109 results about "Perfluoroacetic Acid" patented technology

The invention provides chlorotrifluoroethylene continuously prepared based on a microchannel reactor and a preparation method of the chlorotrifluoroethylene, and the chlorotrifluoroethylene comprises the following raw materials in parts by weight: 1, 1, 2-trifluoro-1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The low-temperature refrigerant refrigerant is prepared from the following components in parts by weight: 90 to 100 parts of 1, 2-trichloroethane, 1 to 5 parts of a zinc fluoride induced palladium-copper bimetallic catalyst, 8 to 15 parts of a cyclohexyl dimethyl ether-formic acid composite hydrogen donor, 0.5 to 2 parts of trifluoroacetic anhydride, 0.1 to 0.5 part of a perfluoropolyether lubricant, a proper amount of a low-temperature mixed refrigerant and 15 to 20 percent by weight of diluted hydrochloric acid. According to the invention, the preparation efficiency and product purity of chlorotrifluoroethylene can be improved, and stable operation of the preparation system and reasonable treatment of byproducts can be guaranteed.

The invention provides a green and efficient production method of hexafluoropropylene oxide, and belongs to the technical field of synthesis of organic fluorine compounds. The method comprises the following steps: carrying out a continuous oxidation reaction on hexafluoropropylene, oxygen and a perfluoro solvent in an immersed supergravity reactor to generate HFPO and byproducts carbonyl fluoride and trifluoroacetyl fluoride, removing the solvent from the reacted liquid, feeding the liquid into an acyl fluoride rectifying tower, separating low-boiling-point acyl fluoride from the tower top, enriching HFPO, unreacted HFP and a small amount of acyl fluoride from the tower bottom, and carrying out a continuous oxidation reaction on the HFPO and the byproducts carbonyl fluoride and trifluoroacetyl fluoride. Converting acyl fluoride into anhydrous trifluoroacetic acid from a high-boiling-point substance at the bottom of the tower through a hydrolysis tower, carrying out alkali washing on the synthesis gas to obtain an HFPO crude product, and further carrying out drying and extractive distillation to obtain an HFPO product; acyl fluoride rectified by an acyl fluoride rectifying tower is directly used for producing PAVE, and long-chain perfluoroacyl fluoride accumulated in a solvent of oxidation reaction is hydrolyzed to synthesize a non-PFOA emulsifier. The method has the advantages of high HFPO selectivity, short reaction time and high safety; the method realizes resource comprehensive utilization of byproducts, and is environment-friendly and economical.

The invention belongs to the technical field of medical nano-materials, and particularly relates to a preparation method of a nano-metal covalent organic framework material for enhancing cell ferroptosis by consuming glutathione as well as an obtained product and application of the nano-metal covalent organic framework material. The material is prepared by the following steps: firstly, preparing a metal organic ligand Cu3-PyCA3; the preparation method comprises the following steps: firstly, preparing a metal organic ligand Cu3-PyCA3, then mixing the metal organic ligand Cu3-PyCA3, 2, 5-diethoxybenzene-1, 4-bis (formylhydrazine), mesitylene, 1, 4-dioxane and a trifluoroacetic acid solution, and then reacting to obtain a nano metal covalent organic framework Cu3-MCOF; and finally, uniformly mixing the activated hyaluronic acid solution and the Cu3-MCOF, and intensely stirring to obtain the Cu3-MCOF-coated HA. The nano-metal covalent organic framework provided by the invention can consume glutathione to enhance cell ferroptosis, and the nano-metal covalent organic framework Cu3-MCOF can quickly react with glutathione, so that the framework structure of the Cu3-MCOF is seriously damaged, the crystalline state disappears, a large number of ribbons are further assembled and generated, glutathione is consumed, and the ferroptosis of cells is enhanced. The ferroptosis tumor treatment enhancer has an application prospect.

