86 results about "Bond cleavage" patented technology

Compositions and methods for modulating the activity of RNA and DNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. Reactive portions which act, alternatively, through phosphorodiester bond cleavage, through backbone sugar bond cleavage or through base modification are preferrably employed. Groups which improve the pharmacodynamic and pharmacokinetic properties of the oligonucleotides are also useful in accordance with certain embodiments of this invention. Delivery of the reactive or non-reactive functionalities into the minor groove formed by the hybridization of the composition with the target RNA is also preferrably accomplished. Therapeutics, diagnostics and research methods and also disclosed. Synthetic nucleosides and nucleoside fragments are also provided useful for elaboration of oligonucleotides and oligonucleotide analogs for such purposes.

The present invention relates to the detection of a target nucleic acid sequence by a PCEC (PTO Cleavage and Extension-Dependent Cleavage) assay. The present invention is characterized by generating a cleavage site for a nucleolytic enzyme on the extended duplex of which the formation is dependent on the presence of a target nucleic acid sequence. The present investion detects the occurrence of the cleavage of the extended duplex, thereby determining the presence of the target nucleic acid sequence.

To provide a method of producing a polyoxyalkylene-modified polysiloxane composition that is free of acid-mediated carbon-oxygen bond and silicon-oxygen bond cleavage, that is substantially deodorized and also does not generate odor with elapsed time, and that is therefore well suited for use in cosmetic applications, e.g., for hair cosmetics, skin cosmetics, and so forth. A production method of this invention is characterized by removing the odor-causing substance from a polyoxyalkylene-modified polysiloxane composition that has been synthesized by a hydrosilylation reaction, by subjecting the polyoxyalkylene-modified polysiloxane composition to a hydrolysis treatment in the presence of an acidic inorganic salt that is a solid at 25° C. and gives a specific pH at 25° C. in aqueous solution; for example, potassium hydrogensulfate.

A silver halide color photosensitive material comprises a blue-sensitive layer, a green-sensitive layer, a red-sensitive layer and a non-light-sensitive layer on a support. The silver halide color photosensitive material contains a compound selected from the following type 1 and type 2 compounds, and wherein the blue-sensitive layer meets the relationship of the following formula (I):

S_B(370 nm)/S_B(420 nm)<0.7  (I)

wherein S_B(λ) represents a spectral sensitivity at a wavelength of λ,

(type 1) a compound capable of undergoing a one-electron oxidation to thereby form a one-electron oxidation product thereof, wherein the one-electron oxidation product is capable of releasing further one or more electrons accompanying a subsequent bond cleavage reaction, and (type 2) a compound capable of undergoing a one-electron oxidation to thereby form a one-electron oxidation product thereof, wherein the one-electron oxidation product is capable of releasing further one or more electrons accompanying a subsequent bond-forming reaction.

A method to cleave C—C and C—O bonds in β-O-4 linkages in lignin or lignin sub-units is described. The method includes oxidizing at least a portion of secondary benzylic alcohol groups in β-O-4 linkages in the lignin or lignin sub-unit to corresponding ketones and then leaving C—O or C—C bonds in the oxidized lignin or lignin sub-unit by reacting it with an organic carboxylic acid, a salt of an organic carboxylic acids, and/or an ester of an organic carboxylic acids. The method may utilize a metal or metal-containing reagent or proceed without the metal or metal-containing reagent.

The invention discloses a preparation method for a 2,3-disubstituted benzo-gamma-pyrone derivative. The 2,3-disubstituted benzo-gamma-pyrone derivative is prepared by one-step reaction of substituted alkynone with quinoline oxynitride; the reaction process comprises intermolecular regioselective 1,3-dipolar cycloaddition, an N-O bond cleavage reaction and then molecular oxyarylation; so the 2,3-disubstituted benzo-gamma-pyrone derivative is prepared through the one-pot method. The method of the invention has the advantages of easy availability of raw materials, high yield, mild reaction conditions, moderate reaction time, wide substrate scope, strong reaction specificity, simple post-treatment and environmental friendliness.

The invention belongs to the field of organic chemistry and relates to a polysubstituted decalin compound, and a synthesis method and an application thereof. The structural formula of the polysubstituted decalin compound is shown above. The preparation of the polysubstituted decalin compound includes septs as follows: AB fragment which is obtained by the c-bond cleavage of an oleanane type or an ursolic alkane type pentacyclic triterpenoid compound is treated with different reduction methods to obtain a compound 2 or 3. The polysubstituted decalin compound of the invention is used to synthesize the medicine or the apice and the analogues which contain the structural fragment of the polysubstituted decalin. The invention has the advantages of simplicity, practicability, low cost, high yield and being capable of industrialization.

The invention provides a new bioorthogonal deprotection method for preparing heterocyclic compounds by bond cleavage using palladium. The methods have general application in the field of biological synthetic chemistry. Compounds, such as prodrugs, which are useful in such methods are also provided.

The invention discloses a method for preparing aldehyde/ketone by breaking a C-C bond, which comprises the following step of: in an organic solvent system under an anaerobic condition, by taking alcohol as a reaction raw material, selectively breaking a C-C bond under the combined action of an iron catalyst, organic alkali and an additive to obtain aldehyde/ketone. According to the method, the alcohol and the iron catalyst are cheap and easy to obtain, the substrate range is wide, post-treatment is simple, the yield and purity of the product are high, a new synthesis route and method are developed for aldehyde and ketone compounds, and the method has good application potential and research value.

