162results about How to "Atom utilization is high" patented technology

The invention discloses a catalytic synthesis method of 1, 1, 3, 3, 3-pentafluoropropylene, which comprises the following steps: (1) introducing a raw material 1, 1, 1, 3, 3, 3-hexafluoropropane into a reactor, and reacting under the action of a catalyst to obtain crude 1, 1, 3, 3, 3-pentafluoropropylene, the catalyst containing Cr2O3 and one of metal oxides of Al, Bi and Co; (2) carrying out water washing, alkali washing and drying on the crude 1, 1, 3, 3, 3-pentafluoropropene, and then introducing the crude 1, 1, 3, 3, 3-pentafluoropropene into a first rectifying tower for separation to obtain a mixture containing 1, 1, 1, 3, 3-pentafluoropropene and a small amount of by-products; and (3) introducing the mixture containing 1, 1, 1, 3, 3-pentafluoropropylene and a small amount of by-products into a second rectifying tower, and separating to obtain a 1, 1, 1, 3, 3-pentafluoropropylene product. The method has the advantages of simple process, high catalyst activity, low cost and environmental protection.

The invention discloses a nano-carbon supported ruthenium cluster nano-catalyst as well as a preparation method and application thereof. According to the present invention, the synthesis process of the catalyst is simple and easy to perform, the reaction process is controllable, the nanocarbon with characteristics of rich defects and large specific surface area is adopted as the carrier, the ruthenium cluster is loaded on the surface of the nanocarbon, and the nanometer catalyst with characteristics of high specific surface area and high atom utilization rate is synthesized. The catalyst can catalyze persulfate (PDS) to generate products with strong oxidation activity, namely sulfate free radicals (SO4.-), hydroxyl free radicals (. OH) and singlet oxygen (1O2), so that effective inactivation of bacteria is realized. In the invention, the reaction of activating the persulfate to disinfect by the catalyst is carried out at room temperature under neutral conditions, and in a mild reaction environment, the nanocarbon-loaded ruthenium cluster nanocatalyst shows good capability of catalyzing the persulfate to inactivate bacteria, and has huge potential in practical application of water disinfection.

The invention relates to a non-noble metal fuel cell oxygen reduction catalyst based on a self-assembled semi-interpenetrating polymer network and a preparation method and application thereof, and belongs to the technical field of fuel cell oxygen reduction catalysts. The preparation method of the catalyst comprises the following steps: S1, dissolving polysaccharide in ultrapure water, heating and stirring, then adding a polymer monomer, a polymerization initiator, a salt template and a non-noble metal source solution, heating and stirring until uniform orange red hydrogel is obtained, then adding a nitrogen source, continuously heating and stirring, and evaporating a solvent to dryness, so as to obtain a polysaccharide solution; freezing and drying to obtain an orange powder sample; s2, performing pyrolysis treatment on the orange powder sample to obtain a black powder sample, and performing acid pickling, suction filtration and drying to obtain a precursor product; s3, pyrolyzing the precursor product again to obtain the catalyst. The semi-interpenetrating polymer network hydrogel is synthesized in a self-assembly mode, and the catalyst with high loading capacity and atomic-scale dispersion is formed through pyrolysis.

The invention relates to the technical field of nitrobenzene production, in particular to a method for preparing nitrobenzene by adopting a microreactor under a low-acid condition, the method for preparing nitrobenzene comprises the following steps: introducing a nitrating agent and raw material benzene into the microreactor for nitration reaction to obtain nitrobenzene, the microreactor is provided with at least four reaction modules which are connected in series, a nitrating agent and raw material benzene are fed into the first reaction module, and concentrated sulfuric acid is supplemented into at least one reaction module in other reaction modules except the first reaction module in the nitration reaction process; the effective concentration of sulfuric acid in the nitrating agent is not higher than 77%. The method for preparing nitrobenzene solves the production problems that benzene in a micro-reaction system is poor in reaction stability, incomplete in conversion and large in residual quantity in a low-acid environment, dinitration is affected, and the yield of waste acid is large. Finally, a mechanical application process of the dinitration waste acid and the acidic benzene is realized, the production process is safe and reliable, the operation flexibility is high, and the stability is high.