The invention discloses a method for preparing a perovskite solar cell based on a fused salt doped Spiro-OMeTAD hole transport layer, and the method comprises the steps: dissolving lead iodide and formamidine iodide in a mixed solvent of N, N-dimethylformamide and dimethyl sulfoxide according to a molar ratio of (0.8-1.5): 1 to prepare an FAPbI3 perovskite precursor solution; the method comprises the following steps: mixing cyclohexylamine trifluoroacetic acid and 4-tert-butylpyridine according to a molar ratio of 1: (8-14), dissolving the mixture in a 70-110 mg / mL Spiro-OMeTAD chlorobenzene solution, adding an acetonitrile solution of LiTFSi, and stirring at normal temperature to obtain a hole transport material Spiro-OMeTAD solution; spin-coating the FTO substrate with an electron transport layer material, spin-coating the electron transport layer with the FAPbI3 perovskite precursor solution, and annealing to form a perovskite thin film; the method comprises the following steps: spin-coating an ammonium butyrate iodide solution on a perovskite thin film to obtain an interface modification layer, spin-coating a hole transport material Spiro-OMeTAD solution on the interface modification layer to obtain a cyclohexylamine trifluoroacetic acid doped Spiro-OMeTAD hole transport layer, and evaporating an interface modification layer and a metal electrode on the Spiro-OMeTAD hole transport layer.

The application provides a method for synchronously separating active substances of Haematococcus pluvialis, and relates to the technical field of natural product extraction, and comprises an extraction phase with a mass ratio of 20%-50%, and the balance is water; the extraction phase is a quaternary phosphonium ionic liquid or a eutectic solvent; the quaternary phosphonium ionic liquid comprises tetrabutylphosphonium trifluoroacetate or tributyl octyl phosphonium bromide; and the eutectic solvent comprises a quaternary phosphonium ionic liquid and a fatty acid with a molar ratio of 1:1-5:3. The extraction phase has weak acidity, the ability to form van der Waals forces and hydrogen bond interactions, the Haematococcus pluvialis cell wall breaking effect and high solubility. The extraction phase can form liquid-liquid phase separation, can realize the synchronous extraction of Haematococcus pluvialis cell wall breaking, astaxanthin, carbohydrates and proteins, and has no organic solvent, is simple to operate, has short extraction time and high extraction efficiency. The method solves the technical problem that the extraction agent in the prior art cannot effectively separate multiple active substances of Haematococcus pluvialis.

The invention discloses a preparation method and application of a silicon-based functionalized fluorenyl polysubstituted acetylene copolymer and a gas separation membrane thereof. Belongs to the technical field of polymer material and gas separation. The invention provides a new thought for preparation of a high-permeability gas separation membrane material. The preparation method comprises the following steps: carrying out copolymerization on 1-phenyl-2-(7-trimethylsilyl-9, 9-bis (trimethylsilyl-fluorene-2-yl) acetylene and 1-phenyl-2-(7-trimethylsilyl-9, 9-dimethyl-fluorene-2-yl) acetylene under the catalysis of TaCl5-n-Bu4Sn, so as to prepare a copolymer with high molecular weight; the preparation method comprises the following steps of: carrying out film casting on a solution of the nano-silver oxide, and then carrying out desiliconization treatment by using normal hexane / trifluoroacetic acid to obtain a gas separation membrane with the thickness of 100-220 microns, the specific surface area of 298-492 m / g and the total pore volume of 0.134-0.299 cm / g. The prepared separation membrane has the advantages that the COpermeability is up to 36,900 Barrer, the Opermeability is 19,800 Barrer, the thermal decomposition temperature exceeds 420 DEG C, the separation membrane can be used for separating gases such as COO, ON and the like, the preparation process is simple and convenient, and the industrial potential is realized.

The invention relates to a method for analyzing and detecting a non-azonetin enantiomer, which adopts normal-phase high performance liquid chromatography and takes normal hexane-ethanol-trifluoroacetic acid as a mobile phase to detect the non-azonetin enantiomer, and the specific chromatographic conditions are as follows: a chromatographic column is prepared by covalently bonding amylose-tri (3, 4, 6-trimethyl-1, 3-pentanediol) on the surface of silica gel; 2, 5-dichlorophenyl carbamate is used as a filling agent (IE, 4.6 * 250 mm, 5.0 [mu] m); a mobile phase: n-hexane: ethanol: trifluoroacetic acid = 500: 500: 1 (V / V / V); the flow rate is 1.0 ml / min; the column temperature is 30 DEG C; the sample size is 20 [mu] l; the detection wavelength is 280 nm; the elution gradient is isocratic elution. The invention provides a high performance liquid chromatography method for analyzing the enantiomer of the fiazonetin, the complete separation of the fiazonetin and the enantiomer of the fiazonetin can be realized by adopting the method, and the separation degree of a main component and the enantiomer is greater than 1.5.

