13 results about "Propionyl chloride" patented technology

The invention discloses a solvent-participation-free synthesis process of p-ethyl propiophenone, which comprises the following steps: by taking ethylbenzene and propionyl chloride as raw materials and phosphorus trichloride and lewis acid as catalysts, carrying out Friedel-Crafts acylation reaction without adding other reaction solvents to obtain the p-ethyl propiophenone. Compared with the prior art, the method has the advantages that the generation of disubstituted impurity 1-(2, 4-diethyl phenyl) propan-1-ketone is unexpectedly and effectively avoided, the impurity generation amount is less than 5%, the yield and the purity of p-ethyl propiophenone are greatly improved, and the synthesis process is green, environment-friendly, low in cost and convenient for realizing industrial production, and can be used for industrial production of eperisone.

The utility model discloses a reaction kettle for propionyl chloride production, which comprises a working table and a shell, the shell is arranged on the top surface of the working table, the shell is a reaction kettle body, a top cover is arranged on the top surface of the shell, a placing shell is arranged on the inner circumferential surface of the shell, the whole placing shell is of a cylindrical structure, the inner side part of the placing shell protrudes out of the inner circumferential surface of the shell, and the outer side part of the placing shell protrudes out of the inner circumferential surface of the shell. The utility model provides a reaction kettle for propionyl chloride production, which comprises a shell and a plurality of placing shells, the placing shells are arranged in an annular array, the length of each placing shell is matched with the height of the shell, a heating rod is placed in each placing shell, and the heating rods are electrically connected with a working table. The middle-layer stock solution and the upper-layer stock solution cannot be well heated, so that the practical use is not facilitated.

The invention discloses a device for synthesizing propionyl chloride through a thionyl chloride method, and relates to the technical field of chemical production, the device comprises a reaction kettle, the top of the reaction kettle is sleeved with a kettle cover, the middle of the kettle cover is provided with a feeding assembly, the reaction kettle comprises a kettle body, the kettle cover comprises a top cover, the feeding assembly comprises a fixed seat, and the fixed seat is provided with a screw. According to the present invention, the uniform mixing of the raw materials can be achieved, the mixing effect can be improved, the premixing can be performed during the additive adding process, the mixing efficiency can be improved, the addition amount can be accurately controlled during the additive adding, and in addition, the raw material mixing efficiency can be improved. According to the feeding assembly, the adhesion amount of the additive on the inner wall of the container and the surfaces of the parts can be effectively reduced, the loss of the additive is reduced, the adding precision and the product quality are improved, in addition, the sealing performance can be compensated in time when liquid leakage occurs between the parts of the feeding assembly due to the reduction of the sealing performance, and liquid leakage is prevented.

The application discloses a preparation method of 2-(3-(4-hydroxyphenyl)propionylamino)benzoic acid, which comprises the following steps: S1, mixing an intermediate 2, an organic solvent, a base and 4-hydroxyphenyl propionyl chloride for reaction, and performing solid-liquid separation to obtain an intermediate 3; S2, mixing the intermediate 3 and an acid catalyst for reaction to obtain 2-(3-(4-hydroxyphenyl)propionylamino)benzoic acid; the preparation method disclosed by the application takes the intermediate 2 as a raw material, and 2-(3-(4-hydroxyphenyl)propionylamino)benzoic acid can be prepared through two steps of amidation and deprotection, the method has high yield and less environmental pollution.

The invention provides a preparation method of a brucea javanica picrol derivative, which comprises the following steps: adding anhydrous pyridine into brucea javanica picrol in an ice-water bath, dissolving, stirring at room temperature, dropwise adding propionyl chloride into the system under the protection of nitrogen, stirring at room temperature, completing a thin-layer monitoring reaction, and purifying to obtain the brucea javanica picrol derivative, and also provides application of the brucea javanica picrol derivative. The brucea javanica bitter alcohol derivative is used for preparing drugs for dual targeting inhibition of abnormal lipid metabolism of cells and repairing of mitochondrial functions. The brucea javanica bitter alcohol derivative prepared by the invention can be obtained by performing functional group modification on brucea javanica bitter alcohol, has the activity of dual targeting regulation of cell lipid metabolism and mitochondrial function, and has application potential in preparation of drugs for treating metabolic diseases.

