143 results about "Naphthoic acid" patented technology

The invention discloses a preparation method of a permanent red pigment for an acid and alkali resistant coating, and belongs to the technical field of pigment preparation, a 2B acid derivative is diazotized and then coupled with 2-hydroxy-3-naphthoic acid, then a calcium chloride aqueous solution is added for color lake to obtain pigment particles, and finally the surfaces of the pigment particles are coated with silicon dioxide to obtain the permanent red pigment for the acid and alkali resistant coating. According to the permanent red pigment for the acid and alkali resistant coating prepared by the preparation method disclosed by the invention, the acid and alkali resistance and environmental stability of the pigment are further enhanced while the excellent characteristics of original pigment red 48: 2 are maintained, and the application performance of the pigment is remarkably improved.

The invention provides a polyarylester nanofiber and a preparation method thereof, and the preparation method comprises the following steps: firstly, carrying out acetylation reaction on 4-hydroxybenzoic acid (HBA) and 6-hydroxy-2-naphthoic acid (HNA) to obtain acetylated HBA and acetylated HNA, and then carrying out copolymerization on acetylated HBA and acetylated HNA and 4-hydroxybutyric acid (GHB) to obtain HBA / GSB / HNA copolymerized arylester granules B; the preparation method comprises the following steps: carrying out blending spinning on granules B and HBA / HNA copolymerized aromatic ester granules A obtained by copolymerizing acetylated HBA and acetylated HNA in the prior art, putting the obtained blended polyarylate fibers into an organic solvent containing a strong base, carrying out chemical etching and deprotonation, carrying out disassembly from top to bottom to obtain a polyarylate nanofiber suspension, and finally carrying out suction filtration and drying to obtain the polyarylate nanofibers. According to the preparation method disclosed by the invention, the blended polyarylester fiber containing an aliphatic chain is subjected to etching and deprotonation treatment through strong base to disassemble the polyarylester nanofiber, and a certain amount of-CH2-structure is introduced into a main chain, so that disassembly preparation of the nanofiber is facilitated, and the polyarylester nanofiber with uniform diameter and length and controllable length-diameter ratio is obtained.

The invention discloses a method for preparing high molecular weight thermotropic liquid crystal polyester through melt coupling solid phase polycondensation. The method comprises the following steps: mixing p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic acid and a catalyst 1-methylimidazole according to a specific molar ratio of (70-75): (25-30) to synthesize a liquid crystal polyester prepolymer with specific logarithmic viscosity; the preparation method comprises the following steps: crushing and drying a liquid crystal polyester prepolymer, placing prepolymer particles in a solid phase polycondensation device, accurately controlling the time and temperature of the polycondensation reaction, carrying out heating reaction in a nitrogen atmosphere to obtain high molecular weight thermotropic liquid crystal polyester, taking out the high molecular weight liquid crystal polyester, and carrying out viscosity test. In the preparation process of the prepolymer, the prepolymer with proper logarithmic viscosity can be effectively prepared by controlling the reaction temperature and time, so that the controllable preparation of the polymer is realized; the solid-phase polycondensation time required for obtaining the high-molecular-weight polymer is shortened by crushing the prepolymer into particles with different diameters, so that the solid-phase polycondensation efficiency is improved.

The present invention relates to a photovoltaic water-based soldering flux and a preparation method and application thereof, comprising the following raw materials in parts by weight: 1-5 parts of cosolvent, 0.1-3 parts of wetting agent, 0.1-3 parts of polyethylene glycol, 1-8 parts of activator microcapsules, 0.1-1 parts of antioxidant, and 100 parts of water; wherein the activator microcapsules include capsule cores and capsule materials wrapping the capsule cores, and the capsule cores are composite activators; wherein the composite activator is a composition of an organic acid and a protective agent; the organic acid is a composition of 3-hydroxy-2-naphthoic acid, oleic acid and methylsuccinic acid; the protective agent is a composition of trimethylsiloxane and a quaternary ammonium salt cationic fluorocarbon surfactant. The soldering flux of the present invention uses water as the main solvent, and the soldering flux is more suitable for the preparation of photovoltaic cell chip assemblies with a hot welding temperature of 150-230°C, and the soldering flux can continuously provide activity during welding.

