48 results about "Pillararene" patented technology

The invention discloses a method and a device for preparing a single-walled carbon nanotube based on the host-guest interaction of pillararene and metallocene. The method comprises the following steps: enabling a host compound and a guest compound to form a host-guest complex; the host compound comprises pillararene or a derivative thereof, and the guest compound comprises a cyclopentadienyl metal complex or a derivative thereof; the method comprises the following steps: reacting a mixed reaction system containing a host-guest compound and a polymerization inhibitor at a high temperature to obtain nano-scale catalyst particles; and contacting the nano-catalyst particles with a carbon source, and decomposing and growing the carbon source on the surfaces of the nano-catalyst particles to prepare the single-walled carbon nanotubes. The method disclosed by the invention is mainly based on the strong inclusion behavior of the host compound and the guest compound, and by utilizing the compatibility of the host compound, the solubility of the metallocene in an organic solvent is effectively improved, the decomposition time of the metallocene at high temperature is prolonged, and the in-situ controllable preparation of nano-scale catalyst particles is achieved; and furthermore, the yield and the quality of the single-walled carbon nanotubes are improved.

The invention relates to the technical field of biological materials, in particular to a pillararene-based photoresponse MOF-based ion gating nanochannel and a preparation method thereof. According to the pillararene-based photoresponse MOF-based ion gating nano-channel, a bullet-shaped nano-channel is prepared by taking PET (Polyethylene Terephthalate) as a substrate, and the substrate can provide structural support; p5A-MOF-1 based on pillararene is used as a core functional layer, and the core functional layer can provide a stable cavity environment; a P5A-MOF-1 cavity is filled with an organic aromatic azo compound, so that the light response structure change is realized. And the effective volume of the P5A-MOF-1 cavity is regulated and controlled through the photoisomerization effect of the azo group, so that precise gating of ion transmission is achieved. The preparation method provided by the invention is simple and convenient to operate, mild and controllable in condition and beneficial to large-scale production.

The invention is applicable to the technical field of metal organic framework materials, and provides a pillararene-based metal organic framework material and a preparation method thereof.The pillararene-based metal organic framework material takes a compound PY2-P5 as a ligand, and the material is one of PMOF1, PMOF2 and PMOF3; the PMOF1 is of a Cu4I4 cubic tetramer structure; the PMOF2 is of a Cu4I4 ladder tetramer structure, and the Cu4I4 ladder tetramer structure is a And the PMOF3 has a CuI one-dimensional chain structure. By introducing the pillararene ligand and regulating and controlling the coordination mode of the pillararene ligand and cuprous iodide, the metal organic framework material with stable structure and functional characteristics is constructed, the metal organic framework material has the dual advantages of host recognition site and fluorescence signal response, and can selectively distinguish 1-bromoalkane and 2-bromoalkane; a remarkable fluorescent blue shift signal is shown in the adsorption process, so that the visualization of molecular recognition and sensing is realized; the excellent molecular recognition capability of pillararene is maintained, the stability and reusability of the material are improved through framing, and a new way is provided for selective detection and separation of volatile organic compounds.

The invention relates to the technical field of single-molecule devices and sensors, in particular to a graphene single-molecule sensing device based on pillararene as well as a preparation method and application of the graphene single-molecule sensing device. The sensor comprises a pillararene molecule, the functional molecule is covalently connected between a graphene electrode pair through nucleophilic substitution reaction or amide condensation reaction under an alkaline condition, and the stability and the conductive reliability of a molecule-electrode interface are enhanced. According to the present invention, the column aromatic hydrocarbon molecules can selectively perform inclusion on the perfluorocarboxylic acid, and the combination of different types of perfluorocarboxylic acids and the column aromatic hydrocarbon molecules can show the difference characteristic of the conductive state so as to achieve the distinguishing of different perfluorocarboxylic acids, such that the method is hopeful to be used in the detection of perfluorocarboxylic acid. Meanwhile, perfluorocarboxylic acid can be effectively desorbed through methanol treatment, and an I-V signal is recovered to an initial state, so that the device has reusability. The preparation method provided by the invention is stable in process, high in repeatability and beneficial to large-scale production.

