27 results about "Perfluoroacetic Acid" patented technology

The present application relates to a method for synthesizing leu-enkephalin by Fmoc method, which uses Fmoc-protected amino acid as monomer, and sequentially connects amino acid to resin. In the synthesis of leu-enkephalin, all the amino acids do not have any side chain protection group. The Fmoc protection group is removed by using a solution of 1.00 mol / L imidazole and 0.02 mol / L tricyclohexylphosphine in tetrahydrofuran, and finally leu-enkephalin is obtained by removing the resin with aqueous trifluoroacetic acid. The present application first uses imidazole and tricyclohexylphosphine as components of Fmoc deprotection agent, instead of traditional pyridine. The deprotection agent is not controlled by "controlled chemicals", is cheap and easy to obtain, is stable in nature, and is low in toxicity, volatility and corrosion. The deprotection agent has excellent Fmoc removal ability, does not cause phenolic ring acylation side reaction of tyrosine side chain, does not need any side chain protection, simplifies the production process of polypeptide, reduces the preparation cost of polypeptide, and provides great improvement space for the design of synthesis strategy of polypeptide containing basic sensitive side chain protection group.

An object of the present disclosure is to provide a nonaqueous electrolytic solution and a lithium ion secondary battery using same, the nonaqueous electrolytic solution having both excellent battery safety when used at a high temperature, an important feature for secondary batteries to be installed in modern vehicles such as electric vehicles, and having excellent battery characteristics. The nonaqueous electrolytic solution of the present disclosure is a nonaqueous electrolytic solution including an electrolyte salt dissolved in a nonaqueous solvent, the nonaqueous solvent containing from 80 to 100 vol % in total of at least one selected from ethylene carbonate, propylene carbonate, and γ-butyrolactone, and the nonaqueous electrolytic solution further including a trifluoroacetic acid ester having an alcohol group with a carbon chain length of from 6 to 8.

The present application relates to a kind of high efficient stable perovskite solar cell based on chlorophyll derivative and preparation method thereof, belong to perovskite solar cell technical field.Solve the problem that the photoelectric conversion efficiency and stability of existing perovskite solar cell still need to be further improved.The perovskite solar cell of the present application includes transparent conductive glass anode, hole transport layer, chlorophyll derivative lower layer containing trifluoroacetate and central copper ion, perovskite layer, chlorophyll derivative upper layer containing trifluoroacetate and central copper ion, electron transport layer, hole blocking layer and metal cathode in turn from bottom to top.The present application sets up chlorophyll derivative layer as interface modification layer by being arranged in the upper and lower of perovskite layer, and by selecting suitable chlorophyll derivative containing trifluoroacetate and central copper ion as chlorophyll derivative layer material, further improve the photoelectric conversion efficiency and stability of perovskite solar cell, and its photoelectric conversion efficiency is as high as 26.34%.

This application discloses an analytical method for N-nitrosamine vortioxetine in vortioxetine hydrobromide tablets, belonging to the field of pharmaceutical impurity analysis. The method employs high-performance liquid chromatography (HPLC), with the following chromatographic conditions: a 4.6 mm × 250 mm column packed with octadecylsilane-bonded silica gel, with a particle size of 5 μm; mobile phase A is a 90:10 water-acetonitrile mixture containing 0.025%–0.035% trifluoroacetic acid (v / v); mobile phase B is acetonitrile; gradient elution; column temperature 38–42 °C; flow rate 0.9–1.1 ml / min; injection volume 50 μl; and detection wavelength 226 nm. This analytical method effectively eliminates excipient interference and exhibits excellent detection performance (specificity, sensitivity, linearity, precision, accuracy, and robustness), accurately detecting the content of N-nitrosamine vortioxetine in vortioxetine hydrobromide tablets, meeting quality control requirements.