The invention relates to the technical field of chemical intermediates, and particularly discloses a preparation method of a givelastat intermediate.According to the preparation method, an initiator compound 5 can be synthesized by adopting cheap 2-hydroxy-6-naphthoic acid (CAS: 16712-64-4, 141 yuan / kg), and the preparation method is different from a method in the prior art. A gemvelastat intermediate compound 4 is synthesized from a compound 5 through a three-step reaction, compared with the prior art, the yield is high, industrial amplification production is more facilitated, in the process of synthesizing a compound 6 from the compound 5, acetonitrile can be adopted as a cyanide source in a reaction system, activated hydroxyl is subjected to a coupling reaction, and the yield is high. In the process of synthesizing a compound 6 from a compound 7 instead of a traditional metal cyanide, or in the process of synthesizing a compound 6 from another compound 5, a cheap cuprous cyanide and cuprous iodide system is adopted for a coupling reaction, and in the process of synthesizing a compound 4 from a compound 7, an acetic acid and sodium triacetoxyborohydride reaction system is adopted, so that the compound 6 is synthesized. And the important intermediate of the givelastat can be obtained with high yield.

The present invention provides 1-hydroxy-2-naphthoate or pamoate of cariprazine, and / or its new solid forms, as well as its pharmaceutical compositions, preparation methods and uses. The salts and solid forms of cariprazine provided by the present invention, especially cariprazine 1-hydroxy-2-naphthoate among the poorly soluble salts of cariprazine, conform to the advantages of long-acting sustained-release preparations, can be developed into suspension injections, and at the same time can overcome the risks of dissociation of existing salt forms such as cariprazine hydrochloride or the problem of not having a sustained-release effect, can achieve the effect of long-term drug administration, and greatly improve the compliance of patients as well as the bioavailability and drug safety of the drug.

The invention discloses a preparation method of a pigment for low-oil-absorption pigment red 57: 1 printing ink, and belongs to the technical field of pigment synthesis. 4-aminotoluene-3-sulfonic acid is diazotized and then coupled with 3-hydroxy-2-naphthoic acid, a carboxyl-terminated hyperbranched polymer and an ionic liquid are added into a pigment crude product compound obtained after the coupling reaction is completed, and the pigment for low-oil-absorption pigment red 57: 1 printing ink is obtained. And finally adding a calcium chloride aqueous solution for color lake. The pigment for low-oil-absorption pigment red 57: 1 printing ink, prepared by the invention, not only has lower oil absorption, but also has the advantages of strong tinting strength, easiness in dispersion and high stability, and has good processing and application performance.

To provide a fine granulated agent replenishing liquid for a plating liquid, with the replenishing liquid being excellent in the initial stability and safety, and the replenished plating liquid being excellent in the aging stability, without damaging the appearance of a plating film when replenished for a long period of time nor dissolving an organic resist film present on a material to be plated.SOLUTION: A fine granulated agent replenishing liquid for a plating liquid, replenishing a fine granulated agent to a tin-based plating solution including one or two or more kinds of compounds selected from the group consisting of benzaldehyde, 1-naphthaldehyde, 1-naphthoic acid, 1-acetonaphthone, DL-1-(1-naphthyl)ethylamine, and benzylidene acetone, includes a phenyl glycol-based surfactant, the fine granulated agent and water, with a content of the fine granulated agent therein being in a range of 0.1 g / L or more and 10.0 g / L or less, a content of the phenyl glycol-based surfactant therein being in a range of 5 g / L more and 50 g / L or less, and a content of alcohol being less than 1 mass%.SELECTED DRAWING: None

The invention provides a corrosion-resistant film, a pipe and a preparation method and application of the corrosion-resistant film, the corrosion-resistant film at least contains modified LCP, the modified LCP comprises p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic acid and 3, 4-dihydroxythiophene methyl diformate, the p-hydroxybenzoic acid, the 6-hydroxy-2-naphthoic acid and the 3, 4-dihydroxythiophene methyl diformate are used as raw materials, and the 6-hydroxy-2-naphthoic acid and the 3, 4-dihydroxythiophene methyl diformate are used as raw materials. And the molar ratio of the 2, 4-dihydroxy thiophene methyl dicarboxylate is (60-80): (5-40): (0.5-3). The corrosion-resistant thin film provided by the invention is excellent in mechanical property and corrosion resistance, and the corrosion-resistant pipe provided by the invention is high in combining capacity with the thin film and good in corrosion resistance.