The invention discloses macrocyclic pillararene with a structural formula shown in the specification. The invention also discloses an organic boron luminescent compound based on macrocyclic pillar arene, and the structural formula is shown in the specification; wherein R < 1 >, R < 2 >, R < 3 >, R < 4 >, R < 6 >, R < 7 >, R < 8 > and R < 9 > are any one of hydrogen, deuterium, trifluoromethyl and tert-butyl, R < 5 > and R < 10 > are hydrogen or alkyl, the alkyl contains 1-10 carbon atoms, and X is oxygen or sulfur. Macrocyclic pillararene is innovatively introduced into a boron-containing polycyclic aromatic skeleton, a rigid macrocyclic cavity of the skeleton forms a natural large-steric-hindrance group, and plane accumulation of multiple resonance molecules is hindered from the root of molecular design; according to the present invention, the TADF material is used as the main material, and is matched with the tert-butyl double large steric hindrance modification, such that the molecular steric hindrance is further increased, the intermolecular pi-pi interaction is effectively inhibited, the aggregation quenching problem caused by the high coplanarity of the traditional multi-resonance TADF material is solved, and the stability and the consistency of the luminescence property of the material in the film state are ensured;

The invention belongs to the technical field of pharmaceutical chemistry, radiopharmaceutical chemistry and clinical nuclear medicine, and particularly relates to a rotaxane protection-based radioactive halogen labeled compound as well as a preparation method and application thereof. A rotaxane protection-based radioactive halogen labeled compound comprises: a macrocyclic compound having a cavity, the macrocyclic compound comprising one of cyclodextrin, cucurbituril, calixarene and pillararene; a radioactive halogen-labeled compound: the radioactive halogen-labeled position is located in the cavity of the macrocyclic compound; and the end-capping group is positioned at the opening end of the cavity, is connected to two ends of the radioactive halogen-labeled compound and is used for preventing the radioactive halogen-labeled compound from sliding out of the cavity. The rotaxane protection-based radioactive halogen labeled compound provided by the invention has good in-vivo stability, and solves the problem of poor in-vivo stability caused by dissociation of radioactive halogen and a tracer agent in the existing radioactive halogen labeled compound.

The invention discloses a supramolecular polymer material based on a pseudorotaxane structure as well as a preparation method and application of the supramolecular polymer material, a matrix of the supramolecular polymer material is polydisulfide, a macrocyclic main body is complexed on a side chain of the polydisulfide, and the macrocyclic main body is a macrocyclic containing an electron-rich cavity structure. A quasi rotaxane structure is constructed by complexing a column [5] arene cavity and a lipoic acid alkyl chain, and the polymer material is endowed with excellent shear hardening performance by utilizing time dependence of dynamic dissociation of quasi rotaxane. Under relatively low-speed impact, pillararene slowly slips off from a side chain, and under high-speed impact, dissociation behaviors cannot be completed in time, so that a subject-object topological structure becomes a rigid site, impact force is dispersed to a nearby area in a spatial scale to prevent stress concentration, instantaneous impact force is dispersed in a time scale due to hysteresis of subject-object dissociation, and thus, the stability of the subject-object dissociation is improved. And the stress peak value is effectively reduced, so that the purpose of impact resistance protection is achieved.

The application discloses a D-amino acid modified pillararene compound and a preparation method and application thereof. The D-amino acid modified pillararene delivers D-amino acids to a biological membrane or cells by using pillararene as a carrier, exhibits synergistic activity of anti-biofilm and antibacterial, and is expected to be used for developing a novel anti-biofilm agent and an antibacterial drug. The compound can not only efficiently inhibit the growth of a bacterial biofilm, but also can be used in combination with an antibiotic to enhance antibacterial activity, and provides a new strategy for coping with biofilm-related infections and drug resistance.

