132 results about "HEXA" patented technology

The present invention relates to novel hexa-arm polyethylene glycol (6-arm PEG) and its derivatives. The core of 6-arm PEG derivatives is sorbitol and the end groups can be derivatized into many different reactive functionalities that are useful in conjugating with many different targets. The present invention also provides a biodegradable polymeric hydrogel-forming composition comprising the 6-arm PEG and its derivatives, and methods of using such 6-arm PEG derivatives as surgical or biological implants or sealants.

The invention provides a fluorine-18-marked pyridazinone analogue. The general structural formula of the analogue is shown as a formula (A), wherein G is selected from S, O or NH; R1 is alkyl with 1-6 carbon atoms; R2 is halogen or halogenation alkyl; L is phenyl, cyclohexyl or a hexa-heterocycle radical containing heteroatoms; m is 1, 2, 3, 4, 5 or 6; n is an integer of 1-15; and M is methylene or ethoxy. A compound marking method is simple, and has high radiation chemistry yield, high stability, a high myocardium initial uptake value, high target to non-target ratio and low using cost. The pyridazinone analogue is applied to the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine as a novel fluorine-18-marked myocardial perfusion developing agent.

The invention discloses (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives, and a synthesis method and application thereof. The structural formula of the compounds is shown as a general formula I. Hexa hydro-pyrazino-pyridino-indoldione compounds are structurally modified by natural amino acid, the water solubility and in-vivo absorption are improved and the anti-thrombotic activity is improved. In-vitro and in-vivo anti-thrombotic activity experiments indicate that the compounds in the general formula I have excellent anti-thrombotic activity, and can be prepared into anti-thrombotic medicines.

The invention relates to a preparation and quality control method of Mitiglinide Calcium comprising steps: 1,synthesis of cis- cyclohexyl-1,2-dimethylacid imide; 2,synthesis of cis-hexa-hydrogen isoindole; 3,synthesis of alpha-benzyldiethyl malonate; 4,synthesis of benzylsuccinic acid; 5,S- benzylsuccinic acid methylbenzylamine salt; 6,synthesis of s- benzylsuccinic acid; 7,synthesis of (2S)-2- benzyl-3-(cis-hexa-hydrogen isoindole-2- carbonyl) propanoic acid; 8,synthesis of Mitiglinide Calcium; 9,purity of Mitiglinide Calcium. This invention also contains the method for quality control of Mitiglinide Calcium comprising steps: watching deseription, messureing specific rotation, authenticating, checking, content messureing for Mitiglinide Calcium.

The invention discloses a hexa-rotor aircraft, comprising a centre frame, six arms uniformly distributed at the periphery of the centre frame and a foot rest arranged below the centre frame, wherein a battery is arranged at the bottom surface of the centre frame, a holder is arranged below the centre frame, a camera is fixed on the holder, the front end of each arm is provided with a blade, and the front part of each arm is provided with a motor connected with the battery and located below a corresponding blade. The hexa-rotor aircraft provided by the invention can more easily realize horizontal and stable hovering in the process of flight; moreover, the aircraft employs electricity for a power system, so interference to an electric transmission line is not generated, the problem that a common aircraft cannot closely look over, monitor and shoot an electric transmission line is overcome, and the hexa-rotor aircraft has better security.

The present invention provides a method for purifying recombinant peptides, polypeptides or proteins away from truncated or other full-length forms of these molecules. In particular the invention contemplates a method of purifying a vascular endothelial growth factor (VEGF) molecule by subjecting a biological sample containing the molecule to be purified to affinity chromatography under conditions sufficient for the full length molecules to bind and not the truncated or clipped forms. In the preferred embodiment there are two columns, the first is based on affinity for a poly his tag, the second column based on heparin binding affinity. Particularly preferred VEGF molecules are untagged VEGF-B167, hexa-His-tagged VEGF-B167, hexa-His-tagged VEGF-B186 and hexa-His-tagged VEGF-B10-108.

