electrically-controlled light-adjusting film. The prepared thin film has an electro-optical characteristic of the inverse electrically-controlled light-adjusting film. Meanwhile, the transmittance rate of near-infrared light can be adjusted in an intelligent manner according to changes in external temperature.

The invention discloses a material for photocuring three-dimensional manufacturing and an application of the material. The material comprises a monomer and / or prepolymer, a photoinitiator and a thermoplastic polyurethane elastomer, and the end of the monomer and / or prepolymer is sealed by a reaction-type protective group, wherein the thermoplastic polyurethane elastomer is in a solid particle shape under a normal-temperature state. The thermoplastic polyurethane elastomer and a liquid photosensitive material are mixed and are subjected to three-dimensional formation together, and then, a polymerization reaction is carried out on the monomer and / or prepolymer through the photoinitiator for forming a three-dimensional formed part. The thermoplastic polyurethane elastomer is distributed in ahigh-molecular network structure formed by the polymerization of the photosensitive material, the reaction-type protective group is separated from the polymer under the effect of radiation, and the thermoplastic polyurethane elastomer fusion molecular chain is expanded, so that the thermoplastic polyurethane elastomer can be further connected with the photosensitive material for forming a compactnetwork structure, and the mechanical property of the photosensitive material is greatly improved after the photosensitive material is cured.

The invention discloses a space-time diagram convolutional neural network and feature fusion-based human body action classification method. According to the invention, the method comprises the steps:constructing a space-time diagram of human body motion in a video in combination with a skeleton key point sequence of a human body, dividing sub-networks in time and space, and employing a graph convolutional neural network for training on the basis of the sub-networks. In addition, for the phenomenon of partial feature redundancy, a feature fusion method is introduced, and the accuracy of a model detection result is enhanced on the basis of an original model. According to the method, the problem of feature redundancy can be effectively avoided, and the accuracy and robustness of the model for human body action classification are improved.

A multiple-unit oral sustained release preparation is provided which allows controlled release of imidafenacin [4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide]. The preparation serves to ensure a prolonged effect of imidafenacin and prevent rapid elevation in the blood levels of imidafenacin.Specifically, granules or powders comprising imidafenacin dispersed in a water-insoluble polymer or a higher alcohol are used in the preparation. These preparations achieve sustained release of imidafenacin since the molecular network structure that the water-insoluble polymer or the higher alcohol forms during the preparation of the granules or powders serves to control the rate of diffusion of imidafenacin in water. Granules comprising a core granule having two layers of an inner imidafenacin coating and an outer water-insoluble polymer coating are used in the preparation. The water-insoluble polymer coating serves to control the rate of diffusion of imidafenacin in water and ensure sustained release of imidafenacin. The multiple-unit oral sustained release preparation is provided in the forms of capsules and tablets containing the granules or powders that allow controlled release of imidafenacin. The preparation achieves controlled release of imidafenacin over a prolonged period of time.

The invention relates to the field of waterproof coiled materials, and discloses a high temperature-resistant and waterproof coiled material. The coiled material comprises a polymer substrate layer, ahot melt adhesive layer, a metal foil layer and a heatproof butyl rubber layer which are sequentially laminated, wherein the butyl rubber layer comprises, by mass, 15-30 parts of a plasticizer, 10-40parts of butyl rubber, 20-50 parts of a high temperature-resistant filler, 30-60 parts of a tackifying resin, 0.5-2 parts of a coupling agent and 0.5-2 parts of an anti-aging agent. The high molecular weight butyl rubber and the high molecular weight plasticizer are combined and reacted with the tackifying resin that is compatible with the butyl rubber to form grid-shaped butyl rubber, so the intermolecular slip rate is reduced; and the combination of the coupling agent and the high temperature-resistant filler makes the surface of the high temperature-resistant filler wrapped with an oily group in order to improve the compatibility of the high temperature-resistant filler and the butyl rubber, so that filler particles are uniformly embedded in the molecular network of the grid-shaped butyl rubber, and the deformation and sliding of the butyl rubber molecular net under the action of a high temperature are reduced, thereby the heatproof property of the heatproof butyl rubber layer is improved.

The present disclosure relates to a wireless communication device, a high speed, high capacity dedicated mobile network system, and a method for transmitting information streams across a molecular network to end users without using IEEE 802 LAN, ATM or TCP / IP connection-oriented standards and protocols.

A graphical user interface that generates a molecule function network with an arbitrary range according to the designation by a user and displays the said molecule function network graphically; a graphical user interface with a molecule network window which displays a molecule network included in the molecule function network and an information window which displays one or more information items selected form a group comprising molecules, molecule pairs and bio-events included in the said molecule function network, which is characterized by that items in the molecule network window and in the information window related with each other are operated interlinked with each other. A molecule function network with information on bio-events including pathological events can be processed and displayed flexibly using a computer.

The present disclosure provides advantageous systems and methods for identifying molecular vulnerabilities in biological pathways and networks. The present disclosure generally involves conceptualizing a disease / disorder at the molecular level as a faulty physiological system, wherein one or more molecules in the complex intracellular signaling network are dysfunctional. This is accomplished by modeling a given physiological system as a digital logic circuit. More particularly, in exemplarily embodiments, binary logic equations are derived by analyzing the interactions between the input and output nodes of a target biological system. These equations are then used to produce a digital circuit representation for the system. Once a digital circuit representation is created, this circuit may advantageously be analyzed, using fault analysis techniques, in order to determine the vulnerability levels of the molecules of the targeted system.