This invention relates to an electromagnetic radiation-resistant flame-retardant control cable and its preparation method, belonging to the field of control cable technology. The control cable includes a core, a metal foil, and a modified sheath. The modified sheath uses PVC resin as a base material and adds a reinforcing agent of 10-15 phr. The reinforcing agent is prepared via a four-step process: N-phenyl-p-phenylenediamine reacts with trifluoroacetic anhydride to obtain a passivated matrix, which is then oxidized with 4,4-diaminodiphenylamine to obtain a tetramer intermediate. This intermediate is then protected by alkali desorption to obtain a terminal amino tetramer monomer, which is finally polymerized with thiodiacetic acid to obtain the final product. This agent chelates onto the surface of the metal foil through a thioamide structure, forming an aniline tetramer enrichment layer. This imparts excellent bending resistance, self-healing shielding performance, and a synergistic effect of high-temperature charring and flame retardancy to the cable, effectively solving the problems of easy bending and damage to the metal foil shielding layer and shielding failure under continuous ignition.

Provided is an adhesion prevention film that sufficiently swells upon contact with moisture and is less prone to breaking. This adhesion prevention film contains a bioabsorbable polymer compound. The adhesion prevention film has a thickness of 10-500 µm, and a swelling ratio of 200-500 vol% after 15-minute immersion in phosphate buffer at pH 6.0. In the case where 1H-NMR measurement of the film is performed, using a sample solution prepared by adding the film and 1.2 mg of pyrazine to 1.1 mL of deuterated trifluoroacetic acid, with the resonance peak of pyrazine as a standard substance referenced to 9.45 ppm, when the integral value of the maximum resonance peak measured in the range of 9.4-9.5 ppm is defined as A and the integral value of the maximum resonance peak measured in the range of 5.0-5.2 ppm is defined as B, B / A is 0.10 or less.

The present application relates to the technical field of COF film, and discloses a kind of fast large size COF film and its preparation method and application.By dissolving monomer in trifluoroacetic acid system, precursor solution is first spread on the surface of substrate to form a continuous liquid film, then solvent removal, monomer concentration and rapid condensation are promoted by vacuum condition, integration of film forming process and skeleton generation process is realized.Vacuum environment can speed up solvent removal and reactant enrichment, so that the film layer can quickly cross the formation stage from dispersed state to continuous film state, thereby improving the film forming efficiency.The reaction is carried out in spreading state, so it is more conducive to obtain large size film layer.The COF film is applied to alkaline fuel cell, and its excellent hydroxyl ion conduction capacity significantly improves the output power density and energy conversion efficiency of the battery.Meanwhile, combined with the effective screening effect of ultra-micropore diameter on carbonate / bicarbonate, the high discharge performance of the battery in long-term operation is further ensured, and finally the overall performance is comprehensively improved.

This invention relates to the field of detection and analysis technology, and discloses a pre-column derivatization-liquid chromatography-tandem mass spectrometry (LC-MS / MS) method for the detection of perfluorocarboxylic acids and their substitutes. The highly sensitive and selective method provided by this invention, based on 3-nitrophenylhydrazine pre-column derivatization-LC-MS / MS, achieves good correlation (R0) of nine target analytes (C2-C9 perfluorocarboxylic acids and GenX) within a wide linear range of 0.0001-100 ng / mL. 2 The method has a detection limit as low as 0.83 ng / L and a quantitation limit of 2.76 ng / L, with a sensitivity of 0.83 ng / L for short-chain trifluoroacetic acid, significantly better than traditional gas chromatography. The spiked recoveries in ultrapure water matrix range from 88.2% to 115.7%, with inter-day and intra-day precisions of 0.2% to 17.61% and 3.5% to 16.3%, respectively, demonstrating good accuracy and reproducibility. This method incorporates highly polar short-chain perfluorocarboxylic acids, previously only analyzable by GC-MS, into the LC-MS / MS detection system. It also achieves trace detection of the novel pollutant GenX at the ng / L level, with significantly higher sensitivity than existing methods.

This invention discloses a compound for preparing an antiviral drug, its preparation method, and its application, relating to the field of antiviral drug technology. The compound is obtained through a three-step organic synthesis: first, condensation of tert-butyloxycarbonyl-phenylalanine with p-fluorobenzylamine yields tert-butyl(1-((4-fluorobenzyl)amino)-1-oxo-3-phenylprop-2-yl)carbamate; then, deprotection with trifluoroacetic acid yields 2-amino-N-(4-fluorobenzyl)-3-phenylpropionamide; finally, sulfonylation with 5-bromothiophene-2-sulfonylchlorosulfonation gives the final product. This compound specifically targets the influenza virus HA protein, blocking viral invasion of host cells, exhibiting broad-spectrum antiviral activity against influenza A and B viruses, low cytotoxicity, and a mild and controllable preparation process. It can be used to prepare drugs for the prevention and treatment of influenza virus infection, providing a new candidate for the development of new antiviral drugs.