The invention discloses a synthesis method of a 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative, and belongs to the technical field of organic synthesis.The 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative is obtained by synthesizing 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] in the presence of visible light, a photocatalyst and alkali. CF3Br and a 3-(3-hydroxypropyl) indole derivative are subjected to a free radical tandem cyclization reaction in an organic solvent to prepare the 3-(3-hydroxypropyl) indole derivative. According to the 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative and the preparation method thereof, CF3Br is used as a trifluoromethyl source under photocatalysis for the first time, trifluoromethyl is directly introduced into an indoline ring of 4, 5-dihydro-spiro [furan-2, 3 '-indoline], the 2'-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3 '-indoline] derivative is obtained, and the compound has good activity and selectivity on cancer cells such as Huh-7, A549 and A549 / DDP.

The present invention discloses a Pt-based catalyst and its preparation method and application, belonging to the technical field of dehydrogenation catalysts. The preparation method of the Pt-based catalyst comprises the following steps: mixing an aqueous solution I containing magnesium ions, aluminum ions and platinum ions with an aqueous solution II containing a hydroxide-containing alkaline compound and a carbonate, and reacting to obtain a Pt-based catalyst. The preparation method of the present invention utilizes PtCl6 2‑ The strong electrostatic interaction with the magnesium-aluminum hydrotalcite layer (positively charged) and the change of Pt loading amount realize the microstructural regulation of Pt in the Pt-based catalyst. The Pt-based catalyst prepared by this method has a small Pt particle size, a highly dispersed state, and a high atomic utilization rate. When it is used for the dehydrogenation reaction of methylcyclohexane, compared with the catalyst prepared by the traditional impregnation method, under the same reaction conditions, the methylcyclohexane conversion rate is increased by 3.3 times, and it also has good stability.

The invention belongs to the technical field of chemical energy materials, and particularly relates to a rare earth element doped Ru-based catalyst and a preparation method and application thereof. The molecular formula of the catalyst is RuxREy-NMC, and Ru metal ions and rare earth metal ions are loaded on a nitrogen-doped mesoporous polymer; wherein x is equal to 0.5 to 3, and y is equal to 0.01 to 0.1. The preparation method comprises the following steps: firstly obtaining a nitrogen-doped mesoporous polymer through a hydrothermal reaction, then introducing Ru and RE through a wet chemical impregnation method, and finally sintering at a high temperature in a protective atmosphere, and Ru nanoparticles coexist with Ru monatomic atoms and RE monatomic atoms. According to the catalyst, the adsorption behavior of a reaction intermediate is regulated and controlled by introducing rare earth elements, hydrogen evolution reaction kinetics is accelerated, meanwhile, the catalyst has a hierarchical porous structure and a large specific surface area, and full utilization of active sites is facilitated. The catalyst shows catalytic performance superior to that of commercial Pt / C under alkaline ampere-level current density, and the preparation method is simple and low in cost.

The invention discloses an application of cobalt-loaded nitrogen-doped hollow carbon spheres in hydrodechlorination of electric catalytic florfenicol. According to the invention, cobalt is loaded on nitrogen-doped hollow carbon spheres to obtain cobalt-loaded nitrogen-doped hollow carbon spheres (Co / N-HCS). The cobalt-loaded nitrogen-doped hollow carbon spheres (Co / N-HCS) can efficiently remove carbon-chlorine bonds in antibiotic florfenicol molecules, and show very high florfenicol degradation rate and dechlorination rate.