The invention discloses a polyphenyl ether resin composition, a polyphenyl ether composite material and a preparation method and application thereof. The polyphenyl ether resin composition is obtained by reacting polyphenyl ether and naphthoic acid compounds in a melt, the polyphenyl ether has a repeating unit with the following structure: R1, R2, R3 and R4 are respectively and independently hydrogen, halogen, primary or secondary lower alkyl, phenyl, halogenated alkyl, alkoxy or halogenated alkoxy; the naphthoic acid compound is at least one of naphthoic acid or hydroxyl naphthoic acid. Compared with polyphenyl ether resin, the polyphenyl ether resin not only can improve the gas barrier property of the polyphenyl ether composite material in a melt, but also can improve the high-temperature injection molding processing stability of the polyphenyl ether composite material.

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and / or salt co-crystals are also provided.

The invention discloses application of 1, 4-dihydroxy-2-naphthoic acid in improvement of animal growth performance and intestinal health, and belongs to the technical field of feed additives. According to the invention, the 1, 4-dihydroxy-2-naphthoic acid is added into the basic feed, and tests prove that after the 1, 4-dihydroxy-2-naphthoic acid is added, the average daily gain and the average daily feed intake of broilers and piglets can be improved, and the feed conversion ratio is reduced; the piglet diarrhea can be improved, the development of the stomach and the small intestine of the piglet can be promoted, the morphological structure of the jejunum of the piglet can be improved, the development of the intestinal tract can be promoted, the activity of stem cells of the intestinal tract of the piglet can be regulated, and then the development of the gastrointestinal tract is promoted. Therefore, by adding the 1, 4-dihydroxy-2-naphthoic acid into the feed, the growth performance and the intestinal health of animals can be improved, the development of gastrointestinal tracts is promoted, the activity of the intestinal stem cells is regulated and controlled, and a new strategy is provided for improving the growth performance and the intestinal health of the animals.

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and / or salt co-crystals are also provided.

The invention relates to a 2-succinyl-5-enol acetonyl-6-hydroxy-3-cyclohexene-1-carboxylic acid synthase mutant and application thereof, and belongs to the technical field of enzyme engineering. According to the invention, a key residue of 2-succinyl-5-enolacetonyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase is obtained by combining protein sequence comparison and alanine scanning strategies, the key residue is subjected to random mutation, and the menadione pathway resistant intermediate metabolite 1, 2, 3, 4-tetracarboxylic acid synthase is obtained through multiple rounds of screening. The mutant MenDW322IR323F which is subjected to feedback inhibition by using 2, 4-dihydroxy-2-naphthoic acid is synthesized, the heptaene menadione production capacity of the recombinant bacillus subtilis constructed according to the method is improved, the yield is 1.22 times that of a control strain, and the final yield reaches 186.5 mg / L. The invention not only provides a new direction for transformation of a menadione approach of bacillus subtilis, but also is beneficial to industrial expanded production of heptaene menadione.

The invention relates to the field of extraction of uranium from seawater and new materials, and particularly provides a bis-naphthyl anthracene compound, a synthesis method of the bis-naphthyl anthracene compound and application of the bis-naphthyl anthracene compound to preparation of uranium extraction MOF (30-Zr) from seawater, and the prepared bis-naphthyl anthracene compound is 4-[10-(4-carboxyl naphthalene-1-yl) anthracene-9-yl] naphthalene-1-formic acid (H2NAN). The MOF (30-Zr) with ultrahigh stability is synthesized by taking H2NAN as a ligand and a zirconium-containing compound through a one-pot method, so that the stability of the material is ensured, the material has very high uranium adsorption capacity, and a new direction is provided for using the MOF as a material for extracting uranium from seawater.