Disclosed are an oxidation-responsive water-soluble cationic pillararene, and a preparation method and application thereof, the oxidation-responsive water-soluble cationic pillararene is a cyclic small-molecule nucleic acid vector, and is obtained by quaternization reaction of 4-methylborate and tertiary amine-modified pillararene. According to the invention, a delivery vector with a high positive charge density is obtained through small molecule synthesis, the delivery vector is capable of being tightly complexed with negatively charged nucleic acid substances to form a nano-composite, and after the nano-composite enters cells, vector positive charges fall off to release the nucleic acid substances in an oxidation environment, and nucleic acid is efficiently translated and expressed. The delivery vector has the characteristics of simplicity and convenience in synthesis, high delivery efficiency and good biological safety, and has a good application prospect.

The purpose of the present invention is to provide a composite which has excellent heat resistance, particularly excellent thermal decomposition resistance, and which is easy to introduce functional groups. The composite according to the present invention contains a polymer and one or more cyclic compounds including the polymer, the polymer having at least one selected from the group consisting of a glass transition temperature and a melting point at 130 DEG C or higher, and the cyclic compounds including a compound represented by formula (I). [In formula (I), A each independently represents a divalent C4-50 organic group containing one or more elements selected from the group consisting of-OR and-CO-at each occurrence, R each independently represents a hydrogen atom or an organic group optionally containing one or more fluorine atoms at each occurrence, and n represents an integer from 4 to 20. ] # imgabs0 #

The invention provides a mechanical interlocking epoxy resin polymer as well as a preparation method and application thereof. The mechanical interlocking epoxy resin polymer is prepared from raw materials including pillararene daisy chain polyurethane, epoxy resin and a cross-linking agent. According to the invention, the pillararene daisy chain polyurethane, the epoxy resin and the cross-linking agent are subjected to ring opening polymerization to form a mechanical interlocking polymer containing a daisy chain, the polymer containing the daisy chain is cross-linked by the cross-linking agent to form a network, and the prepared mechanical interlocking epoxy resin polymer has dynamic property; the dynamic nature mainly comes from the subject-object recognition effect of pillararene and triazole, the mechanical property and energy dissipation of traditional epoxy resin can be improved, the epoxy resin can bear larger stress, the toughness of the epoxy resin is enhanced, and the maximum elongation and ductility are promoted under the condition that the mechanical strength of a polymer is not sacrificed.

The invention relates to nano copper paste based on pillararene host-guest interaction and a preparation method and application thereof, and belongs to the technical field of conductive copper paste. The nano copper paste based on the pillararene host-guest interaction is prepared from the following components in parts by weight: 92 to 95 parts of nano copper powder coated with a pillararene supramolecular assembly, 4 to 8 parts of resin, 2 to 6 parts of an organic solvent, 0.1 to 1 part of a thixotropic agent, 0.1 to 1 part of a dispersing agent, 0.1 to 1 part of a coupling agent and 0.1 to 1 part of other auxiliaries. The nano-copper powder coated with the pillararene supramolecular assembly is of a core-shell structure, a host-guest compound serves as a shell, and nano-copper powder serves as a core; the host-guest compound takes glycidyl methacrylate grafted pillararene as a host and benzyltrialkyl quaternary ammonium salt as a guest; and the object is connected with the surface of the nano copper powder through a coordinate bond. The nano copper paste disclosed by the invention has the characteristics of good conductivity, low sintering temperature, strong adhesive force, excellent oxidation resistance and the like.

The invention discloses a preparation method of superfine fibers for high-fastness dope-dyed suede, and belongs to the technical field of new textile materials.The method comprises the steps that an inorganic nano pigment is coated with calixarene or pillararene, then the calixarene or pillararene coated with the inorganic nano pigment is fully stirred with polyester and an antioxidant, and the mixture is stirred to be uniform; polyester color master batches of calixarene or pillararene coated inorganic pigment are obtained after twin-screw extrusion granulation, the color master batches and polyester chips are subjected to a melt spinning process to produce nascent filaments, and the superfine fiber filaments are obtained through procedures such as drafting and the like. The superfine fiber filament prepared by the method can be used for preparing a suede fabric, and the prepared suede fiber does not change color and discolor in the traditional splitting process, is excellent in washing fastness, friction fastness and light fastness, and has excellent solvent resistance. The method is suitable for producing the superfine fibers for the dope-dyed suede.