The invention discloses a synthesis method of 2-chloro-4-nitro-6-bromo-aniline, and relates to the technical field of chemical industry of disperse dye intermediates. When 2-chloro-4-nitro-6-bromo-aniline is synthesized, silicon dioxide coated magnetic nanoparticles are firstly prepared, then doped heteropoly acid is prepared, and further modification is performed to prepare modified heteropoly acid; loading the modified heteropolyacid on the silicon dioxide coated magnetic nanoparticles to prepare a magnetic loaded heteropolyacid catalyst; according to the method, 2-chloroaniline is used as a raw material and is firstly nitrified and then brominated under the catalytic action of a magnetic supported heteropolyacid catalyst to obtain the product 2-chloro-4-nitro-6-bromo-aniline. The method for synthesizing the 2-chloro-4-nitro-6-bromo-aniline has the advantages of high raw material conversion rate, good selectivity, high product purity and small wastewater amount.

The invention discloses a preparation method of a self-supporting carbon nanofiber loaded high-spinning Fe monatomic catalyst and application of the self-supporting carbon nanofiber loaded high-spinning Fe monatomic catalyst in a flexible zinc air battery, and the self-supporting carbon nanofiber loaded high-spinning Fe monatomic catalyst (Fe-N4 / NGC-C) is prepared by using an electrostatic spinning technology in combination with a high-temperature pyrolysis strategy; the carbon nanofiber has the advantages of high length-width ratio, large specific surface area, strong stability and the like, can realize uniform distribution of metal Fe monatomic, and inhibits aggregation of electrocatalytic active sites in the carbonization process. According to the preparation method, the atom utilization rate and the conductivity can be improved, and low load and high catalytic performance are realized.

The invention provides an aviation kerosene catalyst and a preparation method and application thereof. The preparation method of the aviation kerosene catalyst comprises the following steps: dissolving a triblock copolymer P123 in an inorganic acid aqueous solution, stirring for a period of time to fully dissolve the triblock copolymer P123, and uniformly mixing; adding an aluminum source, and stirring for a period of time; adding a cerium source and / or a lanthanum source, and stirring for a period of time; adding a cobalt source, and stirring for a period of time; dropwise adding a silicon source, and stirring for a period of time to obtain a mixture; after the mixture is subjected to crystallization reaction, the obtained product is at least subjected to cooling, washing, solid-liquid separation, drying and roasting, and the aviation kerosene catalyst is obtained. The aviation kerosene catalyst provided by the invention is prepared by the preparation method. The invention also provides application of the aviation kerosene catalyst in preparation of aviation kerosene from synthesis gas. The catalyst can improve the selectivity of C8-C16 aviation kerosene components.

The invention discloses a method for synthesizing N,N'-bis(2,4,6-trimethoxyphenyl)oxalamide. The method comprises the following steps: adding 1,3,5-trimethoxybenzene to an organic solvent, adding a bromination reagent for reaction, adding water for crystallization, separating and drying after the reaction is completed to obtain 2,4,6-trimethoxybromobenzene; adding 2,4,6-trimethoxybromobenzene to an organic solvent, adding ammonia water, a base, a catalyst and a ligand, the reaction temperature is 90-120 DEG C, after the reaction is completed, extracting, salifying, filtering and drying to obtain 2-amino-1,3,5-trimethoxybenzene hydrochloride; and amidation reaction: adding 2-amino-1,3,5-trimethoxybenzene hydrochloride to an organic solvent, adding a base and oxalyl chloride, the reaction temperature is 0-30 DEG C, after the reaction is completed, filtering, concentrating, crystallizing, filtering and drying to obtain N,N'-bis(2,4,6-trimethoxyphenyl)oxalamide. The invention avoids nitration reaction and hydrogenation reduction reaction, improves the safety of the reaction, avoids the generation of nitration waste acid, and is environmentally friendly; the reaction yield is increased to 66.1%.