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

The invention provides a multi-disease mutation site analysis method based on a function network. The method comprises the following steps: (1) detecting mutant genes by sequencing; (2) performing function enrichment analysis; (3) constructing the function network; (4) mining a molecular function network module; and (5) recognizing a molecular network module shared among diseases. According to the method, a correlation relationship among the diseases is built from the perspective of a molecular function by analysis of differences among genome levels of different diseases, so that the molecular function module shared among different diseases can be recognized more systematically; pathogenic mechanisms of diseases with similar phenotypes are analyzed effectively; differences among the diseases are revealed from the aspect of genomes; comprehensive understanding of the diseases is improved; and clinical diagnosis and treatment are facilitated.

The invention discloses preparation of a zein based porous hydrophobic oil absorption material. The preparation comprises the following steps: zein and polyvinyl alcohol are used as raw materials, physical crosslinking is carried out in order to obtain composite hydrogel, Fe2+ and Fe3+ are used as precipitating agents, and coprecipitation is used in order to generate magnetic iron oxide in a composite hydrogel high-molecular network for carrying out hydrophobic modification of the hydrogel; and then the hydrogel is immersed in an alcoholic solution of a silane coupling agent for carrying out lipophilic modification. The oil absorption material has good adsorptivity for petrochemical industry oil products, such as diesel oil, vacuum pump oil, n-hexane, chloroform and the like; the product has good adsorptivity for edible oil, such as rapeseed oil, and good selective adsorptivity for various oil products in an oil water mixture; the product can be applied to the fields of oil contamination treatment or oil and water separation.

The invention discloses a preparation method of free-agglomeration MgAl2O4 (magnesia-alumina spinel) nanometer particle powder. The preparation method comprises the following steps of: adding network agent C3H5NO and C7H10N2O2 to a mixed saline solution of magnesium salt and aluminum salt; then mechanically stirring, uniformly mixing, and then adding an initiating agent (NH4)2S2O8 to initiate the polymerization reaction of a high-molecular network agent to form a high-molecular three-dimensional network in the mixed saline solution so that a mixed system becomes wet gel; carrying out drying processing on the wet gel to obtain dried gel, namely an MgAl2O4 precursor; and then calcining the dried gel at 850-1000 DEG C, and pickling and washing a calcined product to obtain a free-agglomeration MgAl2O4 target product.

The invention discloses a non-target screening analysis method for intoxicating organic pollutants in wastewater based on a molecular network. The method comprises the following steps of: a) carryingout solid-phase extraction on pretreated wastewater to obtain an organic pollutant concentrated solution; b) fractionating the organic pollutant concentrated solution by using a high performance liquid chromatograph equipped with an automatic fraction collector to obtain a to-be-detected fraction; c) analyzing and detecting the to-be-detected fraction in the step b) by adopting a high performanceliquid chromatography-time-of-flight mass spectrometer; and d) processing the mass spectrum data detected in the step c) by using open source analysis software, generating a molecular network associated with the organic pollutants, and analyzing substances of network nodes. According to the non-target screening analysis method for the intoxicating organic pollutants in the wastewater based on themolecular network, the pollutant molecular network is generated, the network nodes display the response intensity of the substance in different components in a pie chart form, and the concentrations of the same substance in different components can be visually compared.

The invention provides a quantitative analysis method used for quantifying and comparing change degrees of modules in biological molecular networks before and after drug intervention. According to the method, topological parameters of different dimensionalities (attributes) of the modules are integrated, an integrated comprehensive index for quantifying changes of the modules is established, and the change degrees of the modules in the biological molecular networks before and after drug intervention are quantitatively analyzed. The method includes the steps that firstly, the biological molecular networks before and after drug intervention are built respectively, and module recognition is conducted; secondly, the changed modules in biological molecular networks before and after drug intervention are matched, and a changed module pair is determined; thirdly, the topological parameters representing different dimensionalities of the modules are integrated, a module comprehensive evaluation system is built by means of weights of the topological parameters, and the change degree of overall conformation of the modules in the biological molecular networks before and after drug intervention is calculated. The method can be used in the fields of biological network analysis, new drug research, development and design, pharmacological mechanism research and the like.

The invention provides a multi-disease variable site analysis platform based on a function network. The multi-disease variable site analysis platform comprises a variable gene sequencing detection module, a function enrichment analysis module, a function network construction module, a function network mining module and a shared molecular network identification module, wherein the variable gene sequencing detection module is used for finishing the fundamental analysis of sequencing data; the function enrichment analysis module is used for utilizing a function enrichment analysis tool to analyze a variable gene function; the function network construction module is used for constructing the function network according to a function enrichment analysis result; the function network mining module is used for screening stable network modules from the function network; and the shared molecular network identification module is used for identifying molecular modules shared by different diseases according to the network module. The multi-disease variable site analysis platform analyses differences of different diseases on an aspect of genomic level, establishes an incidence relationship among the diseases from the perspective of molecular function, can systematically identity a shared modular function module among different diseases, effectively analyzes the nosogenesis of similar phenotype diseases, discloses differences between the diseases from the level of genome, increases the comprehensive understanding of the diseases and is favorable for clinic diagnosis and treatment.

The invention provides a composition containing acrylic acid (ester) / sodium acryloyl nitrogen copolymer as well as a preparation and a preparation method thereof. The composition further comprises acrylic acid (ester) / sodium acryloyl nitrogen copolymer, PEG-240 / HDI copolymer bis-decyl tetradecanol polyetherdecyl-20 ether and lithium magnesium silicate. By means of a static space steric hindrance stabilization effect, gel of a three-dimensional molecular network structure wrapping oil drops is formed to achieve a good emulsion stabilization function, and the system quickly disintegrates to quickly release an oil phase.