The invention discloses a preparation method for a C.I. pigment red 53:1. The preparation method comprises the following steps of: the preparation of diazo liquid, the preparation of coupling liquid, coupling, laking reaction and post treatment. By the preparation method, the adverse effect on environment and human bodies when the component of the diazo liquid, namely 2-amino-5-chlorin-4-methyl benzene sulfonic acid is dissolved is effectively avoided; the problems that the heavy metal barium in the product exceeds the standard due to the addition of excess barium chloride in the laking reaction, and the heat resistance of the product is reduced due to the use of rosin are effectively solved; simultaneously, the pigment prepared by the method is bright in color, easy to disperse, and floppy in pigment particles; and moreover, the content of the soluble heavy metal barium in the product is below 80 mg/kg.