The invention discloses a 99mTc-labelled isonitrile-containing glucose derivative and a preparation method and an application of the 99mTc-labelled isonitrile-containing glucose derivative, wherein the general molecular formula of the 99mTc-labelled isonitrile-containing glucose derivative is [99mTc-(CNDG)6]+. The derivative takes 99mTc+ as a central core, an isonitrile carbon atom in the CNDG and 99mTc (I) coordinate to form hexa-coordination compound [99mTc-(CNDG)6]+. The [99mTc-(CNDG)6]+ derivative is prepared through the synthesis of the ligand CNDG and the preparation of a CNDG freeze-drying medicine box. The derivative is good in stability and convenient in preparation, is higher in uptake and excellent in retention on a tumor part, is high in tumor / target-to-nontarget ratio, is a high-performance novel 99mTc-labelled isonitrile-containing glucose derivative used for tumor imaging, and is convenient to popularize and apply.

The invention relates to an optical diffusion barrier which comprises a substrate, a diffusion layer and a back layer, wherein the diffusion layer is ultraviolet-cured on any one of the surfaces of the substrate by coating solution comprising optical diffusion particles A, resin A and photo-initiator, wherein the resin A consists of epoxy acrylate resin and urethane acrylate with 8 degrees of functionality in the weight ratio of 1:9-9:1; the back layer is ultraviolet-cured on the other surface of the substrate by coating solution comprising optical diffusion particles B, resin B, photo-initiator and antistatic agent, wherein the resin B consists of pentaerythritol triacrylate and caprolactone modified dipentaerythritol penta / hexa-acrylate in the weight ratio of 1:9-9:1; the optical diffusion particles A consist of high polymer micro-spheres in particle sizes of 10-25 microns and inorganic particles in the particle sizes of 1-4 microns, in the weight ratio of 2:1-4:1; the optical diffusion particles B are inorganic particles in the particle sizes of 2-4 microns; and the diffusion barrier has high hardness, thin coating layer and high transmittance, full diffusion performance and good antistatic property and can meet the development direction of a flat panel display in large size, thinning, light weight and low cost.

Disclosed are compositions and methods related to nucleic acid constructs containing a HexB encoding element and a HexA encoding element. These constructs can be used in the treatment of Tay-Sachs and Sandoff disease.

The invention discloses a crystal of (+)-cis-9-(2-(4-((S)-(3-chlorphenyl)-2-oxygen-1, 3, 2-dioxo phosphorus heterocyclic hexa-ring-2-methylene)-1-ethyl) adenine mesylate (Pradefovir), a drug of the crystal, a preparation method of the crystal and the like.

Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formulawhere A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC / targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.

An overcoat layer for an organic photoconductor drum of an electrophotographic image forming device is provided. The overcoat layer is prepared from a curable composition including a hexyl-based urethane resin having six radical polymerizable functional groups and a charge transport molecule having at least one radical polymerizable functional group. The amount of the hexyl-based urethane resin having six radical polymerizable functional groups in the curable composition is about 20 percent to about 80 percent by weight. The amount of the charge transport molecules having at least one radical polymerizable functional group in the curable composition is about 20 percent to about 80 percent by weight. This overcoat layer improves wear resistance of the organic photoconductor drum without negatively altering the electrophotographic properties, thus protecting the organic photoconductor drum from damage and extending its service life.

The invention discloses a photoinitiator containing asymmetric hexa-aryl diimidazole and a preparation method thereof. The invention mainly solves the problems that a photoinitiator containing symmetric hexa-aryl diimidazole is not sensitive to long-wave ultraviolet light and visible light during a photo-curing process; and the residual photoinitiator is migrated to the surface of photoresist material after photo-curing to form an atomization phenomenon, thereby impacting the quality, and production, use environment and the like of a photoresist product, and restricting the application of the photoinitiator in the field of microelectronic material. The preparation method adopts the main raw materials of 3, 4-dialkoxy benzaldehyde, benzaldehyde, and the benzaldehyde having the substituent of fluorine or chlorine atoms. The photoinitiator containing asymmetric hexa-aryl diimidazole is obtained through a plurality of synthesis steps such as benzoin synthesis, benzyl synthesis, and the like. The alkoxy and fluorine or chlorine atoms with higher activity are introduced into the asymmetric hexa-aryl diimidazole to improve the solubility of the photoinitiator. In addition, the photoinitiator has good absorption of ultraviolet light and visible light, reconditions and improves the production and application environment of the photoresist product, and reduces the emission of pollutants.

