92results about "Organic halogenation" patented technology

To provide a fluorinating agent that can be produced using a simple method, and a fluorination method that uses a fluorinating agent that can be produced using a simple method.SOLUTION: The present disclosure provides a fluorinating agent that comprises a fluorine-containing compound and fluoride ions.SELECTED DRAWING: None

Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off-target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a novel method for synthesizing trifluoromethyl heteroaromatic hydrocarbon. The invention provides a novel method for synthesizing a trifluoromethyl heteroaromatic compound, the reaction system is mild, the substrate application range is wide, and the functional group compatibility is good. Specifically, in a rotating magnetic field, a metal conductor cuts magnetic induction lines to generate electron transfer, so that trifluoromethyl sulfosalt is reduced to generate trifluoromethyl free radicals, and the trifluoromethyl free radicals react with heteroaromatic hydrocarbon to synthesize trifluoromethyl heteroaromatic hydrocarbon. The method for synthesizing the trifluoromethyl heteroaromatic hydrocarbon comprises the following steps that firstly, heteroaromatic hydrocarbon, trifluoromethyl sulfosalt, a solvent and a metal rod are placed in a reaction tube and react in a multi-energy field coupling device, the magnetic field intensity (B) is set to be 0.01-3.00 T, the rotation frequency is set to be 5-50 Hz, the reaction time is set to be 1-24 h, finally, the trifluoromethyl heteroaromatic hydrocarbon is prepared, and the general formula of the trifluoromethyl heteroaromatic hydrocarbon is shown in the specification.

To provide a new method for producing a fluorinated organic compound in which removal or separation of an auxiliary is easy and which is advantageous in production cost.SOLUTION: A compound represented by the following formula (1): wherein R1, R2 and n are as defined in the description. The method comprises reacting the compound represented by the formula (1) with (A) at least one fluorine source selected from hydrogen fluoride, a hydrogen fluoride salt and a fluoride salt, (B) at least one iodine source selected from iodine and ammonium iodide, and (C) a compound having at least one fluorinated quaternary nitrogen atom in the molecule. A step of difluorinating the compound represented by the formula (1), wherein the amount of the iodine source (B) used is less than 1.0 mol per 1 mol of the compound represented by the formula (1).SELECTED DRAWING: None

The invention discloses a COF-based heterogeneous iodobenzene catalyst and its preparation method and application, belonging to the field of catalyst preparation technology. The COF-based heterogeneous iodobenzene catalyst is obtained by polymerizing a hydrazide monomer containing an iodophenyl group unit and 1,3,5-tris(4-formylphenyl)triazine; the structural formula of the hydrazide monomer containing an iodophenyl group unit is: The COF-based heterogeneous iodobenzene catalyst can be used as a catalyst for the chlorination reaction of anisole, catalyzing the chlorination reaction of anisole, achieving heterogeneous catalysis, and using a small amount, easy to recover, improving the utilization rate of the catalyst, and reducing the cost of anisole chlorination.

The invention discloses a method for efficiently synthesizing aryl halide through biomimetic catalysis aerobic oxidation halogenation, and belongs to the technical field of organic synthesis. The method is characterized in that under the condition of oxygen or air in the presence of a simple catalyst (alurea) and a cheap reducing agent (ascorbic acid), (hetero) aromatic hydrocarbon (I) and halide salt (II) react to efficiently and specifically obtain halogenated aromatic hydrocarbon (III). Aromatic halide is an important organic synthesis element and a drug molecule building block, but according to the biomimetic catalysis oxidation halogenation method, various brominated, iodinated and chlorinated products can be generated with high yield and high selectivity by utilizing cheap and green halide salt under mild conditions; and the reaction has the advantages of green and cheap reagents, mild conditions, simple operation, easy amplification, wide substrate range, good functional group tolerance, compatibility with unpurified primary raw materials and suitability for precise later modification of complex active molecules, and shows good economic practicability and industrial application prospects.

Provided is a method for efficiently producing a fluorinated alkyl compound by directly converting an aliphatic alkylamine widely existing in nature into a fluorine substituent, the method being characterized in that an alkylamine compound in which at least one amino group is bonded to an alkyl carbon is reacted with a deamination-fluorination agent to produce the fluorinated alkyl compound.

Minimum-boiling, heterogeneous azeotropic and azeotrope-like compositions including 1,1,2,2,3-pentachloropropane (HCC-240aa) and hydrogen fluoride (HF), as well as methods for using these azeotropic or azeotrope-like compositions in the production of trifluorochloropropenes.

Disclosed is a method for producing a fluorine-containing ester compound, the method comprising fluorination of an ester compound having at least one atom that can be fluorinated in a liquid that contains the ester compound, wherein: the liquid additionally contains at least one compound that is selected from the group consisting of a compound having a hydroxyl group, a compound having a carboxy group and sodium fluoride; and relative to 100 parts by mass of the ester compound, the content of the compound having a hydroxyl group is 0.5 part by mass or less, the content of the compound having a carboxy group is 2.0 parts by mass or less and the content of the sodium fluoride is 2.0 parts by mass or less.