The present application relates to the technical field of separation membrane, and particularly relates to a composite membrane based on diethanolamine functionalized pillararene and a preparation method and application thereof. Diethanolamine functionalized pillararene is designed and synthesized as a key water phase monomer for the first time. The innovative molecule simultaneously introduces a tertiary amine and a highly reactive strong hydrophilic hydroxyl group. The bifunctional design enables the pillararene and the acyl chloride monomer to form a polyester membrane on the surface of the base membrane through an interfacial polymerization reaction, thereby realizing the synergistic and precise regulation of the hydrophilicity, crosslinking density and selectivity of the membrane separation layer, and breaking through the performance bottleneck of relying only on the monofunctionality of the hydroxyl group. The composite membrane provided by the present application not only focuses on the flux and retention rate, but also takes the anti-pollution performance, high flux recovery rate and long-term running stability in actual wastewater as core evaluation indexes and optimization targets, and is directly aimed at and solves the application problems in the actual water treatment, different dye molecules and antibiotic separation processes.

The present invention relates to an amino acid-modified compound comprising a pillararene moiety, a linker having a divalent triazole ring, and an amino acid-modified group, a method for preparing the same, and a use thereof. The amino acid-modified compound of the present invention can be obtained in a simple and high-yield synthesis method, and the amino acid-modified compound is capable of spontaneously fusing into a cell membrane, exhibits high water transport efficiency and selectivity, is capable of significantly accelerating cell migration, and has excellent eardrum repair ability, and has low ototoxicity.

The invention belongs to the technical field of packaging materials, and particularly relates to acrylate pillararene, a preparation method, a packaging composition and application, the packaging composition comprises, by weight, 5-10 parts of acrylate pillararene, 8-20 parts of a fluorine-containing diluent, 20-60 parts of a fluorine-free diluent, 10-30 parts of a crosslinking accelerator and 1-10 parts of a photoinitiator; the preparation method comprises the following steps: adding the acrylate pillararene, the fluorine-containing diluent, the fluorine-free diluent, the crosslinking accelerator and the photoinitiator into a container according to a mass ratio, stirring for 30-60 minutes under a dark condition, and standing to obtain the packaging composition. According to the packaging composition, the dielectric constant of the acrylate pillararene is low, the acrylate pillararene has a rigid cavity structure, and the acrylate pillararene is compounded with the fluorine-containing diluent according to a specific proportion, so that the packaging composition has relatively high visible light transmittance, strength, toughness and barrier property and relatively low dielectric constant after being formed into a film.

The present application relates to the technical field of biological materials, and particularly relates to a pillar arene-based photoresponsive MOF-based ion gate nano-channel and a preparation method thereof. The pillar arene-based photoresponsive MOF-based ion gate nano-channel is prepared by taking PET as a substrate to prepare a bullet-shaped nano-channel, the substrate can provide structural support; taking a pillar arene-based P5A-MOF-1 as a core functional layer, the functional layer can provide a stable cavity environment; filling an organic aromatic azo compound in the cavity of the P5A-MOF-1 to realize a photoresponsive structural change. The effective volume of the cavity of the P5A-MOF-1 is regulated through photoisomerization of the azo group, and then precise gating of ion transmission is achieved. The preparation method is simple in operation, mild and controllable in conditions, and is conducive to large-scale production.

The invention discloses amphiphilic pillararene and application thereof, and belongs to the technical field of chemistry. Amphiphilic column aromatic hydrocarbon with nine trimethylamine salt hydrophilic ends and a terpyridyl hydrophobic end is designed and synthesized, the amphiphilic column aromatic hydrocarbon and Mn (CO) 5Br can be self-assembled in water to form nano particles after being coordinated, and the nano particles have a potential tumor CO treatment effect.