The present invention discloses a manufacturing method for sodium hexa-titanate whiskers. Adopting the melting-quenching method of synthesis, the method comprises: mixing titanium-containing raw material, sodium-containing raw material and fluxing agents first; sintering in a high-temperature container until the mixture becomes molten; taking out the molten mixture and quenching on a special quenching device; dissolving part sodium ions in an acid solution; sintering after filtering, washing and drying, then finished product can be obtained; the technological flow is simple and feasible; and the whole process has no pollution. The sodium hexa-titanate whiskers synthesized with the method of the present invention has low cost, low thermal conductivity and high infrared-ray reflectivity. The sodium hexa-titanate whiskers are 10-50 micrometers in average length and 1-5 micrometers in average diameter and can be used as enhancing material, friction material, heat insulation material, etc.

The invention discloses an N-P flameresistant material and a preparation method thereof and application in textiles. The chemical name of a flame retardant of the material is hexa(1-oxo-phospha-2,6,7-trioxabicyclo[2,2,2]octane-4-methylenedioxy)cyclotriphosphazene (HCPPA); the preparation method of the material comprises the steps of synthesizing hexachlorocyclotriphosphazene (HCPP) by reacting ammonium chloride with phosphorus pentachloride, wherein a catalyst is pyridine and ZnO; then synthesizing 1-oxo-phospha-4-hydroxymethyl-2,6,7-trioxabicyclo[2,2,2]octane (PEPA) by reacting pentaerythritol with phosphorus oxychloride; finally synthesizing the HCPPA by reacting the HCPP with the PEPA. According to the preparation method, NaH is used as a catalyst, so that the synthesis reactions can be performed quickly, the reaction time is greatly shortened, and the product yield is improved. When the N-P flame retardant is used for retarding a flame of a cotton fabric, high limit oxygen index and char yield are achieved, and the wash durability is good.

This invention discloses hexachloro ring trimerization phosphonitrile catalysis synthesis method. 1.1-1.5mol ammonium chloride, complex catalyst made uo by 0.012-0.022mol metal compound and 0.030-0.070mol pyridine substance are added into reaction kettle, and then 1000-1300 ml chlorobenzene is added and heated to dissolve. 1mol phosphoric chloride is added at back flow state, then 1 mol phosphoric chloride is added and continue back flow 3-5 hours, then stoped and cooled down to room temperature, and filter off unreacted ammonium chloride and distill out chlorobenzene. 550-600ml petroleum ether is added into residual, then they are heated back flow and extracting for 0.5 to 1 hours, then they are cooled down and filtrated, distilled petroleum ether, finally the crystal is recrystallized and sublimed by normal heptane, and pure white srystal hexachloro ring trimerization phosphonitrile is got. The catalysis synthesis method in this invention uses special complex catalyst, that is metal compound and pyridine or its alkyl substitute to shorten reaction time to 3-5 hours, and improves yield to 80-90 percent, its operation is simple, so is worth extending.

The invention relates to a method for preparing corresponding 1, 6-hexadiisocyanate heated and cracked by hexamethylene aminomethyl formate liquid phase, which adopts ion liquid as reaction solvent and supported metal oxide as catalyst. The main character of the method is mild, clean and green in reaction condition, little in volatility, high in purity of the separated and obtained product and relatively less in by-product.

A supported membrane is provided comprising an inorganic, solid porous filtration membrane supported by an inorganic, solid porous support, said supported membrane comprising nanoparticles of a metal coordination polymer with CN ligands comprising Mn+ cations, where M is a transition metal and n is 2 or 3; and Alk+y[M′(CN)m]x− anions where Alk is an alkaline metal, y is 0, 1 or 2, M′ is a transition metal, x is 3 or 4, and m is 6 or 8; said Mn+ cations of the coordination polymer being bound through an organometallic or coordination bond to an organic group of an organic graft chemically attached to the surface of the filtration membrane, inside the pores of the filtration membrane, and optionally inside the pores of the support. The supported membrane may be used in a process for separating at least one metal cation and solid particles from a liquid medium containing the same.

Systems and methods are provided for the removal and disposal of chromium form an aqueous medium. The systems and methods include the removal of chromium from a source by contact with either natural or synthetic zeolite that has been modified with a ferrous ion or other like substance. The spent zeolite is disposed of and replaced with freshly modified zeolite. In some cases the systems and methods are performed under de-oxidizing conditions.