The present invention provides a method for producing a fluorine-containing compound by introducing a fluorine atom into a wide variety of oxygen-containing compounds having a ketone group, an aldehyde group, a hydroxy group, or the like using SF5− stabilized by forming a salt with a glyme-coordinated alkali metal ion as a deoxofluorinating agent under relatively mild conditions.The present invention pertains to a method for producing a fluorine-containing compound, the method in which a fluorine-containing compound is produced by the deoxofluorination of an oxygen-containing compound having an aldehyde group, a ketone group, a carboxy group, or a hydroxy group in one or more solvents selected from the group consisting of DMPU, G4, DMA, HMPA, and MeCN using a deoxofluorinating agent represented by a general formula (E1) [in the formula, M represents Cs+, K+, or Rb+; G4 represents a tetraethylene glycol dimethyl ether; and n represents an integer of 1 to 4].

Provided are a fluorinating agent that can be produced using a simple method, and a fluorination method that uses a fluorinating agent that can be produced using a simple method. The present disclosure provides a fluorinating agent that comprises a fluorine-containing compound and fluoride ions.

This invention discloses a method for preparing fluorophenylethane compounds, belonging to the field of organic chemical synthesis technology. The preparation method includes the following steps: mixing a photocatalyst 4CzIPN, a solvent DCE, a reducing agent DIPEA, and a reaction substrate, reacting them under blue light irradiation in a sulfur hexafluoride gas atmosphere; the reaction substrate is a compound with the structural formula [insert structural formula here], where R is H, an alkoxy group, or a cyano group. Beneficial effects: This invention uses sulfur hexafluoride as the fluorinating agent, selects a certain ratio of raw materials and catalyst, and efficiently prepares fluorophenylethane compounds. The reaction raw materials are inexpensive, the preparation process is safe and mild, has good substrate compatibility, and improves preparation efficiency.

A first object of the present invention is to provide an amino acid compound having the α-position fluorinated by fluorinating the α-position with high yields. A second object of the present invention is to provide an amino acid compound having the α-position fluorinated by fluorinating the α-position with high enantioselectivity. Provided are amino acids having fluorine at the α-position and their derivatives.

The application discloses a method for constructing fluorine-containing compounds by decarboxylation of alkyl carboxylic acid catalyzed by ketone compounds. The method uses alkyl carboxylic acid with a structure as shown in formula as a reaction raw material, and performs reaction under the joint action of ketone compounds, fluorine-containing reagents and alkali to obtain fluorides shown in formula (1) and formula (2), wherein R 1 are respectively and independently selected from hydrogen, a heterocyclic ring, substituted or unsubstituted aryl, and substituted or unsubstituted hydrocarbyl; R 2 are respectively and independently selected from hydrogen, a heterocyclic ring, substituted or unsubstituted aryl, and substituted or unsubstituted hydrocarbyl; R 3 are respectively and independently selected from hydrogen, a heterocyclic ring, substituted or unsubstituted aryl, and substituted or unsubstituted hydrocarbyl. The reaction method has the advantages of low cost, mild conditions, high reaction efficiency, high yield and high selectivity, and the like. The ketone compounds are used to replace traditional metal catalysts, which can not only provide a fluorine-containing compound library with various structures for candidate drug screening, but also can be applied to positron emission tomography imaging.

The invention relates to a compound of general formula (I), wherein A is selected from the group consisting of (II) and a six-membered aromatic ring, which optionally contains a heteroatom selected from the group consisting of N, S, or O; n is 0, 1, 2, or 3; m is 1 or 2; Y is an ethyl or propyl group.

A method for producing a fluorine-containing ester compound, which comprises fluorinating an ester compound having at least one fluorinated atom in a liquid containing the ester compound, the liquid further containing at least one compound selected from the group consisting of a compound having a hydroxyl group, a compound having a carboxyl group, and sodium fluoride, the content of the compound having a hydroxyl group is 0.5 parts by mass or less, the content of the compound having a carboxyl group is 2.0 parts by mass or less, and the content of the sodium fluoride is 2.0 parts by mass or less with respect to 100 parts by mass of the ester compound.

A method for producing a fluorine-containing compound, in which a fluorine-containing compound is obtained by fluorinating an organic compound in a liquid containing the organic compound having at least one fluorine-containing atom, said fluorine-containing compound being a fluoride having an average number of the fluorine-containing atoms per molecule of 0.01 or more.

A method for functionalization of an aromatic amino acid or a nucleobase with a fluoroalkyl-containing moiety RF, wherein the aromatic amino acid is reacted in the presence of at least one reductant with at least one hypervalent iodine fluoroalkyl reagent carrying the fluoroalkyl-containing moiety RF is disclosed. Novel hypervalent iodine fluoroalkyl reagents is also disclosed.

The invention provides an azeotropic or near-azeotropic composition consisting essentially of chloromethane (R-40) and hydrogen fluoride (HF).

