30results about How to "Atom utilization is high" patented technology

The invention relates to the technical field of synthesis of antibody-coupled drug linkers, in particular to a synthesis method of MC-Val-Cit-PAB. The synthesis method comprises the following steps: carrying out amide condensation reaction on L-citrulline and M1 to form M2; carrying out amide condensation reaction on L-valine and M3 to form M4; and carrying out amide condensation reaction on M2 and M4 to form M5. The synthesis method improves the problems of low product purity, high initial raw material cost, low reaction conversion rate and the like in the existing synthesis method.

The application discloses a preparation method of a silodosin key intermediate and belongs to the technical field of drug chemical synthesis. The silodosin key intermediate is prepared from indoline as raw material through halogenation, cyanation, N-benzoylpropylamine protection, substitution, amination, reduction and salt formation, and the silodosin key intermediate is compound 1. The synthesis line is novel, the raw reagents are easy to obtain or prepare, high-risk and high-pollution reagents are not used, the method is safe, environment-friendly, mild in reaction condition, easy and controllable to operate, the prepared silodosin key intermediate is good in purity, high in yield and high in atom utilization rate, and the industrial production problem of silodosin can be practically solved.

The invention discloses a preparation method of an intermediate of macloxvir. The preparation method comprises the following steps: step 1, carrying out halogenation reaction; step 2, elimination reaction; step 3, addition reaction; step 4, ring closing reaction; the starting raw materials, the solvent and the catalyst selected in the invention are industrial-grade cheap and easily available products, have the advantage of low production raw material cost, and provide economic feasibility support for industrial large-scale production; reaction conditions of each step in the reaction process are mild, byproducts are few, the yield is high, and a target product can be prepared more efficiently; meanwhile, the synthesis route is high in atom utilization rate and excellent in atom economy, the used solvent and reagent are high in stability and easy to recycle and reuse, generation and emission of industrial three wastes are greatly reduced, the environment-friendly treatment cost is reduced, and the concept of green chemistry and sustainable development is met; the method gives consideration to economy, high efficiency and environmental friendliness, and solves the problems of low yield, violent reaction conditions and high cost of raw materials and auxiliary materials in the existing method.

This invention discloses an axially chiral 1,4'-biquinolinone and its derivatives, and a synthetic method thereof. The method uses MBH carbonate and quinoline-2(1 H Using β-ketones as raw materials, (DHQD)₂PYR as catalyst, and DME as solvent, a centrally chiral β-substituted allyl intermediate was synthesized; then, using iron powder as a reducing agent and acetic acid as solvent, enantiomeric enriched centrally chiral γ-lactam compounds were obtained; finally, using DBN as a base and DME as solvent, enantiomeric enriched compounds were obtained. (S) -Axial chiral 1,4'-biquinolinone or its derivatives. The method of this invention has mild reaction conditions, readily available raw materials, high enantioselectivity of the product, and excellent yield. The synthesized 1,4'-biquinolinone or its derivatives can be further used to synthesize novel substituted quinolinone phosphonate compounds, and to synthesize drugs with antibacterial, antimalarial, anticancer, antitumor, or herbicidal activities, showing broad application prospects.

The application discloses a preparation method of a metal catalyst material and application of the metal catalyst material in controllable degradation of polysaccharides, and the preparation comprises the following steps: mixing and reacting a ligand material with a metal ion solution, solid-liquid separation, washing, and drying; grinding the dried solid into powder, and then high-temperature calcining to obtain a metal monatomic catalyst, namely the metal catalyst material; or uniformly mixing and grinding the obtained metal monatomic catalyst with a metal organic framework material, and then high-temperature calcining to obtain a composite metal catalyst material. The metal catalyst material prepared by the application can make up for the limitations of Fenton oxidation principle in degrading polysaccharides, such as large iron consumption, strong pollution, and difficult control, and can avoid the adverse effects caused by the corrosiveness of hydrogen peroxide in actual production and operation. Different molecular weight polysaccharides can be obtained by adjusting the proportion and dosage of the metal catalyst material, the method can prepare polysaccharides with different molecular weights, and the prepared polysaccharides have good uniformity.

