5 results about "Bond cleavage" patented technology

This invention discloses a visible light-induced method for synthesizing α,β-unsaturated acetylide amides, belonging to the field of organic synthesis. The invention constructs a visible light-responsive aromatization-driven carbamoyl radical precursor—a dihydroquinazolinone derivative precursor containing a carbamoyl segment. Under direct visible light irradiation, a single-electron process is triggered, leading to C-C bond cleavage and aromatization, thereby efficiently releasing a carbamoyl radical in situ. Subsequently, this radical undergoes selective acetylation transfer and coupling with an acetylation-based high-valent iodine reagent, achieving the rapid construction of the target α,β-unsaturated acetylide amide. This process can be completed via a one-pot pathway of "visible light direct-driven—radical generation—acetylation transfer / coupling," avoiding the introduction of additional photocatalysts, making the reaction system simpler, the cost more controllable, and the post-processing more convenient.

This invention relates to a method for preparing deuterated compounds, using peroxides (such as D₂O₂) as the key deuterium source, which provides the deuterium atoms required for the reaction. When the peroxide comes into contact with the target compound and under the action of a selected catalyst, the energy of ultraviolet light can excite the reaction system, causing the OD bonds in the peroxide to break and releasing active deuterium atoms. These active deuterium atoms can then exchange with hydrogen atoms in the target compound, completing a hydrogen-deuterium substitution. The advantage of this method is that it can be operated under relatively mild conditions—that is, without the need for extreme temperature or pressure conditions—while still achieving high deuteration rates and yields. This means that this method may be more economically feasible on an industrial scale, reducing energy consumption and the generation of byproducts.

The application provides a preparation method of an electrocatalytic SCF-substituted dihydrofuran compound, and belongs to the technical field of compound preparation. The application uses diazonium and ethylene compounds as substrates, uses an SCF source as a sulfur-containing and fluorine-containing fragment donor, realizes a one-pot cascade reaction of ring formation through electrolysis, and thus constructs the SCF-substituted dihydrofuran compound. The raw material of the application has a wide source, uses electric current as a reaction driving force, avoids or reduces the use of additional photosensitizers and chemical oxidation-reduction reagents, and has the one-pot cascade characteristics of ring C-N bond breaking, C-O bond construction, trifluoromethylation and ring formation and the like, so that the step economy can be improved.

This invention belongs to the field of industrial catalysis and bioenergy conversion technology, and relates to a method for selectively cleaving C-C bonds in lignin to prepare alkanes using a Ni-Co spinel catalyst and its applications. The method of selectively cleaving C-C bonds in lignin using a Ni-Co spinel catalyst can achieve efficient C-C bond cleavage under mild conditions (250~290°C, 2-4 MPa) and a hydrogen atmosphere, without the need for excessively high temperatures and pressures. It exhibits good cleavage activity for various C-C bond types in lignin (such as α-1, 5-5′, β-1, β-β′, etc.), showing broad substrate applicability. When used to prepare cycloalkanes from o-benzylphenol, the catalytic conversion rate can reach over 99%, and the cycloalkane yield can reach over 70%. The cycloalkane yield from the catalytic cleavage of real lignin ranges from 7% to 25%. The method of this invention does not require the use of precious metals and has low cost.

The present application relates to the technical field of stereoselective monofluoroolefination of indolines at C7 position, in particular to a method for stereoselective C-H bond monofluoroolefination of indolines at C7 position catalyzed by ruthenium, comprising the following steps: under the action of a ruthenium catalyst and a base, carrying out C-H bond monofluoroolefination reaction of indolines represented by formula (I) with gem-difluoroalkenes represented by formula (II) or 3-(2,2-difluorovinyl)thiophene or 4-(2,2-difluorovinyl)benzo[d][1,3]dioxole to prepare compounds represented by formula (III). The present application uses inexpensive ruthenium catalyst, and through C-H bond activation / C-F bond cleavage, a series of Z-type alpha-monofluoroolefination pyridine indolines are obtained, and the method has strong site and stereoselectivity, is efficient and low in cost. In addition, the target compounds obtained by synthesis have certain antibacterial activity, and can provide a basis for the development of such lead compounds.