The present application relates to a method for synthesizing leu-enkephalin by Fmoc method, which uses Fmoc-protected amino acid as monomer, and sequentially connects amino acid to resin. In the synthesis of leu-enkephalin, all the amino acids do not have any side chain protection group. The Fmoc protection group is removed by using a solution of 1.00 mol / L imidazole and 0.02 mol / L tricyclohexylphosphine in tetrahydrofuran, and finally leu-enkephalin is obtained by removing the resin with aqueous trifluoroacetic acid. The present application first uses imidazole and tricyclohexylphosphine as components of Fmoc deprotection agent, instead of traditional pyridine. The deprotection agent is not controlled by "controlled chemicals", is cheap and easy to obtain, is stable in nature, and is low in toxicity, volatility and corrosion. The deprotection agent has excellent Fmoc removal ability, does not cause phenolic ring acylation side reaction of tyrosine side chain, does not need any side chain protection, simplifies the production process of polypeptide, reduces the preparation cost of polypeptide, and provides great improvement space for the design of synthesis strategy of polypeptide containing basic sensitive side chain protection group.

An object of the present disclosure is to provide a nonaqueous electrolytic solution and a lithium ion secondary battery using same, the nonaqueous electrolytic solution having both excellent battery safety when used at a high temperature, an important feature for secondary batteries to be installed in modern vehicles such as electric vehicles, and having excellent battery characteristics. The nonaqueous electrolytic solution of the present disclosure is a nonaqueous electrolytic solution including an electrolyte salt dissolved in a nonaqueous solvent, the nonaqueous solvent containing from 80 to 100 vol % in total of at least one selected from ethylene carbonate, propylene carbonate, and γ-butyrolactone, and the nonaqueous electrolytic solution further including a trifluoroacetic acid ester having an alcohol group with a carbon chain length of from 6 to 8.

The invention relates to a preparation method of a hyperbranched polymer containing phthalic dicarboxaldehyde, which comprises the following steps: dissolving a chain transfer agent, a monomer ADP containing a phthalic dicarboxaldehyde protecting group, dimethylacrylamide and azodiisobutyronitrile in tetrahydrofuran, and reacting for 8-24 hours at 70 DEG C in an inert atmosphere; cooling to normal temperature, adding trifluoroacetic acid, and continuously reacting for 1-3 hours; and stopping the reaction and precipitating, and then drying in vacuum to obtain the hyperbranched polymer containing o-phthalaldehyde. The hyperbranched polymer prepared by the invention can be efficiently cross-linked and fixed with sclera collagen, and is used for intervention treatment of myopia progress.

This invention discloses a molecularly imprinted modified electrode for detecting trifluoroacetic acid in water, its preparation method, and its application. An integrated composite sensing interface is constructed, comprising an enrichment layer, a recognition layer, and a conductive layer, wherein a monolayer Ti3C2T is used. x A three-dimensional conductive network is constructed as the conductive layer, significantly enhancing the electron transfer rate. A molecularly imprinted polymer is used as the conversion layer; its pre-designed specific recognition cavity accurately captures target molecules and converts the specific binding behavior of trifluoroacetic acid into a detectable electrochemical signal. UiO-66-F4 is used as the enrichment layer; leveraging the fluoride-loving interactions between fluorine atoms, trifluoroacetic acid molecules in the water sample are efficiently enriched at the electrode interface, significantly reducing the detection limit to as low as 6.94 ng / L. This molecularly imprinted modified electrode exhibits good selectivity and anti-interference capabilities, along with good repeatability, reducing the detection cost per sample and enabling sensitive and rapid detection of trifluoroacetic acid under complex water conditions.

This invention belongs to the field of responsive material production technology, specifically relating to a high-viscosity fluoropolymer solution and its applications. The preparation method of the high-viscosity fluoropolymer solution is as follows: (meth)acrylate naphthyl ester, fluorinated methacrylate, and vinylcarbazole are dissolved in a solvent and stirred to obtain a clear and transparent solution. Then, an initiator is added, and the mixture is heated to 60-90℃ under magnetic stirring for 16-24 hours to polymerize. After the reaction is completed, a transparent high-viscosity polymer solution with a viscosity range of 800-8000 Pa·s is obtained. After the high-viscosity fluoropolymer solution forms a film on the substrate, it forms an anti-counterfeiting coating that can be stimulated by ultraviolet light and trifluoroacetic acid, exhibiting excellent multi-stimulus responsiveness. The preparation method of this anti-counterfeiting coating is simple, has good film-forming properties, long service life, and low cost. It can be industrially produced and provides dual anti-counterfeiting capabilities, showing great application prospects in anti-counterfeiting, information encryption, and other fields.