The invention provides a preparation method of gemcitabine hydrochloride, and belongs to the technical field of medicine synthesis. The preparation method of gemcitabine hydrochloride comprises the following steps: firstly, carrying out condensation reaction on a compound in a formula I and protected cytosine II to obtain a gemcitabine hydrochloride compound III; the method comprises the following steps: synthesizing a gemcitabine hydrochloride compound III (alpha / beta configuration mixture), splitting the synthesized gemcitabine hydrochloride compound III (alpha / beta configuration mixture), and carrying out configuration conversion on a key compound III (alpha / beta configuration mixture) in a splitting mother solution by adopting a continuous flow technology to realize recovery of an alpha configuration product, so that the purity and yield of the gemcitabine hydrochloride compound III beta are improved, and the method is suitable for industrial production. And thus, high-quality gemcitabine hydrochloride is obtained. The purity of the key compound is improved through resolution and configuration transformation, and the purity reaches 99.2% after resolution. The gemcitabine hydrochloride is prepared from the high-purity key compound III, so that the product purity is high; the product loss is reduced, and the product yield is improved.

The application discloses a kind of carbon black supported iron manganese composite oxide cluster catalyst's Joule heat preparation method and its application in electrocatalytic nitrate reduction preparation ammonia, belong to electrocatalytic ammonia preparation technical field.The catalyst Ketjenblack EC-600JD carbon black is used as carbon carrier, iron manganese composite oxide cluster is uniformly dispersed on the surface of carbon carrier, and the carbon carrier is worm-like mesoporous structure, with high specific surface area and high defect concentration.The application uses sodium citrate as complexing agent, acetylacetone iron and manganese acetate as metal precursor, after complexing, loading, gelation, freeze drying, the target catalyst is prepared by Joule heat instantaneous heat treatment under nitrogen atmosphere;The preparation process has high heat conversion efficiency, low energy consumption, can realize atomic dispersion of iron manganese composite oxide cluster, effectively improves the exposure degree of catalytic active site.The catalyst shows high catalytic activity, high selectivity and excellent stability in electrocatalytic nitrate reduction preparation ammonia reaction, and the ammonia preparation faraday efficiency can reach more than 85%, and the preparation process does not need noble metal and toxic reagent, and the process is green and efficient, easy to scale production, can efficiently convert nitrate wastewater into ammonia, with environmental governance and nitrogen resource recycling value.

This invention provides a method for manufacturing dibenzylamine. Benzonitrile and a reaction solvent are mixed in a high-pressure reactor, and a hydrogenation reaction is carried out under the action of a ruthenium-iron bimetallic catalyst supported on cerium oxide to obtain a crude product. After cooling and filtering the catalyst, the crude product is purified by distillation to obtain the final dibenzylamine. This method features mild reaction conditions, high atom utilization, and meets the requirements of clean and green production.

The application belongs to the field of agricultural chemistry, and particularly relates to an activator based on structural modification of L-methionine and a synthesis method and application thereof; the application takes L-methionine as a core raw material, which is of natural origin, cheap and easy to obtain and excellent in biocompatibility, and performs structural modification through one-step esterification to synthesize a target compound 2-(diethylamino)ethyl-L-methionine ester; biological activity experiments prove that the compound can effectively promote the germination rate of crops at a low concentration, significantly optimize the growth state of roots and stems, and greatly enhance the stress resistance potential of seedlings; in addition, the compound has outstanding industrialization advantages, and is simple in production process, controllable in raw material cost and excellent in water solubility, with a solubility in water of greater than or equal to 30 g / L at 25 DEG C, so that it can be mass-produced without complex post-treatment, thereby not only effectively reducing the input cost of agricultural production, but also significantly improving the yield and quality of crops, and providing a new path for the development of green and environmentally-friendly plant growth activators.

This invention discloses a parallel-interface engineered viologen-based defective carbon nitride composite material, its preparation method, and its applications, belonging to the field of energy catalysis and photochemical materials technology. The material comprises: a defective graphitic carbon nitride support; single-atom platinum catalytic sites supported on the support; and a selenium-containing viologen compound anchored by covalent bonds in a configuration parallel to the support surface. Through a bilateral covalent bonding strategy, viologen molecules are stably anchored in a parallel configuration to the single-atom platinum-modified defective carbon nitride surface, constructing a highly efficient and stable "electron bridge" structure, significantly enhancing interfacial bonding and photogenerated electron transport efficiency. This composite material exhibits excellent photocatalytic hydrogen evolution activity and efficient coupling ability with benzylamine oxidation under visible light, and its activity retention rate reaches over 92% after 144 hours of cycling. It provides a new paradigm for solving the problem of poor interfacial stability in photocatalysts and has significant application prospects in the field of solar fuel synthesis.

