The invention discloses a preparation method of 2, 3, 5, 6-phenylcarbinol
tetrafluoride; the preparation method is as follows: the 2, 3, 4, 5, 6-cyanobenzene
pentafluoride is taken as initial
raw material; cyano group is firstly reduced by
catalytic hydrogenation, and then diazotization and
hydrolysis reaction are carried out for obtaining
hydroxide radical, and then contraposition defluorination is carried out for obtaining the 2, 3, 5, 6-phenylcarbinol
tetrafluoride; or the 2, 3, 4, 5, 6-cyanobenzene
pentafluoride is taken as initial
raw material, the contraposition defluorination is carried out for obtaining the 2, 3, 5, 6-cyanobenzene
pentafluoride, the
hydroxide radical is reduced by the
catalytic hydrogenation, and then the diazotization and the
hydrolysis reaction are carried out for obtaining the 2, 3, 5, 6-phenylcarbinol
tetrafluoride. The two synthetic routes of the invention both comprises the three reaction steps of
catalytic hydrogenation, diazotization and
hydrolysis and contraposition defluorination; wherein, in the catalytic
hydrogenation process, acid is added for obtaining amine salt, and the diazotization and the hydrolysis reaction are carried out by a one pot process, thus leading byproducts to be greatly reduced, the main products to have high purity and the yield coefficient to reach more than 74 percent; in addition, the whole process has simple operation, mild reaction condition and cheap and easily obtained
raw material; catalyst and
solvent can be recycled and used, thus reducing
pollution, being environment-friendly, having economic value and being suitable for industrialization.