The application belongs to the field of pharmaceutical chemistry, and discloses a preparation method of a PARP inhibitor intermediate. The preparation method provided by the application does not involve the steps of noble metal catalytic coupling and chiral resolution, has low requirements on equipment, is simple to operate, is beneficial to industrial production, and when the amino protecting group is a trifluoroacetic acid group, the yield of the ring closure reaction is significantly improved.

The application belongs to the technical field of biological medicine, and discloses a super-small nanometer radiotherapy sensitizer as well as a preparation method and application thereof. The super-small nanometer radiotherapy sensitizer comprises a super-small hafnium oxide matrix doped with functional metal ions, preferably, the surface of the super-small hafnium oxide matrix doped with functional metal ions has a surface modification layer. The preparation method comprises the following steps: dissolving hafnium source in anhydrous ethanol, adding sufficient trifluoroacetic acid, and constant-temperature stirring, then vacuum rotary evaporation drying to obtain hafnium trifluoroacetate powder; adding the hafnium trifluoroacetate, an organic solution containing metal ions that can be doped into the super-small hafnium oxide matrix and oleylamine into a container and stirring, programmed heating and constant-temperature reaction for a period of time under vacuum or inert gas alternating protection, adding excess ethanol into the container to precipitate after cooling to room temperature, washing and drying the precipitate; then removing the organic matter on the surface of the obtained dry powder to obtain super-small metal ion doped hafnium oxide, i.e. the super-small nanometer radiotherapy sensitizer.

This invention belongs to the field of heterocyclic compound technology, specifically relating to a protein hydrolysis-targeted chimera for the treatment of multiple myeloma, its preparation method, and its application. Compounds 2, 3, and HATU are dissolved in THF, then DIPEA is added and the reaction is stirred. Water is added to terminate the reaction, followed by extraction, washing, drying, and column chromatography to obtain product 4. Under argon protection, product 4 is dissolved in dichloromethane, then trifluoroacetic acid is added and the reaction is carried out. Toluene is added, and the mixture is distilled under reduced pressure to obtain product 5. Product 5, compound 6, HATU, and DIPEA are dissolved in THF and the reaction is stirred. Water is added to terminate the reaction, followed by extraction, washing, drying, and column chromatography to obtain the protein hydrolysis-targeted chimera for the treatment of multiple myeloma. The protein hydrolysis-targeted chimera for the treatment of multiple myeloma in this invention exhibits significant anti-proliferative activity against RPMI-8266 multiple myeloma cells. The preparation process is simple and suitable for industrial production.

This invention discloses a solvent-resistant filter membrane and its application in the degelation process of cis-butadiene rubber solution polymerization, belonging to the fields of polymer materials technology and chemical separation. The filter membrane, from bottom to top, comprises a pretreated nonwoven fabric, a polyetherimide base layer, and a polyimide selective layer. The preparation method includes raw material pretreatment, polyetherimide base layer preparation, in-situ generation of the polyimide selective layer, and post-treatment. Performance optimization is achieved through amine ring-opening crosslinking, interfacial polymerization doping with perfluorodecyl mercaptan, cyclohexane pre-expansion, and trifluoroacetic anhydride post-treatment. It is applied to multiple nodes in the cis-butadiene rubber solution polymerization process. This invention constructs a stable filter membrane structure through multi-dimensional innovative methods, solving problems such as insufficient solvent resistance, easy interlayer peeling, and poor anti-fouling of traditional filter membranes. It achieves efficient retention of gel particles and catalyst residues, significantly reduces the rubber gel content, and maintains long-term stable operation, adapting to stringent process requirements.