The present invention belongs to the field of novel photocatalytic materials, and particularly relates to a photocatalyst for the efficient catalytic synthesis of halogenated aromatic hydrocarbons, as well as a preparation method and application thereof. The photocatalyst prepared by the present invention comprises titanium dioxide and a 1,4-dihydropyridine compound supported on the surface of the titanium dioxide; wherein the mass ratio of the 1,4-dihydropyridine compound to the titanium dioxide is 1:1 to 100; the present invention generates halogenated aromatic hydrocarbons by inducing a photocatalytic reaction using a visible light source. The scheme used is green, safe, and has high atomic utilization efficiency, avoids the use of toxic solvents, reduces energy consumption by reacting at room temperature, and the catalyst can be recycled and reused multiple times, reducing costs.

This method for producing fluorine-containing compounds comprises introducing, in a reactor having an inner surface inert to fluorine gas, a gas containing fluorine gas into a composition containing an organic compound having at least one atom capable of being fluorinated, and thereby fluorinating the organic compound.

The present invention refers to a process for the functionalization such as a deaminative halogenation of an aromatic or heteroaromatic amino compound. With the inventive process, the in-situ nitrate reduction allows the direct ipso-halogenation of anilines and aminoheterocycles via an aryldiazonium or heteroaryl diazonium salt as a fleeting intermediate in solution.

The present invention relates to the technical field of fine chemical engineering, and discloses a method for preparing 2,2-dibromoacetophenone by C-S bond cleavage. The specific steps are as follows: Using 1-phenylethyl methyl sulfide as the reaction raw material, dichlorodimethylhydantoin and water as important additives, heating and reacting in an organic solvent to obtain the target product 2,2-dibromoacetophenone. This method has the advantages of simple operation, avoiding the use of additional catalysts and the use of highly toxic and corrosive liquid bromine, and has potential application value.

The present invention relates to process for halogenation of aromatic and / or heteroaromatic compounds with polymers derived from dihalogenated monomers or plastic waste products thereof as halide source under additive-free electrochemical conditions working in an undivided cell to produce halogenated aromatic and / or heteroaromatic compounds and / or dehalogenated polymers in a batch mode and / or a continuous flow mode. Further, present invention provides a process for the preparation of value-added products from the dehalogenated polymers by deconstructing and / or depolymerizing via cross-metathesis and other reactions.

Provided is a method for producing a fluorinated organic compound by fluorinating an organic compound in the presence of a fluorinating composition comprising IF5, iodine, and an amine, the composition comprising the iodine in an amount of 0.12 mol or less per mole of the IF5. This production method can synthesize a fluorinated organic compound with high efficiency.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

To provide a fluorinating agent that can be produced using a simple method, and a fluorination method that uses a fluorinating agent that can be produced using a simple method.SOLUTION: The present disclosure provides a fluorinating agent that comprises a fluorine-containing compound and fluoride ions.SELECTED DRAWING: None

A novel method for producing a fluorinated organic compound is provided. The method for producing a fluorinated organic compound comprises a step in which a compound represented by formula (1) (wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, or an organic group or may have formed a ring in cooperation with two carbon atoms adjacent thereto, n is 1 or 2, and the two R1 moieties may be the same or different and the two R2 moieties may be the same or different or the two R1 moieties or the two R2 moieties may have formed a ring in cooperation with carbon atom adjacent thereto) is reacted with (A) at least one fluorine source selected from the group consisting of hydrogen fluoride, hydrogen fluoride salts, and fluoride salts and (B) a source of a halogen other than fluorine which is represented by the formula R3(OX)m (wherein R3 is a hydrogen atom, a cation, or an organic group, X is a halogen atom which is not a fluorine atom, and m is an integer corresponding to the valence of R3), thereby causing both a fluorine atom and a non-fluorine halogen atom to be added to the double bond or triple bond.

The present disclosure relates to processes for the fluorination of molecules. One aspect provides a process for incorporating a fluorine atom into a molecule, said process comprising converting a compound of formula X—SG into a compound of formula X—F, wherein G is an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group, and X is an organic group; and wherein the SG group is attached to a secondary or tertiary carbon atom in the organic group X; said process comprising treating said compound of formula X—SG with (i) an activator compound selected from the group consisting of N-halosuccinimides, N-halobenzenesulfonimides, N-halobenzenesulfonamides, dialkylaminodihalosulfinium salts, heterocyclylaminodihalosulfinium salts, dialkylaminosulfur trihalides, XeF2, difluoroiodotoluene, di-and tri-bromoisocyanuric acids, bromine, chlorine, hypervalent iodine compounds with I2; and other sources of Br+, Cl+, F+, l+, bromonium, iodonium, or chloronium; and (ii) a source of fluoride. Uses of the process in the preparation of various fluorinated molecules as well as uses of certain compounds as intermediates in the processes of the present disclosure are also provided.

A method for producing a fluorine-containing ester compound, which comprises fluorinating an ester compound having at least one fluorinated atom or bond in an organic solvent into which fluorine gas is introduced, the organic solvent containing a compound having a C-H bond, the amount of the compound having a C-H bond is at least 0.1 times the mass of the ester compound having at least one fluorinated atom or bond.