The present application relates to a kind of high efficient stable perovskite solar cell based on chlorophyll derivative and preparation method thereof, belong to perovskite solar cell technical field.Solve the problem that the photoelectric conversion efficiency and stability of existing perovskite solar cell still need to be further improved.The perovskite solar cell of the present application includes transparent conductive glass anode, hole transport layer, chlorophyll derivative lower layer containing trifluoroacetate and central copper ion, perovskite layer, chlorophyll derivative upper layer containing trifluoroacetate and central copper ion, electron transport layer, hole blocking layer and metal cathode in turn from bottom to top.The present application sets up chlorophyll derivative layer as interface modification layer by being arranged in the upper and lower of perovskite layer, and by selecting suitable chlorophyll derivative containing trifluoroacetate and central copper ion as chlorophyll derivative layer material, further improve the photoelectric conversion efficiency and stability of perovskite solar cell, and its photoelectric conversion efficiency is as high as 26.34%.

The intermediate (3) is obtained by addition under alkaline condition, and then ring closure under acidic condition to synthesize 2-perfluoroalkyl-4H-pyrane-4-ketone derivative (4). The addition reaction is carried out by using perfluoroalkyl acyl chloride, so that the yield of the addition reaction is effectively improved; efficient ring closure is realized at room temperature through a trifluoroacetic acid / ethanol system; high-temperature conditions and easily-made-poisoning reagents are avoided, and the method has an industrial application prospect.

The invention provides a biological sustained-release stent as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The biological sustained-release stent is prepared from the following raw materials in parts by weight: 35 parts of alkoxy-terminated polydimethylsiloxane, 15 parts of cyclopentanosiloxane, 5 parts of recombinant mussel mucin, 0.3 part of trifluoroacetic acid, 3 parts of trehalose and 2 parts of thioether-containing PTU polymer. The nucleotide sequence of the gene for coding the recombinant mussel mucin is as shown in SEQ ID NO. 1. According to the invention, the biological response type sustained-release stent is constructed through dynamic crosslinking of a mussel adhesive protein DOPA group and silicone molecules, and a wound microenvironment (pH / ROS) self-adaptive release function can be realized. The biological sustained-release scaffold is high in tensile strength and high in active ingredient retention rate, and various functional active ingredients in the biological scaffold have a synergistic effect.

The invention discloses an HPLC (High Performance Liquid Chromatography) detection method for ipragmine hydrochloride enantiomers, and belongs to the technical field of pharmaceutical analysis. The HPLC detection method provided by the invention comprises the following steps: dissolving ipragmine hydrochloride to be detected in a diluent to prepare a test solution; detecting the test solution by adopting normal-phase high performance liquid chromatography; the stationary phase of the normal-phase high performance liquid chromatography is silica gel of which the surface is covalently bonded with cellulose-tri (3-chloro-4-methyl phenyl carbamate); a mobile phase of the normal-phase high performance liquid chromatography is a mixed solution of normal hexane, isopropanol, trifluoroacetic acid and diethylamine. According to the detection method established by the invention, the ipragmine hydrochloride main peak and the S-configuration enantiomer impurity peak can be subjected to baseline separation, the separation degree can reach 4.5 or above, the method is high in specificity and sensitivity, and various methodology verification parameters all meet the drug quality control requirements.

The invention belongs to the technical field of separation membrane materials, and relates to a preparation method and application of a one-step bionic beetle catalytic membrane, and the preparation method comprises the following steps: directly dispersing a hydrophilic nano-catalyst in a trifluoroacetic acid membrane casting solution of PET, and carrying out one-step molding through a non-solvent induced phase separation technology. In the phase inversion process, the catalyst spontaneously segregates and is anchored on the surface of the membrane and in pore channels to form a'hydrophilic bulge-hydrophobic substrate 'heterogeneous wetting structure simulating the backs of desert beetles, so that one-step in-situ integration of a membrane matrix, bionic morphology and a catalytic function is realized. The prepared membrane has excellent oil-water separation performance and catalytic degradation capability, the water-in-oil emulsion separation efficiency is greater than 99.5%, and organic pollutants can be rapidly degraded in the presence of hydrogen peroxide. The invention has the advantages of simple and efficient process, low cost and stable structure, and is suitable for advanced treatment and synchronous purification of complex oily wastewater.