The application discloses a preparation method of a monoamine oxidase B inhibitor, and comprises the following steps: 6-fluoroindole and 1-(dimethylamino)-2-nitroethylene are subjected to trifluoroacetic acid catalysis to generate 6-fluoro-3-[(E)-2-nitrovinyl]-1H-indole, and then subjected to sodium borohydride and iron powder / hydrochloric acid reduction to generate 6-fluoro-tryptamine; under an acidic condition, Pictet-Spengler reaction is carried out between 6-fluoro-tryptamine and ethyl glyoxylate to generate ethyl 7-fluoro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate and 7-fluoro-4,9-dihydro-3H-pyrido[3,4-b]indole-1-carboxylate, and then subjected to oxidative dehydrogenation aromatization reaction to generate ethyl 7-fluoro-9H-pyrido[3,4-b]indole-1-carboxylate; under the catalysis of aluminum trichloride, amine ester exchange reaction is carried out between ethyl 7-fluoro-9H-pyrido[3,4-b]indole-1-carboxylate and 3-fluorobenzylamine to generate a target compound. The method has high overall yield.

This invention provides a copper-based covalent organic framework material, its preparation method, and its application. The method comprises: S1, dissolving copper nitrate trihydrate and 1H-pyrazole-4-formaldehyde in a mixed solvent of N,N-dimethylformamide, ultrapure water, and anhydrous ethanol, stirring until homogeneous, heating, cooling, centrifuging, and washing to obtain trinuclear copper complex crystals; S2, mixing the trinuclear copper complex crystals obtained in step S1 with 2,5-diaminobenzoic acid in a mixed solvent of 1,2-dichlorobenzene, n-butanol, and trifluoroacetic acid, ultrasonicating, followed by thawing and degassing via a refrigeration pump, heating for reaction, filtering, washing, and vacuum drying to obtain Cu3-COOH-COF. This invention successfully and stably introduces carboxyl groups into the COFs framework and, through systematic research, confirms that enhanced hydrophilicity can significantly improve the efficiency of CO2 reduction to formic acid—a structure-activity relationship that fills a theoretical gap in the field of COFs photocatalyst interface microenvironment regulation, providing a universal strategy for the design of subsequent high-performance photocatalysts.

The application discloses a perovskite solar cell containing a double-layer trifluoroacetate modification layer and a preparation method thereof. The perovskite solar cell comprises, from bottom to top, a conductive glass, an electron transport layer, an electron transport layer modification layer, a perovskite layer, a perovskite modification layer, a hole transport layer and an electrode; the electron transport layer modification layer and the perovskite modification layer are one of methylamine trifluoroacetate, formamidine trifluoroacetate, dimethylamine trifluoroacetate, ethylamidine trifluoroacetate, ethylenediamine trifluoroacetate and guanidine trifluoroacetate. The application simultaneously fills and modifies defects of the electron transport layer and the perovskite layer, passivates oxygen defects in the tin oxide and ion vacancies in the perovskite layer through hydrogen bonds and chemical interactions, and solves the problems of the perovskite solar cell, such as many defects in the electron transport layer and the perovskite layer, low efficiency and poor stability.

This application relates to the field of wastewater treatment technology, specifically to a method for removing ultrashort-chain PFAS from wastewater. The method includes: filtering the wastewater; adding an ionic strength regulator to the filtered water to obtain conditioned water; adjusting the pH of the conditioned water to obtain primary acidified water; adding a portion of modified activated carbon to the primary acidified water and stirring, then adding the remaining modified activated carbon and allowing it to stand to obtain carbon-containing water; adjusting the pH of the carbon-containing water to obtain secondary acidified water; applying a weak magnetic field to the secondary acidified water, then sequentially stirring and allowing it to stand for adsorption to obtain adsorbed water; performing solid-liquid separation on the adsorbed water to obtain purified effluent and adsorbed modified activated carbon; and adjusting the pH of the purified effluent to obtain neutralized effluent. This application can significantly improve the removal efficiency of ultrashort-chain PFAS, represented by trifluoroacetic acid and perfluorobutyl sulfonic acid.

Crystalline polymorphic forms of the neurotrophic agent 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide (J147) and methods for producing the crystalline polymorphic forms are provided.

