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3 results about "Asialoglycoprotein receptor" patented technology
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The asialoglycoprotein receptors are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes , several human carcinoma cell lines and liver cancers. It is also weakly expressed by glandular cells of the gallbladder and the stomach. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.
ASGPR-binding compounds for the degradation of extracellular proteins
ActiveUS12667620B2Extracellular proteinsAsialoglycoprotein receptor
Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
Owner:AVILAR THERAPEUTICS INC
Antisense nucleic acid targeting APOC3
The present invention provides an antisense oligomer having the base sequence depicted in SEQ ID NO: 26, an antisense oligomer having a base sequence resulting from substitution, deletion, insertion, or addition of 1 to 6 bases in the base sequence depicted in SEQ ID NO: 26, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable hydrate thereof, an oligonucleotide conjugate in which the antisense oligomer is bound with a molecule capable of binding to an asialoglycoprotein receptor, and a pharmaceutical composition containing the same.
Owner:NAT CEREBRAL & CARDIOVASCULAR CENT +1
Novel ligands for desialyl glycoprotein receptors
This disclosure provides novel piperidine and guanosine-derived ligands that specifically bind to the desialyl glycoprotein receptor (ASGPR) and nucleotide analogs conjugated thereto, said nucleotide analogs being incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNA.
Owner:SANOFI SA(FR)