The invention relates to the technical field of electrocatalysts, in particular to a platinum-based quaternary alloy electrocatalyst as well as a preparation method and application of the platinum-based quaternary alloy electrocatalyst. Platinum-palladium-ruthenium-iridium quaternary alloy rich in defects is loaded on a hollow carbon nano microsphere carrier with a high specific surface area; wherein the catalytic active sites comprise metal atom species and lattice defects on a (111) crystal face, and the lattice defects can significantly enhance the catalytic performance of adjacent metal atoms, so that the prepared platinum-based quaternary alloy catalyst has the advantages of small density, high stability, acid and alkali corrosion resistance, and porous characteristic, and can be used for preparing a catalyst. According to the present invention, the reaction activation energy can be substantially reduced, the electron / ion transfer and the mass transfer rate of the intermediate product can be substantially reduced, the catalytic activity and the cycle stability of the catalyst can be further improved, the maximum atom utilization rate (100%) can be achieved, and the catalyst material can be used as the catalyst material during the electro-catalytic oxygen reduction (ORR) reaction in the fuel cell and the metal-air cell.

The invention provides a preparation method of a liflozin intermediate compound, the structure of the liflozin intermediate compound is shown as a compound I. The preparation method of the liflozin intermediate compound comprises the following steps: step 1, carrying out Grignard reaction on metal magnesium and a compound IV to obtain a compound III; step 2, carrying out nucleophilic addition and deprotection reaction on the compound III and a compound V to obtain a compound II; and step 3, carrying out methylation reaction on the compound II to obtain a compound I. The preparation method of the liflozin intermediate compound provided by the invention is mild in reaction condition, high in atom utilization rate, high in yield, high in product quality and small in waste salt and waste residue amount, and solves the production problems of high material cost, harsh reaction conditions, low atom utilization rate and the like in the traditional process.

The invention relates to the technical field of electrochemical synthesis, in particular to an electrochemical preparation method of dimethyl sulfoxide, which comprises the following steps: uniformly mixing a solvent, dimethyl sulfide, water and electrolyte to obtain an electrolysis system, and carrying out electrolytic reaction on the obtained electrolysis system to obtain dimethyl sulfoxide. According to the electrochemical preparation method of the dimethyl sulfoxide, the dimethyl sulfide is taken as a raw material, and the dimethyl sulfoxide is obtained in one step with high Faraday efficiency. Compared with a traditional dimethyl sulfoxide synthesis method, the method has the advantages of small pollution, high atom utilization rate and weak corrosion to devices, and meets the requirements of green and safe production. According to the electrochemical preparation method of the dimethyl sulfoxide, an additional oxidant is not needed, and the only by-product is hydrogen, so that the requirement of green synthesis is met. And moreover, the Faraday efficiency of the reaction is high, and the method has a better industrial application prospect.

The invention discloses a preparation method of a polysulfide ionic conductor, which efficiently generates ionic conductors with various performances and complex structures through rapid polymerization of polysulfide, and overcomes the contradiction between the complex structure and efficient manufacturing in a polymer ionic conductor. The mechanical property and conductivity of the polysulfide ionic conductor are regulated and controlled by utilizing a copolymerization strategy, the ionic liquid and the lithium salt, the comonomers involved in the invention are rich in variety, the generated polymer is diversified in structure and adjustable in performance, synchronous improvement of the mechanical property and the ionic conductivity in the ionic conductor is realized, and the polysulfide ionic conductor can be suitable for various ionic electric devices. The scheme is simple in process and high in atom utilization rate, meets the requirements of green chemistry, and has practical industrial feasibility. The polysulfide ionic conductor has abundant dynamic covalent bonds (such as disulfide bonds) and non-covalent interactions (such as hydrogen bonds and lithium bonds), so that the synthesized ionic conductor can be self-repaired, degraded and recycled, and the service life and life cycle of the material are prolonged.

The invention relates to the technical field of synthesis of antibody-coupled drug linkers, in particular to a synthesis method of MC-Val-Cit-PAB. The synthesis method comprises the following steps: carrying out amide condensation reaction on L-citrulline and M1 to form M2; carrying out amide condensation reaction on L-valine and M3 to form M4; and carrying out amide condensation reaction on M2 and M4 to form M5. The synthesis method improves the problems of low product purity, high initial raw material cost, low reaction conversion rate and the like in the existing synthesis method.