This invention relates to the field of functional polymer materials and discloses a method for preparing an antibacterial composite nanofiber material with cascade activity. The method includes: dissolving a gold precursor in a solvent; adding a polymer to obtain a polymer solution; reacting with a sodium borohydride solution; electrospinning to obtain an Au composite nanofiber membrane; dissolving TCPP in a mixed solvent of N-N-dimethylformamide / ethanol; adding Cu₂O, polyvinylpyrrolidone, and trifluoroacetic acid; reacting to obtain Cu-TCPP; adding the Cu-TCPP dispersion to the surface of the Au composite nanofiber membrane under vacuum filtration; and drying. In the antibacterial composite nanofiber material of this invention, Cu-TCPP is stably anchored on the surface of the nanofiber membrane, preventing excessive encapsulation of Cu-TCPP and thus reducing the therapeutic effect. In a weakly alkaline environment conducive to infection, this antibacterial composite nanofiber material can utilize Au nanozymes as initial enzymes to continuously catalyze the production of gluconic acid and H₂O₂ from glucose, thereby activating the POD-Like activity of Cu-TCPP to catalyze the generation of hydroxyl radicals to kill bacteria.

The present disclosure provides a gene delivery nanoparticle, and its preparation and application, pertaining to the technical field of biomedicine. In the preparation method, 2-((tert-butoxycarbonyl)amino)ethyl methacrylate as monomer, mPEG5k-RAFT as macromolecular chain transfer agent and azobisisobutyronitrile as initiator are subjected to reversible addition-fragmentation chain transfer polymerization in dimethylformamide, dialysis and freeze-drying to obtain an intermediate; the intermediate is dissolved in dichloromethane, added with trifluoroacetic acid and reacted to yield polyethylene glycol-poly(aminoethyl methacrylate); sparfloxacin is dissolved in a hydrochloric acid solution, and added with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and a solution of polyethylene glycol-poly(aminoethyl methacrylate) in dimethyl sulfoxide to produce a mixture; the mixture is subjected to dialysis and freeze-drying to obtain the final product polyethylene glycol-poly(sparfloxacin), which is placed in an aqueous solution to allow self-assembly, thereby forming the desired nanoparticle.

The application belongs to the technical field of separation membrane materials, and relates to a preparation method of a one-step biomimetic beetle catalytic membrane and application thereof, the preparation method comprising directly dispersing a hydrophilic nano catalyst in a PET trifluoroacetic acid casting solution, and one-step forming through a non-solvent induced phase separation technology. In the phase inversion process, the catalyst is spontaneously segregated and anchored on the membrane surface and in the pores, forming a "hydrophilic protrusion-hydrophobic substrate" heterogeneous wetting structure similar to the back of a desert beetle, realizing one-step in-situ integration of the membrane matrix, biomimetic morphology and catalytic function. The prepared membrane has excellent oil-water separation performance and catalytic degradation capacity, the separation efficiency of the oil-in-water emulsion is greater than 99.5%, and the organic pollutants can be rapidly degraded in the presence of hydrogen peroxide. The application has the advantages of simple and efficient process, low cost and stable structure, and is suitable for deep treatment and synchronous purification of complex oily wastewater.

The present application relates to a size exclusion chromatography method for polymer analysis in GHRH analogues, belonging to the technical field of biological medicine analysis. The present application develops a size exclusion chromatography method for polymer analysis in GHRH analogues, the sample to be measured is GHRH analogue, and an Agilent AdvanceBio SEC column is used; the mobile phase is a mixed solution of water, acetonitrile and trifluoroacetic acid, and isocratic elution is carried out; the method is especially suitable for tesamorelin or semorelin. The exclusive, efficient, accurate and stable size exclusion chromatography method developed by the present application is used for the analysis of polymer impurities in tesamorelin or semorelin, solves the technical problems of poor separation effect and insufficient detection sensitivity in the prior art, perfects the quality control system of GHRH analogues, comprehensively guarantees the safety and stability of the drug, and solves the technical problems urgently needed to be solved by the technical personnel in the field.

