55 results about "Pillararene" patented technology

The invention discloses quinoline-modified pillararene which is obtained through a one-step etherification reaction of a bromine-alkylated 5-pillararene and 8-hydroxyquinoline. Due to the fact that new quinolyl groups are introduced to modify the alkoxy structures at the two ends of the pillararene, the pillararene can achieve the good fluorescence property, and therefore the pillararene can serve as a good fluorescence sensor to be applied to detection of anions. Fluorescence emission spectrum experiments show that in a DMSO / H2O system (the volume percentage of H2O is 20-25%), when the concentration of the quinoline-modified pillararene is more than 2*10<-4>mol / L, the quinoline-modified pillararene can perform fluorescence identification on CN<-> specifically and selectively and has the high sensitivity.

The invention provides a pillar[5]arene and 2-hydroxy-3-naphthoic acid complex.Copolymerized pillar[5]arene serves as a subject, 2-hydroxy-3-naphthoic acid serves as an object, C-H......pi and electrostatic attraction serve as driving force, partial 2-hydroxy-3-naphthoic acid provided with negative charges is included into a cavity of pillararene in an alkaline environment, the assembling process of the subject and the object is completed, and the stable pillar[5]arene and 2-hydroxy-3-naphthoic acid complex is formed.Iron ions are added to an alkaline aqueous solution of the complex, and the subject and the object are subjected to fluorescence quenching; fluorine ions are added, a complex is formed by the fluorine ions and the iron ions, so that the iron ions are separated from the cavity of copolymerized pillar[5]arene, and molecular fluorescence of the complex is reopened.Therefore, Fe<3+> can be determined through the pillar[5]arene and 2-hydroxy-3-naphthoic acid complex, and F<-> can be continuously identified through fluorescence quenching of the solution.

The invention discloses a method of adsorbing and separating palladium with high-molecular-based pillararene. The method includes a step of mixing an adsorbent with a nitrate solution containing various metal ions, wherein the palladium ion is adsorbed and separated by the adsorbent. The adsorbent is prepared by supporting the compound represented as the structure formula (I) on a carrier, wherein 1 g of the adsorbent is mixed with 20-30 ml of the nitrate solution. The carrier is medium-polarity macroporous resin. Concentration of nitric acid in the nitrate solution is 0.4-8 M. The method of adsorbing and separating palladium with the high-molecular-based pillararene is free of addition of other organic compounds, has good selectivity, is high in separation speed, is easy to operate and is easy to promote.

The invention discloses an amino-functionalized water-soluble pillar[6]arene and a preparation method thereof. The preparation method for amino-functionalized water-soluble pillar[6]arene comprises the following steps: (1) preparing 1,4-bis(2-bromoethoxy)benzene (I) from hydroquinone dihydroxyethyl ether; (2) preparing bromo-functionalized pillararene (II) from 1,4-bis(2-bromoethoxy)benzene (I); (3) preparing azido-functionalized pillararene (III) from bromo-functionalized pillararene (II); and (4) preparing the amino-functionalized water-soluble pillar[6]arene with azido-functionalized pillararene (III) as a raw material. The amino-functionalized water-soluble pillar[6]arene prepared in the invention has a pillar framework which is composed of six benzene rings and six methylene groups and connected with twelve amino groups and contains a plurality of recognition sites; the amino-functionalized water-soluble pillar[6]arene has good dissolvability in both methanol and an aqueous acidic solution; and the preparation method has the advantages of mild reaction conditions, simple operation, high product yield, large molecular cavity and the like.

The invention provides a pillararene-based supramolecular polymer photoelectric material, a preparation method therefor and an application of the supramolecular polymer photoelectric material. The supramolecular polymer photoelectric material contains a unit A1, a unit A2, a functional group B and a functional group C, wherein the functional groups (B and C) are separately connected with the A1 and the A2; and the units (A1 and A2) are conjugate unit containing oligomers or conjugate unit containing micromolecular ingredients, the functional group B is pillararene, the functional group C is neutral alkylimidazole, and the functional group B and the functional group C are connected through interaction between a plurality of C-H...O(N) hydrogen bonds and C-H...[PI]. Through introducing a novel macrocyclic supramolecular main body material, i.e., a pillararene structural unit, the condition selectivity of forming of a supramolecular polymer is lowered. Through introducing different functionalized oligomers, the application of the supramolecular polymer photoelectric material is extended.

The invention belongs to the technical field of medicines and relates to a pillararene type compound as well as a preparation method, a pharmaceutical composition and application thereof. Specifically, the invention relates to a compound shown as a formula I as well as a preparation method, a pharmaceutical composition and application thereof. According to the compound provided by the invention, the stability of a medicine is improved and the inhibition effect of the medicine on tumor cells is also enhanced. The preparation method of the compound is simple and the compound has very important meaning on secondary development and utilization of the medicine. The formula I is shown in the description.