This invention discloses a viscosity reducer and a slurry preparation method suitable for preparing coal-water slurry from high-viscosity organic wastewater. The high-viscosity organic wastewater viscosity reducer is prepared by adding naphthoic acid (obtained from methylnaphthalene oxidation) to ethylene oxide and propylene oxide in a certain proportion. The slurry preparation method involves adding sodium naphthalenesulfonate as an additive to the high-viscosity organic wastewater after viscosity reduction to obtain the coal-water slurry. This invention overcomes the disadvantage that high-viscosity organic wastewater is unsuitable for preparing coal-water slurry, successfully using a viscosity reducer to reduce the viscosity of high-viscosity organic wastewater and obtain a high-coal-content coal-water slurry.

Provided are: an optical material composition that makes it possible to increase the in-plane retardation of an optical member; a resin composition containing the optical material composition; and a resin molded article of the same.　An optical material composition according to the present invention contains a trehalose derivative. The trehalose derivative is preferably one or more selected from the group consisting of trehalose benzoate, trehalose acetate, and trehalose naphthoate. This optical material composition makes it possible to increase the in-plane retardation of an optical member.

The invention discloses a europium-functionalized metal-organic framework-based dual-emission fluorescent probe and a preparation method and application thereof, and relates to the field of organic metal frameworks and fluorescence detection.The preparation method comprises the steps that ZrCl4, pyromellitic acid, 6-hydroxy-2-naphthoic acid and water are mixed, acetic acid is added, and a mixture is obtained; heating and refluxing the mixture, centrifuging to obtain residues, washing and drying to obtain UCHNA; the preparation method comprises the following steps: dispersing UCHNA in an aqueous solution of Eu (NO3) 3.6 H2O, heating to react, collecting white precipitate, washing and drying to obtain the Eu (NO3) 3.6 H2O. The invention has the beneficial effects that the UiO-66 type MOF is modified by using the luminous ligand 6-hydroxy-2-naphthoic acid, post-modification is performed by using Eu < 3 + >, the Eu < 3 + >-MOF with dual emission of blue and red wavebands is reasonably designed and synthesized, crystal violet (CV) and quinine (QN) are selectively and quickly responded through different response modes, the detection limit is low, and the Eu < 3 + >-MOF is superior to most reported sensors.

This invention discloses a phenylnaphthic acid derivative and its application in phosphorescent information encryption. The preparation method involves using 3,5-bis(ethoxycarbonyl)phenylboronic acid and methyl 6-bromo-2-naphthylcarboxylate as raw materials, and then performing a Suzuki coupling reaction under tetra(triphenylphosphine)palladium(O) catalysis to obtain the intermediate ethyl 2-(3,5-bis(ethoxycarbonyl)phenyl)-6-naphthylcarboxylate. This intermediate is then subjected to alkaline hydrolysis and acidification to obtain the target product, 2-(3,5-dicarboxyphenyl)-6-naphthylcarboxylic acid. This phosphorescent material has a simple preparation method, lower cost compared to noble metal phosphorescence systems, a simple guest synthesis method with high yield, and exhibits significant and stable phosphorescence effects. Furthermore, precise emission color control of high-performance doped thin films is achieved through the triplet-to-singlet Förster fluorescence resonance energy transfer (TS-FRET) mechanism, establishing a multicolor long-lifetime emission system. In addition, the material has multi-color adjustable properties and excellent long afterglow emission performance, showing great application potential in cutting-edge application fields such as multi-dimensional information encryption and high-end anti-counterfeiting.

The invention discloses a construction method of a saccharomyces cerevisiae strain capable of biologically synthesizing 1, 4-dihydroxy-2-naphthoic acid (DHNA). Six different plasmids are constructed by means of genetic engineering, metabolic engineering, homologous recombination and the like, homologous fragments are obtained through polymerase chain reaction, key heterologous genes synthesized by DHNA are integrated into chromosomes of saccharomyces cerevisiae by means of efficient homologous recombination of the saccharomyces cerevisiae, the DHNA is generated through biosynthesis, first synthesis of the DHNA in the saccharomyces cerevisiae is achieved, and the yield of the DHNA in the saccharomyces cerevisiae is increased. And a prerequisite substance is provided for constructing biosynthesis of MK-7 in the saccharomyces cerevisiae in the future.