The invention provides a sodium secondary battery and a power utilization device. The sodium secondary battery comprises a positive pole piece, a negative pole piece, a diaphragm and electrolyte, the electrolyte comprises electrolyte salt and a solvent, the solvent comprises an ether solvent and a nitrile fluoride solvent, the electrolyte salt comprises first electrolyte salt and second electrolyte salt, the first electrolyte salt comprises sodium hexafluorophosphate, and the second electrolyte salt comprises sodium hexafluorophosphate. The second electrolyte salt comprises at least one of sodium tetrafluoroborate, sodium nitrate and sodium trifluoroacetate. The sodium secondary battery provided by the invention has high capacity retention ratio and excellent cycle performance under a low-temperature condition.

This application discloses an analytical method for N-nitrosamine vortioxetine in vortioxetine hydrobromide tablets, belonging to the field of pharmaceutical impurity analysis. The method employs high-performance liquid chromatography (HPLC), with the following chromatographic conditions: a 4.6 mm × 250 mm column packed with octadecylsilane-bonded silica gel, with a particle size of 5 μm; mobile phase A is a 90:10 water-acetonitrile mixture containing 0.025%–0.035% trifluoroacetic acid (v / v); mobile phase B is acetonitrile; gradient elution; column temperature 38–42 °C; flow rate 0.9–1.1 ml / min; injection volume 50 μl; and detection wavelength 226 nm. This analytical method effectively eliminates excipient interference and exhibits excellent detection performance (specificity, sensitivity, linearity, precision, accuracy, and robustness), accurately detecting the content of N-nitrosamine vortioxetine in vortioxetine hydrobromide tablets, meeting quality control requirements.

The application discloses an adamantane-modified antibacterial peptide mimetic and application thereof. The application obtains a carboxyl end fatty amine-modified compound protected by adamantane amine or Boc through Fmoc amino acid amide condensation, then removes the Fmoc group through piperidine to obtain a series of crude products containing adamantane amine modification and intermediate compounds of Boc-protected fatty amine modification; the intermediate compounds are further modified by adamantane acid through amide condensation to obtain a compound with an amino end, and then other protecting groups are cleaved through trifluoroacetic acid to obtain a series of crude products of adamantane acid modification; after the crude products are purified, the adamantane-modified peptidomimetic is obtained. The adamantane-modified peptidomimetic is used for preparing drugs for infectious diseases caused by sensitive bacteria and drug-resistant bacteria, has high efficient antibacterial activity, low toxicity and is not affected by traditional drug resistance mechanisms.

Disclosed herein are oral care compositions comprising docosahexaenoic acid (DHA) and at least one of (i) a stannous ion source, such as stannous fluoride, or (ii) tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, optionally further comprising arginine or a salt thereof, and methods of using the oral care compositions to treat inflammation in the oral cavity.

The invention relates to a hypoxia targeting hyaluronic acid nano delivery system and a construction method and application thereof, the construction method comprises the following preparation method: S1, dissolving 2-nitroimidazole and K2CO3 in dimethylformamide, carrying out high temperature alkali treatment, adding N-Boc-bromoethylamine, and carrying out high temperature reaction to obtain Boc-NIH; s2, dissolving the Boc-2-NIH in dichloromethane, adding trifluoroacetic acid for deprotection, and adjusting the pH value to be neutral, so as to obtain 2-NIH; s3, dissolving HA in deionized water, sequentially adding EDC and NHS to activate carboxyl, then adding 2-NIH, reacting at room temperature, and dialyzing to obtain a hypoxic targeting hyaluronic acid nano delivery carrier HA-NIH; s4, HA-NIH loads a drug, and the hypoxia targeted hyaluronic acid nano delivery system is formed. According to the invention, a bifunctional nano system with CD44 active targeting and hypoxia response release is successfully constructed, a dynamic regulation and control mechanism of HA molecular weight on a targeting-permeation-retention effect is provided, and a synergistic effect of tumor stem cell microenvironment specific response and drug space-time release is realized.