The invention discloses a double-pillararene mercury ion fluorescence sensor. Ethanol is taken as a solvent, amidated pillar[5]arene and p-phthalaldehyde are taken as substrates, the solvent and the substrates are subjected to refluxing under the catalytic action of glacial acetic acid, suction filtration is performed, a product is washed with ethanol and subjected to vacuum drying, and light yellow solids are obtained. The sensor can emit stronger yellow green fluorescence in a DMSO-H2O amphiphilic solution on the basis of aggregation. 16 common cation solutions are respectively added to theDMSO-H2O solution of the mercury ion sensor, it is discovered that fluorescence quenching of the mercury ion sensor can be realized only when mercury ions are added, besides, the fluorescence quenching and recognition processes are not disturbed by other ions, fluorescence detection limit of QS for Hg<2+> is 4.3*10<-8> M, and higher sensitivity is achieved. Besides, the sensor has self-aggregationbehavior, and a gel film prepared from the sensor can be applied to a safe display material of Hg<2+>.

The invention discloses a nanometer material based on pillararene and up-conversion nanocrystalline self-assembly as well as a preparation method and application of the nanometer material. The nanometer material is self-assembled by pillararene and up-conversion nanocrystalline, wherein an inert NaGdF4 layer or an inert NaNdF4 layer is coated on the surface of the up-conversion nanocrystalline; and the surface of the inert NaGdF4 layer or the inert NaNdF4 layer is modified by carboxyl modified cetyl trimethyl ammonium bromide. The preparation method is simple, and the repeatability is high. The nanometer material has diagnosis and treatment integrated functions, can be applied to preparing imaging agents for fluorescence imaging or magnetic resonance imaging, has drug delivery and pH-responsive release effects and can serve as a drug preparation carrier.

The invention discloses a water-soluble pillararene chiral amplification agent, and a preparation method and an application thereof, and belongs to the technical field of chiral compound detection. The water-soluble pillararene chiral amplification agent is a percarboxy ammonium salt pillararene or percarboxyl sodium salt pillararene having a structure represented by formula (I) shown in the description. The water-soluble pillararene chiral amplification agent is prepared by synthesizing a perester pillararene from a perhydroxyl pillararene and reacting the perester pillararene with an alkali.The water-soluble pillararene chiral amplification agent and a chiral small molecule are mixed, and the circular dichroism spectrum signal of the chiral small molecule can be enhanced by complexation, so that the circular dichroism spectrum signal can be detected. A circular dichroism spectrum chiral signal amplification method based on the water-soluble pillararene chiral amplification agent issimple, easy, convenient and fast. In the formula (I), n is 1 or 2, and M is NH4 or Na.

The invention discloses a magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, a preparation method and an application thereof, and belongs to the technicalfield of the compound drug-loading system. The preparation method comprises the following steps: using Fe3O4 as a nuclear matrix, enabling MOFs reaction mother solution to directly react with the nuclear matrix through an in-situ growth mode to form the magnetic putamen MOFs, and modifying 'connecting shaft' molecules on the magnetic putamen MOFs material loaded with the drug through a post-modification mode and performing the follow-up installation of the pillararene nano-valve mediated by a subjective and objective acting force, and realizing the controlled-release under the stimulation oflesion environment factors. Through changing the types of the pillararene nano-valve and the 'connecting shaft' molecules, the slow release of the drugs under the stimulation response can be realized.The whole compound material diagnosis and treatment system is capable of realizing the targeting drug release and the controllable drug release behavior by using the controllability of the nano-valveas the opportunity. The multi-functional point-fixing, timing and positioning treatment can be realized by organically combining the molecular chemistry and the material chemistry, so the disease treatment efficiency is improved.

The invention provides a covalent macrocyclic polymer based on pillar [5] arene as well as a preparation method and application thereof. The structure of the covalent macrocyclic polymer is shown as a formula I, the covalent macrocyclic polymer not only has a microporous structure formed by crosslinking monomers, but also has a cavity structure of pillararene, is a novel multistage microporous structure material, is large in specific surface area and excellent in thermal stability, can remarkably improve the color fading rate of a photochromic material, and is a new strategy for regulating and controlling the color fading rate.