The method comprises the following steps: adding 1-[3-chloro-5-(trifluoromethyl) phenyl]-2, 2, 2-trifluoroethanone and 4-acetyl naphthoic acid into a solvent, adding alkali, completely reacting at 50-80 DEG C, then adding DMAP, dropwise adding acetic anhydride, completely reacting, then adding tetrabutylammonium bromide, and reacting at 50-80 DEG C for 2-3 hours to obtain the arfamarana. Adding an aqueous solution of sodium hydroxide and hydroxylamine hydrochloride, and reacting at 0-5 DEG C to obtain an intermediate; reacting the intermediate with acyl chloride under the action of DMF (Dimethyl Formamide) and dichloromethane to obtain 4-(5-(3-chloro-5-(trifluoromethyl) phenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazole-3-yl)-1-naphthoyl chloride; the preparation method comprises the following steps of: adding a catalyst into an organic solvent, dropwise adding into a dichloromethane solution of 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide hydrochloride and alkali, and reacting at the temperature of between 0 and 5 DEG C, so as to obtain the arfola sodium. The method is short in route, high in yield and suitable for large-scale industrial production.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of a benzofuran compound. In an inert gas environment, a 2-fluorotoluene compound as shown in a formula 1 and a methyl benzoate compound as shown in a formula 2 are mixed and reacted with an organic solvent methyl tert-butyl ether in the presence of bis (trimethylsilyl) amino cesium and cesium sulfate, and the benzofuran compound as shown in a formula 3 is synthesized under a heating condition. Wherein the methyl benzoate compound as shown in the formula 2 can also be replaced by 2-naphthoic acid methyl ester or 1-naphthoic acid methyl ester. The research develops a benzofuran synthesis strategy without transition metal catalysis. According to the method, on the basis of commercially available raw materials, the construction of a benzofuran skeleton is realized through a simple and efficient path. Due to the mild and green reaction characteristic, a route with practical value is provided for synthesis of active medicine molecules and key intermediates of the active medicine molecules.

In order to increase the total light transmittance while maintaining a high haze value of the thermoplastic liquid crystal polymer, a thermoplastic liquid crystal polymer molded body is produced with a haze value of 99% or more, a coefficient of thermal expansion of 16 to 27 ppm / °C, and a correlation between the absorption coefficient (ε) and the thickness (x) satisfying ε ≤ 0.21x<supgt;‑0.55< / supgt>. The thermoplastic liquid crystal polymer may be a polyester containing repeating units derived from a substance selected from the group consisting of p-hydroxybenzoic acid and 6-hydroxy-2-naphthoic acid; 6-hydroxy-2-naphthoic acid, terephthalic acid, and p-aminophenol; p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic acid, and terephthalic acid; 6-hydroxy-2-naphthoic acid, terephthalic acid, p-aminophenol, isophthalic acid, hydroquinone, and naphthalenedicarboxylic acid; and p-hydroxybenzoic acid, terephthalic acid, and 4,4'-dihydroxybiphenyl.

The invention relates to the technical field of flue gas desulfurization catalysts, and discloses an activated carbon catalyst for flue gas desulfurization and a preparation method thereof.The preparation method comprises the steps that water and copper salt are added into a container, stirring is conducted, amino naphthoic acid grafted cellulose is added, ionic crosslinking is conducted, a crosslinking product is placed into a tubular furnace, calcination and activation are conducted, and the activated carbon catalyst for flue gas desulfurization is obtained. The activated carbon catalyst for flue gas desulfurization is obtained. The porous activated carbon with a high specific surface area and a high-stability carbon skeleton is formed by taking a cellulose matrix and a naphthalene ring with high char-forming property as carbon sources, the porous activated carbon is large in specific surface area and rich in pores, contains a large number of copper oxide catalytic active components, can effectively reduce the content and concentration of sulfur dioxide in flue gas, and forms an active nitrogen structure in the activated carbon matrix through high-temperature calcination, so that the content of sulfur dioxide in flue gas is reduced. The SO2 adsorption capacity of the activated carbon can be improved.