This utility model relates to the field of triethylsilane synthesis technology and discloses an apparatus for triethylsilane synthesis, comprising: a raw material storage component for storing synthesis raw materials; a mixing device for mixing the raw materials output from the raw material storage component; and a fixed-bed reactor filled with a catalyst. By providing the temperature required for the reaction, the mixed raw materials react with each other on the catalyst surface under certain pressure and temperature to generate the desired substance. This utility model provides a production apparatus for triethylsilane, which is a fully continuous process device including reaction and separation processes. This apparatus supports the production of triethylsilane from tetrahydrosilane and ethylene via fixed-bed catalytic reaction. The apparatus has a simple process, high atom utilization, simplified flow, no solvent use, low waste, and can achieve continuous and automated operation.

The present application relates to a kind of natural (6S) -5-methyl tetrahydrofolate and its preparation method, wherein the natural (6S) -5-methyl tetrahydrofolate is prepared by reducing process with folic acid as raw material, and no heavy metal such as platinum or lead, and formaldehyde, benzene sulfonic acid and its ester and other raw materials are used in production process;The content of the natural (6S) -5-methyl tetrahydrofolate is not less than 98%, the amount of JK12A is not higher than 0.1%, methyl tetrahydropterin is not detected, benzene sulfonic acid and its ester are not detected, and enzyme protein residue is not higher than 1 ng / g;The present application has the advantages of convenient post-processing, green environmental protection, high product purity and the like due to the use of green biological production process.

The invention discloses an oxygen reduction electrocatalyst and a preparation method and application thereof, and relates to the field of catalysis. The oxygen reduction electrocatalyst comprises a carrier and a metal monatomic loaded on the carrier, the carrier is nitrogen-sulfur double-doped porous carbon, the coordination structure of the metal monatomic and the nitrogen-sulfur double-doped porous carbon is N3S1M1, and M is a metal element corresponding to the metal monatomic. The oxygen reduction electrocatalyst provided by the invention does not contain noble metal, is relatively low in cost, is a monatomic catalyst in nature, and has extremely high atom utilization rate. The oxygen reduction electrocatalyst has a relatively large specific surface area, shows excellent oxygen reduction catalytic activity in an alkaline medium, and shows excellent long cycle stability in a water system and a flexible zinc air battery positive electrode, so that the oxygen reduction electrocatalyst has great application potential.

The present application relates to a kind of 2-oxopentanedioic acid preparation method.The invention method is as follows: 2-methylene pentanedioic acid is dissolved in a certain amount of dimethyl carbonate, a certain amount of V2O5 / K2O / zeolite composite catalyst is added, air (or oxygen) is introduced at reflux temperature for a certain time.Oxidation is carried out.After reaction, the catalyst is removed by filtration, dimethyl carbonate is removed by vacuum distillation, 2-oxopentanedioic acid crude product is obtained, the yield is 98.5%, and refined 2-oxopentanedioic acid is obtained by recrystallization with water, the purity is 99.2%.The synthesis process of the present application is simple, the yield and product purity are high, the process cost is low, and it is an environment-friendly 2-oxopentanedioic acid synthesis method.

According to the method for green treatment of phosphorus-containing wastewater in alendronate sodium synthesis, in the alendronate sodium synthesis process, phosphorous acid and phosphorus trichloride are adopted for participation in literature, but a large amount of phosphorus-containing wastewater can be generated in the post-treatment process, great pollution is caused to the environment, and therefore how to convert phosphorus-containing compounds in a green and environment-friendly mode becomes a difficult problem. Synthesis of alendronate sodium belongs to the field of medicine synthesis processes. Comprising the following steps: adding gamma-4-aminobutyric acid into methanesulfonic acid, adding phosphorous acid, adding phosphorus trichloride, reacting, hydrolyzing, adjusting the pH value by using a sodium hydroxide aqueous solution, and filtering to obtain alendronate sodium. Filtered filtrate is subjected to the following operation: 1) non-polar solvent extraction and 2) reduced pressure distillation, the filtrate is subjected to post-treatment operation, acid waste liquid is converted into a sodium methanesulfonate byproduct, phosphorus-containing wastewater is converted into a sodium dihydrogen phosphate byproduct which is widely applied, the atom utilization rate is remarkably improved, and the method has important significance on environmental protection.