The invention belongs to the technical field of lithium metal batteries, and particularly relates to a preparation method and application of laser-induced ZnO / ZnF2 heterogeneous carbon cloth. The preparation method comprises the following steps: adding zinc trifluoroacetate powder into N, N-dimethylformamide, uniformly stirring to obtain a precursor solution containing ZnO / ZnF2, soaking carbon cloth (CC) in the precursor solution, standing at room temperature to obtain a ZnO / ZnF2-coated CC precursor, drying overnight, carrying out laser treatment, and forming ZnO / ZnF2-containing composite nanoparticles by laser induction to obtain the laser-induced ZnO / ZnF2 heterogeneous carbon cloth. The ZnO / ZnF2 heterogeneous interface and a built-in electric field formed by the ZnO / ZnF2 heterogeneous interface can induce ordered and uniform deposition of metal lithium and inhibit growth of lithium dendrites. Meanwhile, the prepared ZnO / ZnF2 composite nanoparticles can be used as a host material of a negative electrode of a lithium metal battery, the nucleation overpotential is reduced, the cycling stability is improved, the cycle life of the lithium metal battery is prolonged, and the stability of the lithium metal battery is improved.

The invention relates to the technical field of nano biological medicine, and discloses a Ce-Cu bimetal MOF nano enzyme prepared based on a microwave method and a preparation method and application thereof.The preparation method comprises the following steps that cupric nitrate trihydrate and pyrazole-4-carboxylic acid are completely dissolved in N, N-dimethylformamide through oscillation dissolution or ultrasonic dissolution, and a solution A is prepared; ultrasonically dispersing the Ce6 cluster in water to prepare a solution B; mixing the solution A with the solution B, and slowly adding trifluoroacetic acid to prepare a mixed solution C; the mixed solution C is placed in a microwave reactor, the reaction temperature ranges from 80 DEG C to 100 DEG C, the microwave power ranges from 300 W to 400 W, and the reaction time ranges from 15 min to 30 min; and centrifuging and washing to obtain the Ce-Cu bimetal MOF nano-enzyme with the particle size of 100 to 200 nm. The reaction is rapid, the morphology is controllable, and the SOD and CAT simulation activity is high.

The utility model relates to the technical field of trifluoroacetic acid processing, and discloses a solvent separation system for trifluoroacetic acid production. The first-stage extraction tanks and the second-stage extraction tanks are arranged, and one second-stage extraction tank corresponds to a plurality of first-stage extraction tanks, so that in the extraction layering process of the plurality of first-stage extraction tanks, liquid at a part of boundary lines can be fed into the second-stage extraction tanks to be extracted again, on one hand, continuous operation of the whole equipment is guaranteed, and on the other hand, the extraction efficiency is improved; on the other hand, the purity of the extracted finished product is improved. The liquid outlet pipe is respectively connected with the first discharge pipe, the second discharge pipe and the first pipeline to respectively correspond to the lower-layer liquid, the liquid at the middle interface and the upper-layer liquid of the first extraction tank, and the liquid is respectively drained into the first liquid collecting tank, the second liquid collecting tank and the material collecting tank.

The invention provides a method for synthesizing celecoxib by a one-pot aqueous phase method. The preparation method comprises the following steps: firstly, directly reacting p-methylacetophenone and ethyl trifluoroacetate in one pot under the action of N, N-dimethyl butylamine to obtain a beta-diketone intermediate; in the other pot, p-chlorobenzenesulfonamide and hydrazine hydrate are used as raw materials, a p-hydrazinobenzenesulfonamide solution is generated under the action of N, N-dimethyl butylamine, and the operation is carried out in the two pots at the same time; and finally, adding the p-hydrazinobenzenesulfonamide solution into the beta-diketone intermediate material liquid, combining in two pots, adjusting the acid, heating for reaction, and cooling for crystallization to obtain celecoxib. According to the method disclosed by the invention, the p-hydrazinobenzenesulfonamide aqueous solution is creatively used for participating in the synthesis reaction of the celecoxib, and solid p-hydrazinobenzenesulfonamide hydrochloride does not need to be independently used for participating in the reaction, so that the use of a large amount of acid and the generation of high-temperature acid waste liquid during the production of the p-hydrazinobenzenesulfonamide hydrochloride are avoided. The method does not need any post-treatment operation and high-temperature salt forming link, and is more suitable for industrial production.