The invention relates to a method for preparing a methyl propionate palladium complex through free coordination cage effect stabilization ethylene hydrogen esterification, which aims at the problem that central metal of the palladium complex for preparing methyl propionate through ethylene methyl esterification is easy to gather and inactivate, and utilizes the cage effect of a stabilizer to construct a cage network around the palladium complex; meanwhile, the free coordination effect is utilized to cooperate with a bidentate phosphine ligand, so that the formation of palladium black inactivation of an active component palladium is effectively slowed down, the stabilization time is maximally prolonged by 360 hours, the TOF value is as high as 20000 h <-1 >, and the selectivity is 100%. The hydrogen esterification reaction system comprises ethylene, CO, methanol, a stabilizer and a palladium complex catalyst; the palladium complex catalyst comprises palladium acetate, 1, 2-bis (di-tert-butylphosphinomethyl) benzene and an acid accelerant. According to the method, the stability of the palladium complex is greatly improved while high catalytic activity and selectivity of the reaction are guaranteed, the reaction condition is mild, the atom utilization rate is high, and the method has a good application prospect in the reaction for synthesizing methyl propionate through ethylene hydrogen esterification.

The invention discloses a liquid crystal monomer efficient green synthesis method and product, the synthesis method comprises the following steps: S1. in the preparation of biphenyl monomers by Suzuki coupling reaction, or the preparation of ether monomers by Williamson reaction, firstly, the raw materials used for Suzuki coupling reaction or Williamson reaction are added into water, water is used as reaction medium, and stainless steel autoclave is used as reaction equipment; S2. then, the autoclave is sealed, stirring is started, nitrogen is replaced in the stainless steel autoclave, the temperature is increased, after sufficient reaction, the temperature is decreased and the material is discharged, the solid is obtained by suction filtration, and the solid is returned to the stainless steel autoclave; S3. water is added again, stirring is started, the temperature is increased, water is washed, the temperature is decreased, and the liquid crystal monomer product is obtained. The invention is green and environmentally friendly, safe and energy-saving, low in cost, and conducive to industrial production.

The application discloses a preparation method of a silodosin key intermediate and belongs to the technical field of drug chemical synthesis. The silodosin key intermediate is prepared from indoline as raw material through halogenation, cyanation, N-benzoylpropylamine protection, substitution, amination, reduction and salt formation, and the silodosin key intermediate is compound 1. The synthesis line is novel, the raw reagents are easy to obtain or prepare, high-risk and high-pollution reagents are not used, the method is safe, environment-friendly, mild in reaction condition, easy and controllable to operate, the prepared silodosin key intermediate is good in purity, high in yield and high in atom utilization rate, and the industrial production problem of silodosin can be practically solved.

The invention discloses a synthesis method of chiral quaternary carbon glucoside, and belongs to the technical field of organic synthesis. The method disclosed by the invention comprises the following steps: a coupling reagent (aryl bromide, alkenyl bromide, alkynyl bromide, electron-deficient olefin and the like) and glucoside are fully reacted under the irradiation of purple light through catalysis of a photocatalyst or catalysis of the photocatalyst with one or more of a metal catalyst, a ligand and alkali, and the functionalized chiral quaternary carbon-containing glucoside is obtained. According to the invention, synthesis of the glucoside compound containing the chiral quaternary carbon center is realized by utilizing a light / metal concerted catalysis strategy. The method not only is mild in condition and wide in substrate adaptability, but also has the advantages of low cost, high atom utilization rate and economical steps due to the fact that simple and stable glucoside is directly used as a raw material. Through subsequent conversion, synthesis of an anti-cancer drug acetylcholine analogue can also be realized by containing chiral quaternary carbon glycoside, and the chiral quaternary carbon glycoside has a huge synthesis value.