The invention provides 8-hydroxyquinoline functionalizedpillar[5]arene. The 8-hydroxyquinoline functionalizedpillar[5]arene (PQ8) is a white solid obtained by taking acetonitrile as a solvent, bilateral 1,4-dibromobutane modified pillararene and 8-hydroxyquinoline as reaction substrates, performing reacting at 80-85 DEG C for 70-72 hours under the action of K2CO3 and KI and the protection of N2 and carrying out separating by column chromatography after the reaction is finished. The PQ8 solid powder is exposed in steam of acetonitrile, dichloromethane, chloroform, formaldehyde, pyridine, tetrahydrofuran, ammonia water, n-propylamine, n-butylamine, 1,6-hexamethylenediamine, 1,10-decamethylene diamine and ethidene diamine, and only the steam of ethidene diamine enables the fluorescence color of the solid powder of the 8-hydroxyquinoline functionalized pillar[5]arene to change from blue to faint yellow, so single selective detection of ethylenediamine can be realized; and meanwhile, the PQ8 can realize the adsorption of the ethanediamine, and the molar adsorption rate of the ethanediamine can reach 176.19%.

The invention discloses a folic acid recognition and pillararene nano-valve controlled-release double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, a preparationmethod and application of the compound system, and belongs to the technical field of compound medical materials. The preparation method includes that polypyrrole nanoparticles (PPy NPs) are used as anuclear matrix, a metal organic frame material (MOFs) reaction mother solution directly reacts with the nuclear matrix by means of in-situ growth to form a PPy-MOFs compound nanomaterial, and 'connecting shaft' molecules are modified on the PPy-MOFs compound nanomaterial by means of post-modification for subsequent mounting of a pillararene nano-valve mediated by subject-object acting force; polyethyleneimine polymer (PEI-Fa) modified by folic acid is post-modified on a compound material equipped with a supermolecule nano-valve. Design of the whole compound material therapy system brings synergism of all parts into full play, organic combination of chemotherapy and photothermal therapy is realized, and targeted and controlled drug release is realized through controllability of the nano-valve and folic acid recognition.

The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.

The invention relates to flower water essential oil and multi-flavor flower water essential oil. The flower water essential oil is prepared by mixing fresh flower aromatic water with a pillararene derivative, then adding an organic solvent for extracting, separating an organic phase and removing the organic solvent in the organic phase; the pillararene derivate is at least one of hydrobromic acidall trimethylamine propyl column [6] arene, all trimethylamine ethyl column [6] arene and all trimethylamine butyl column [6] arene. According to the flower water essential oil disclosed by the invention, the pillararene derivative is applied to the extraction process of the fresh flower aromatic water; the pillararene derivative has the advantages that the efficiency of the extraction process canbe improved, the transfer of water-soluble essential oil components in the fresh flower aromatic water to an organic phase can be promoted and the extraction transfer rate of functional components isimproved, and thereby the problem that enrichment and transfer of water-soluble essential oil components such as terpene alcohol and aromatic alcohol cannot be realized by a traditional liquid-liquidextraction mode can be effectively solved.

The invention relates to a pillararene modification cyanide ion fluorescence detection test paper and a preparation method thereof and a detection method thereof. The cyanide ion fluorescence detection test paper is oxidized by the filter paper and placed in the pillararene solution for immersion treatment, then immersed in the sodium borohydride solution after washing, washed, dried, and then immersed in the 10-methyl acridine solution, after cleaning and drying, cyanide ions used for detecting the 10-3~10-7M concentration range are obtained. The method is advantaged in that the cyanide ion fluorescence detection test paper is used for detecting the cyanide ion concentration in the solution, the to-be-detected solution is dropped to the test paper for detection, through observing change of fluorescence intensity on the test paper, the cyanide ion concentration can be quantitatively detected through naked eyes, the response speed is fast, the result can be rapidly determined, and the cyanide ion concentration in the solution can be simply, conveniently, rapidly and economically detected.

The invention discloses a bifunctional pillararene derivative ligand, a metal organic cage and a preparation method. The pillararene derivative ligand has a structure shown as a formula (I); a pillararene and tetraphenyl ethylene with large steric hindrance are modified onto a ligand simultaneously, and coordinating with Pd (CH3CN) 4 (BF4) is carried out 2 to obtain the bifunctional pillararenederivative metal organic cage. Tetraphenyl ethylene on the inner side of the derivative ligand has an aggregation-induced emission effect, and the pillararene on the outer side of the derivative ligand has host-guest recognition capacity, can recognize guest molecules and is further coordinated with heavy metal salt, so that the multi-functional metal organic cage is obtained and used for buildinga supramolecular platform based on The pillararene compound. The preparation method provided by the invention overcomes the difficulty that the inner side and the outer side of the ligand are difficult to be modified with different functional groups at the same time, can prepare the bifunctional group modified metal organic cage, and expand the application field of the metal organic cage.