The utility model discloses a propionyl chloride rectifying still residue treatment device. The propionyl chloride rectifying still residue treatment device comprises a distillation retort, a support is installed on the distillation retort, and an adjusting mechanism is arranged between the distillation retort and the support; the adjusting mechanism comprises a gear ring fixedly installed on the distillation retort, a gear is installed on the outer side of the gear ring in a meshed mode, a driving assembly is arranged between the gear and the support, and the gear is driven by the driving assembly to rotate. According to the propionyl chloride rectifying still residue treatment device provided by the utility model, the distillation retort and the bracket are arranged, and the adjusting mechanism comprising the gear ring, the gear and the driving assembly is arranged between the distillation retort and the bracket, so that the distillation retort can be rotated after the bracket is horizontally and fixedly mounted, and the orientation of a pipeline connecting flange of the distillation retort is adjusted; alignment with a flange of a connecting pipeline is facilitated, and butt joint installation of the distillation retort and the connecting pipeline is facilitated.

The invention relates to the field of filter bags, and discloses a PPS dust removal filter bag and a preparation method thereof, the dust removal filter bag comprises polyphenylene sulfide resin, a modified composite filler and a hyperbranched additive; the modified composite filler is prepared by grafting a modified silane coupling agent and the composite filler; according to the modified silane coupling agent, cyanuric chloride and an aminated antioxidant prepared through a reaction of 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionyl chloride and p-phenylenediamine are subjected to substitution to prepare a triazine ring substituent, and then N, N '-bis-(2, 2, 6, 6-tetramethyl-4-piperidyl)-1, 2, 4-triazine-1, 3, 5-triazine-1, 3, 5-triazine-1, 3, 5-triazine-1, 3, 5-triazine-1, 3, 5-triazine-1, 3-triazine-1, 3-triazine-1 the triazine ring intermediate is prepared by reacting 1, 6-hexamethylenediamine with a triazine ring substituent, and the triazine ring intermediate is grafted with 3-aminopropyltriethoxysilane. The hyperbranched additive is prepared by carrying out ester exchange on an additive intermediate prepared by reacting tris (2-hydroxyethyl) isocyanurate and ethyl bromoacetate and diphenyl dihydroxysilane. The material prepared by the invention has good mechanical properties, oxidation resistance, high temperature resistance, wear resistance and ultraviolet resistance.

The invention provides a preparation method of a key intermediate of a gemfibrozil impurity A, and belongs to the technical field of chemical synthesis. According to the invention, a brand-new synthetic route of the gemfibrozil impurity A is designed firstly, and efficient preparation methods of three key intermediates are provided on the basis of the brand-new synthetic route. Specifically, the preparation method comprises the following steps: firstly, reacting with propionyl chloride in a 1, 2-dichloroethane environment under the catalysis of aluminum trichloride, and cooling, layering and drying a product to obtain a first intermediate; taking the first intermediate as a raw material, reacting with benzyl bromide in a DMF (Dimethyl Formamide) environment by taking potassium carbonate as an acid-binding agent, collecting an organic phase, dissolving with methanol, carrying out reduction reaction by using sodium borohydride under the catalysis of cerium chloride heptahydrate, and collecting to obtain a second intermediate; taking the second intermediate as a raw material, dissolving the second intermediate in methylbenzene, and performing dehydration reaction under the catalysis of TsOH.H2O to obtain a third intermediate; on the basis of the three intermediates, efficient synthesis of the gemfibrozil impurity A can be achieved, the synthesis route is short, and the process efficiency is high.