The invention provides a preparation method of an organic titanium precursor polymer TPP-I (Triphenyl Phosphate) and the application thereof in electrostatic conductive coatings and belongs to the technical field of preparation and application of new materials. The preparation method of the organic titanium precursor polymer TPP-I includes the steps of placing a mixture of titanium hydride powder,epoxy resin, nanodispersant, titanate coupling agents, silane coupling agents and solvent in a ball mill reaction tank for ball milling reaction under ultrasonic conditions, allowing titanium powderto initiate the chemical bond of the polymer and the lattice bond cleavage on the surface of titanium nanoparticles during a nanocrystallization process, producing ions or groups of extremely high surface activity, degrading polymers into small molecular oligomers that can conduct graft polymerization at high temperatures and pressures, realizing molecular structure reforming and obtaining the organic titanium precursor polymer TPP-I. The organic titanium precursor polymer TPP-I can be used for preparing primers and topcoat for the electrostatic conductive coatings.

The invention relates to a method for preparing aromatic acid through oxidation reaction of 1, 2, 3-grade alkyl substituted aromatic compounds under iron catalysis. The method comprises the following steps: under the action of an iron compound, providing proper temperature and/or light energy, and in the presence of an oxidant and/or an additive, carrying out C-C bond breakage on benzyl positions of aromatic compounds in a solvent to realize selective oxidation so as to obtain a corresponding oxidation compound ketone or acid. According to the invention, C-C bond rupture and oxidation are directly and selectively carried out on the benzyl position of the aromatic compound, so that the method has the advantages of simple reaction, simple operation, mild oxidation condition, high atom economy, high reaction yield, easy separation and purification of the product, suitability for synthesis of benzoic acid derivative compounds, and the like; air can be directly used as an oxidizing agent, so that use of a large amount of heavy metal salt is avoided, and the method is very attractive in industrial production; and the method has very large application potential in the fields of metal catalysis, chemical synthesis and the like by using cheap metal for reaction.

The invention discloses a process capable of treating clean spray paint wastewater. First, H2O2+FeSO4 reagents are used to pretreat paint spray wastewater, and then PAM and PAC are added to coagulate and precipitate it. After these two steps of treatment, the effluent further enters the biochemical process. Treatment system, when the pH is low, H2O is decomposed by ferric ions to generate hydroxyl groups with strong oxidizing ability. Through the reaction of hydroxyl groups with strong oxidizing ability and organic matter, the refractory organic matter in the wastewater is oxidized, and the organic matter in the wastewater The C-C bond of the C-C bond breaks, and finally decomposes into H2O and CO2, and reduces CODcr, or couples or oxidizes, changes its electron cloud density and structure, and forms intermediate products with less molecular weight, thereby changing their solubility and mixing. At the same time, Fe2+ is oxidized to Fe(OH)3, and the effluent further removes pollutants through subsequent coagulation sedimentation and biochemical treatment to achieve the purpose of purification. This process makes the treatment of spray paint sewage clean, meets the discharge requirements, and protects the environmental safety.

The invention relates to a preparation method of pyrimidine dione compounds. According to the preparation method, the pyrimidine dione compounds are efficiently synthesized in a solvent by taking cyclic oxime ester compounds and isocyan compounds as reaction raw materials under the protection of inert gases and the catalytic action of univalent silver compounds. The preparation method provided by the invention has the advantages of low price of the raw materials, easy obtaining of the raw materials, short steps, high atom economy (100%) and mild reaction conditions, and can realize large-scale industrial application; by using cyclic oxime ester N-O bond cleavage, the pyrimidine dione compounds are efficiently constructed in one step. The breakthrough progress in chemical synthesis of a system is realized, and the deep expansion of pharmaceutical chemistry studies related to the system is promoted.

The present invention provides a black and white photothermographic material having, on a support, an image forming layer including at least a photosensitive silver halide, a non-photosensitive organic silver salt, and a compound represented by the following formula (1):

• • wherein R¹⁰¹, R¹⁰², R¹⁰⁴, and R¹⁰⁵ each independently represent a hydrogen atom or a substituent; R¹⁰³ represents a halogen atom, an alkyl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an acylamino group, or a sulfonylamino group; and P represents a group forming a phenol compound represented by formula (2) by cleavage of the O—P bond at the time of thermal development.

The invention provides a safe synthesis method of 1,3,5-triamino-2,4,6-trinitrobenzene, wherein the safe synthesis method comprises the steps: based on the isomerism characteristics of 1,3,5-cyclohexyltriketone imine and 1,3,5-triaminobenzene, taking 1,3,5-cyclohexyltriketone as a reaction raw material, and preparing N,N',N''-triacetyl-1,3,5-triaminobenzene through a trioximation reaction, an N-O bond cleavage-isomerism reaction and an N-acylation reaction; and taking N,N',N''-triacetyl-1,3,5-triaminobenzene as a raw material, and preparing TATB through a multi-stage one-pot tri-nitration reaction. The method has the significant characteristic of the multi-stage one-pot tri-nitration reaction, so that the amination step of an explosive multi-nitro-compound is avoided so as to substantially improve the safety, the used reactants or the used catalyst is the common product in the chemical industry, the use of a non-degradable organic solvent is avoided, the green and safe synthesis is achieved; and meanwhile, on the basis of the characteristics of a one-pot method, the operation process is simplified, operations such as separation, purification and collection of an intermediate product are avoided, and large-scale preparation of 1,3,5-triamino-2,4,6-trinitrobenzene is facilitated.

The invention discloses a deacetylation method for chitin. According to the method, by instant pressure release under a high-temperature and a high-pressure environment, moisture in chitin particles structure evaporates rapidly to form a huge vapor pressure, thereby causing bond cleavage between chitin acetyl and nitrogen atoms. The method has advantages of large treating amount, quick reaction, few reaction variables, simple operation, low cost and environmental protection.