The invention discloses an Au NPs coated WP5 / BiOBr composite material as well as a preparation method and application thereof. The Au NPs coated WP5 / BiOBr composite material is prepared by loading Au NPs coated WP5 in a bismuth oxybromide nanoflower lamella, the Au NPs coated WP5 / BiOBr composite material is modified on the surface of a glassy carbon electrode, and the Au NPs coated WP5 / BiOBr composite material is prepared by utilizing the local surface plasma effect of gold nanoparticles under visible light. The host-guest complexing effect of water-soluble pillararene and the photogenerated electron hole acceleration redox reaction of BiOBr under visible light illumination are cooperated to detect the dopamine in the solution. Bovine hemoglobin with different concentrations is sequentially dropwise added into the solution, an electric signal generated by dopamine can be weakened, so that indirect detection of the bovine hemoglobin is achieved, the detection range is 10<-11>-10<-1> mg / mL, and the detection limit is 4.2* 0<-12> mg / mL.

The invention discloses a water-soluble pillararene modified amphiphilic graphene quantum dot, a preparation method and application. The water-soluble pillararene modified amphipathic graphene quantum dot is prepared by modifying an amphipathic graphene quantum dot with water-soluble pillararene so as to obtain the water-soluble pillararene modified amphipathic graphene quantum dot, wherein the amphiphilic graphene quantum dot and the water-soluble pillararene are combined through hydrophobic interaction and electrostatic interaction to form the amphiphilic graphene quantum dot modified by the water-soluble pillararene. According to the invention, the preparation method is easy to operate and good in repeatability; and the prepared modified amphiphilic graphene quantum dot emits strong green fluorescence, wherein after water-soluble pillararene modification, the fluorescence intensity is enhanced, the affinity is high, the quantum dot can penetrate through a cell membrane more easily, and the quantum dot has low toxicity and biocompatibility and can be used for cell imaging.

The invention provides a preparation method of a quasi-polyrotaxane film and a polyrotaxane film prepared thereof. The preparation method comprises the steps that S1, a polymer containing a polycaprolactone chain segment serves as a guest molecule, pillararene containing an azobenzene group serves as a host molecule, the guest molecule and the host molecule are fully dissolved in an organic solvent at the temperature of 0-50 DEG C according to the molar ratio of 1: (1-1000), and a quasi-polyrotaxane solution is formed; and S2, the quasi-polyrotaxane solution is sprayed at the speed of 0.2-60 mL / h through an injection pump by adopting an electrostatic spraying technology under the conditions that the voltage is 5-40 KV, the receiving distance is 5-30 cm and the humidity is 50% RH to 90% RH, so as to obtain the quasi-polyrotaxane film. According to the method, raw materials are easy to obtain, the cost is low, operation is easy, the requirement for equipment is low, and repeated writing and erasing of information on the film can be achieved through color changes caused by light responsiveness of azobenzene groups in the quasi-polyrotaxane film.

The invention belongs to the field of chromatographic analysis, and particularly relates to an amino-functionalized column penta-arene stationary phase, a capillary gas chromatographic column as well as preparation and application of the amino-functionalized column penta-arene stationary phase and the capillary gas chromatographic column. 1, 4-hydroquinone is used as a raw material, and the amino-functionalized pillarolenepentaarene derivative is obtained through five chemical reactions of etherification, cyclization, amination and hydrazinolysis. A long-chain functional group is introduced to the lower edge of a pillararene monomer, and then a host molecule with higher polymer recognition capability is obtained after cyclization. The pillararene integrates the advantages of the first four generations of supramolecular host compounds, and meanwhile, the film-forming property of the pillararene is improved by introducing a long alkyl chain and amino, so that the thermal stability of the pillararene is improved. The prepared P5A-C10-2NH2 serves as a stationary phase of gas chromatography and shows good separation performance in the aspect of separating compounds such as methylnaphthalene isomers, xylenol isomers, benzaldehyde isomers and halogenated benzene isomers, and the preparation method is simple and easy to implement.

The invention discloses a supramolecular polymer, which is obtained by self-assembling and complexing a pillararene derivative and a bipyridine salt at a molar ratio of 2: 1 in DMSO, wherein the supramolecular polymer shows yellow fluorescence in DMSO; aqueous solutions of F<->, Cl<->, Br<->, I<->, AcO<->, H2PO4<->, SO4<2->, ClO4<->, CN<->, SCN<->, N3<-> and OH<-> are respectively added into a DMSO solution of the supramolecular polymer; only the addition of OH<-> can quench florescence of the supramolecular polymer solution, so that the supramolecular polymer can be used for single selectivefluorescence recognition of OH<->; N2, O2, H2 and CO2 gases are respectively introduced into the DMSO solution of the supramolecular polymer containing OH<->; only the CO2 gas can open the fluorescence of the solution, therefore, the supramolecular polymer can subsequently recognize carbon dioxide in the air; and the recognition performance has an important application value in the field of ion recognition.