The invention belongs to the field of pharmaceutical chemistry, and particularly discloses 7-fluoro-substituted Isaindigotone derivatives. The structural formula of the derivatives is disclosed as Formula (I) or Formula (II), wherein X is C or N; R1 is hydrogen, amino, substituted amino, orpenta- or hexa-heterocyclic radical; R2 is hydrogen, hydroxy, amino, C1-C8 alkyl, or C1-C8 alkoxy or halo; R3, R5 and R6 are defined the same as R2; and R4 is hydrogen, hydroxy, amino, phenyl, C1-C8 cycloalkyl, C1-C8 alkyl, C1-C8 alkoxy, C1-C6 alkyl acyloxy, C1-C6 alkynyl, halo, or penta- or hexa-heterocyclic radical. The fluoro-substituted Isaindigotone derivatives can bebondedwith NM23-H2 protein and block the interaction between the NM23-H2 protein and c-myc G-quadruplex DNA, thereby causing the reduction of protooncogene c-myc transcription and translation, and inhibiting the proliferation of multiple tumor cell strains. The fluoro-substituted Isaindigotone derivatives have wide antitumor effects. The fluoro-substituted Isaindigotone derivatives are a novel NM23-H2-protein-targeted transcription regulation blocker, and have wide application space in preparing anticancer drugs.

The invention discloses a six-tooth coordination structure 8-hydroxy quinoline derivant manganese or ferric catalyst and application, wherein the catalyst is the 8-hydroxy quinoline derivant of general formula (I) of catalyst is complex compound of ligand and manganese ion, which forms general formula (II) or (III); the catalyst can be applied in the oxidizing reaction in the olefin, alcohol or cyclohexane and 10-30% hydrogen peroxide, which is 0. 5-5% corresponding to the molar rate of olefin or alcohol or cyclohexane. The invention improves the utility of hydrogen peroxide and epoxidation efficiency with good stability, which uses non-toxic or low-toxic solvent to moderate the reacting condition.

The invention discloses a preparation method of manganese zirconium mixing hexaaluminate catalysts, which mixes and stirs cyclohexane, Isobutanol, OP-10 emulsifier and water according certain volume ratio to prepare reverse microemulsion system; the invention adopts zirconium nitrate, manganous nitrate, aluminium nitrate and carbowax as material to mix and dissolve in deionized water, add into the prepared reverse microemulsion system, drip urea and ammonia precipitant according to certain volume ratio, to produce lodgment; prepare catalyst forequarter by high pressure kettle critical drying agent, manganese zirconium mixing hexaaluminate catalyst of good dispersing, less block and of platy shape is ahcieved after being baked in muffle furnace; the preparation method has simple technics, low cost, small size of crystal grain and stable high temperature.

The invention discloses laser roller-coating vanish paint for woodware. The laser roller-coating vanish paint for woodware is characterized in that the composition is prepared from the following components in percentage by weight: 50-58% of tri-functional aliphatic polyurethane acrylate resin, 10-13% of hexa-functional aliphatic polyurethane acrylate resin, 5-8% of hydroxyethyl methylacrylate, 5-8% of trimethylolpropane triacrylate, 16-20% of 1,6-hexanediol diacrylate, 4-6% of a photoinitiator, and 0.4-0.7 part of an assistant, wherein the assistant consists of 0.2-0.3% of a flatting agent, 0.1-0.2% of a dispersing agent and 0.1-0.2% of a defoaming agent based on the weight of the paint. The laser roller-coating vanish paint for woodware disclosed by the invention has good construction performance and extremely good mirror effect in a constructed film, and has characteristics of good adhesion, high hardness, high wear resistance, high glossiness (over 96 degrees), no roller scratchers, scratching resistance, good yellowing resistance, no smell, good hand feeling, and the like.

The invention provides a primer composition for lysosomal disease gene screening and a kit using the same. The primer composition comprises multiple primer sequences respectively aiming at non-repetitive regions of IDUA, ARSB, MAN2B1, ST3GAL5, SMPD1, CTNS, MFSD8, IDS, GUSB, GBA, ARSA, GNPTAB, SLC17A5, CLN8, SGSH, HYAL1, PSAP, GNPTAG, PPT1, CTSD, NAGLU, FUCA1, GLB1, SUMF1, MCOLN1, TPP1, HGSNAT, NAGA, GM2A, GALC, LIPA, CLN3, GALNS, NEU1, HEXA, GLA, NPC1, CLN5, MANBA, HEXB, ASAH1, NPC2 and CLN6 genes.

