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740 results about "Single sample" patented technology
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A single sample means test is a statistical test that can determine whether or not a population estimate (i.e., sample statistic) is significantly different from a known value.
Method and apparatus for automatically recognizing input audio and/or video streams
InactiveUS7194752B1Improve accuracyMinimal timeSpeech analysisAnalogue secracy/subscription systemsSingle sampleFeature set
A method and system for the automatic identification of audio, video, multimedia, and / or data recordings based on immutable characteristics of these works. The invention does not require the insertion of identifying codes or signals into the recording. This allows the system to be used to identify existing recordings that have not been through a coding process at the time that they were generated. Instead, each work to be recognized is “played” into the system where it is subjected to an automatic signal analysis process that locates salient features and computes a statistical representation of these properties. These features are then stored as patterns for later recognition of live input signal streams. A different set of features is derived for each audio or video work to be identified and stored. During real-time monitoring of a signal stream, a similar automatic signal analysis process is carried out, and many features are computed for comparison with the patterns stored in a large feature database. For each particular pattern stored in the database, only the relevant characteristics are compared with the real-time feature set. Preferably, during analysis and generation of reference patterns, data are extracted from all time intervals of a recording. This allows a work to be recognized from a single sample taken from any part of the recording.
Owner:ICEBERG IND
Precision fluorescently dyed particles and methods of making and using same
InactiveUS6929859B2Reduce variationIncrease rangeLiquid surface applicatorsMicrobiological testing/measurementSingle sampleAnalyte
An improved method of making a series of bead or microsphere or particle populations characterized by subtle variation in a proportion or ratio of at least two fluorescent dyes distributed within a single bead of each population is provided. These beads, when excited by a single excitation light source are capable of giving off several fluorescent signals simultaneously. A set containing as many as 64 distinct populations of multicolored, fluorescent beads is provided and when combined with analytical reagents bound to the surface of such beads is extremely useful for multiplexed analysis of a plurality of analytes in a single sample. Thus, methods of staining polymeric particles, the particles themselves, and methods of using such particles are claimed.
Owner:LUMINEX
Analysis of nucleic acids associated with single cells using nucleic acid barcodes
ActiveUS20150329891A1Bioreactor/fermenter combinationsBiological substance pretreatmentsSingle sampleBinding site
Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.
Owner:ATRECA INC
Fluorescence polarization assay system and method
An instrument is disclosed for fluorescence assays which is capable of reading many independent samples at the same time. This instrument provides enhanced throughput relative to single-sample instruments, and is well-suited to use in general fluorescence, time-resolved fluorescence, multi-band fluorescence, fluorescence resonance energy transfer (FRET), and fluorescence polarization. This invention is beneficial in applications such as high-throughput drug screening, and automated clinical testing. Also disclosed are means and methods for a fluorescence polarization measurement which is highly sensitive, inherently self-calibrated, and unaffected by lamp flicker or photobleaching. This fluorescence polarization invention can be practiced on a variety of fluorescence instruments, including prior-art equipment such as microscopes and multi-well plate readers.
Owner:CAMBRIDGE RES & INSTR
Detection of multiple analytes from a single sample using a multi-well, multi-analyte flow-through diagnostic test device
InactiveUS7052831B2Bioreactor/fermenter combinationsBiological substance pretreatmentsSingle sampleDiagnostic test
Owner:BECTON DICKINSON & CO
Multiplexed quantitative detection of pathogens
InactiveUS20070134652A1Easy to adaptQuantitative precisionMicrobiological testing/measurementSingle samplePolynucleotide
The invention allows for the quantitative detection of a plurality of pathogens in a single sample. The method includes the amplification of a sample with a plurality of pathogen-specific primer pairs to generate amplicons of distinct sizes from each of the pathogen specific primer pairs. The method further includes the use of a plurality of competitor polynucleotide targets that correspond to each of the pathogen-specific primer pairs. The competitor polynucleotides are added to the reaction mixture at a known concentration to allow for the quantitation of the amount of pathogen in the sample. The method can be used for monitoring pathogen infection in an individual, preferably an immunocompromised individual.
