The invention discloses alcohol-soluble polyamide resin for plastic printing ink and a preparation method thereof. The preparation method comprises: adding dimer acid and sebacic acid into a reactionkettle, introducing nitrogen gas, regulating a pressure, heating for 5min, then sequentially adding diamine, a molecular weight regulator, acetic acid and glycerin, warming, and carrying out pressure-maintaining stirring for 3 to 4h so as to obtain polyamide resin; then adding isophthalic acid, diphenolic acid and ethanol amine, regulating the pressure and temperature, stirring for 1 to 2h, then carrying out decompression, discharging water vapor, when the pressure is reduced to 1atm, stopping reaction, and cooling to obtain the alcohol-soluble polyamide resin. According to the alcohol-solublepolyamide resin for the plastic printing ink, which is obtained by adopting the preparation method disclosed by the invention, an acid value is smaller than 6KOHmg / g, an amine value is smaller than 6KOHmg / g, a softening point is 110 to 120 DEG C, and freezing resistance is qualified; the alcohol-soluble polyamide resin has excellent adhesive strength, gelling resistance, weather resistance and low-temperature stability.