The present invention provides a pillararene binaphthol chiral catalyst, its preparation method, and application. The present invention provides a pillararene binaphthol chiral catalyst having the chemical formula shown below, as well as a method for preparing the pillararene binaphthol chiral catalyst. The present method features mild reaction conditions, simple operation, low cost, environmental friendliness, and high yield. The provided pillararene binaphthol chiral catalyst can be used in asymmetric organic catalysis and has broad application prospects in the field of chiral catalysis. #imgabs0#

The invention discloses a basic column aromatic hydrocarbon catalyst and application thereof in efficient catalysis of a Knoevenagel condensation reaction and a Michael addition reaction, belongs to the technical field of catalysts, and particularly discloses a basic column [5] aromatic hydrocarbon catalyst (Interdazole-P [5] A) which efficiently catalyzes aldehyde ketone and active methylene to generate a methylene malononitrile compound in the aspect of the Knoevenagel condensation reaction. In the aspect of Michael addition reaction, the catalyst efficiently catalyzes alpha, beta-unsaturated nitro or carboxyl or ester compounds and active methylene to generate corresponding addition products; meanwhile, the catalyst is also successfully applied to a'one-pot two-step method 'reaction of a Knoevenagel condensation reaction and a Michael addition reaction. According to the catalyst, the defects that a traditional alkaline homogeneous catalyst pollutes the environment and is difficult to recycle are overcome.

The invention provides a method for extracting gutta-percha, which comprises the following steps: mixing a eucommia ulmoides raw material with a supramolecular solution, extracting, separating and drying to obtain crude gutta-percha; wherein the supramolecular solution is obtained by reacting a component A and a component B; the component A is cyclodextrin; the component B is at least one of crown ether, organic acid, organic alcohol and pillararene; according to the method, the specific supramolecular solution is used as the extracting agent to extract the eucommia ulmoides raw material to obtain the crude eucommia ulmoides gum, the extraction process is simple, and the extraction efficiency of the eucommia ulmoides gum can be effectively improved; in addition, the method provided by the invention can effectively reduce the extraction cost and reagent consumption, has small environmental pollution, and is suitable for industrial application.

The invention relates to a pillararene covalent polymer as well as a preparation method and application thereof. The structure of the pillararene covalent polymer is shown as a formula I. The pillararene covalent polymer with the structure shown as the formula I is generated through reaction of bilateral hydrazide pillar [5] arene P4J1 and cyanuric chloride. Due to the porous structure and rich nitrogen sites of the polymer, the polymer has a good adsorption effect on iodine.

The present invention discloses a supramolecular polymer membrane based on pillararenes, a preparation method thereof, and an application in dye separation. The preparation method of the present invention utilizes interfacial polymerization, comprising: mixing a CHCl solution containing MeP5Bpy with an aqueous solution containing tetrakis(4-aminophenyl)methane and acetic acid and allowing the mixture to stand, thereby obtaining a supramolecular polymer membrane based on pillararenes at the interface between the CHCl and aqueous solution. The dye separation process of the present invention is simple to operate and requires low equipment. The separation process does not require a distillation operation, resulting in low energy consumption, energy conservation, and reduced production costs.

The invention relates to the technical field of covalent organic frameworks, in particular to a hierarchical pore COF membrane based on pillararene as well as a preparation method and application of the hierarchical pore COF membrane. The COF membrane is prepared through the synergistic effect of the organic acid catalyst, the TFB and the APP5, the structure of the COF membrane comprises dispersed nanopores and sub-nanopores, and the COF membrane has high porosity and accurate structural arrangement, so that the stability of a COF framework is enhanced, the permeability and selectivity are balanced, and the performance of the COF membrane in organic solvent nanofiltration is remarkably improved. Therefore, the COF membrane has a wide application prospect in the fields of organic solvent recovery, drug concentration and the like.

The application discloses a method and device for preparing single-walled carbon nanotubes based on pillar arene and metallocene host-guest interaction. The method comprises: forming a host-guest complex by allowing a host compound and a guest compound to interact; the host compound comprises a pillar arene or a derivative thereof, and the guest compound comprises a metallocene complex or a derivative thereof; allowing a mixed reaction system comprising the host-guest complex and a polymerization inhibitor to react at high temperature to obtain nanoscale catalyst particles; and then allowing the nanoscale catalyst particles to contact with a carbon source, so that the carbon source is decomposed and grown on the surface of the nanoscale catalyst particles to obtain single-walled carbon nanotubes. The method is mainly based on the strong inclusion behavior of the host compound and the guest compound, and the compatibility of the host compound is utilized to effectively improve the solubility of the metallocene in an organic solvent, prolong the decomposition time of the metallocene at high temperature, realize in-situ controllable preparation of nanoscale catalyst particles, and further improve the yield and quality of the single-walled carbon nanotubes.