Owner:PRIMERADX
Determining Antigen Recognition through Barcoding of MHC Multimers
PendingUS20170343545A1Improve understandingMicrobiological testing/measurementBiological material analysisSingle sampleVaccination
The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.
Owner:IMMUDEX APS +1
Data independent acquisition of product ion spectra and reference spectra library matching
ActiveUS8809770B2Stability-of-path spectrometersMolecular entity identificationSingle sampleConfocal
Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.
Owner:ETH ZZURICH +1
Analysis using a distributed sample
The present invention is directed to the production of a sample microarray for use in detecting one or more target biopolymers in the sample. The sample microarray of this invention is formed by distributing equivalent amounts of a single sample at discrete, spatially defined locations on a substrate. Each site in the microarray, thus, has the same composition of target biopolymers. The microarray is then interrogated by one or more probes specific for one or more the target biopolymers.
Owner:BECKMAN COULTER INC
Method and apparatus for automatically recognizing input audio and/or video streams
InactiveUS20070129952A1Improve accuracyMinimal timeAnalogue secracy/subscription systemsBroadcast information monitoringSingle sampleFeature set
A method and system for the automatic identification of audio, video, multimedia, and / or data recordings based on immutable characteristics of these works. The invention does not require the insertion of identifying codes or signals into the recording. This allows the system to be used to identify existing recordings that have not been through a coding process at the time that they were generated. Instead, each work to be recognized is “played” into the system where it is subjected to an automatic signal analysis process that locates salient features and computes a statistical representation of these properties. These features are then stored as patterns for later recognition of live input signal streams. A different set of features is derived for each audio or video work to be identified and stored. During real-time monitoring of a signal stream, a similar automatic signal analysis process is carried out, and many features are computed for comparison with the patterns stored in a large feature database. For each particular pattern stored in the database, only the relevant characteristics are compared with the real-time feature set. Preferably, during analysis and generation of reference patterns, data are extracted from all time intervals of a recording. This allows a work to be recognized from a single sample taken from any part of the recording.
Owner:ICEBERG IND
Method and apparatus for currency discrimination
InactiveUS7590274B2Efficient discriminationIncrease speedComplete banking machinesPaper-money testing devicesSingle sampleAlgorithm
Owner:CUMMINS-ALLISON CORP
Method and apparatus for network congestion control using queue control and one-way delay measurements
The invention provides a congestion control scheme that is a delay based scheme that includes a scalable queue size and one-way queueing delay measurement to reduce network congestion. Queue size is managed by queue control, a scalable utility function, dynamic alpha tuning, and / or randomized alpha tuning. One-way queueing delay is accomplished by measuring backward queueing delay management using various methods of estimating the receiver clock period. Embodiments include estimating the receiver clock period using single sample and multiple sample periods. The system includes a method for detecting route change.
Owner:CALIFORNIA INST OF TECH
Method for extracting malicious code behavior characteristic
InactiveCN102054149AComprehensive information extractionImprove anti-interference abilityPlatform integrity maintainanceData dependency graphSingle sample
The invention discloses a method for extracting a malicious code behavior characteristic, which belongs to the technical field of network security. The method comprises the following steps of: 1) running a malicious code and extracting executive information of the malicious code, wherein the executive information comprises an executive instruction sequence and a behavior sequence of the maliciouscode; 2) constructing a control dependence graph and a data dependence graph for executing the code according to the executive information; 3) comparing relevance of the control dependence graph and the data dependence graph and recording related relevance information; and 4) comparing the control dependence graphs and the data dependence graphs of different malicious codes and extracting characteristic dependency of each type of samples according to similarity clustering. Compared with the prior art, the method has the characteristics of complete information extraction, high anti-interference performance, certain applicability to varieties of a single sample characteristic, small-sized characteristic library and wide application range.
Owner:GRADUATE SCHOOL OF THE CHINESE ACAD OF SCI GSCAS
Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording
InactiveUS20060289746A1Improve efficiencyFacilitates ion transportTime-of-flight spectrometersMaterial analysis by electric/magnetic meansData recordingLinearity
The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.