The application discloses a catalyst for heptafluoroisobutyramide dehydration reaction and a preparation method thereof, relates to the field of catalysis technology, and the catalyst comprises an active component, a carrier, an additive and a complexing agent, wherein the active component is monodispersed high-valence metal-oxygen species, the carrier is one or more of porous silica or porous gamma-Al2O3, the additive refers to one kind of nitrate salt containing Na, K or Cs, and the complexing agent is one of acetic acid, citric acid, urotropine, cetyltrimethylammonium bromide or cetyltrimethylammonium hydroxide; the high-valence metal-oxygen species refers to M-O x , M is one of W, Mo, V, Cr, Mn or Co, and X=1.0-3.0. The preparation method comprises the steps of dissolving, impregnating, drying, calcining and the like. The active component in the catalyst is highly dispersed, has excellent catalytic dehydration performance, has high atomic utilization rate, the preparation method is simple, no three wastes are discharged, and the catalyst has a good industrial application prospect.

The invention discloses an S-type heterojunction photocatalyst of FMO (at) F and M-ZIS as well as a preparation method and application of the S-type heterojunction photocatalyst. According to the invention, the S-type heterojunction photocatalyst of Fe and Mo co-doped ZnIn2S4 coated FeMoO4 (FMO (at) F and M-ZIS) can be prepared without using a template agent and a surfactant. The catalyst can take tetracycline hydrochloride as a pollutant (40 ppm), the degradation efficiency of the catalyst can reach 100% under a 10 W LED lamp for 20 min, and the degradation rates of high performance liquid chromatography and three-dimensional fluorescence detection are 100% and 97.4% respectively.

The invention discloses a method for preparing amino phosphonic acid resin based on chloromethylation reaction, which comprises the following steps: carrying out chloromethylation reaction on polystyrene resin, paraformaldehyde, concentrated sulfuric acid and thionyl chloride in an organic solvent, and carrying out amination reaction on the obtained chloromethylated polystyrene resin and a diamine compound in trichloromethane to obtain the amino phosphonic acid resin. And mixing the obtained aminated resin with a formaldehyde solution and phosphorous acid, and carrying out phosphonation reaction to obtain the amino phosphonic acid resin. According to the method, polystyrene resin is used as a raw material, chloromethylation reaction is carried out in a novel chloromethylation system constructed by paraformaldehyde, concentrated sulfuric acid and thionyl chloride, the reaction rate and the reaction efficiency of chloromethylation can be effectively improved, amination and phosphonation reactions are carried out on the obtained chloromethylated polystyrene resin, and the yield of the polystyrene resin is improved. The preparation method has the advantages of simplicity in operation, low cost, high synthesis efficiency, environmental friendliness and the like, and industrial application of the amino phosphonic acid resin is conveniently realized.

This invention relates to the field of CO2 resource utilization and hydrogenation catalysis technology, and discloses a highly zinc-loaded mesoporous alumina-based CO2 hydrogenation catalyst, its solvent-free preparation method, and its applications. The preparation method includes: mixing and stirring a structure-directing agent composed of a polyhydroxy organic compound and an organic acid, an inorganic acid, and an aluminum source in a sealed container to form a clear system; then slowly adding a zinc source solution and a copper source solution to obtain a homogeneous precursor; and finally drying and calcining to obtain the catalyst. The highly zinc-loaded mesoporous alumina-based CO2 hydrogenation catalyst (Cu-Zn@Al2O3) prepared by this invention has a specific surface area of ​​100–400 m² / g. 2 / g, with a pore size distribution of 2–50nm, which facilitates mass transfer and diffusion of CO2, H2, and products; the preparation method is solvent-free and uses a one-pot synthesis with few steps, suitable for the hydrogenation reaction of CO2 and H2 under fixed-bed conditions, and can be used to prepare methanol, methane, carbon monoxide and / or C1–C4 low-carbon hydrocarbons and reduce the CO2 content in the feed gas. When methanol is the main product, the methanol selectivity can reach ≥90%.

The application discloses a synthesis method of allyl sulfonyl compounds, and belongs to the technical field of organic synthesis. The method is to use a, beta-unsaturated aldehyde derived sulfonyl hydrazone as raw material, add a base and an organic solvent under the action of a metal catalyst and a ligand, and perform one-pot reaction at a temperature of 70-100 DEG C to obtain the allyl sulfonyl compounds. The method has the advantages of high atom utilization rate, easily obtained raw material, simple operation and short reaction time. The prepared allyl sulfonyl compounds have potential drug activity and biological activity, are important skeletons existing in biological and drug active molecules, and can be used for preparing biological and drug active molecules.