The invention provides subject-object nanoparticles loaded with a protein degradation agent as well as a preparation method and application thereof, and the nanoparticles comprise: 1) functionalized polysialic acid, one part of which is covalently grafted with cyclodextrin, crown ether, pillararene or cucurbituril and other macrocyclic subjects, and the other part of which is covalently grafted with a targeting ligand and is used for crossing a blood brain barrier; 2) a heterodimer composed of a responsive protein degradation agent and a therapeutic drug; and 3) a fluorescent dye or other therapeutic small molecules. The heterodimer, the fluorescent dye and the like are combined with a macrocyclic host in the functionalized polysialic acid through host-guest interaction, and the nanoparticles are formed through self-assembly. The targeting ligand guides the nanoparticles to cross the blood brain barrier, and responds to the specific stimulation of the pathological environment through the responsive bond in the heterodimer, so that the controllable release of the protein degradation agent, the therapeutic drug and the fluorescent dye or other therapeutic small molecules is realized; finally, precise delivery and selective intervention of the medicine in the pathological area of the Alzheimer's disease are realized.

This invention discloses an oxidation-responsive cationic water-soluble pillararene, a method for producing the same, and its use. The oxidation-responsive water-soluble cationic [A2]pilarene is a cyclic low-molecular-weight nucleic acid vector obtained by a quaternization reaction of a 4-methylboronic acid ester with a tertiary amine-modified pillararene. This invention achieves the synthesis of a low-molecular-weight delivery vector having a high positive charge density, which can tightly bind to negatively charged nucleic acid substances to form nanocomplexes. Upon entering a cell, the positive charge of the vector is released in an oxidative environment, the nucleic acid substance is released, and nucleic acid information is efficiently expressed. This delivery vector is easy to synthesize, has high delivery efficiency, and is biologically safe, and is expected to have promising future applications.

The invention relates to the technical field of nano-drug carriers, in particular to a preparation method and application of enzyme-responsive nano-vesicles with pillararene as a carrier, a compound 30 is used as a starting raw material and condensed with a compound 31 under the action of EEDQ to obtain a compound 32, the compound 32 is subjected to Fmoc protection removal through piperidine and diethyl ether precipitation to obtain a compound 33, and the compound 33 is subjected to enzyme-responsive reaction to obtain the enzyme-responsive nano-vesicles with pillararene as the carrier. A compound 33 and a compound 34 react in DMF to obtain a compound 35, the compound 35 is subjected to trifluoroacetic acid deprotection to obtain a compound 36, the compound 36 and a compound 37 react and are subjected to column chromatography separation to obtain a compound 38, the compound 38 and terminal alkyne pillar arene 11 are subjected to 1, 3-dipole addition under the catalysis of Cu I / TBTA to obtain a compound 39, acetyl protecting groups are removed through sodium methoxide to obtain MP5, MP5 is dissolved in deionized water containing 1% of DMSO, dialysis is performed after ultrasonic treatment, and the compound 38 is obtained. The MP5 nano vesicle solves the problem that common antibiotics cannot play a role in intracellular parasitic salmonella, so that infection is difficult to radically treat.

An object of the present disclosure is to provide a composite having excellent heat resistance and / or hydrophobicity and allowing easy introduction of a functional group thereinto. A composite comprising: a fluorine-containing polymer; and one or more cyclic compounds that include the fluorine-containing polymer, where the cyclic compound comprises a compound represented by the following formula (I):where, in the formula, A independently represents a divalent C4-50 organic group comprising one or more selected from —OR and —CO—, R independently represents an organic group optionally comprising one or more fluorine atoms, or a hydrogen atom, and n represents an integer of 4 to 20.

The present invention relates to a pillararene, a solid support, a composition, a process for removing perfluorinated acids from an aqueous stream and the use of the pillararene. The pillararene comprises n monomers independently selected from the group consisting of monomers of formula (I), or a stereoisomer, tautomer, raceme, hydrate, N-oxide or solvate thereof.