The utility model relates to the field of neutralization kettles for production of 1-naphthoic acid, in particular to a neutralization kettle for production of naphthoic acid, which comprises a reaction kettle with functions of conveying, discharging, stirring and the like, a control mechanism mainly comprising a transmission shaft, a stirring shaft and the like and used for realizing the stirring function, and the like. Compared with the prior art, the neutralization kettle device disclosed by the utility model has the advantages that on the basis of a liquid bottom gas transmission method, the stirring control mechanism for fully stirring a solution is additionally arranged, and the reaction solution is stirred and turned over through the spiral blade plate on the mechanism, so that complex water flow is generated in the solution; the water flow carries the input carbon dioxide gas to reach each position in the solution, so that the carbon dioxide gas can be diffused in the solution more quickly and can be distributed more uniformly, the reaction production efficiency is improved, the input carbon dioxide gas is fully utilized, and waste is avoided.

Disclosed in the present invention are a polyphenylene ether resin composition and a polyphenylene ether composite, and preparation methods therefor and the use thereof. The polyphenylene ether resin composition of the present invention is obtained by reacting polyphenylene ether with a naphthoic acid compound in a melt. The polyphenylene ether has a repeat unit of the structure below: (I), wherein R1, R2, R3 and R4 are each independently hydrogen, halogen, primary or secondary lower alkyl, phenyl, haloalkyl, hydrocarbyloxy, or halohydrocarbyloxy. The naphthoic acid compound is at least one of naphthoic acid or hydroxynaphthoic acid. Compared with a polyphenylene ether resin, in a melt, the polyphenylene ether resin composition can not only improve the gas barrier property of the polyphenylene ether composite, but also improve the processing stability of the polyphenylene ether composite during high-temperature injection molding.

The present application relates to the technical field of flue gas desulfurization catalyst, and disclose a kind of active carbon catalyst for flue gas desulfurization and preparation method, the present application is added to container water, copper salt, after stirring, amino naphthalene formic acid graft cellulose is added, ion crosslinking is carried out, crosslinking product is placed in tube furnace, calcination, activation is carried out, and the active carbon catalyst for flue gas desulfurization is obtained. With cellulose matrix and high carbon naphthalene ring as carbon source, form high specific surface area, high stability carbon skeleton porous active carbon, large specific surface area, abundant porosity, contain a large number of copper oxide catalytic active component, can effectively reduce the content and concentration of sulfur dioxide in flue gas, after high temperature calcination in active carbon matrix form active nitrogen structure, can improve the adsorption capacity of active carbon to SO2.

The invention relates to a crystal form of donepezil 1-hydroxy-2-naphthoate ((+ / -)-2-[(1-benzyl-4-piperidyl) methyl]-5, 6-dimethoxy-1-indanone 1-hydroxy-2-naphthoate), a preparation method of the crystal form and application of the donepezil 1-hydroxy-2-naphthoate. The crystal form of donepezil 1-hydroxy-2-naphthoate provided by the invention has the advantages of better stability, lower hygroscopicity, lower solubility, lower pH dependence on solubility, better preparation processability and the like, and has important value for the development of long-acting injection of the drug in the future.

To provide a solid form of sulcardine salts other than sulfuric acid salts of sulcardine.SOLUTION: There is provided a solid form comprising an acid salt of sulcardine, wherein the acid is ethane-1,2-disulfonic acid, naphthalene-1,5-disulfonic acid, 1-hydroxy-2-naphthoic acid, naphthalene-2- sulfonic acid, hydrochloric acid, or hydrobromic acid.SELECTED DRAWING: None

The method comprises the following steps: fully reacting a substituted pyridine compound as shown in a formula (I) and a 2-naphthoic acid methyl ester compound as shown in a formula (II) in a DMSO (Dimethylsulfoxide) solvent by taking palladium acetate and copper acetate as catalysts and taking cesium carbonate as alkali to obtain the 3-pyridyl-2-naphthoic acid methyl ester compound. The product, namely the 3-pyridyl-2-naphthoic acid methyl ester compound, as shown in a formula (III) is prepared. The method has the advantages of low cost, simplicity in operation, excellent yield and the like, and meets the requirement of green synthesis of drug intermediates. # imgabs0 #