Owner:IONWERKS
Graphics system having a super-sampled sample buffer which utilizes a window ID to specify pixel characteristics
InactiveUS20010033287A1Cathode-ray tube indicators3D-image renderingComputational scienceSingle sample
A computer graphics system that utilizes a super-sampled sample buffer and a sample-to-pixel calculation unit for refreshing the display. The graphics system may have a graphics processor, a super-sampled sample buffer, and a sample-to-pixel calculation unit. The graphics processor renders samples into the sample buffer and may utilize a window ID that specifies attributes of pixels on a per object basis. The window ID may specify one or more of a sample mode, filter type, color attributes, or source attributes. The sample mode may include single sample per pixel mode and multiple samples per pixel mode. The graphics system may be further operable to generate a single sample per pixel for certain windows of the screen in order to provide backwards compatibility with legacy systems.
Owner:SUN MICROSYSTEMS INC
Methods for variation detection
ActiveUS7081339B2Improve determinationImproved determinationMicrobiological testing/measurementMaterial analysis by optical meansSingle sampleNucleic acid sequencing
The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herein provide methods for monitoring the amplification of one sequence or two or more sequences from a single sample, as well as methods for monitoring the amplification of one or more than one sequence from two or more samples. The monitoring methods of the invention permit improved determination of the abundance of one or more target nucleic acids, especially target RNA species, in one or more original samples.
Owner:BIOTYPE GMBH
Assay devices and methods of analyte detection
InactiveUS6849414B2Easy to controlHigh detection sensitivityBioreactor/fermenter combinationsBiological substance pretreatmentsControlled releaseSingle sample
Assay devices, kits, and methods for detection of one or more analytes in a sample are provided. The assay device features the controlled release of reagents and hence is particularly suitable for binding assays such as immunoassays. The assay device achieves greater sensitivity than conventional rapid test assays, leading to stronger and / or more stable visual signals than those produced by conventional devices, easier interpretation of results, and reduced occurrence of indeterminate results. The device can be used for detecting analyte in a variety of biological samples without the need for conventional sample filtration techniques, and thus is suitable for use by untrained personnel without specialized equipment. In addition, the device can be used to simultaneously analyze a number of analytes using a single sample.
Owner:GENELABS DIAGNOSTICS PTE
Apparatus and method for space-division multiplexing optical coherence tomography
ActiveUS20140160488A1Increase speedIncrease imaging speedDiagnostic recording/measuringUsing optical meansSingle sampleLight beam
A space-division multiplexing optical coherence tomography apparatus and system is provided. In one embodiment, the system includes a light source, a reference arm, and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned from the sample is collected. In one arrangement, the signals may be combined to produce a single reflected light signal. The reflected light signal(s) and a reference signal are combined to produce an interference signal comprising data representative of digitized images captured of the actual object. In one embodiment, a single sample arm may be used for scanning and collecting image data. A related method is also provided.
Owner:LEHIGH UNIVERSITY
Graphics system having a super-sampled sample buffer and having single sample per pixel support
A computer graphics system that utilizes a super-sampled sample buffer and a sample-to-pixel calculation unit for refreshing the display. The graphics system may have a graphics processor, a super-sampled sample buffer, and a sample-to-pixel calculation unit. The graphics processor renders samples into the sample buffer at computed positions or locations in the sample buffer. The graphics system may utilize a window ID that specifies attributes of pixels on a per object basis. The window ID may specify one or more of a sample mode, filter type, color attributes, or source attributes. The sample mode may include single sample per pixel mode and multiple samples per pixel mode. In implementing a single sample per pixel mode, the graphics system may be further operable to generate a single sample per pixel for certain windows of the screen in order to, for example, provide backwards compatibility with legacy systems with no multi-sampling support. The graphics system may generate samples that have the same value within the region of a single pixel, or the graphics system may utilize a very narrow filter that only selects the center sample in the averaging process.
Owner:ORACLE INT CORP
Methods and apparatus for sequential amplification reactions
ActiveUS20080038737A1Control performanceBioreactor/fermenter combinationsHeating or cooling apparatusSingle sampleLoop control
The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
Owner:CEPHEID INC
Sequential analysis of biological samples
Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.