This invention belongs to the field of electrochromic devices, specifically relating to a room-temperature, in-situ spontaneously polymerizable ionic gel electrolyte composition, which can be used in devices such as smart windows and flexible displays, as well as the electrolyte and its applications. The composition includes a liquid precursor solution and an initiator; the liquid precursor solution is a liquid containing a polymer network framework material, an ionic liquid electrolyte, 1,3-dioxolane, an epoxy crosslinking agent, a viologen derivative electrochromic material, and a ferrocene derivative counter electrode material; the initiator is a combination of lithium bis(trifluoromethanesulfonyl)imide and the initiator trifluoroacetic acid; the cation of the ionic liquid electrolyte is selected from at least one of imidazolium cations, pyrrolidineonium cations, pyridinium cations, and / or quaternary ammonium cations. The composition of this invention can generate a gel electrolyte without external energy input, and the electrochromic device prepared therefrom possesses characteristics such as high ionic conductivity, excellent optical performance, good interfacial stability, and long cycle life.

This invention discloses a method for preparing a polypeptide with L-glutamic acid as the N-terminus, belonging to the field of polypeptide synthesis. The method includes the following steps: ... N -Benzyloxycarbonyl- L The cyclization reaction of glutamic acid protects its carboxyl group. The carboxyl group of the cyclized product is activated using NHS and DCC, and then reacted with different amino acids to obtain a dipeptide. The carboxyl group of the dipeptide is activated again using NHS and DCC, and then reacted with different amino acids to obtain a tripeptide. The ester group of the obtained dipeptide or tripeptide is hydrolyzed to open the ring, yielding a Cbz-protected dipeptide or tripeptide. The Cbz protecting group in the short peptide is removed using trifluoroacetic acid and a reducing agent to obtain the target dipeptide and tripeptide. Compared with existing technologies, the synthesis method provided by this invention has simple operation steps, high raw material conversion rate, high safety in the preparation process, effectively reduces production costs, and is suitable for industrial-scale production, providing a feasible path for the efficient preparation of short peptides.

The application belongs to the technical field of polyethylene resin, and particularly relates to a low-n-hexane extract content HDPE hollow resin, a preparation method thereof and a hollow product. The application uses silicon dioxide as a carrier, loads chromium acetate, chromium titanate and a fluorine modifier composed of trifluoroacetic acid and perfluorooctanoic acid, activates the carrier through high-temperature precise temperature control, and does not reduce the carrier after activation, so that a fluorine-modified chromium metal active center catalyst is obtained, and the resin is prepared through two-stage narrow temperature control polymerization and 1-hexene segmented addition. The obtained HDPE hollow resin has low n-hexane extract content, good processing performance and mechanical properties, and is suitable for high-health-requirement hollow packaging products.

This invention relates to the field of pharmaceutical analysis technology and discloses a method for detecting the content of ezetimibe and rosuvastatin calcium tablets using a reversed-phase chromatography system. The method employs high-performance liquid chromatography (HPLC) with 0.1% trifluoroacetic acid solution as mobile phase A, acetonitrile as mobile phase B, and methanol as mobile phase C. Gradient elution is performed using an octadecylsilane-bonded silica column. The detection wavelength is 242 nm, and the injection volume is 10 μL. The content of ezetimibe and rosuvastatin calcium is calculated using the external standard method. This method can effectively separate the two main components from various degradation impurities, exhibiting good peak shape and excellent resolution. It meets the requirements for pharmaceutical quality control in terms of specificity, limit of quantitation, limit of detection, linear range, precision, accuracy, repeatability, and robustness. The system is stable and provides a reliable technical solution for the quality detection of ezetimibe and rosuvastatin calcium tablets.

The application provides a terguride polymer membrane material with binaphthyl as a skeleton, a preparation method and application thereof, and relates to the fields of polymer materials and gas separation technology. The material is prepared by condensation polymerization of binaphthyl with dimethoxymethane under the catalysis of trifluoroacetic acid, and binaphthyl is used as a diamine monomer. The polymerization reaction has the characteristics of mild reaction condition, high yield and low cost. The obtained terguride polymer is prepared into a gas separation membrane by a solvent evaporation method, and the gas separation membrane has high oxygen permeability and high oxygen / nitrogen selectivity, which exceeds the upper limit of gas separation in 2008. The gas separation membrane material has great development potential.