The invention relates to the technical field of organic synthesis, in particular to a rapid synthesis method of a polysubstituted pyrimidine carboxylic acid compound. The rapid synthesis method of the polysubstituted pyrimidine carboxylic acid compound comprises the following steps: by taking 4, 6-dichloro-5-methoxypyrimidine as a raw material and tetrahydrofuran as a solvent, carrying out Grignard reaction to prepare an intermediate I, then carrying out Suzuki reaction to obtain an intermediate II, carrying out saponification reaction on sodium hydroxide, and then reacting with hydroiodic acid to obtain the polysubstituted pyrimidine carboxylic acid derivative. According to the rapid synthesis method of the polysubstituted pyrimidine carboxylic acid compound, the reaction only needs four steps, the conditions are mild, the atom utilization rate is high, the route is safer and more environmentally friendly, industrial production is facilitated, and the polysubstituted pyrimidine carboxylic acid compound can be used as an important pharmaceutical and chemical building block to be conveniently used for subsequent derivatization.

The present invention proposes a dihydropyrroloquinazolinone compound containing trifluoromethyl and a synthesis method thereof, and belongs to the technical field of organic synthesis. The dihydropyrroloquinazolinone compound containing trifluoromethyl of the present invention is prepared by a free radical tandem cyclization reaction of CF3Br and N-cyano-N-alkenylamide in an organic solvent under visible light induction and the presence of a photocatalyst and a base. The present invention is the first to regulate the regioselectivity of the substrate under photocatalysis, directly introduce the trifluoromethyl group into the dihydropyrroloquinazolinone ring, and obtain a trifluoromethyl-substituted dihydropyrroloquinazolinone, which can be further used to prepare drugs with anti-Alzheimer's disease. The present invention provides a new method for the synthesis of functionalized dihydropyrroloquinazolinone compounds, which has the advantages of cheap and readily available raw materials, short reaction steps, high regioselectivity of the reaction, simple operation, mild reaction conditions, and good reaction yield.

The present invention provides a method for preparing a doped manganese phosphate precursor and a doped manganese phosphate lithium positive electrode material. The precursor preparation method may include: dissolving a manganous salt and a doped metal M salt and mixing them with concentrated phosphoric acid to form a mixed solution; heating the mixed solution and adding a high-valent Mn 3+n Manganese salt, after the reaction is completed, a precursor slurry is obtained, wherein the mixed solution is heated at a temperature of 150°C to 250°C; the precursor slurry is washed, filtered, and dried to obtain a doped manganese phosphate precursor. The positive electrode material preparation method comprises: mixing the doped manganese phosphate precursor with a lithium source and a carbon source, calcining in an inert atmosphere to obtain a carbon-coated LiMn x M 1‑x PO4 / C positive electrode material. The method of the invention has simple preparation process, easy operation, high efficiency, environmental friendliness and low cost, and the prepared doped manganese phosphate precursor has high phase purity, and the particle size can be controlled from nanometer to micrometer level, and has good dispersibility and high crystallinity.

The invention relates to a preparation method of a suvorexant intermediate, and belongs to the field of medical compounds. According to the invention, 2-bromo-5-methyl benzoic acid with low price is used as a reaction raw material, and the Ullmann coupling reaction can be carried out at a lower temperature by adding amine, amino acid or oxamide ligands, so that the yield and selectivity of the product are greatly improved, and the ratio of the product to a regioisomer is remarkably increased. The route is low in cost, high in yield, simple and convenient to operate, mild in reaction condition and safe, and better meets the requirements of industrial production.

The invention provides a preparation method of a micromolecular ALK kinase inhibitor (2-((5-chloro-2-((2-methoxy-4-(9-methyl-3, 9-diazaspiro [5.5] undecyl-3-yl) phenyl) amino) pyrimidine-4-yl) amino) phenyl) dimethyl phosphine oxide (compound I), and the method has the advantages of mild reaction conditions and high yield and purity, and is suitable for industrial production.

