The invention discloses a high-performance fluorine rubber gasket. The high-performance fluorine rubber gasket comprises, by weight, 40-80 parts of binary fluorine rubber, 20-30 parts of silane-modified fluororubber, 12-20 parts of atomized carbon black, 5-10 parts of barium sulfate, 5-15 parts of calcium hydroxide, 1-5 parts of calcium titanate, 1-3 parts of chelate titanate coupling agents, 2-6 parts of molybdenum disulfide, 2-6 parts of phenyl methylpolysilicone resin, 1-2 parts of magnesium oxide, 1-3 parts of dicumyl peroxide, 0.5-1.2 parts of dibenzothiazyl disulfide, 0.5-1.2 parts of triallyl isocyanurate, 1-1.8 parts of bisphenol A, 1-3 parts of hexafluoride isopropylidene diphenol, 1-3 parts of benzyl triphenyl phosphoric chloride, 1-2 parts of sodium stearate, 1-3 parts of palm wax, 1-3 parts of fluorinated polyamide and 1-2 parts of fatty alcohol. The invention further discloses a manufacturing method of the high-performance fluorine rubber gasket. The compression deformation and high-temperature steam resistance of the fluorine rubber gasket are excellent, and the manufacturing method is simple.