The invention relates to a supramolecular onium salt catalyst for synthesizing carbonic ester and a preparation method thereof. The preparation method comprises the following steps: reacting imidazolium ionic liquid with functionalized aromatic hydrocarbon according to a certain weight ratio to prepare the pillararene supramolecular onium salt compound containing an imidazolium ionic liquid structural unit on a main chain ring structure. The functional ionic liquid is directly connected to the main chain structure of the pillararene, so that the functionalization means of the pillararene and the ionic liquid are expanded, and the electronic environment of the pillararene and the ionic liquid is efficiently changed, so that the pillararene and the ionic liquid have the characteristics of non-volatility, functionalization, greenness and environmental protection of the ionic liquid, and the pillararene has the characteristics of high selectivity and good recognition capability. Meanwhile, the two structural units are effectively combined, so that the synergistic effect is achieved in the application process.

The invention discloses a continuous preparation method of high-purity perfluoro-2, 4-dimethyl-3-heptene. The preparation method comprises the following step: in a micro-channel reactor, hexafluoropropylene and a liquid phase catalyst preheated by a preheating module react at 70-140 DEG C to obtain the perfluoro-2, 4-dimethyl-3-heptene. the liquid-phase catalyst is prepared from a component A, a component B, a component C and a component D, the component A is selected from at least one of potassium fluoride, cesium fluoride and potassium bifluoride; the component B is selected from at least one of crown ether, cyclodextrin, polyethylene glycol, calixarene or pillararene; the component C is an amide compound; and the component D is selected from at least one of perfluoro-4-methyl-2-pentene, perfluoro-2-methyl-2-pentene and perfluoro-2-ethyl-3, 3-dimethyl ethylene oxide. The method has the advantages of accurate temperature control, good selectivity, high product purity and the like.

The invention discloses a water-soluble host-guest compound as well as a preparation and application thereof. Water-soluble pillararene is used as a macrocyclic carrier to act with an anticancer drug busulfan, so that the stability of the water-soluble host-guest compound is greatly improved, the hydrolysis rate of the water-soluble host-guest compound is reduced, and the water solubility of the water-soluble host-guest compound is improved. The water-soluble host-guest compound as well as the preparation and application thereof has the advantages that the raw materials of the water-soluble pillararene can be commercially purchased, the synthesis is simple and convenient, the yield is high, the operation of stabilizing anticancer drugs is simple and convenient, the stabilizing effect is good, the hydrolysis rate is greatly inhibited, the water solubility is improved, the problem of hydrolysis of busulfan drugs is expected to be solved. The application prospect in the aspects of treating leukemia and reducing toxic and side effects and the like is wide.

The invention provides a pillar aromatic-based [2]rotaxane and its preparation and application in catalytic coupling reaction, belonging to the technical field of organic synthesis. The present invention utilizes the host-guest complex between the pillararene and the neutral guest to successfully and efficiently construct a new type of pillararene-based [2]rotaxane, and further coordinate the pillararene [2]rotaxane with Pd. A new type of catalyst is prepared, which not only has good catalytic efficiency, but also can be recycled.

The present invention relates to a pillararene-based polypeptide conjugate, its preparation method and its application. The general structural formula of the pillararene-based polypeptide conjugate is: the pillararene-based polypeptide conjugate of the present invention, wherein the polypeptide structure part imparts targeting, solubility, and prevents the conjugate from interacting with plasma proteins. Interaction; as effector molecules, pillar aromatic hydrocarbons have supramolecular host-guest complexation with polyamines in cells, directly downregulate the content of polyamines, inhibit tumor growth, and play a role in tumor therapy.

The invention provides a solid catalyst for preparing an olefin polymer, the solid catalyst comprises the following components or reaction products of the following components: magnesium element, titanium element, halogen, a first internal electron donor and a second internal electron donor, the first internal electron donor comprises a pillararene compound as shown in formula (I), and the second internal electron donor is selected from one or more of an alcohol ester compound, an aromatic carboxylic ester compound, a diether compound and a succinate compound. By introducing the pillararene compound as shown in the formula (I) or the derivative thereof as an internal electron donor into the solid catalyst component, the stereospecificity of the catalyst can be improved, and the molecular weight of a polymerization product can be improved.