The invention discloses a process of synthesizing comprehensive water reducer by using a hexa-carbon monomer. The process comprises the following specific steps: preparing 4560 kg of bottom water in areaction kettle, pumping 3060 kg of the hexa-carbon monomer, and uniformly stirring the mixture; in summer production, starting heat exchanger cooling water to cool a bed charge, and controlling thetemperature of the bed charge at 8-12 DEG C; in winter production, introducing steam, and controlling the temperature of the bed charge at 24-26 DEG C, wherein the temperatures in the reaction processare controlled as follows: the temperature of the whole reaction system is controlled at 10-20 DEG C in summer and the temperature of the whole reaction system is controlled at 25-30 DEG C in winter.By carrying out low-temperature production with a diethylene glycol monovinyl ether, the obtained product is wide in adaptability, can be suitable for various gel materials, has water reducing and slump preventing functions, and can improve the construction performance of concrete. The compounding cost of the water reducer can be saved, the process is simple and convenient to operate, no wastes are available in the production process, and the process is environment-friendly and reliable, and industrial production on a large scale is facilitated.

Disclosed are compositions and methods related to nucleic acid constructs containing a HexB encoding element and a HexA encoding element. These constructs can be used in the treatment of Tay-Sachs and Sandoff disease.

The invention discloses a method for preparing a sheet material adhesive and relates to the field of sheet material production. The method for preparing the sheet material adhesive comprises the steps: (A) adding a protein-containing raw material into water, and stirring uniformly; (B) carrying out ultrasonic treatment on the solution obtained in the step (A); (C) adding sodium dodecylbenzene sulfonate into the solution obtained in the step (B), and stirring; (D) adding boric acid into the solution obtained in the step (C), and stirring; (E) adding hexa-acetamide, a reinforcing agent and an anticorrosive agent into the solution obtained in the step (D), and stirring uniformly, thereby obtaining the sheet material adhesive. According to the method, the sheet material adhesive prepared by the method is used for solving the problems that the existing synthetic resin adhesives release formaldehyde, pollute environment and are harmful to human. The sheet material adhesive is low in cost, high in bonding strength and good in water resistance and corrosion resistance and can cure at normal temperature, and particularly the low-temperature resistance is better than that of other adhesives.

The invention discloses a cosmetic containing active peptide. The cosmetic consists of the following raw materials in parts by weight: 12-16 parts of glycerol, 0.05-0.08 part of a seaweed extract, 2-4 parts of chitosan, 0.2-0.5 part of triethanolamine, 20-30 parts of an aloe extract, 1-2 parts of hexa-peptide, 1-4 parts of an extract of herba leonuri, 0.8-1.5 parts of an extract of radix curcumae longae, 0.5-1.5 parts of 1,2-hexanediol, 3-4 parts of 3,3-dihydroxyl methyl butane-2-hydroxy propionate, 50-70 parts of water, 5-15 parts of the active peptide, 5-8 parts of hyaluronic acid and 10-20 parts of VC. The cosmetic disclosed by the invention is good in effect and free from side effects, and the cosmetic cannot cause damage to consumers' body health.

The invention belongs to molecular biology and biomaterial fields, spider dragline silk gene is used as a base for artificial directed mutation of a part of amino acid sequence, a recombinant spider silk protein is obtained by an escherichia coli overexpression method and a Ni column purification technology, and after electrostatic spinning, a spider-silk-like protein is obtained, and the spider-silk-like protein has better consistency and elasticity than a natural spider silk protein. The spider-silk-like protein is an n-polyploid such as a tri-polyploid, hexa-polyploid or other integer-polyploid of an amino acid sequence shown in SEQ IDNO:5, wherein n is an integer equal to or greater than 1.

The invention discloses a copper-cyclotriphosphazene hexacarboxylic acid derivative coordination framework material and a preparation method and application thereof. The coordination framework material is formed by adopting raw materials comprising copper ions and a ligand L through reaction, wherein the ligand L is hexa-(4-carboxylate benzoxy) cyclotriphosphazene and the chemical formula is C42H30O18N3P3; in addition, the coordination framework material is a three-dimensional framework material and has one-dimensional linear pore passages. By improving the composition and structure of the coordination framework material, various parameters in the preparation method and the like, the structurally ordered copper-cyclotriphosphazene hexacarboxylic acid derivative coordination framework materials can be obtained, the preparation method of the series of materials can effectively guarantee the reaction yield and the actual application is facilitated.