The invention relates to the field of silicone rubber, and discloses heat-conducting and insulating silicone rubber as well as a preparation method and application thereof, the heat-conducting and insulating silicone rubber comprises silicone rubber, a modified composite nano filler, modified nano titanium dioxide and an auxiliary agent; the modified composite nanofiller is prepared by grafting an isocyanated composite nanofiller and a modified additive; the composite nanofiller is prepared by grafting aminated hexagonal boron nitride and graphene oxide; the modified additive is prepared by performing amination modification on a modified intermediate prepared by reacting cyanuric chloride with p-phenylenediamine by using ammonia water, and then reacting the modified intermediate with 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionyl chloride; the modified nano titanium dioxide is prepared by depositing a nano zinc borate sheet on the surface of nano titanium dioxide by using sodium tetraborate and zinc sulfate, then performing amination modification by using a silane coupling agent, and then grafting hyperbranched aromatic polyamide on the surface of the nano titanium dioxide. The material prepared by the invention has good mechanical properties, thermal conductivity, insulativity, flame retardance and aging resistance.

The utility model provides a kind of refining reaction kettle of propionyl chloride synthesis process, including box, the top of box is provided with end cover, the inside of box is provided with rotating shaft passing through end cover, rotating shaft is provided with cross bar, cross bar is slidably provided with sliding block, the bottom of sliding block is provided with rotating shaft, the top of rotating shaft is provided with gear, the bottom of cross bar is provided with L-shaped plate, the bottom of L-shaped plate is provided with rack and pinion with gear meshing, the top of rotating shaft is provided with multiple stirring teeth. Through the refining reaction kettle of propionyl chloride synthesis process described in the utility model, not only can satisfy the basic demand of material processing, but also can stir material by stirring device with higher stirring efficiency, avoid the problem that material in the inside of box has lower stirring efficiency, not satisfy the use of people.

The utility model is suitable for propionyl chloride production technical field provides a kind of filling metering equipment for propionyl chloride production, including placement ring plate, and the bottom of placement ring plate is fixedly connected with support ring table around hole, and the top of support ring table is placed with glass metering tank, and the central position at the top of glass metering tank is provided with feed inlet, and feed inlet is connected with discharge pipe, and the top of glass metering tank is installed with lifting assembly, and signal generating assembly is detachably installed on lifting assembly, and signal receiving assembly is installed on the outer wall of glass metering tank, and lifting assembly controls signal generating assembly to lift to control the feed metering of glass metering tank by signal receiving assembly receiving signal;Signal generator is fixedly installed on connecting cylinder, and connecting cylinder is spirally installed on the side wall of threaded column, and aluminum mirror is installed on mounting cylinder, and mounting cylinder is spirally installed on ring cylinder, so that signal generator and aluminum mirror can be spirally detached, convenient to replace and repair.

The utility model relates to the technical field of injection pumps, in particular to an inert gas injection pump which comprises an injection pump body, a mixing cavity located on the upper portion of the injection pump body is formed in the injection pump body, and a temperature control cavity located on the lower portion of the injection pump body is formed in the injection pump body. A feeding pipe communicating with the mixing cavity is fixedly installed on the side wall of the injection pump body, a nozzle is fixedly installed at the bottom of the nitrogen inlet, an annular pipe communicating with the feeding pipe is fixedly installed at the end of the feeding pipe, and four connecting pipes which are circumferentially arranged at equal intervals and communicate with the annular pipe are fixedly installed in the annular pipe. Nitrogen rapidly circulates in the nozzle through the pneumatic conveying device, then propionyl chloride passes through the interior of the conical pipe through the difference between the internal atmospheric pressure and the external atmospheric pressure, the propionyl chloride is further pressurized through the pneumatic conveying device, the cavity effect is formed when the propionyl chloride passes through the interior of the conical pipe, and solute and solution in the propionyl chloride are fully stirred and mixed.

The utility model relates to the technical field of propionyl chloride preparation, in particular to a device for recovering thionyl chloride by a distillation method, which comprises a distillation kettle, a connecting pipe, a filter box, a filter screen filter, a deep filter, a head tank and a distillation recovery component. According to the utility model, through the arrangement of the filter box, the filter screen filter and the deep filter, a thionyl chloride solution containing impurities firstly passes through the filter screen filter to remove larger particles, and then passes through the deep filter to remove tiny solid impurities, so that the purity of raw materials entering the distillation kettle is ensured, and the interference of the impurities on the distillation effect is reduced; the material conveying is smoother, so that the distillation efficiency is improved and the energy consumption is reduced.