This application discloses an in-situ preparation method for a catalyst, comprising the following steps: gasifying a nitrogen-containing substance and / or a phosphorus-containing substance to obtain a mixed gas, passing it into a reactor containing a support, and performing heat treatment I and heat treatment II to obtain the catalyst. This method enables the uniform introduction of active components and additives, resulting in a uniform distribution of active sites in the prepared catalyst, which is beneficial for improving the catalyst's activity and selectivity. When used in the reaction of acetate and NH3, the catalyst can suppress side reactions and achieve high acetonitrile selectivity. It avoids corrosiveness to reaction equipment, provides mild reaction conditions, has high atom utilization, and is suitable for continuous, stable, and large-scale production.

The invention discloses a preparation method of a boron-doped titanium-based supported catalyst, and belongs to the technical field of catalytic materials and organic synthesis.The preparation method of the boron-doped titanium-based supported catalyst comprises the steps that tetrabutyl titanate and terephthalic acid serve as precursors, a titanium-containing MOF precursor is synthesized through a solvothermal method, then a boron source is introduced to achieve in-situ doping of the boron element, and the boron-doped titanium-based supported catalyst is obtained. Then loading metal on the boron-doped MOF precursor in a monatomic form through an impregnation-coordination-high-temperature pyrolysis process; according to the invention, the electron structure and pore characteristics of the carrier are regulated and controlled through boron doping, and the catalyst is endowed with excellent catalytic performance in combination with high exposure active sites of monatomic metal; the catalyst can efficiently catalyze nitro compounds to be reduced to generate corresponding amines under the conditions of no solvent or existence and mild hydrogenation, the yield of target products is larger than 90%, the conversion rate is larger than 95%, the catalyst is simple in preparation process and high in stability, pollution and safety risks caused by organic solvents can be avoided, the requirements of green chemical development are met, and the method is suitable for industrial production. The method is suitable for large-scale production in the fields of fine chemical engineering, pharmacy and the like.

The application belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 4-methylsulfonyl toluene. Specifically, 4-methylsulfonamide chloride is used as raw material, and under the action of a catalyst, the raw material is reacted with chloromethane Grignard solution at normal pressure, and high-yield and high-purity 4-methylsulfonyl toluene is obtained after purification. The method has the advantages of simple steps, high yield, almost no other impurities, high atomic utilization rate, easy industrialization, and good application value.

The invention discloses a construction method of a spiro [furan-3, 2 '-indole]-3'-ketone compound, and belongs to the technical field of organic synthesis.The spiro [furan-3, 2 '-indole]-3'-ketone compound is obtained by taking a C2 spirocyclopropane indole-3-ketone compound and a carbonyl compound as raw materials and carrying out [3 + 2] cycloaddition reaction in a solvent at 0-room temperature under the action of acid. A series of spiro [furan-3, 2 '-indole]-3'-ketone compounds are designed and synthesized through a conventional simple chemical synthesis method, and [3 + 2] cycloaddition reaction of C2 spiro propane indole-3-ketone and a carbonyl compound is realized for the first time and is applied to construction of indole C2 spiro compounds; the preparation process is simple, the substrate and the catalyst are easy to obtain, large instruments and expensive raw materials are not needed, reaction conditions are mild, and the method has wide application prospects.

The invention relates to the technical field of new energy materials, and discloses a high-performance electrochemical catalyst and a preparation process thereof, and the preparation process comprises the following steps: preparing a composite carrier with a carbon nanotube vertically growing on the surface of graphene through a chemical vapor deposition method; introducing nitrogen and sulfur heteroatoms by adopting plasma-assisted vapor deposition; enabling the metal precursor to be uniformly adsorbed on the carrier in a laminar flow state by utilizing a micro-fluidic reactor; and finally, carrying out stepped heating pyrolysis and annealing treatment to obtain a finished product. The obtained catalyst has a three-dimensional conductive network structure containing rich through pore channels, and iron and cobalt metal active centers are anchored to defect sites of a carrier in a coordination form. According to the process, atomic-scale dispersion of active components is achieved through a microfluidic technology, lattice stress is effectively eliminated in cooperation with stepped pyrolysis, the problem that the activity and stability of the catalyst are difficult to consider at the same time is successfully solved, the oxygen reduction catalytic performance is improved, the cycle life is prolonged, and the mass transfer performance under the large-current working condition is excellent.