The invention belongs to the technical field of epoxy resin coatings, and particularly relates to a bi-component aliphatic polyamine epoxy graphene acid-resistant coating which comprises epoxy resin in a component A and a curing agent in a component B. The curing agent is perfluoroalkyl secondary amine. Alicyclic diamine and perfluoroalkyl ethylene are subjected to a Michael addition reaction under the action of a catalyst cupric trifluoroacetate, the cupric trifluoroacetate catalyst effectively prevents the perfluoroalkyl ethylene and a generated target product secondary amine from being further subjected to an excessive addition reaction, and the reaction efficiency is improved; after the curing agent is subjected to cross-linking reaction with the epoxy resins in the scheme, a large number of ether bonds existing in a traditional phenolic epoxy amine curing system can be eliminated, so that nucleophilic reagent attack sites are reduced, meanwhile, the curing agent perfluoroalkyl secondary amine is converted into a tertiary amine structure, coordination activation of H to nitrogen atoms is reduced, and a coating is more stable.

This invention provides a method for constructing HPLC characteristic chromatograms of processed medicinal slices, standard decoctions, and formulated granules of *Sophora flavescens*, comprising: A) dissolving and extracting the test sample raw material using a solvent to obtain a test solution; B) determining the test solution using high-performance liquid chromatography (HPLC) to obtain HPLC characteristic chromatograms of processed medicinal slices, standard decoctions, and formulated granules of *Sophora flavescens*; the HPLC chromatographic conditions are as follows: a C18 column; mobile phase A is acetonitrile solution, mobile phase B is 0.05% trifluoroacetic acid aqueous solution, and gradient elution is performed; specifically, the gradient elution is as follows: 0–15 min, phase A: 5%–11%, phase B: 95%–89%; 15–40 min, phase A: 11%–18%, phase B: 89%–82%; 40–60 min, phase A: 18%–21%, phase B: 82%–79%. This invention employs high-performance liquid chromatography (HPLC) with acetonitrile-0.05% trifluoroacetic acid solution as the mobile phase for gradient elution. Using magnoflorine, isocoryne, styraxine, and styraxine as references, a method for establishing characteristic HPLC chromatograms of processed slices, standard decoctions, and formulated granules of *Sophora flavescens* was developed. This provides more scientific technical means for controlling the medicinal quality of processed slices, standard decoctions, and formulated granules of *Sophora flavescens*.

This invention relates to an electromagnetic radiation-resistant flame-retardant control cable and its preparation method, belonging to the field of control cable technology. The control cable includes a core, a metal foil, and a modified sheath. The modified sheath uses PVC resin as a base material and adds a reinforcing agent of 10-15 phr. The reinforcing agent is prepared via a four-step process: N-phenyl-p-phenylenediamine reacts with trifluoroacetic anhydride to obtain a passivated matrix, which is then oxidized with 4,4-diaminodiphenylamine to obtain a tetramer intermediate. This intermediate is then protected by alkali desorption to obtain a terminal amino tetramer monomer, which is finally polymerized with thiodiacetic acid to obtain the final product. This agent chelates onto the surface of the metal foil through a thioamide structure, forming an aniline tetramer enrichment layer. This imparts excellent bending resistance, self-healing shielding performance, and a synergistic effect of high-temperature charring and flame retardancy to the cable, effectively solving the problems of easy bending and damage to the metal foil shielding layer and shielding failure under continuous ignition.

Provided is an adhesion prevention film that sufficiently swells upon contact with moisture and is less prone to breaking. This adhesion prevention film contains a bioabsorbable polymer compound. The adhesion prevention film has a thickness of 10-500 µm, and a swelling ratio of 200-500 vol% after 15-minute immersion in phosphate buffer at pH 6.0. In the case where 1H-NMR measurement of the film is performed, using a sample solution prepared by adding the film and 1.2 mg of pyrazine to 1.1 mL of deuterated trifluoroacetic acid, with the resonance peak of pyrazine as a standard substance referenced to 9.45 ppm, when the integral value of the maximum resonance peak measured in the range of 9.4-9.5 ppm is defined as A and the integral value of the maximum resonance peak measured in the range of 5.0-5.2 ppm is defined as B, B / A is 0.10 or less.