The present invention discloses a portable hydrogen generating device based on water free radical cations, and the technical scheme thereof is as follows: comprising a housing, a power source, a reaction chamber with an air inlet and an air outlet, a benzene generator for generating a benzene gas flow, and a deionized water generator for generating a deionized water gas flow, wherein the benzene generator and the deionized water generator are both connected to the air inlet of the reaction chamber, an anode plate and a cathode plate are respectively provided on both sides of the reaction chamber, a plurality of corona needles arranged toward the cathode plate are provided on the anode plate, and the anode plate and the cathode plate are both connected to the power source. Compared with the prior art, the hydrogen generating device of the present invention is easy to use, the conditions required for the preparation of hydrogen are simple, the hydrogen production concentration is high, the energy consumption is low, dry burning does not occur, and the safety is good.

The invention discloses a preparation method of an intermediate of macloxvir. The preparation method comprises the following steps: step 1, carrying out halogenation reaction; step 2, elimination reaction; step 3, addition reaction; step 4, ring closing reaction; the starting raw materials, the solvent and the catalyst selected in the invention are industrial-grade cheap and easily available products, have the advantage of low production raw material cost, and provide economic feasibility support for industrial large-scale production; reaction conditions of each step in the reaction process are mild, byproducts are few, the yield is high, and a target product can be prepared more efficiently; meanwhile, the synthesis route is high in atom utilization rate and excellent in atom economy, the used solvent and reagent are high in stability and easy to recycle and reuse, generation and emission of industrial three wastes are greatly reduced, the environment-friendly treatment cost is reduced, and the concept of green chemistry and sustainable development is met; the method gives consideration to economy, high efficiency and environmental friendliness, and solves the problems of low yield, violent reaction conditions and high cost of raw materials and auxiliary materials in the existing method.

The invention discloses a method for preparing cyclopropanecarboxylic acid by using phosphorus trichloride as a chlorination reagent, and belongs to the technical field of medicines and pesticides, the method comprises the following steps: adding cyclopropanecarboxylic acid into a reactor, starting stirring, heating to the reaction temperature of 40-60 DEG C, introducing nitrogen to carry out nitrogen replacement, carrying out nitrogen sealing in the whole process, starting dropwise adding phosphorus trichloride, controlling the dropwise adding speed, and reacting for 1-2 hours; the temperature of the reaction system is maintained at the reaction temperature, and the fluctuation temperature does not exceed + / -2 DEG C; after the dropwise adding of the phosphorus trichloride is finished, continuously carrying out heat preservation reaction for 0.5-2 hours, and then standing and separating the reaction liquid to obtain an upper layer which is a cyclopropanecarbonyl chloride crude product; and distilling the crude product of cyclopropanecarbonyl chloride to obtain a refined product of cyclopropanecarbonyl chloride. The method provided by the invention solves the problems of low chlorine atom utilization rate, incomplete catalysis of the adopted catalyst, easy generation of impurities, generation of toxic by-products sulfur dioxide and carbon monoxide, great threat to the environment, and three-waste emission in the existing acyl chloride preparation method.

This invention discloses an axially chiral 1,4'-biquinolinone and its derivatives, and a synthetic method thereof. The method uses MBH carbonate and quinoline-2(1 H Using β-ketones as raw materials, (DHQD)₂PYR as catalyst, and DME as solvent, a centrally chiral β-substituted allyl intermediate was synthesized; then, using iron powder as a reducing agent and acetic acid as solvent, enantiomeric enriched centrally chiral γ-lactam compounds were obtained; finally, using DBN as a base and DME as solvent, enantiomeric enriched compounds were obtained. (S) -Axial chiral 1,4'-biquinolinone or its derivatives. The method of this invention has mild reaction conditions, readily available raw materials, high enantioselectivity of the product, and excellent yield. The synthesized 1,4'-biquinolinone or its derivatives can be further used to synthesize novel substituted quinolinone phosphonate compounds, and to synthesize drugs with antibacterial, antimalarial, anticancer, antitumor, or herbicidal activities, showing broad application prospects.