This invention discloses a highly stable platinum / palladium-based ammonia oxidation catalyst with a bilayer gradient support, its preparation method, and its applications. The catalyst possesses a multi-level synergistic structure of "atomic-scale dispersed Pd or Pt / V-O-W oxide / hydroxylated TiO₂@(ZrO₂ / Al₂O₃ / CeO₂ or its composite oxide) bilayer gradient support," forming a Pd-O-V / Pt-O-V bonded electronic synergistic system and constructing a protective outer layer with a precise pore size of 2-5 nm. It is constructed through a precise sequential process including hydrothermal hydroxylation modification, atomic layer deposition, sol-gel, and low-temperature reduction post-treatment. The ammonia oxidation catalyst provided by this invention achieves a synergistic effect of intrinsic anti-poisoning and high activity over a wide temperature range. The ZrO₂-CeO₂ composite oxide outer layer further enhances its antioxidant protection capability; the atomic-scale dispersion of Pd or Pt achieves ultra-low loading and high atomic utilization, significantly reducing costs. This invention solves the core technical problems of traditional Pd or Pt-based catalysts being prone to poisoning and deactivation, and having poor low-temperature activity.

The invention belongs to the technical field of chemical synthesis of medicines, and particularly relates to a synthesis method of an LXH-1211 intermediate. The preparation method comprises the following steps: carrying out stirring reaction on phenylhydrazine, 3-aminocrotonitrile and a reaction solvent to obtain an intermediate IM-1; mixing the intermediate IM-1 and a reaction solvent, cooling, adding phosphorus oxychloride, and heating for reaction to obtain an intermediate IM-2; and dissolving the intermediate IM-2 in a reaction solvent, adding ethyl cyanoacetate, and carrying out a stirring reaction to obtain the LXH-1211 intermediate. The raw materials are easy to obtain, use of highly toxic and explosive materials, column chromatography and other operations are avoided, the yield is remarkably improved, special equipment is not needed, industrial amplification is facilitated, and the environmental protection cost is effectively reduced.

The present application relates to brassinosteroid intermediate preparation and its purification method, belong to the field of medicine and chemical technology. The present application provides the preparation method of formula 1 brassinosteroid intermediate, reaction as follows: wherein, wherein R1 And R2 Independently selected from -COR3, C1-C8 Alkyl or R1 And R2 Together form R3 Selected from C1-C 20 Linear or branched alkyl, substituted C1-C 20 Alkyl, phenyl, substituted phenyl, preferably C1-C8 Linear or branched alkyl, phenyl or substituted phenyl, substituted phenyl is selected from the phenyl group, F, Cl, Br, nitro, methoxy arbitrary substitution C1-C6 Alkyl; comprising the following steps: step 1: formula 2 compound in solvent under the action of oxidant formula 3 obtains formula 1 compound. As described above, the preparation method of brassinosteroid intermediate of the present application, has the advantages of high selectivity, low cost and simplification of post-processing.

This invention discloses a photo-initiated method for preparing phenyl or substituted phenyl γ-ketoamides, belonging to the field of pharmaceutical compound synthesis. The method provided by this invention uses a transition metal salt as a catalyst, reacts in an air atmosphere, and yields phenyl or substituted phenyl γ-ketoamide products at room temperature and under light irradiation. This catalyst exhibits high catalytic efficiency and can produce phenyl or substituted phenyl γ-ketoamide products in high yield. This invention addresses the limitation of synthetic routes for phenyl or substituted phenyl γ-ketoamide compounds by providing a simple and direct preparation route. The method does not require expensive metal catalysts or external strong oxidants, has mild reaction conditions, and simple operation and post-processing. It is suitable for the synthesis and large-scale preparation of phenyl or substituted phenyl γ-ketoamide compounds, and features high efficiency, environmental friendliness, safety, and cost-effectiveness.

The invention belongs to the technical field of ceramic pigments, and discloses a coated ceramic pigment, a preparation method thereof and ink-jet printing ceramic ink. The preparation method of the coated ceramic pigment comprises the following steps: adding a zirconium source and a cadmium source into water, and mixing to obtain a solution A; adding a sulfur source, a selenium source, a silicon source and inorganic base into water, and mixing to obtain a solution B; dropwise adding the solution A and the solution B into an aqueous solution containing a dispersing agent together, and stirring to obtain a mixed solution; dropwise adding an aqueous solution of alkali metal salt into the mixed solution, continuously stirring, and carrying out suction filtration and drying to obtain a precursor; and mixing the precursor with a mineralizing agent, and calcining to obtain the catalyst. The ceramic ink for ink-jet printing is excellent in flowing property, and only 20-32 min is needed for suction filtration of 500 mL of ink; after high-temperature calcination, the product is bright and bright red, and the Lab values of the product are respectively 56.5 to 58.8, 27.4 to 30.1 and 17.0 to 23.0.