Owner:LEICA MICROSYSTEMS CMS GMBH
Self-contained modular analytical cartridge and programmable reagent delivery system
InactiveUS20160038942A1Simplifies fluid controlSpaceMaterial analysis by optical meansLaboratory glasswaresSingle sampleComputer module
A modular system for constructing a variety of self-contained analytical cartridges enabled to perform a number of symmetrical or asymmetrical tests on a single sample source within a single device. Said cartridges are embodied as a readily reversible assemblage of two or more modules that are, in turn, operable to perform one or more tasks of an analytical test as discrete articles-of-manufacture. A programmable reagent delivery system comprising one or more serialized reagent clusters having one or more wet cells (individually packaged reagents) and zero or more dry cells (calibrated spacers); wherein, said wet cells are arranged in a linear series corresponding to prescribed temporal release sequence and dry cells are interpositioned between wet cells in a manner that enables two or more test protocols having asymmetrical release sequences to be synchronized such that a single mechanism can actuate more than one test protocol simultaneously.
Owner:ROBERTS LESLIE DON
Detection And Quantification Of Biomarkers Via A Piezoelectric Cantilever Sensor
InactiveUS20090078023A1High sensitivityShort timeMaterial analysis using sonic/ultrasonic/infrasonic wavesMicrobiological testing/measurementEscherichia coliMultiple sensor
Quantification of a target analyte is performed using a single sample to which amounts of the target analyte are added. Calibration is performed as part of quantification on the same sample. The target analyte is detectable and quantifiable using label free reagents and requiring no sample preparation. Target analytes include biomarkers such as cancer biomarkers, pathogenic Escherichia coli, single stranded DNA, and staphylococcal enterotoxin. The quantification process includes determining a sensor response of a sensor exposed to the sample and configured to detect the target analyte. Sensor responses are determined after sequential additions of the target analyte to the sample. The amount of target analyte detected by the sensor when first exposed to the sample is determined in accordance with the multiple sensor responses.
Owner:DREXEL UNIV
Sequential analysis of biological samples
Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
Owner:LEICA MICROSYSTEMS CMS GMBH
Method and apparatus for sample deposition
A method and apparatus is disclosed to prepare a sample or a plurality of samples for subsequent analysis. A single sample deposition apparatus, and a multiplexed sample deposition apparatus are shown. The apparatus allows for a system that can provide a high throughput deposition of samples to form chromatograms by discrete droplet deposition or as continuous traces. The system can achieve high resolution digitization by pulsing the fluid emanating from the chromatographs by applying a voltage to the target plate that operates at frequencies equal to or greater than about 10 Hz, and up to and including about 1 KHz. The system also allows for analogue recording (i.e., approaching infinite resolution) by nebulizing the fluid coming from multiple columns and simultaneously collecting it on a target plate as a continuous trace.
Owner:APPLIED BIOSYST CANADA
Data Independent Acquisition of Product Ion Spectra and Reference Spectra Library Matching
ActiveUS20130206979A1Stability-of-path spectrometersMolecular entity identificationSingle sampleQuantum electrodynamics
Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.
Owner:ETH ZZURICH +1
Space-division multiplexing optical coherence tomography apparatus
ActiveCN104854423ALow priceExtended imaging depth rangePhase-affecting property measurementsDiagnostic recording/measuringSingle sampleLight beam
A space-division multiplexing optical coherence tomography apparatus arid system is provided, in one embodiment, the system includes a light source, a reference arm. and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned from the sample is collected. In one arrangement, the signals may be combined to produce a single reflected light signal The reflected light sigtial(s) and a reference signal are combined to produce an interference signal comprising data representative of digitized images captured of the actual object, in one embodiment, a single sample arm may be used for scanning and collecting image data. A related method is also provided.
Owner:周超
Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording
InactiveUS20090140140A1Improve efficiencyReduce divergenceTime-of-flight spectrometersMaterial analysis by electric/magnetic meansDense bodyData recording
The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.
Owner:IONWERKS
Sequential analysis of biological samples
ActiveUS20080118916A1Bioreactor/fermenter combinationsBiological substance pretreatmentsSingle sampleChemical agent
Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
Owner:LEICA MICROSYSTEMS CMS GMBH
Analytical systems, devices, and cartridges therefor
ActiveCN1964789AAnalysis using chemical indicatorsInvestigating moving sheetsSingle sampleSpecific detection
Owner:POLYMER TECH SYST
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